Mechanism of action of mRNA-based vaccines

Direct Gene Transfer into Mouse Muscle in Vivo

Wolff, J. A., Malone, R. W., Williams, P., Chong, W., Acsadi, G., Jani, A., & Felgner, P. L. (1990) · Science · doi:10.1126/science.1690918 · Cited by 4,173 · cited 2× · see citing works

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947 · see citing works

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444 · see citing works

Non-viral vectors for gene-based therapy

Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123 · see citing works

Interferon-stimulated genes: A complex web of host defenses

Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067 · see citing works

Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728 · see citing works

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474 · see citing works

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

Ulmer, J. B., Donnelly, J., Parker, S. E., Rhodes, G. H., Felgner, P. L., Dwarki, V., Gromkowski, S. H., Deck, R. R., DeWitt, C. M., Friedman, A., et al. (1993) · Science · doi:10.1126/science.8456302 · Cited by 2,318 · see citing works

Control of adaptive immunity by the innate immune system

Iwasaki, A., & Medzhitov, R. (2015) · Nature Immunology · doi:10.1038/ni.3123 · Cited by 2,160 · cited 1× · see citing works

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

Karikó, K., Muramatsu, H., Welsh, F. A., Ludwig, J., Kato, H., Akira, S., & Weissman, D. (2008) · Molecular Therapy · doi:10.1038/mt.2008.200 · Cited by 1,930 · see citing works

Chloroquine is a potent inhibitor of SARS coronavirus infection and spread

Vincent, M. J., Bergeron, É., Benjannet, S., Erickson, B. R., Rollin, P. E., Ksiazek, T. G., Seidah, N. G., & Nichol, S. T. (2005) · Virology Journal · doi:10.1186/1743-422x-2-69 · Cited by 1,813 · see citing works

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Kranz, L. M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K. C., Meng, M., Fritz, D., Vascotto, F., Hefesha, H., et al. (2016) · Nature · doi:10.1038/nature18300 · Cited by 1,771 · see citing works

Genetic immunization is a simple method for eliciting an immune response

Tang, D.-C. C., DeVit, M. J., & Johnston, S. A. (1992) · Nature · doi:10.1038/356152a0 · Cited by 1,504 · see citing works

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

Boczkowski, D., Nair, S. K., Snyder, D., & Gilboa, E. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.2.465 · Cited by 915 · see citing works

Modified mRNA vaccines protect against zika virus infection

Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.02.017 · Cited by 909 · see citing works

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

Pardi, N., Hogan, M. J., Pelc, R. S., Muramatsu, H., Andersen, H., DeMaso, C. R., Dowd, K. A., Sutherland, L. L., Scearce, R. M., Parks, R., et al. (2017) · Nature · doi:10.1038/nature21428 · Cited by 884 · see citing works

Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells

Bedoui, S., Whitney, P. G., Waithman, J. C., Eidsmo, L., Wakim, L. M., Caminschi, I., Allan, R. S., Wojtasiak, M., Shortman, K., Carbone, F., et al. (2009) · Nature Immunology · doi:10.1038/ni.1724 · Cited by 707 · see citing works

Nonviral delivery of self-amplifying RNA vaccines

Geall, A. J., Verma, A., Otten, G. R., Shaw, C. A., Hekele, A., Banerjee, K., Cu, Y., Beard, C. W., Brito, L. A., Krucker, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209367109 · Cited by 675 · cited 1× · see citing works

Influenza Virus Aerosols in Human Exhaled Breath: Particle Size, Culturability, and Effect of Surgical Masks

Milton, D. K., Fabian, M. P., Cowling, B. J., Grantham, M. L., & McDevitt, J. J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003205 · Cited by 669 · see citing works

Preclinical and clinical demonstration of immunogenicity by mRNA vaccines against H10N8 and H7N9 influenza viruses

Bahl, K., Senn, J. J., Yuzhakov, O., Bulychev, A., Brito, L. A., Hassett, K. J., Laska, M. E., Smith, M., Almarsson, Ö., Thompson, J., et al. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.03.035 · Cited by 642 · see citing works

Developing mRNA-vaccine technologies

Schlake, T., Thess, A., Fotin-Mleczek, M., & Kallen, K.-J. (2012) · RNA Biology · doi:10.4161/rna.22269 · Cited by 622 · see citing works

Impact of Influenza Vaccination on Seasonal Mortality in the US Elderly Population

Simonsen, L., Reichert, T. A., Viboud, C. G., Blackwelder, W. C., Taylor, R. J., & Miller, M. A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.3.265 · Cited by 541 · see citing works

Immunopathogenesis of coronavirus infections: implications for SARS

Dandekar, A. A., & Perlman, S. M. (2005) · Nature reviews. Immunology · doi:10.1038/nri1732 · Cited by 499 · see citing works

Induction of virus‐specific cytotoxic T lymphocytes <i>in vivo</i> by liposome‐entrapped mRNA

Martinon, F., Krishnan, S., Lenzen, G., Magné, R., Gomard, E., Guillet, J., Lévy, J., & Meulien, P. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230749 · Cited by 473 · see citing works

A cluster randomised trial of cloth masks compared with medical masks in healthcare workers

MacIntyre, C. R., Seale, H., Dung, T. C., Hien, N. T., Nga, P. T., Chughtai, A. A., Rahman, B., Dwyer, D. E., & Wang, Q. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-006577 · Cited by 471 · see citing works

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

Petsch, B., Schnee, M., Vogel, A. B., Lange, E., Hoffmann, B., Voss, D., Schlake, T., Thess, A., Kallen, K.-J., Stitz, L., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2436 · Cited by 461 · see citing works

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and <i>Toxoplasma gondii</i> challenges with a single dose

Chahal, J. S., Khan, O. F., Cooper, C. L., McPartlan, J. S., Tsosie, J. K., Tilley, L. D., Sidik, S. M., Lourido, S., Langer, R., Bavari, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600299113 · Cited by 414 · see citing works

TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages

Sarén, P., Welgus, H. G., & Kovanen, P. T. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.9.4159 · Cited by 407 · see citing works

Engineering Nano‐ and Microparticles to Tune Immunity

Moon, J. J., Huang, B., & Irvine, D. J. (2012) · Advanced Materials · doi:10.1002/adma.201200446 · Cited by 402 · see citing works

Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN

van Gisbergen, K. P. J. M., Sánchez‐Hernández, M., Geijtenbeek, T. B. H., & van Kooyk, Y. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041276 · Cited by 401 · see citing works

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

Weide, B., Pascolo, S., Scheel, B., Derhovanessian, E., Pflugfelder, A., Eigentler, T. K., Pawelec, G., Hoerr, I., Rammensee, H.-G., & Garbe, C. (2009) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181a00068 · Cited by 378 · see citing works

Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial

Senti, G., Prinz Vavricka, B. M., Erdmann, I., Diaz, M. I., Markus, R., McCormack, S. J., Simard, J. J., Wüthrich, B., Crameri, R., Graf, N., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803725105 · Cited by 364 · see citing works

Post-transcriptional regulation of gene expression in innate immunity

Carpenter, S. B., Ricci, E. P., Mercier, B. C., Moore, M. J., & Fitzgerald, K. A. (2014) · Nature reviews. Immunology · doi:10.1038/nri3682 · Cited by 361 · see citing works

Immunization with Modified Vaccinia Virus Ankara-Based Recombinant Vaccine against Severe Acute Respiratory Syndrome Is Associated with Enhanced Hepatitis in Ferrets

Weingartl, H. M., Czub, M., Czub, S., Neufeld, J., Marszal, P., Gren, J., Smith, G. A., Jones, S. E., Proulx, R., Deschambault, Y., et al. (2004) · Journal of Virology · doi:10.1128/jvi.78.22.12672-12676.2004 · Cited by 344 · see citing works

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

Brito, L. A., Chan, M., Shaw, C. A., Hekele, A., Carsillo, T., Schaefer, M., Archer, J., Seubert, A., Otten, G. R., Beard, C. W., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.133 · Cited by 338 · see citing works

Messenger RNA-based Vaccines With Dual Activity Induce Balanced TLR-7 Dependent Adaptive Immune Responses and Provide Antitumor Activity

Fotin-Mleczek, M., Duchardt, K. M., Lorenz, C., Pfeiffer, R., Ojkić-Zrna, S., Probst, J., & Kallen, K.-J. (2011) · Journal of Immunotherapy · doi:10.1097/cji.0b013e3181f7dbe8 · Cited by 335 · cited 1× · see citing works

Effectiveness of N95 respirators versus surgical masks in protecting health care workers from acute respiratory infection: a systematic review and meta-analysis

Smith, J. D., MacDougall, C. C., Johnstone, J., Copes, R. A., Schwartz, B., & Garber, G. E. (2016) · Canadian Medical Association Journal · doi:10.1503/cmaj.150835 · Cited by 328 · see citing works

Antibody-Dependent Enhancement of Virus Infection and Disease

Cancel-Tirado, S. M., & Yoon, K. J. (2003) · Viral Immunology · doi:10.1089/088282403763635465 · Cited by 316 · see citing works

Intranodal Vaccination with Naked Antigen-Encoding RNA Elicits Potent Prophylactic and Therapeutic Antitumoral Immunity

Kreiter, S., Selmi, A., Diken, M., Koslowski, M., Britten, C. M., Huber, C., Türeci, Ö., & Sahin, U. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0699 · Cited by 309 · see citing works

Survival of airborne influenza virus: Effects of propagating host, relative humidity, and composition of spray fluids

Schaffer, F. L., Soergel, M. E., & Straube, D. C. (1976) · Archives of Virology · doi:10.1007/bf01317930 · Cited by 302 · see citing works

Effectiveness of masks and respirators against respiratory infections in healthcare workers: a systematic review and meta-analysis

Offeddu, V., Yung, C. F., Low, M. S. F., & Tam, C. C. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix681 · Cited by 297 · see citing works

An initial investigation of the association between the SARS outbreak and weather: with the view of the environmental temperature and its variation

Tan, J., Mu, L., Huang, J., Yu, S., Chen, B., & Yin, J. (2005) · Journal of Epidemiology & Community Health · doi:10.1136/jech.2004.020180 · Cited by 288 · see citing works

<i>In Vitro</i> and <i>in Vivo</i> mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

Su, X., Fricke, J., Kavanagh, D. G., & Irvine, D. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100390w · Cited by 287 · see citing works

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

Kübler, H., Scheel, B., Gnad-Vogt, U., Miller, K., Schultze-Seemann, W., vom Dorp, F., Parmiani, G., Hampel, C., Wedel, S., Trojan, L., et al. (2015) · Journal for Immunotherapy of Cancer · doi:10.1186/s40425-015-0068-y · Cited by 287 · see citing works

Face masks to prevent transmission of influenza virus: a systematic review

Cowling, B. J., Zhou, Y., Ip, D., Leung, G. M., & Aiello, A. E. (2010) · Epidemiology and Infection · doi:10.1017/s0950268809991658 · Cited by 285 · see citing works

Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles

Kanasty, R. L., Whitehead, K. A., Vegas, A. J., & Anderson, D. G. (2012) · Molecular Therapy · doi:10.1038/mt.2011.294 · Cited by 281 · see citing works

Early death after feline infectious peritonitis virus challenge due to recombinant vaccinia virus immunization

Vennema, H., de Groot, R. J., Harbour, D. A., Dalderup, M. J. M., Gruffydd-Jones, T., Horzinek, M. C., & Spaan, W. J. M. (1990) · Journal of Virology · doi:10.1128/jvi.64.3.1407-1409.1990 · Cited by 276 · see citing works

TLR signaling in B-cell development and activation

Hua, Z., & Hou, B. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.61 · Cited by 267 · see citing works

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

Weide, B., Carralot, J.-P., Reese, A., Scheel, B., Eigentler, T. K., Hoerr, I., Rammensee, H.-G., Garbe, C., & Pascolo, S. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31815ce501 · Cited by 261 · see citing works

Blocking Monoclonal Antibodies Specific for Mouse IFN- α / β Receptor Subunit 1 (IFNAR-1) from Mice Immunized by In Vivo Hydrodynamic Transfection

Sheehan, K. C. F., Lai, K. S., Dunn, G. P., Bruce, A. T., Diamond, M. S., Heutel, J. D., Dungo-Arthur, C., Carrero, J. A., White, J. M., Hertzog, P. J., et al. (2006) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2006.26.804 · Cited by 260 · see citing works

Toll‐like receptors – sentries in the B‐cell response

Bekeredjian-Ding, I., & Jego, G. (2009) · Immunology · doi:10.1111/j.1365-2567.2009.03173.x · Cited by 249 · see citing works

Type I IFN counteracts the induction of antigen-specific immune responses by lipid-based delivery of mRNA vaccines

Pollard, C., Rejman, J., De Haes, W., Verrier, B., Van Gulck, E., Naessens, T., De Smedt, S., Bogaert, P., Grooten, J., Vanham, G., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.202 · Cited by 248 · see citing works

Minimum Infective Dose of the Major Human Respiratory and Enteric Viruses Transmitted Through Food and the Environment

Yezli, S., & Otter, J. A. (2011) · Food and Environmental Virology · doi:10.1007/s12560-011-9056-7 · Cited by 241 · see citing works

mRNA transcript therapy

Weissman, D. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2015.973859 · Cited by 228 · see citing works

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

Rittig, S. M., Haentschel, M., Weimer, K. J., Heine, A., Muller, M. R., Brugger, W., Horger, M. S., Maksimovic, O., Stenzl, A., Hoerr, I., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2010.289 · Cited by 226 · see citing works

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

Kuhn, A. N., Diken, M., Kreiter, S., Selmi, A., Kowalska, J., Jemielity, J., Darzynkiewicz, E., Huber, C., Türeci, Ö., & Sahin, U. (2010) · Gene Therapy · doi:10.1038/gt.2010.52 · Cited by 226 · see citing works

A novel, disruptive vaccination technology: Self-adjuvanted RNActive ^® vaccines

Kallen, K.-J., Heidenreich, R., Schnee, M., Petsch, B., Schlake, T., Thess, A., Baumhof, P., Scheel, B., Koch, S. D., & Fotin-Mleczek, M. (2013) · Human Vaccines &amp; Immunotherapeutics · doi:10.4161/hv.25181 · Cited by 223 · see citing works

Cationic lipids activate intracellular signaling pathways

Lonez, C., Vandenbranden, M., & Ruysschaert, J.-M. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.05.009 · Cited by 221 · see citing works

Modified mRNA Vaccines Protect against Zika Virus Infection

Richner, J. M., Himansu, S., Dowd, K. A., Butler, S. L., Salazar, V., Fox, J. M., Julander, J. G., Tang, W. W., Shresta, S., Pierson, T. C., et al. (2017) · Cell · doi:10.1016/j.cell.2017.03.016 · Cited by 221 · see citing works

Randomized, double-blind, Phase 1 trial of an alphavirus replicon vaccine for cytomegalovirus in CMV seronegative adult volunteers

Bernstein, D. I., Reap, E. A., Katen, K., Watson, A., Smith, K., Norberg, P., Olmsted, R. A., Hoeper, A., Morris, J., Negri, S., et al. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.09.135 · Cited by 212 · see citing works

An mRNA Vaccine Encoding Rabies Virus Glycoprotein Induces Protection against Lethal Infection in Mice and Correlates of Protection in Adult and Newborn Pigs

Schnee, M., Vogel, A. B., Voss, D., Petsch, B., Baumhof, P., Kramps, T., & Stitz, L. (2016) · PLOS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0004746 · Cited by 212 · cited 2× · see citing works

Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent

Probst, J., Weide, B., Scheel, B., Pichler, B. J., Hoerr, I., Rammensee, H.-G., & Pascolo, S. (2007) · Gene Therapy · doi:10.1038/sj.gt.3302964 · Cited by 206 · see citing works

Selective uptake of naked vaccine RNA by dendritic cells is driven by macropinocytosis and abrogated upon DC maturation

Diken, M., Kreiter, S., Selmi, A., Britten, C. M., Huber, C. G., Türeci, Ö., & Şahin, U. (2011) · Gene Therapy · doi:10.1038/gt.2011.17 · Cited by 192 · see citing works

Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

Edwards, D. K., Jasny, E., Yoon, H., Horscroft, N., Schanen, B., Geter, T., Fotin-Mleczek, M., Petsch, B., & Wittman, V. (2017) · Journal of Translational Medicine · doi:10.1186/s12967-016-1111-6 · Cited by 186 · see citing works

Enhancing the T-cell Stimulatory Capacity of Human Dendritic Cells by Co-electroporation With CD40L, CD70 and Constitutively Active TLR4 Encoding mRNA

Bonehill, A., Tuyaerts, S., Nuffel, A. M. T. V., Heirman, C., Bos, T. J., Fostier, K., Neyns, B., & Thielemans, K. (2008) · Molecular Therapy · doi:10.1038/mt.2008.77 · Cited by 185 · see citing works

Potent Immune Responses in Rhesus Macaques Induced by Nonviral Delivery of a Self-amplifying RNA Vaccine Expressing HIV Type 1 Envelope With a Cationic Nanoemulsion

Bogers, W. M., Oostermeijer, H., Mooij, P., Koopman, G., Verschoor, E. J., Davis, D., Ulmer, J. B., Brito, L. A., Cu, Y., Banerjee, K., et al. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu522 · Cited by 181 · see citing works

A Viral RNA Structural Element Alters Host Recognition of Nonself RNA

Hyde, J., Gardner, C. L., Kimura, T., White, J. P., Gai, L., Trobaugh, D. W., Huang, C., Tonelli, M., Paessler, S., Takeda, K., et al. (2014) · Science · doi:10.1126/science.1248465 · Cited by 179 · see citing works

Infectious Cell Entry Mechanism of Influenza Virus

Yoshimura, A., Kuroda, K., Kawasaki, K., Yamashina, S., Maeda, T., & Ohnishi, S. (1982) · Journal of Virology · doi:10.1128/jvi.43.1.284-293.1982 · Cited by 164 · see citing works

Recent Developments in Nucleic Acid Delivery with Polyethylenimines

Neuberg, P., & Kichler, A. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800148-6.00009-2 · Cited by 163 · see citing works

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes

Mockey, M., Bourseau, E., Voshavar, C., Chaudhuri, A., Lafosse, S., Cam, É. L., Quesniaux, V. F. J., Ryffel, B., Pichon, C., & Midoux, P. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701072 · Cited by 161 · see citing works

Alphavirus Infection: Host Cell Shut-Off and Inhibition of Antiviral Responses

Fros, J. J., & Pijlman, G. P. (2016) · Viruses · doi:10.3390/v8060166 · Cited by 158 · see citing works

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

Brazzoli, M., Magini, D., Bonci, A., Buccato, S., Giovani, C., Kratzer, R., Zurli, V., Mangiavacchi, S., Casini, D., Brito, L. M., et al. (2016) · Journal of Virology · doi:10.1128/jvi.01786-15 · Cited by 154 · see citing works

Protein expression from exogenous mRNA: Uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway

Lorenz, C., Fotin‐Mleczek, M., Roth, G. D., Becker, C., Dam, T. C., Verdurmen, W. P. R., Brock, R. E., Probst, J., & Schlake, T. (2011) · RNA Biology · doi:10.4161/rna.8.4.15394 · Cited by 152 · see citing works

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer

Sebastian, M., Papachristofilou, A., Weiß, C., Früh, M., Cathomas, R. L., Hilbe, W., Wehler, T., Rippin, G., Koch, S. D., Scheel, B., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-748 · Cited by 142 · see citing works

Immunostimulating capacities of stabilized RNA molecules

Scheel, B., Braedel, S., Probst, J., Carralot, J., Wagner, H., Schild, H., Jung, G., Rammensee, H., & Pascolo, S. (2004) · European Journal of Immunology · doi:10.1002/eji.200324198 · Cited by 138 · see citing works

Self-replicating alphavirus RNA vaccines

Ljungberg, K., & Liljeström, P. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2015.965690 · Cited by 137 · see citing works

Challenges and advances towards the rational design of mRNA vaccines

Pollard, C., Koker, S. D., Saelens, X., Vanham, G. L., & Grooten, J. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.09.002 · Cited by 134 · see citing works

Staufen1 senses overall transcript secondary structure to regulate translation

Ricci, E. P., Küçükural, A., Cenik, C., Mercier, B. C., Singh, G., Heyer, E. E., Ashar-Patel, A., Peng, L., & Moore, M. J. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2739 · Cited by 130 · see citing works

Epidemiological and clinical features of human coronavirus infections among different subsets of patients

Cabeça, T. K., Granato, C. F. H., & Bellei, N. (2013) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.12101 · Cited by 130 · see citing works

Intratumoral Delivery of TriMix mRNA Results in T-cell Activation by Cross-Presenting Dendritic Cells

Lint, S. V., Renmans, D., Broos, K., Goethals, L., Maenhout, S. K., Benteyn, D., Goyvaerts, C., Four, S. D., der Jeught, K. V., Bialkowski, L., et al. (2016) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-15-0163 · Cited by 130 · see citing works

Nucleoside modified mRNA vaccines for infectious diseases

Pardi, N., & Weissman, D. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-6481-9_6 · Cited by 129 · see citing works

Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge

Magini, D., Giovani, C., Mangiavacchi, S., Maccari, S., Cecchi, R., Ulmer, J. B., Gregorio, E. D., Geall, A. J., Brazzoli, M., & Bertholet, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161193 · Cited by 127 · see citing works

Type I interferons interfere with the capacity of mRNA lipoplex vaccines to elicit cytolytic T cell responses

De Beuckelaer, A., Pollard, C., Van Lint, S., Roose, K., Van Hoecke, L., Naessens, T., Udhayakumar, V. K., Smet, M., Sanders, N., Lienenklaus, S., et al. (2016) · Molecular Therapy · doi:10.1038/mt.2016.161 · Cited by 122 · see citing works

Particle-mediated intravenous delivery of antigen mRNA results in strong antigen-specific T-cell responses despite the induction of type I interferon

Broos, K., Van der Jeught, K., Puttemans, J., Goyvaerts, C., Heirman, C., Dewitte, H., Verbeke, R., Lentacker, I., Thielemans, K., & Breckpot, K. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2016.38 · Cited by 121 · see citing works

Intralymphatic Injections as a New Administration Route for Allergen-Specific Immunotherapy

Martínez-Gómez, J. M., Johansen, P., Erdmann, I., Senti, G., Crameri, R., & Kündig, T. M. (2009) · International Archives of Allergy and Immunology · doi:10.1159/000210381 · Cited by 117 · see citing works

Modified mRNA as an alternative to plasmid DNA (pDNA) for transcript replacement and vaccination therapy

Youn, H., & Chung, J.-K. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1057563 · Cited by 114 · see citing works

ISCOMATRIX Adjuvant Combines Immune Activation with Antigen Delivery to Dendritic Cells In Vivo Leading to Effective Cross-Priming of CD8+ T Cells

Duewell, P., Kisser, U., Heckelsmiller, K., Hoves, S., Stoitzner, P., Koernig, S., Morelli, A. B., Clausen, B. E., Dauer, M., Eigler, A., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004114 · Cited by 112 · see citing works

Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli

Jefford, M., Schnurr, M. M., Toy, T., Masterman, K., Shin, A., Beecroft, T., Tai, T. Y., Shortman, K., Shackleton, M. J., Davis, I. D., et al. (2003) · Blood · doi:10.1182/blood-2002-12-3854 · Cited by 110 · see citing works

Uses of granulocyte-macrophage colony-stimulating factor in vaccine development

Warren, T. L., & Weiner, G. J. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200005000-00007 · Cited by 110 · see citing works

Type I Interferons Modulate CD8 + T Cell Immunity to mRNA Vaccines

Beuckelaer, A. D., Grooten, J., & Koker, S. D. (2017) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2017.01.006 · Cited by 109 · see citing works

Therapeutic anti‐tumor immunity triggered by injections of immunostimulating single‐stranded RNA

Scheel, B., Aulwurm, S., Probst, J., Stitz, L., Hoerr, I., Rammensee, H., Weller, M., & Pascolo, S. (2006) · European Journal of Immunology · doi:10.1002/eji.200635910 · Cited by 108 · see citing works

The 5′ and 3′ ends of alphavirus RNAs – Non-coding is not non-functional

Hyde, J., Chen, R., Trobaugh, D. W., Diamond, M., Weaver, S. C., Klimstra, W. B., & Wilusz, J. (2015) · Virus Research · doi:10.1016/j.virusres.2015.01.016 · Cited by 105 · see citing works

Effect of pH and temperature on the infectivity of human coronavirus 229E

Lamarre, A., & Talbot, P. J. (1989) · Canadian Journal of Microbiology · doi:10.1139/m89-160 · Cited by 105 · see citing works

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect

Fotin‐Mleczek, M., Zanzinger, K., Heidenreich, R., Lorenz, C., Thess, A., Duchardt, K. M., & Kallen, K. (2012) · The Journal of Gene Medicine · doi:10.1002/jgm.2605 · Cited by 103 · see citing works

Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity

Kowalczyk, A., Doener, F., Zanzinger, K., Noth, J., Baumhof, P., Fotin-Mleczek, M., & Heidenreich, R. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.05.046 · Cited by 101 · see citing works

The enhancement of virus infectivity by antibody

Hawkes, R. A., & Lafferty, K. J. (1967) · Virology · doi:10.1016/0042-6822(67)90144-4 · Cited by 99 · see citing works

Transient Pretreatment With Glucocorticoid Ablates Innate Toxicity of Systemically Delivered Adenoviral Vectors Without Reducing Efficacy

Seregin, S. S., Appledorn, D. M., McBride, A. J., Schuldt, N. J., Aldhamen, Y. A., Voss, T. T., Wei, J.-P., Bujold, M., Nance, W., Godbehere, S., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2008.297 · Cited by 97 · see citing works

Venezuelan Equine Encephalitis Virus Disrupts STAT1 Signaling by Distinct Mechanisms Independent of Host Shutoff

Simmons, J. D., White, L., Morrison, T. E., Montgomery, S. A., Whitmore, A. C., Johnston, R. E., & Heise, M. T. (2009) · Journal of Virology · doi:10.1128/jvi.01041-09 · Cited by 95 · see citing works

The ReNAissanCe of mRNA-based cancer therapy

Van Lint, S., Renmans, D., Broos, K., Dewitte, H., Lentacker, I., Heirman, C., Breckpot, K., & Thielemans, K. (2015) · Expert Review of Vaccines · doi:10.1586/14760584.2015.957685 · Cited by 95 · see citing works

Regulation and dysregulation of 3′UTR-mediated translational control

Jia, J., Yao, P., Arif, A., & Fox, P. L. (2013) · Current Opinion in Genetics &amp; Development · doi:10.1016/j.gde.2012.12.004 · Cited by 92 · see citing works

A Cell-Based, High-Throughput Screen for Small Molecule Regulators of Hepatitis C Virus Replication

Kim, S. S., Peng, L. F., Lin, W., Choe, W. H., Sakamoto, N., Schreiber, S. L., & Chung, R. T. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.032 · Cited by 91 · see citing works

Alphavirus-Based Vaccines

Lundstrom, K. H. (2014) · Viruses · doi:10.3390/v6062392 · Cited by 91 · see citing works

Recent innovations in mRNA vaccines

Ulmer, J. B., & Geall, A. J. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.05.008 · Cited by 91 · see citing works

Uptake of synthetic naked RNA by skin-resident dendritic cells via macropinocytosis allows antigen expression and induction of T-cell responses in mice

Selmi, A., Vascotto, F., Kautz‐Neu, K., Türeci, Ö., Şahin, U., von Stebut, E., Diken, M., & Kreiter, S. (2016) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-016-1869-7 · Cited by 90 · see citing works

CD 8 T‐cell priming upon mRNA vaccination is restricted to bone‐marrow‐derived antigen‐presenting cells and may involve antigen transfer from myocytes

Lazzaro, S., Giovani, C., Mangiavacchi, S., Magini, D., Maione, D., Baudner, B. C., Geall, A. J., Gregorio, E. D., D’Oro, U., & Buonsanti, C. (2015) · Immunology · doi:10.1111/imm.12505 · Cited by 88 · see citing works

Characterization of the ribonuclease activity on the skin surface

Probst, J., Brechtel, S., Scheel, B., Hoerr, I., Jung, G., Rammensee, H.-G., & Pascolo, S. (2006) · Genetic Vaccines and Therapy · doi:10.1186/1479-0556-4-4 · Cited by 84 · see citing works

A novel RNA‐based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

Heidenreich, R., Jasny, E., Kowalczyk, A., Lutz, J., Probst, J., Baumhof, P., Scheel, B., Voss, S., Kallen, K., & Fotin‐Mleczek, M. (2014) · International Journal of Cancer · doi:10.1002/ijc.29402 · Cited by 80 · see citing works

Human cytomegalovirus gH/gL/UL128/UL130/UL131A complex elicits potently neutralizing antibodies in mice

Wen, Y., Monroe, J. E., Linton, C. E., Archer, J. F., Beard, C. W., Barnett, S. W., Palladino, G., Mason, P. W., Carfı́, A., & Lilja, A. E. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.05.004 · Cited by 80 · see citing works

Potential Therapeutic Applications of Rna Cap Analogs

Ziemniak, M., Strenkowska, M., Kowalska, J., & Jemielity, J. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.96 · Cited by 76 · see citing works

Use of surgical face masks to reduce the incidence of the common cold among health care workers in Japan: a randomized controlled trial

Jacobs, J. L., Ohde, S., Takahashi, O., Tokuda, Y., Omata, F., & Fukui, T. (2009) · American Journal of Infection Control · doi:10.1016/j.ajic.2008.11.002 · Cited by 74 · see citing works

Ribosomal binding to the internal ribosomal entry site of classical swine fever virus

KOLUPAEVA, V. G., Pestova, T. V., & Hellen, C. U. T. (2000) · RNA · doi:10.1017/s1355838200000662 · Cited by 72 · see citing works

Alphavirus Replicon Particles Expressing TRP-2 Provide Potent Therapeutic Effect on Melanoma through Activation of Humoral and Cellular Immunity

Avogadri, F., Merghoub, T., Maughan, M. F., Hirschhorn-Cymerman, D., Morris, J., Ritter, E., Olmsted, R. A., Houghton, A. N., & Wolchok, J. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0012670 · Cited by 66 · see citing works

Long-term survival correlates with immunological responses in renal cell carcinoma patients treated with mRNA-based immunotherapy

Rittig, S. M., Haentschel, M., Weimer, K. J., Heine, A., Müller, M., Brugger, W., Horger, M., Maksimovic, O., Stenzl, A., Hoerr, I., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1108511 · Cited by 66 · see citing works

mRNA

Lint, S. V., Heirman, C., Thielemans, K., & Breckpot, K. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.22661 · Cited by 59 · see citing works

Enhancement of protein expression by alphavirus replicons by designing self-replicating subgenomic RNAs

Kim, D. Y., Atasheva, S., McAuley, A. J., Plante, J. A., Frolova, E. I., Beasley, D. W. C., & Frolov, I. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408677111 · Cited by 57 · see citing works

Modulation of type I IFN induction by a virulence determinant within the alphavirus nsP1 protein

Cruz, C. C., Suthar, M. S., Montgomery, S. A., Shabman, R. S., Simmons, J. D., Johnston, R. E., Morrison, T. E., & Heise, M. T. (2010) · Virology · doi:10.1016/j.virol.2009.12.031 · Cited by 54 · see citing works

Introduction to RNA Vaccines

Kramps, T., & Elbers, K. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6481-9_1 · Cited by 50 · see citing works

Duration of Antigen Expression In Vivo following DNA Immunization Modifies the Magnitude, Contraction, and Secondary Responses of CD8+ T Lymphocytes

Hovav, A., Panas, M. W., Rahman, S., Sircar, P., Gillard, G. O., Cayabyab, M. J., & Letvin, N. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.10.6725 · Cited by 48 · see citing works

Intralymphatic immunotherapy

Senti, G., & Kündig, T. M. (2015) · World Allergy Organization Journal · doi:10.1186/s40413-014-0047-7 · Cited by 47 · see citing works

Control of alphavirus-based gene expression using engineered riboswitches

Bell, C. L., Yu, D. L., Smolke, C. D., Geall, A. J., Beard, C. W., & Mason, P. W. (2015) · Virology · doi:10.1016/j.virol.2015.04.023 · Cited by 44 · see citing works

A Kunjin Replicon Virus-like Particle Vaccine Provides Protection Against Ebola Virus Infection in Nonhuman Primates

Pyankov, O. V., Боднев, С. А., Pyankova, O. G., Solodky, V. V., Pyankov, S. A., Setoh, Y. X., Volchkova, V. A., Suhrbier, A., Volchkov, V. E., Agafonov, A. P., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv019 · Cited by 44 · see citing works

Mutanome Engineered RNA Immunotherapy: Towards Patient-Centered Tumor Vaccination

Vormehr, M., Schrörs, B., Boegel, S., Löwer, M., Türeci, Ö., & Şahin, U. (2015) · Journal of Immunology Research · doi:10.1155/2015/595363 · Cited by 42 · see citing works

The 'anti-hype' vaccine

DeFrancesco, L. (2017) · Nature Biotechnology · doi:10.1038/nbt.3812 · Cited by 38 · see citing works

Kinetic and Phenotypic Analysis of CD8+ T Cell Responses after Priming with Alphavirus Replicons and Homologous or Heterologous Booster Immunizations

Knudsen, M., Ljungberg, K., Kakoulidou, M., Kostic, L., Hallengärd, D., García-Arriaza, J., Merits, A., Esteban, M., & Liljeström, P. (2014) · Journal of Virology · doi:10.1128/jvi.02223-14 · Cited by 36 · see citing works

Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles

McCullough, K. C., Milona, P., Thomann, L., Démoulins, T., Englezou, P. C., Suter, R., & Ruggli, N. (2014) · Vaccines · doi:10.3390/vaccines2040735 · Cited by 33 · see citing works

A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding

Iavarone, C., Ramsauer, K., Kubarenko, A. V., Debasitis, J. C., Leykin, I., Weber, A. N. R., Siggs, O. M., Beutler, B., Zhang, P., Otten, G. R., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003585 · Cited by 33 · see citing works

A Glucocorticoid Reduces Adverse Effects of Adenovirus Vectors in the Cochlea

Ishimoto, S.-I., Kawamoto, K., Stöver, T., Kanzaki, S., Yamasoba, T., & Raphael, Y. (2003) · Audiology and Neurotology · doi:10.1159/000069000 · Cited by 31 · see citing works

Deviation from major codons in the Toll‐like receptor genes is associated with low Toll‐like receptor expression

Zhong, F., Cao, W., Chan, E., Tay, P. N., Cahya, F. F., Zhang, H., & Lu, J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.02007.x · Cited by 26 · see citing works

Co-Administration of Lipid Nanoparticles and Sub-Unit Vaccine Antigens Is Required for Increase in Antigen-Specific Immune Responses in Mice

Thoryk, E. A., Swaminathan, G., Meschino, S., Cox, K., Gindy, M. E., Casimiro, D. R., & Bett, A. J. (2016) · Vaccines · doi:10.3390/vaccines4040047 · Cited by 20 · see citing works

Engineered alphavirus replicon vaccines based on known attenuated viral mutants show limited effects on immunogenicity

Maruggi, G., Shaw, C. A., Otten, G. R., Mason, P. W., & Beard, C. W. (2013) · Virology · doi:10.1016/j.virol.2013.07.021 · Cited by 14 · see citing works

Delivery of Tumor-Antigen-Encoding mRNA into Dendritic Cells for Vaccination

Michiels, A., Tuyaerts, S., Bonehill, A., Heirman, C., Corthals, J., & Thielemans, K. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-194-9_10 · Cited by 14 · see citing works

Lysosomotropic Agents Ameliorate Macrophage Dysfunction Following the Phagocytosis of IgG-Coated Erythrocytes: A Role for Lipid Peroxidation

Raley, M. J., Schwacha, M. G., & Loegering, D. J. (1997) · Inflammation · doi:10.1023/a:1027386206458 · Cited by 10 · see citing works

[The strategies of endosomal escape for intracellular gene delivery].

Wang, W., Dai, K., Hong, L., Cai, T., & Tang, L. (2014) · PubMed · Cited by 3 · see citing works

Untitled work

Hoerr, I. (2000) · doi:10.1002/1521-4141(200001)30:1

Delivering the Messenger: Advances in Technologies for Therapeutic mRNA Delivery

Kowalski, P. S., Rudra, A., Miao, L., & Anderson, D. G. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.02.012 · Cited by 1,127 · see citing works

Advances in mRNA Vaccines for Infectious Diseases

Zhang, C., Maruggi, G., Shan, H., & Li, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00594 · Cited by 680 · see citing works

COVID-19 vaccine development and a potential nanomaterial path forward

Shin, M. D., Shukla, S., Chung, Y. H., Beiss, V., Chan, S. K., Ortega-Rivera, O. A., Wirth, D. M., Chen, A., Sack, M., Pokorski, J. K., et al. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0737-y · Cited by 652 · see citing works

Advances in COVID-19 mRNA vaccine development

Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601 · see citing works

Opportunities and Challenges in the Delivery of mRNA-Based Vaccines

Wadhwa, A., Aljabbari, A., Lokras, A., Foged, C., & Thakur, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020102 · Cited by 584 · see citing works

New Vaccine Technologies to Combat Outbreak Situations

Rauch, S., Jasny, E., Schmidt, K. E., & Petsch, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01963 · Cited by 579 · see citing works

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.020 · Cited by 507 · see citing works

A Comparison of Plasmid DNA and mRNA as Vaccine Technologies

Liu, M. A. (2019) · Vaccines · doi:10.3390/vaccines7020037 · Cited by 428 · see citing works

mRNA Vaccine Era—Mechanisms, Drug Platform and Clinical Prospection

Xu, S., Yang, K., Li, R., & Zhang, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186582 · Cited by 368 · see citing works

Immune-mediated approaches against COVID-19

Florindo, H. F., Kleiner, R., Vaskovich‐Koubi, D., Acúrcio, R. C., Carreira, B., Yeini, E., Tiram, G., Liubomirski, Y., & Satchi‐Fainaro, R. (2020) · Nature Nanotechnology · doi:10.1038/s41565-020-0732-3 · Cited by 342 · see citing works

An Update on Self-Amplifying mRNA Vaccine Development

Blakney, A. K., Ip, S., & Geall, A. J. (2021) · Vaccines · doi:10.3390/vaccines9020097 · Cited by 288 · see citing works

An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine Development

Wang, F., Kream, R. M., & Stefano, G. B. (2020) · Medical Science Monitor · doi:10.12659/msm.924700 · Cited by 243 · see citing works

Formulation and Delivery Technologies for mRNA Vaccines

Zeng, C., Zhang, C., Walker, P. G., & Dong, Y. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_217 · Cited by 221 · see citing works

A trans-amplifying RNA vaccine strategy for induction of potent protective immunity

Beissert, T., Perkovic, M., Vogel, A., Erbar, S., Walzer, K. C., Hempel, T., Brill, S., Haefner, E., Becker, R., Türeci, Ö., et al. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2019.09.009 · Cited by 212 · see citing works

Comparison of DNA and mRNA vaccines against cancer

Jahanafrooz, Z., Baradaran, B., Mosafer, J., Hashemzaei, M., Rezaei, T., Mokhtarzadeh, A., & Hamblin, M. R. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.12.003 · Cited by 202 · see citing works

Review of COVID-19 mRNA Vaccines: BNT162b2 and mRNA-1273

Teo, S. P. (2022) · Journal of Pharmacy Practice · doi:10.1177/08971900211009650 · Cited by 191 · see citing works

Delivery of self-amplifying mRNA vaccines by cationic lipid nanoparticles: The impact of cationic lipid selection

Lou, G., Anderluzzi, G., Schmidt, S., Woods, S., Gallorini, S., Brazzoli, M., Giusti, F., Ferlenghi, I., Johnson, R. N., Roberts, C. W., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.06.027 · Cited by 172 · see citing works

Nanotechnology Responses to COVID‐19

Ruiz‐Hitzky, E., Darder, M., Wicklein, B., Ruiz‐García, C., Martín‐Sampedro, R., del Real, G., & Aranda, P. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000979 · Cited by 169 · see citing works

Recent Advancement in mRNA Vaccine Development and Applications

Fayez, N. A., Nassar, M. S., Alshehri, A. A., Alnefaie, M. K., Almughem, F. A., Alshehri, B. Y., Alawad, A. O., & Tawfik, E. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071972 · Cited by 177 · see citing works

mRNA cancer vaccines: Advances, trends and challenges

He, Q., Gao, H., Tan, D., Zhang, H., & Wang, J. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.03.011 · Cited by 167 · see citing works

Strategies for controlling the innate immune activity of conventional and self-amplifying mRNA therapeutics: Getting the message across

Minnaert, A.-K., Vanluchene, H., Verbeke, R., Lentacker, I., De Smedt, S. C., Raemdonck, K., Sanders, N. N., & Remaut, K. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113900 · Cited by 157 · see citing works

Co-delivery of nucleoside-modified mRNA and TLR agonists for cancer immunotherapy: restoring the immunogenicity of immunosilent mRNA

Verbeke, R., Lentacker, I., Wayteck, L., Breckpot, K., Van Bockstal, M., Descamps, B., Vanhove, C., De Smedt, S. C., & Dewitte, H. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.09.041 · Cited by 132 · see citing works

mRNA Vaccines Encoding the HA Protein of Influenza A H1N1 Virus Delivered by Cationic Lipid Nanoparticles Induce Protective Immune Responses in Mice

Zhuang, X., Qi, Y., Wang, M., Yu, N., Nan, F., Zhang, H., Tian, M., Li, C., Lu, H., & Jin, N. (2020) · Vaccines · doi:10.3390/vaccines8010123 · Cited by 132 · see citing works

Antigen Presentation of mRNA-Based and Virus-Vectored SARS-CoV-2 Vaccines

Rijkers, G. T., Weterings, N., Obregón‐Henao, A., Dutt, T., Dutt, T. S., van Overveld, F. J., & Henao-Tamayo, M. I. (2021) · Vaccines · doi:10.3390/vaccines9080848 · Cited by 134 · see citing works

Lipid carriers for mRNA delivery

Zhang, W., Jiang, Y., He, Y., Boucetta, H., Wu, J., Chen, Z., & He, W. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.11.026 · Cited by 130 · see citing works

mRNA vaccine trafficking and resulting protein expression after intramuscular administration

Hassett, K. J., Rajlic, I. L., Bahl, K., White, R. A., Cowens, K. B., Jacquinet, E., & Burke, K. E. (2023) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2023.102083 · Cited by 125 · see citing works

Ex vivo pulsed dendritic cell vaccination against cancer

Gu, Y., Zhao, X., & Song, X. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0415-5 · Cited by 115 · see citing works

mRNA vaccines for COVID-19 and diverse diseases

Hussain, A., Yang, H., Zhang, M., Liu, Q., Alotaibi, G., Irfan, M. F., He, H., Chang, J. K., Liang, X., Weng, Y., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.03.032 · Cited by 117 · see citing works

Vaccines and global health: In search of a sustainable model for vaccine development and delivery

Rappuoli, R., BLACK, S. B., & Bloom, D. E. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw2888 · Cited by 105 · see citing works

mRNA-Based Cancer Vaccines: A Therapeutic Strategy for the Treatment of Melanoma Patients

Bidram, M., Zhao, Y., Shebardina, N. G., Baldin, A. V., Bazhin, A. V., Ganjalikhany, M. R., Zamyatnin, A. A., & Ganjalıkhani-Hakemi, M. (2021) · Vaccines · doi:10.3390/vaccines9101060 · Cited by 106 · see citing works

Current Developments and Challenges of mRNA Vaccines

Chen, J., Chen, J., & Xu, Q. (2022) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110220-031722 · Cited by 106 · see citing works

The role of nanoparticle format and route of administration on self-amplifying mRNA vaccine potency

Anderluzzi, G., Lou, G., Woods, S., Schmidt, S., Gallorini, S., Brazzoli, M., Johnson, R., Roberts, C. W., O’Hagan, D. T., Baudner, B. C., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.12.008 · Cited by 98 · see citing works

Nanocarrier vaccines for SARS-CoV-2

Machhi, J., Shahjin, F., Das, S., Patel, M., Abdelmoaty, M. M., Cohen, J. D., Singh, P., Baldi, A., Bajwa, N., Kumar, R., et al. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.002 · Cited by 80 · see citing works

Advances in gene-based vaccine platforms to address the COVID-19 pandemic

Pushparajah, D., Jimenez, S., Wong, S. L., Alattas, H., Nafissi, N., & Slavcev, R. A. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.01.003 · Cited by 98 · see citing works

Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections

Versteeg, L., Almutairi, M. M., Hotez, P. J., & Pollet, J. B. K. (2019) · Vaccines · doi:10.3390/vaccines7040122 · Cited by 93 · see citing works

Microfluidic production of mRNA-loaded lipid nanoparticles for vaccine applications

Lopes, C., Cristóvão, J. S., Silvério, V., Lino, P. R., & Fonte, P. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2135502 · Cited by 85 · see citing works

Broadening the Message: A Nanovaccine Co-loaded with Messenger RNA and α-GalCer Induces Antitumor Immunity through Conventional and Natural Killer T Cells

Verbeke, R., Lentacker, I., Breckpot, K., Janssens, J., Calenbergh, S. V., Smedt, S. C. D., & Dewitte, H. (2019) · ACS Nano · doi:10.1021/acsnano.8b07660 · Cited by 82 · see citing works

Nanoparticles as Adjuvants and Nanodelivery Systems for mRNA-Based Vaccines

Alfagih, I. M., Aldosari, B. N., AlQuadeib, B. T., Almurshedi, A. S., & Alfagih, M. M. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010045 · Cited by 79 · see citing works

Lipid Nanoparticles as Promising Carriers for mRNA Vaccines for Viral Lung Infections

Asr, M. H., Dayani, F., Segherloo, F. S., Kamedi, A., Neill, A. O., MacLoughlin, R. J., & Doroudian, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041127 · Cited by 73 · see citing works

Nanomaterials for mRNA ‐based therapeutics: Challenges and opportunities

Li, D., Liu, Q., Yang, M., Xu, H., Zhu, M., Zhang, Y., Xu, J., Tian, C., Yao, J., Wang, L., et al. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10492 · Cited by 71 · see citing works

Recent advances in mRNA vaccine delivery

Tan, L., & Sun, X. (2018) · Nano Research · doi:10.1007/s12274-018-2091-z · Cited by 70 · see citing works

Emerging biomaterial-based strategies for personalized therapeutic in situ cancer vaccines

Viswanath, D. I., Liu, H., Huston, D. P., Chua, C. Y. X., & Grattoni, A. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121297 · Cited by 69 · see citing works

Perspectives on RNA Vaccine Candidates for COVID-19

Borah, P., Deb, P. K., Al‐Shar’i, N. A., Dahabiyeh, L. A., Venugopala, K. N., Singh, V., Shinu, P., Hussain, S., Deka, S., Chandrasekaran, B., et al. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.635245 · Cited by 66 · see citing works

Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice

Samsa, M. M., Dupuy, L. C., Beard, C. W., Six, C. M., Schmaljohn, C. S., Mason, P. W., Geall, A. J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2018.12.013 · Cited by 63 · see citing works

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

Anderluzzi, G., Lou, G., Gallorini, S., Brazzoli, M., Johnson, R., O’Hagan, D. T., Baudner, B. C., & Perrie, Y. (2020) · Vaccines · doi:10.3390/vaccines8020212 · Cited by 57 · see citing works

Targeting materials and strategies for RNA delivery

Lin, L., Su, K., Cheng, Q., & Liu, S. (2023) · Theranostics · doi:10.7150/thno.87316 · Cited by 61 · see citing works

ROS‐Responsive Injectable Hydrogel Loaded with SLC7A11‐modRNA Inhibits Ferroptosis and Mitigates Intervertebral Disc Degeneration in Rats

Gao, T., Xu, G., Ma, T., Lu, X., Chen, K., Luo, H., Chen, G., Song, J. G., Ma, X., Fu, W. E., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202401103 · Cited by 59 · see citing works

Development and applications of mRNA treatment based on lipid nanoparticles

Wang, Z., Ma, W., Fu, X., Qi, Y., Zhao, Y., & Zhang, S. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108130 · Cited by 57 · see citing works

Challenges of influenza A viruses in humans and animals and current animal vaccines as an effective control measure

Yoo, S. J., Kwon, T., & Lyoo, Y. S. (2018) · Clinical and Experimental Vaccine Research · doi:10.7774/cevr.2018.7.1.1 · Cited by 57 · see citing works

Nanotechnologies in Delivery of DNA and mRNA Vaccines to the Nasal and Pulmonary Mucosa

Tang, J., Cai, L., Xu, C., Sun, S., Liu, Y., Rosenecker, J., & Guan, S. (2022) · Nanomaterials · doi:10.3390/nano12020226 · Cited by 54 · see citing works

Vaccination with Messenger RNA: A Promising Alternative to DNA Vaccination.

Tombácz, I., Weissman, D., & Pardi, N. (2021) · Methods in molecular biology · doi:10.1007/978-1-0716-0872-2_2 · Cited by 43 · see citing works

Advances in mRNA-Based Cancer Vaccines

Ni, L. (2023) · Vaccines · doi:10.3390/vaccines11101599 · Cited by 56 · see citing works

High-Resolution capillary electrophoresis separation of large RNA under non-aqueous conditions

Lu, T., Klein, L. J., Ha, S., & Rustandi, R. R. (2020) · Journal of Chromatography A · doi:10.1016/j.chroma.2020.460875 · Cited by 53 · see citing works

The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview

Machado, B. A. S., Hodel, K. V. S., Fonseca, L. M. D. S., Mascarenhas, L. A. B., Andrade, L. P. C. D. S., Rocha, V. P. C., Soares, M. B. P., Berglund, P., Duthie, M. S., Reed, S. G., et al. (2021) · Vaccines · doi:10.3390/vaccines9111345 · Cited by 52 · see citing works

Nano-Enabled COVID-19 Vaccines: Meeting the Challenges of Durable Antibody Plus Cellular Immunity and Immune Escape

Nel, A. E., & Miller, J. F. (2021) · ACS Nano · doi:10.1021/acsnano.1c01845 · Cited by 50 · see citing works

The Potential of Cell-Penetrating Peptides for mRNA Delivery to Cancer Cells

Kim, Y., Kim, H., Kim, E. H., Jang, H., Jang, Y., Chi, S.-G., Yang, Y., & Kim, S. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061271 · Cited by 50 · see citing works

mRNA vaccines in the prevention and treatment of diseases

Gu, Y., Duan, J., Yang, N., Yang, Y., & Zhao, X. (2022) · MedComm · doi:10.1002/mco2.167 · Cited by 51 · see citing works

Nano-Microparticle Platforms in Developing Next-Generation Vaccines

Cappellano, G., Abreu, H., Casale, C., Dianzani, U., & Chiocchetti, A. (2021) · Vaccines · doi:10.3390/vaccines9060606 · Cited by 50 · see citing works

Messenger RNA chromatographic purification: advances and challenges

Xue, F., Su, Z. G., Cheng, Y., Ma, G., & Zhang, S. (2023) · Journal of Chromatography A · doi:10.1016/j.chroma.2023.464321 · Cited by 49 · see citing works

From Bench to the Clinic: The Path to Translation of Nanotechnology-Enabled mRNA SARS-CoV-2 Vaccines

Lopez-Cantu, D. O., Wang, X., Carrasco-Magallanes, H., Afewerki, S., Zhang, X., Bonventre, J. V., & Ruiz‐Esparza, G. U. (2022) · Nano-Micro Letters · doi:10.1007/s40820-021-00771-8 · Cited by 48 · see citing works

Recent Advances, Approaches and Challenges in the Development of Universal Influenza Vaccines

Lim, C. M. L., Komarasamy, T. V., Adnan, N. A. A., Radhakrishnan, A. K., & Balasubramaniam, V. R. M. T. (2024) · Influenza and Other Respiratory Viruses · doi:10.1111/irv.13276 · Cited by 48 · see citing works

Lipid Nanoparticle-Based Delivery SystemA Competing Place for mRNA Vaccines

Zhang, X., Li, Y., & Zhou, Z. (2024) · ACS Omega · doi:10.1021/acsomega.3c08353 · Cited by 43 · see citing works

Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages

Eisfeld, H. S., Simonis, A., Winter, S., Chhen, J., Stroh, L. J., Krey, T., Koch, M., Theobald, S. J., & Rybniker, J. (2021) · Viruses · doi:10.3390/v13102076 · Cited by 44 · see citing works

Polymers Strive for Accuracy: From Sequence-Defined Polymers to mRNA Vaccines against COVID-19 and Polymers in Nucleic Acid Therapeutics

Ishaqat, A., & Herrmann, A. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c08484 · Cited by 42 · see citing works

Review: Vaccine Myth-Buster – Cleaning Up With Prejudices and Dangerous Misinformation

Löffler, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.663280 · Cited by 42 · see citing works

Technological approaches to streamline vaccination schedules, progressing towards single-dose vaccines

Lofano, G., Mallett, C. P., Bertholet, S., & O’Hagan, D. T. (2020) · npj Vaccines · doi:10.1038/s41541-020-00238-8 · Cited by 41 · see citing works

Are inhaled mRNA vaccines safe and effective? A review of preclinical studies

Jansen, E. M., Frijlink, H. W., Hinrichs, W. L. J., & Ruigrok, M. J. R. (2022) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2022.2131767 · Cited by 37 · see citing works

Evolution and Progress of mRNA Vaccines in the Treatment of Melanoma: Future Prospects

Bafaloukos, D. I., Gazouli, I., Koutserimpas, C., & Samonis, G. (2023) · Vaccines · doi:10.3390/vaccines11030636 · Cited by 41 · see citing works

Advances in mRNA LNP-Based Cancer Vaccines: Mechanisms, Formulation Aspects, Challenges, and Future Directions

Ramadan, E., Ismeal, A. A. A., & Naguib, Y. W. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14111092 · Cited by 38 · see citing works

Overview on LNP-mRNA encapsulation unit operation: Mixing technologies, scalability, and influence of formulation & process parameters on physico-chemical characteristics

Hourdel, L., Lebaz, N., Peral, F., Ripoll, M., Briançon, S., Bensaid, F., Luthra, S., & Cogné, C. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125297 · Cited by 37 · see citing works

Exploiting vita-PAMPs in vaccines

Blander, J. M., & Barbet, G. (2018) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2018.05.012 · Cited by 34 · see citing works

Polymeric nanostructure vaccines: applications and challenges

Simón‐Vázquez, R., Peleteiro, M., & González‐Fernández, Á. (2020) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2020.1776259 · Cited by 36 · see citing works

Demystifying mRNA vaccines: an emerging platform at the forefront of cryptic diseases

Rouf, N. Z., Biswas, S., Tarannum, N., Oishee, L. M., & Muna, M. M. (2022) · RNA Biology · doi:10.1080/15476286.2022.2055923 · Cited by 36 · see citing works

Design-of-experiments in vitro transcription yield optimization of self-amplifying RNA

Samnuan, K., Blakney, A. K., McKay, P. F., & Shattock, R. J. (2022) · F1000Research · doi:10.12688/f1000research.75677.1 · Cited by 36 · see citing works

mRNA COVID-19 Vaccines and Long-Lived Plasma Cells: A Complicated Relationship

Giannotta, G., & Giannotta, N. (2021) · Vaccines · doi:10.3390/vaccines9121503 · Cited by 32 · see citing works

Emerging advances in delivery systems for mRNA cancer vaccines

Jiang, Z., Xu, Y., Du, G., & Sun, X. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.04.039 · Cited by 34 · see citing works

mRNA-based VP8* nanoparticle vaccines against rotavirus are highly immunogenic in rodents

Roier, S., Prasad, V. M., McNeal, M., Lee, K. K., Petsch, B., & Rauch, S. (2023) · npj Vaccines · doi:10.1038/s41541-023-00790-z · Cited by 32 · see citing works

Emerging prospects of mRNA cancer vaccines: mechanisms, formulations, and challenges in cancer immunotherapy

Laila, U. E., An, W., & Xu, Z.-X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1448489 · Cited by 34 · see citing works

Sustainable vaccine development: a vaccine manufacturer's perspective

Rappuoli, R., & Hanon, E. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.04.019 · Cited by 32 · see citing works

mRNA-Based Vaccines and Mode of Action

Gergen, J., & Petsch, B. (2020) · Current topics in microbiology and immunology · doi:10.1007/82_2020_230 · Cited by 32 · see citing works

Low energy nebulization preserves integrity of SARS-CoV-2 mRNA vaccines for respiratory delivery

van Rijn, C. J. M., Vlaming, K. E., Reinout, A., Dekker, R. J., Poortinga, A. T., Breit, T. M., van Leeuwen, S. M., Ensink, W. A., van Wijnbergen, K., van Hamme, J. L., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-35872-4 · Cited by 30 · see citing works

Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity

Luo, X., McAndrews, K. M., Arian, K. A., Morse, S. J., Boeker, V., Kumbhar, S. V., Hu, Y., Mahadevan, K. K., Church, K. A., Chitta, S., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.08.017 · Cited by 30 · see citing works

Synergistic integration of mRNA-LNP with CAR-engineered immune cells: Pioneering progress in immunotherapy

Chen, Z., Shu, J., Hu, Y., & Mei, H. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.09.019 · Cited by 31 · see citing works

COVID‐19: Clinical status of vaccine development till date

Kumar, S., Basu, M., Ghosh, P., Ansari, A., & Ghosh, M. (2022) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.15552 · Cited by 18 · see citing works

Vacunas frente a SARS-CoV-2 y piel

Galván‐Casas, C., Català, A., & Muñoz‐Santos, C. (2021) · Actas Dermo-Sifiliográficas · doi:10.1016/j.ad.2021.05.011 · Cited by 29 · see citing works

Advancing personalized medicine in brain cancer: exploring the role of mRNA vaccines

Lin, F., Lin, E. Z., Anekoji, M., Ichim, T. E., Hu, J. K., Marincola, F. M., Jones, L. D., Kesari, S., & Ashili, S. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04724-0 · Cited by 28 · see citing works

Advances in Nonviral mRNA Delivery Materials and Their Application as Vaccines for Melanoma Therapy

Neill, B., Romero, A. R., & Fenton, O. S. (2023) · ACS Applied Bio Materials · doi:10.1021/acsabm.3c00721 · Cited by 30 · see citing works

Strategies to deliver RNA by nanoparticles for therapeutic potential

Cox, A., Lim, S. A., & Chung, E. J. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100991 · Cited by 27 · see citing works

Long-term antibody persistence and exceptional vaccination response on previously SARS-CoV-2 infected subjects

Ferrari, D., Resta, C. D., Tomaiuolo, R., Sabetta, E., Pontillo, M., Motta, A., & Locatelli, M. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.06.020 · Cited by 26 · see citing works

Recent Advancements in Mosquito-Borne Flavivirus Vaccine Development

Wu, B., Qi, Z., & Qian, X. (2023) · Viruses · doi:10.3390/v15040813 · Cited by 26 · see citing works

Universal Flu mRNA Vaccine: Promises, Prospects, and Problems

Deviatkin, A. A., Simonov, R. A., Trutneva, K. A., Maznina, A. A., Khavina, E. M., & Volchkov, P. (2022) · Vaccines · doi:10.3390/vaccines10050709 · Cited by 25 · see citing works

Modeling of MT. P495, an mRNA-based vaccine against the phosphate-binding protein PstS1 of Mycobacterium tuberculosis

Shahrear, S., & Islam, A. B. M. M. K. (2022) · Molecular Diversity · doi:10.1007/s11030-022-10515-4 · Cited by 24 · see citing works

The Coming of Age of Nucleic Acid Vaccines during COVID-19

Rando, H. M., Lordan, R., Kolla, L., Sell, E., Lee, A. J., Wellhausen, N., Naik, A. S., Kamil, J. P., Gitter, A., Greene, C. S., et al. (2023) · mSystems · doi:10.1128/msystems.00928-22 · Cited by 29 · see citing works

Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach

Goyal, F., Chattopadhyay, A., Navik, U., Jain, A., Reddy, P. H., Bhatti, G. K., & Bhatti, J. S. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300255 · Cited by 24 · see citing works

Co-administration of GM-CSF expressing RNA is a powerful tool to enhance potency of SAM-based vaccines

Manara, C., Brazzoli, M., Piccioli, D., Taccone, M., D’Oro, U., Maione, D., & Frigimelica, E. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.04.028 · Cited by 23 · see citing works

SARS-CoV-2: phylogenetic origins, pathogenesis, modes of transmission, and the potential role of nanotechnology

Sahu, A. K., Sreepadmanabh, M., Rai, M., & Chande, A. G. (2021) · VirusDisease · doi:10.1007/s13337-021-00653-y · Cited by 22 · see citing works

Development of an RNA Expression Platform Controlled by Viral Internal Ribosome Entry Sites

Ko, H. L., Park, H., Kim, J., Kim, H., Youn, H., & Nam, J. (2019) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1811.11019 · Cited by 22 · see citing works

Advances in the study of LNPs for mRNA delivery and clinical applications

Wang, B., Shen, B., Xiang, W., & Shen, H. (2024) · Virus Genes · doi:10.1007/s11262-024-02102-6 · Cited by 21 · see citing works

mRNA Vaccine - A New Cancer Treatment Strategy

Tan, T., Deng, S., Wu, B.-H., Yang, Q., Wu, M., Wu, H., Cao, C., & Xu, C. S. (2023) · Current Cancer Drug Targets · doi:10.2174/1568009623666230222124424 · Cited by 21 · see citing works

A review of RNA nanoparticles for drug/gene/protein delivery in advanced therapies: Current state and future prospects

Vosoughi, P., Naghib, S. M., Kangarshahi, B. M., & Mozafari, M. R. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.139532 · Cited by 20 · see citing works

Design and delivery of messenger RNA-based vaccines

Pichon, C., & Perche, F. (2021) · The Biochemist · doi:10.1042/bio_2021_151 · Cited by 6 · see citing works

The mRNA Vaccine Heralds a New Era in Vaccinology

Shinde, K., Bendre, S., Kale, N., & Gilda, S. (2022) · Asian Journal of Pharmacy and Technology · doi:10.52711/2231-5713.2022.00042 · Cited by 9 · see citing works

Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity

Kowalczyk, A., Doener, F., Zanzinger, K., Noth, J., Baumhof, P., Fotin-Mleczek, M., & Heidenreich, R. (2016) · Vaccine · doi:10.1016/j.vaccine.2016.05.046 · Cited by 101 · see citing works

mRNA vaccine designs for optimal adjuvanticity and delivery

Mochida, Y., & Uchida, S. (2024) · RNA Biology · doi:10.1080/15476286.2024.2333123 · Cited by 55 · see citing works

Bioengineering strategies for improving the immunogenicity of mRNA vaccines

Wang, H., Zhuo, R., Wu, J., & Ouyang, S. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02991-z