The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development
Open accessAbstract
Despite the importance of cell fusion for mammalian development and physiology, the factors critical for this process remain to be fully defined, which has severely limited our ability to reconstitute cell fusion. Myomaker ( Tmem8c ) is a muscle-specific protein required for myoblast fusion. Expression of myomaker in fibroblasts drives their fusion with myoblasts, but not with other myomaker-expressing fibroblasts, highlighting the requirement of additional myoblast-derived factors for fusion. Here we show that Gm7325 , which we name myomerger, induces the fusion of myomaker-expressing fibroblasts. Thus, myomaker and myomerger together confer fusogenic activity to otherwise non-fusogenic cells. Myomerger is skeletal muscle-specific and genetic deletion in mice results in a paucity of muscle fibres demonstrating its requirement for normal muscle formation. Myomerger deficient myocytes differentiate and harbour organized sarcomeres but are fusion-incompetent. Our findings identify myomerger as a fundamental myoblast fusion protein and establish a system that begins to reconstitute mammalian cell fusion.
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SNAREpins: Minimal Machinery for Membrane Fusion
Weber, T., Zemelman, B. V., McNew, J. A., Westermann, B., Gmachl, M., Parlati, F., Söllner, T. H., & Rothman, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81404-x · Cited by 2,475
Haeussler, M., Schönig, K., Eckert, H., Eschstruth, A., Mianné, J., Renaud, J.-B., Schneider-Maunoury, S., Shkumatava, A., Teboul, L., Kent, J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1012-2 · Cited by 1,756
Harrison, S. C. (2015) · Virology · doi:10.1016/j.virol.2015.03.043 · Cited by 697
Myomaker is a membrane activator of myoblast fusion and muscle formation
Millay, D. P., O’Rourke, J. R., Sutherland, L. B., Bezprozvannaya, S., Shelton, J. M., Bassel-Duby, R., & Olson, E. N. (2013) · Nature · doi:10.1038/nature12343 · Cited by 577
Self-citationGenerating genetically modified mice using CRISPR/Cas-mediated genome engineering
Yang, H., Wang, H., & Jaenisch, R. (2014) · Nature Protocols · doi:10.1038/nprot.2014.134 · Cited by 551
Myoblast fusion: lessons from flies and mice
Abmayr, S. M., & Pavlath, G. K. (2012) · Development · doi:10.1242/dev.068353 · Cited by 529
IL-4 Acts as a Myoblast Recruitment Factor during Mammalian Muscle Growth
Horsley, V., Jansen, K. M., Mills, S. T., & Pavlath, G. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00319-2 · Cited by 508
Durbeej, M., & Campbell, K. P. (2002) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(02)00309-x · Cited by 435
Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release
Ma, C., Su, L., Seven, A. B., Xu, Y., & Rizo, J. (2013) · Science · doi:10.1126/science.1230473 · Cited by 409
Control of muscle formation by the fusogenic micropeptide myomixer
Bi, P., Ramirez-Martinez, A., Li, H., Cannavino, J., McAnally, J. R., Shelton, J. M., Sánchez-Ortiz, E., Bassel-Duby, R., & Olson, E. N. (2017) · Science · doi:10.1126/science.aam9361 · Cited by 396
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The microprotein Minion controls cell fusion and muscle formation
Zhang, Q., Vashisht, A. A., O’Rourke, J., Corbel, S. Y., Moran, R., Romero, A., Miraglia, L., Zhang, J., Durrant, E., Schmedt, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15664 · Cited by 267
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Metadata
- Authors
- Quinn, M. E., Goh, Q., Kurosaka, M., Gamage, D. G., Petrany, M. J., Prasad, V., & Millay, D. P.
- Venue
- Nature Communications
- Published
- 2017-06-01
- Volume
- 8
- Issue
- 1
- Pages
- 15665-15665
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2621121460
- Cited by
- 264
- References
- 37
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- gold
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- Quinn, M. E., Goh, Q., Kurosaka, M., Gamage, D. G., Petrany, M. J., Prasad, V., & Millay, D. P. (2017). Myomerger induces fusion of non-fusogenic cells and is required for skeletal muscle development. Nature Communications. https://doi.org/10.1038/ncomms15665
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