The DOI matches its Crossref record; 169 of the 170 references it cites were found in a registry or an index.
Gut microbiota, inflammation and colorectal cancer
Open accessAbstract
Although genes contribute to colorectal cancer, the gut microbiota are an important player. Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression. A variety of bacterial species and tumor-promoting virulence mechanisms have been investigated. Significant advances have been made in understanding the composition and functional capabilities of the gut microbiota and its roles in cancer. In the current review, we discuss the novel roles of microbiota in the progression of colon cancer. Although microbiota technically include organisms other than bacteria e.g., viruses and fungi, this review will primarily focus on bacteria. We summarize epidemiological studies of human microbiome and colon cancer. We discuss the progress in the scientific understanding of the interplay between the gut microbiota, barrier function, and host responses in experimental models. Further, we discuss the potential application in prevention, diagnosis, and therapy of colon cancer by targeting microbiota. We discuss the challenges lie ahead and the future direction in studying gut microbiome in colon cancer to close the gap between the basic sciences and clinical application.
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“Strategies to detect specific bacteria or bacterial DNA sequences might be used in screening for early-stage colorectal adenomas or carcinomas.60, 61”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [60]
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1 retracted
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BackgroundDiversity of the Human Intestinal Microbial Flora
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“Another bacterial product Peptidoglycan (PTGN) modulates peripheral immune function via a patternrecognition receptor, oligomerization domain-containing protein-1 (NOD1) and depletion of the microbiota in mice.(133) Lower systemic PTGN concentration leads to less ability to kill certain bacterial pathogens.”
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Flagged first, then by citations
1 of the 170 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- WCRF/AICR, 2011, Continuous update project report: food, nutrition, physical activity, and the prevention of colorectal cancer, Colorectal Cancer 2011 Rep Lond WCRF/AICR, 1
Cited by
Sorted by citations
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752
The Gut Microbiota and Inflammation: An Overview
Bander, Z. A., Nitert, M. D., Mousa, A., & Naderpoor, N. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207618 · Cited by 804
Tumor biomarkers for diagnosis, prognosis and targeted therapy
Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 836
Salguero, M. V., Al-Obaide, M. A. I., Singh, R., Siepmann, T., & Vasylyeva, T. L. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7943 · Cited by 270
“The present study identified five previously reported genera in the phylum Bacteroidetes, including Porphyromonas , Prevotella , Paraprevotella and Flavobacterium (38,39).”
Metadata
- Authors
- Sun, J., & Kato, I.
- Affiliations
- University of Illinois Chicago (US)
- Wayne State University (US)
- Corresponding author
- Sun, Jun
- ORCID
- Venue
- Genes & Diseases
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 3
- Issue
- 2
- Pages
- 130-143
- ISSN
- 2352-3042 (ISSN-L)
- PMC
- PMC5221561
- OpenAlex
- W2338446464
- Cited by
- 257
- References
- 170
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 25 · 2023: 27 · 2022: 34 · 2021: 29 · 2020: 39 · 2019: 29 · 2018: 27 · 2017: 14
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Genes & Diseases (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK105118)
- Cancer Center, University of Illinois at Chicago
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, colorectal cancer, inflammation, tumor progression, chronic infection, bacterial virulence factors, host-microbe interactions, intestinal barrier function, cancer prevention, cancer diagnosis
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