Distributing signaling proteins in space and time: the province of cytonemes
Open accessAbstract
During development, cells use specialized filopodia called cytonemes to deploy the signaling proteins that coordinate growth and direct morphogenesis. Cytonemes are dynamic structures that can extend long distances across tissues to either deliver or take up signaling proteins. Signaling proteins transfer between cells at the tips of cytonemes where specific contacts termed morphogenetic synapses form. This review summarizes our current understanding of the roles and functions of cytonemes, and it explores some of the conceptual issues relevant to the cytoneme mechanism of contact-dependent cell-cell signaling.
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Bamsey, J. L., Brunt, L. H., & Scholpp, S. (2025) · Trends in Cell Biology · doi:10.1016/j.tcb.2024.12.005 · Cited by 1 · see citing works
Visualizing Wnt secretion from Endoplasmic Reticulum to FilopodiaPreprint
Moti, N., Yu, J., Boncompain, G., Perez, F., & Virshup, D. M. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/271684 · Cited by 1 · see citing works
Taberner, L., Bañón, A., & Alsina, B. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3431416 · Cited by 1 · see citing works
Long-range Notch-mediated tissue patterning requires actomyosin contractilityPreprint
Hunter, G. L., He, L., Perrimon, N., Charras, G., Giniger, E., & Baum, B. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/259341
Investigação do desenvolvimento do placóide do cristalino in vivo
de Magalhães, C. G. (2019) · doi:10.11606/d.42.2019.tde-04092019-105146
Sawa, H. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733814364.793549824
The open to closed D-loop conformational switch determines length in filopodia-like actin bundles
Gadsby, J. R., Ioannou, P. S., Butler, R., Mason, J., Smith, A. J., Dobramysl, U., Chin, S. E., Dobson, C., & Gallop, J. L. (2024) · Biochemical Journal · doi:10.1042/bcj20240367
Asperous coordinates regenerative timing by regulating damage-induced WNT SignalingPreprint
Cave, S., Sonowal, M., Dankovskyy, M., Hieronymus, J., Hazel, C. V., Fromme, P., & Harris, R. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.24.661394
Garcia, R. A. G. (2020) · theses.fr (ABES) · doi:10.70675/3efaf973z49ccz4fa2zaa8ezaf9a0060ddd9
FiloAnalyzer: a deep learning approach for cell filopodia segmentation
Pastore, V. P., Rorato, R., Touijer, L., Via, R. D., Odone, F., Galli, L. M., Burrus, L. W., & Bianco, S. (2026) · BMC Bioinformatics · doi:10.1186/s12859-026-06437-9
Asperous coordinates regeneration timing by regulating damage-induced WNT signaling
Cave, S., Sonowal, M., Dankovskyy, M., Hieronymus, J., Hazel, C. V., Fromme, P., & Harris, R. E. (2026) · iScience · doi:10.1016/j.isci.2026.116823
- Authors
- Kornberg, T. B.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Kornberg, Thomas B
- ORCID
- Kornberg, Thomas B
- Venue
- Current Opinion in Genetics & Development
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 45
- Pages
- 22-27
- ISSN
- 0959-437X (ISSN-L)
- PMC
- PMC5502195
- OpenAlex
- W2589247049
- Cited by
- 69
- References
- 50
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 13 · 2018: 13 · 2017: 3
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Current Opinion in Genetics & Development (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (GM030637, GM105987)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- cytonemes, filopodia, morphogenesis, cell growth, developmental patterning
- MeSH terms
- Animals, Cell Communication, Extracellular Matrix, Models, Theoretical, Proteins, Pseudopodia, Signal Transduction, Paracrine Communication
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