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Mechanisms of myoblast fusion during muscle development
Open accessAbstract
The development and regeneration of skeletal muscles require the fusion of mononulceated muscle cells to form multinucleated, contractile muscle fibers. Studies using a simple genetic model, Drosophila melanogaster, have discovered many evolutionarily conserved fusion-promoting factors in vivo. Recent work in zebrafish and mouse also identified several vertebrate-specific factors required for myoblast fusion. Here, we integrate progress in multiple in vivo systems and highlight conceptual advance in understanding how muscle cell membranes are brought together for fusion. We focus on the molecular machinery at the fusogenic synapse and present a three-step model to describe the molecular and cellular events leading to fusion pore formation.
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Cited by
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
Petrany, M. J., Swoboda, C. O., Sun, C., Chetal, K., Chen, X., Weirauch, M. T., Salomonis, N., & Millay, D. P. (2020) · Nature Communications · doi:10.1038/s41467-020-20063-w · Cited by 389
The microprotein Minion controls cell fusion and muscle formation
Zhang, Q., Vashisht, A. A., O’Rourke, J., Corbel, S. Y., Moran, R., Romero, A., Miraglia, L., Zhang, J., Durrant, E., Schmedt, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15664 · Cited by 267
Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development
Quinn, M. E., Goh, Q., Kurosaka, M., Gamage, D. G., Petrany, M. J., Prasad, V., & Millay, D. P. (2017) · Nature Communications · doi:10.1038/ncomms15665 · Cited by 264
Polyploidy in liver development, homeostasis and disease
Donne, R., Saroul-Aïnama, M., Cordier, P., Celton-Morizur, S., & Desdouets, C. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0284-x · Cited by 188
Polyploidy in tissue homeostasis and regeneration
Øvrebø, J. I., & Edgar, B. A. (2018) · Development · doi:10.1242/dev.156034 · Cited by 171
Metadata
- Authors
- Kim, J. H., Jin, P., Duan, R., & Chen, E. H.
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 32
- Pages
- 162-170
- ISSN
- 0959-437X (ISSN-L)
- OpenAlex
- W241332058
- Cited by
- 239
- References
- 0
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, J. H., Jin, P., Duan, R., & Chen, E. H. (2015). Mechanisms of myoblast fusion during muscle development. Current Opinion in Genetics & Development. https://doi.org/10.1016/j.gde.2015.03.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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