Cited by 69Developmental Biology and Gene RegulationAxon Guidance and Neuronal SignalingCellular Mechanics and Interactions

Distributing signaling proteins in space and time: the province of cytonemes

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Kornberg, Thomas B·2017·Current Opinion in Genetics & Development

Abstract

During development, cells use specialized filopodia called cytonemes to deploy the signaling proteins that coordinate growth and direct morphogenesis. Cytonemes are dynamic structures that can extend long distances across tissues to either deliver or take up signaling proteins. Signaling proteins transfer between cells at the tips of cytonemes where specific contacts termed morphogenetic synapses form. This review summarizes our current understanding of the roles and functions of cytonemes, and it explores some of the conceptual issues relevant to the cytoneme mechanism of contact-dependent cell-cell signaling.

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Crossref · 10.1016/j.gde.2017.02.010

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  • TGF-β3 is clearly expressed by stromal CAFs and mesenchymal tumor cells.

    “However, TGF-β3 is clearly expressed by stromal CAFs and mesenchymal tumor cells41,70,247”

    From TGFβ biology in cancer progression and immunotherapy (2021) · cites this paper as [247]

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Authors
Kornberg, T. B.
Affiliations
University of California, San Francisco (US)
Corresponding author
Kornberg, Thomas B
Venue
Current Opinion in Genetics & Development
Publisher
Elsevier BV
Published
2017-08
Volume
45
Pages
22-27
ISSN
0959-437X (ISSN-L)
OpenAlex
W2589247049
Cited by
69
References
50
Citations by year
2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 13 · 2018: 13 · 2017: 3
FWCI
0.92
Type
journal article
Language
en
Open access
Locations
  • Current Opinion in Genetics & Development (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institutes of Health (GM030637, GM105987)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
cytonemes, filopodia, morphogenesis, cell growth, developmental patterning
MeSH terms
Animals, Cell Communication, Extracellular Matrix, Models, Theoretical, Proteins, Pseudopodia, Signal Transduction, Paracrine Communication

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