The DOI matches its Crossref record; 169 of the 170 references it cites were found in a registry or an index.
Gut microbiota, inflammation and colorectal cancer
Open accessAbstract
Although genes contribute to colorectal cancer, the gut microbiota are an important player. Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression. A variety of bacterial species and tumor-promoting virulence mechanisms have been investigated. Significant advances have been made in understanding the composition and functional capabilities of the gut microbiota and its roles in cancer. In the current review, we discuss the novel roles of microbiota in the progression of colon cancer. Although microbiota technically include organisms other than bacteria e.g., viruses and fungi, this review will primarily focus on bacteria. We summarize epidemiological studies of human microbiome and colon cancer. We discuss the progress in the scientific understanding of the interplay between the gut microbiota, barrier function, and host responses in experimental models. Further, we discuss the potential application in prevention, diagnosis, and therapy of colon cancer by targeting microbiota. We discuss the challenges lie ahead and the future direction in studying gut microbiome in colon cancer to close the gap between the basic sciences and clinical application.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Strategies to detect specific bacteria or bacterial DNA sequences might be used in screening for early-stage colorectal adenomas or carcinomas.60, 61”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [60]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Duca, F. A., Sakar, Y., Lepage, P., Devime, F., Goustard, B., Dore, J. M., & Covașă, M. (2014) · Diabetes · doi:10.2337/db13-1526 · Cited by 169
RetractedCancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · cited 1×
“While low energy diet induces change in microbial compositions increasing gene richness,(107) microbiome itself also contributes energy harvest to the host, as demonstrated in mice models where transfer of obese microbiome to lean animals led to an increase in body adiposity in a diet dependent manner.(108,109) Other…”
BackgroundDiet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · cited 1×
“Although meat intake itself has been rarely studied, removal of animal products (vegan diet) was recently tested in a few clinical trials, showing changes in the Firmicutes/Bacteroidetes ratio and abundance of bacteria capable of triggering inflammation.(112,113) Moreover, as discussed above, meats are one of the susp…”
BackgroundDiversity of the Human Intestinal Microbial Flora
Eckburg, P. B., Bik, E. M., Bernstein, C. N., Purdom, E., Dethlefsen, L., Sargent, M., Gill, S. R., Nelson, K. E., & Relman, D. A. (2005) · Science · doi:10.1126/science.1110591 · Cited by 7,913
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · cited 1×
“Obese and lean individuals are known to harbor different types of gut microbiota.(106) While low energy diet induces change in microbial compositions increasing gene richness,(107) microbiome itself also contributes energy harvest to the host, as demonstrated in mice models where transfer of obese microbiome to lean a…”
BackgroundSokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413
Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy
Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888
Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature · doi:10.1038/nature08530 · Cited by 3,241 · cited 2×
“Another bacterial product Peptidoglycan (PTGN) modulates peripheral immune function via a patternrecognition receptor, oligomerization domain-containing protein-1 (NOD1) and depletion of the microbiota in mice.(133) Lower systemic PTGN concentration leads to less ability to kill certain bacterial pathogens.”
BackgroundSuerbaum, S., & Michetti, P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020542 · Cited by 2,984
The global health burden of infection‐associated cancers in the year 2002
Parkin, D. M. (2006) · International Journal of Cancer · doi:10.1002/ijc.21731 · Cited by 2,932
Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., & Plummer, M. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70137-7 · Cited by 2,540
The Global Burden of Nontyphoidal Salmonella Gastroenteritis
Majowicz, S. E., Musto, J., Scallan, E., Angulo, F. J., Kirk, M., O’Brien, S. J., Jones, T. F., Fazil, A., & Hoekstra, R. M. (2010) · Clinical Infectious Diseases · doi:10.1086/650733 · Cited by 2,465
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263
Round, J. L., & Mazmanian, S. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909122107 · Cited by 2,233 · cited 1×
“Polysaccharide A, produced by a commensal bacteria, increases local interleukin 10 by inducing Foxp3þ regulatory T-cell and this effect is mediated by Toll like receptor 2 signaling.(156,157) Although recent studies provide insights into the roles of the bacterial products, the molecular mechanisms of the beneficial e…”
BackgroundFusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043 · cited 1×
“These observations were further confirmed by quantitative (q) PCR and in situ hybridization in tumor tissue.(16,86,89) Using qPCR, McCoy et al studied F counts in normal rectal mucosa of the cases with or without colorectal adenoma, revealing a 3 fold increase in risk of adenoma among subjects with highest tertile of…”
MethodGenomic analysis identifies association of Fusobacterium with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960 · cited 2×
“These observations were further confirmed by quantitative (q) PCR and in situ hybridization in tumor tissue.(16,86,89) Using qPCR, McCoy et al studied F counts in normal rectal mucosa of the cases with or without colorectal adenoma, revealing a 3 fold increase in risk of adenoma among subjects with highest tertile of…”
BackgroundDietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · cited 2×
“BFT binds to a specific colonic epithelial receptor activating Wnt and NF-kB signaling pathways with increased cell proliferation, epithelial release of proinflammatory mediators, and induction of DNA damage(78,79) and ETBF promotes tumor formation in experimental animals.(79,80) Despite these laboratory data, to date…”
BackgroundSchwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689
Schistosomes, liver flukes and Helicobacter pylori.
(1994) · PubMed Central · Cited by 1,536
Exercise and associated dietary extremes impact on gut microbial diversity
Clarke, S. F., Murphy, E. F., O'Sullivan, O., Lucey, A. J., Humphreys, M., Hogan, A., Hayes, P., O'Reilly, M., Jeffery, I. B., Wood-Martin, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-306541 · Cited by 1,439 · cited 1×
“A study from Ireland found that athletes hard significantly higher microbial diversity than controls.(114) Alcoholics have been reported to carry greater abundance of Proteobacteria or its family Enterobacteriaceae(115,116) than control subjects.”
BackgroundPotential of fecal microbiota for early-stage detection of colorectal cancer
Zeller, G., Tap, J., Voigt, A. Y., Sunagawa, S., Kultima, J. R., Costea, P. I., Amiot, A., Böhm, J., Brunetti, F., Habermann, N., et al. (2014) · Molecular Systems Biology · doi:10.15252/msb.20145645 · Cited by 1,375
Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth
Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327
Structural segregation of gut microbiota between colorectal cancer patients and healthy volunteers
Wang, T., Cai, G., Qiu, Y., Fei, N., Zhang, M., Pang, X., Jia, W., Cai, S., & Zhao, L. (2012) · The ISME Journal · doi:10.1038/ismej.2011.109 · Cited by 1,287 · cited 1×
“Others did not find differences in these alpha diversity indices.(9,10,15,16) With or without using additional quantitative PCR (qPCR), these studies have also found that specific bacterial groups were more common or less common in colorectal cancer cases than control specimens.”
BackgroundAlleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme
Wallace, B. D., Wang, H., Lane, K. T., Scott, J. E., Orans, J., Koo, J. S., Venkatesh, M., Jobin, C., Yeh, L.-A., Mani, S., et al. (2010) · Science · doi:10.1126/science.1191175 · Cited by 1,080
Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
Joossens, M., Huys, G., Cnockaert, M., De Preter, V., Verbeke, K., Rutgeerts, P., Vandamme, P., & Vermeire, S. (2011) · Gut · doi:10.1136/gut.2010.223263 · Cited by 1,063 · cited 2×
“However, there have been only sporadic studies reporting a significant association with colorectal cancer itself,(101,102) while others found higher prevalence or density of these bacteria in IBD than in controls, which was further correlated with disease activity.(4,103,104) In addition to F.”
BackgroundResultHuman Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer
Chen, W., Liu, F., Ling, Z., Tong, X., & Xiang, C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039743 · Cited by 1,054
Fat, fibre and cancer risk in African Americans and rural Africans
O’Keefe, S. J. D., Li, J. V., Lahti, L., Ou, J., Carbonero, F., Mohammed, K., Posma, J. M., Kinross, J., Wahl, E., Ruder, E., et al. (2015) · Nature Communications · doi:10.1038/ncomms7342 · Cited by 982
Human Gut Microbiome and Risk for Colorectal Cancer
Ahn, J., Sinha, R., Pei, Z., Dominianni, C., Wu, J., Shi, J., Goedert, J. J., Hayes, R. B., & Yang, L. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt300 · Cited by 947 · cited 1×
“The potential association of this bacterium with colorectal cancer may be further corroborated by several other metagenomic studies that observed the overrepresentation of genus Porphyromonas or Porphyromonadaceae family in colorectal cancer specimens than control specimens.(10,13,92) Overall, the information availabl…”
ResultA bacterial driver–passenger model for colorectal cancer: beyond the usual suspects
Tjalsma, H., Boleij, A., Marchesi, J. R., & Dutilh, B. E. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2819 · Cited by 903 · cited 1×
“Cancer incidence in the large intestine is also known to be approximately 12-fold higher than that of the small intestine, which has been attributed to several magnitude greater bacterial density in the large intestine (w10(12) cells per ml) compared with that in the small intestine (w10(2) cells per ml).(3) With adva…”
BackgroundCorrelation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota
Albenberg, L., Esipova, T. V., Judge, C. P., Bittinger, K., Chen, J., Laughlin, A., Grunberg, S., Baldassano, R. N., Lewis, J. D., Li, H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.020 · Cited by 886 · cited 1×
“But it is now clear that bacterial populations in feces and mucosa are distinct.(6,7) As summarized in Table 1, the majority of these studies have demonstrated beta diversity by principal coordinate or component analysis illustrating structural difference of gut microbiome, where samples belonging to different disease…”
BackgroundFusobacterium nucleatum: a commensal-turned pathogen
Han, Y. W. (2015) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.11.013 · Cited by 869 · cited 1×
“nucleatum is perhaps best appreciated for its role as a component of oral plaque, where by virtue of its adhesive abilities it serves as a bridge organism between early and late colonizers of this biofilm and consequently is implicated in various forms of periodontal diseases.(84) Until recently, F.”
BackgroundMicrobial Dysbiosis in Colorectal Cancer (CRC) Patients
Sobhani, I., Tap, J., Roudot‐Thoraval, F., Roperch, J. P., Letulle, S., Langella, P., Corthier, G., Nhieu, J. T. V., & Furet, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016393 · Cited by 859
Colonic microbiome is altered in alcoholism
Mutlu, E. A., Gillevet, P. M., Rangwala, H., Sikaroodi, M., Naqvi, A., Engen, P. A., Kwasny, M., Lau, C. K., & Keshavarzian, A. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00380.2011 · Cited by 775
Martin, H., Campbell, B. J., Hart, C. A., Mpofu, C., Nayar, M. K., Singh, R., Englyst, H. N., Williams, H. F., & Rhodes, J. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.054 · Cited by 719
Microbiota organization is a distinct feature of proximal colorectal cancers
Dejea, C. M., Wick, E. C., Hechenbleikner, E. M., White, J. R., Mark Welch, J. L., Rossetti, B. J., Peterson, S. N., Snesrud, E. C., Borisy, G. G., Lazarev, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406199111 · Cited by 700
Tlaskalová-Hogenová, H., Štěpánková, R., Kozáková, H., Hudcovic, T., Vannucci, L., Tučková, L., Rossmann, P., Hrnčíř, T., Kverka, M., Zákostelská, Z., et al. (2011) · Cellular & Molecular Immunology · doi:10.1038/cmi.2010.67 · Cited by 693 · cited 1×
“, probiotics and prebiotics) whose administration may aid in disease prevention and treatment.(122)”
BackgroundMantovani, A. (2008) · Nature · doi:10.1038/457036b · Cited by 657 · cited 2×
“Accumulating evidence suggests that chronic infection and the ensuing inflammation contributes to tumor initiation and tumor progression.(137,154) A variety of bacterial species and tumorpromoting virulence mechanisms have been investigated, using mouse models.”
BackgroundStool microbiome and metabolome differences between colorectal cancer patients and healthy adults
Weir, T. L., Manter, D. K., Sheflin, A. M., Barnett, B. A., Heuberger, A. L., & Ryan, E. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070803 · Cited by 642 · cited 1×
“Others did not find differences in these alpha diversity indices.(9,10,15,16) With or without using additional quantitative PCR (qPCR), these studies have also found that specific bacterial groups were more common or less common in colorectal cancer cases than control specimens.”
BackgroundThe Bacteroides fragilis toxin gene is prevalent in the colon mucosa of colorectal cancer patients
Boleij, A., Hechenbleikner, E. M., Goodwin, A. C., Badani, R., Stein, E. M., Lazarev, M. G., Ellis, B., Carroll, K. C., Albesiano, E., Wick, E. C., et al. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/ciu787 · Cited by 625
Goodwin, A. C., Shields, C. E. D., Wu, S., Huso, D. L., Wu, X., Murray-Stewart, T. R., Hacker-Prietz, A., Rabizadeh, S., Woster, P. M., Sears, C. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010203108 · Cited by 612 · cited 1×
“BFT binds to a specific colonic epithelial receptor activating Wnt and NF-kB signaling pathways with increased cell proliferation, epithelial release of proinflammatory mediators, and induction of DNA damage(78,79) and ETBF promotes tumor formation in experimental animals.(79,80) Despite these laboratory data, to date…”
BackgroundTowards the Human Colorectal Cancer Microbiome
Marchesi, J. R., Dutilh, B. E., Hall, N., Peters, W. H. M., Roelofs, R., Boleij, A., & Tjalsma, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020447 · Cited by 552 · cited 2×
“, imbalance in of normal intestinal microbiota, can promote chronic inflammatory conditions and the production of carcinogenic metabolites, leading to neoplasia.(4,5) Gut microbiota represents a complex ecosystem that develops in close parallel with hosts and depends on the physiological environment of hosts.”
BackgroundThe human gut microbiome as a screening tool for colorectal cancer
Zackular, J. P., Rogers, M. A. M., Ruffin, M. T., & Schloss, P. D. (2014) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0129 · Cited by 551 · cited 1×
“The potential association of this bacterium with colorectal cancer may be further corroborated by several other metagenomic studies that observed the overrepresentation of genus Porphyromonas or Porphyromonadaceae family in colorectal cancer specimens than control specimens.(10,13,92) Overall, the information availabl…”
ResultHigh Prevalence of Mucosa-Associated E. coli Producing Cyclomodulin and Genotoxin in Colon Cancer
Buc, E., Dubois, D., Sauvanet, P., Raisch, J., Delmas, J., Darfeuille-Michaud, A., Pezet, D., & Bonnet, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056964 · Cited by 535 · cited 2×
“coli positive to the pks island or genes in the island has been recently found more common in the mucosa of colorectal cancer and IBD patients than that of control subjects.(71,75,76) Epithelial proliferation and E.”
BackgroundFusobacterium Is Associated with Colorectal Adenomas
McCoy, A. N., Araújo-Pérez, F., Azcárate-Peril, M. A., Yeh, J. J., Sandler, R. S., & Keku, T. O. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053653 · Cited by 533 · cited 1×
“Using qPCR, McCoy et al studied F counts in normal rectal mucosa of the cases with or without colorectal adenoma, revealing a 3 fold increase in risk of adenoma among subjects with highest tertile of F counts.(90) Ito et al(91) also demonstrated that F.”
BackgroundAssociation of Streptococcus bovis with Carcinoma of the Colon
Klein, R. S., Recco, R. A., Catalano, M. T., Edberg, S. C., Casey, J. I., & Steigbigel, N. H. (1977) · New England Journal of Medicine · doi:10.1056/nejm197710132971503 · Cited by 532
Zhao, M. D., Yang, M., Li, X., Jiang, P., Baranov, E., Li, S., Xu, M., Penman, S., & Hoffman, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408422102 · Cited by 488 · cited 1×
“In animal models, Salmonella and its derivatives have been observed invading transformed tissue more efficiently than normal tissue.(141,142) Salmonella AvrA is a multifunctional protein that influences eukaryotic cell pathways by altering ubiquitination and acetylation of target proteins.”
BackgroundCougnoux, A., Dalmasso, G., Martinez, R., Buc, E., Delmas, J., Gibold, L., Sauvanet, P., Darcha, C., Déchelotte, P., Bonnet, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305257 · Cited by 486
Intestinal floras of populations that have a high risk of colon cancer
Moore, W. E., & Moore, L. H. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.9.3202-3207.1995 · Cited by 483 · cited 1×
“Using culture methods, Moore and Moore observed that the abundance of Bacteroides and bifidobacteria was associated with increased risk of colon polyps, whereas Lactobacillus and Eubacterium aerofaciens were protective.(135) An association between the abundance of Fusobacterium, E.”
MethodColonization of the Human Gut by E. coli and Colorectal Cancer Risk
Bonnet, M., Buc, E., Sauvanet, P., Darcha, C., Dubois, D., Pereira, B., Déchelotte, P., Bonnet, R., Pezet, D., & Darfeuille-Michaud, A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1343 · Cited by 475 · cited 1×
“coli positive to the pks island or genes in the island has been recently found more common in the mucosa of colorectal cancer and IBD patients than that of control subjects.(71,75,76) Epithelial proliferation and E.”
BackgroundGut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells
Belcheva, A., Irrazabal, T., Robertson, S. J., Streutker, C., Maughan, H., Rubino, S., Moriyama, E. H., Copeland, J. K., Surendra, A., Kumar, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.04.051 · Cited by 473
Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Tahara, T., Yamamoto, E., Suzuki, H., Maruyama, R., Chung, W., Garriga, J., Jelinek, J., Yamano, H.-O., Sugai, T., An, B., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1865 · Cited by 465 · cited 1×
“These observations were further confirmed by quantitative (q) PCR and in situ hybridization in tumor tissue.(16,86,89) Using qPCR, McCoy et al studied F counts in normal rectal mucosa of the cases with or without colorectal adenoma, revealing a 3 fold increase in risk of adenoma among subjects with highest tertile of…”
MethodA possible role of Bacteroides fragilis enterotoxin in the aetiology of colorectal cancer
Ulger Toprak, N., Yagci, A., Gulluoglu, B. M., Akin, M. L., Demirkalem, P., Celenk, T., & Soyletir, G. (2006) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2006.01494.x · Cited by 454
Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients
Wu, N., Yang, X., Zhang, R., Li, J., Xiao, X., Hu, Y., Chen, Y., Yang, F., Lu, N., Wang, Z., et al. (2013) · Microbial Ecology · doi:10.1007/s00248-013-0245-9 · Cited by 454 · cited 2×
“The potential association of this bacterium with colorectal cancer may be further corroborated by several other metagenomic studies that observed the overrepresentation of genus Porphyromonas or Porphyromonadaceae family in colorectal cancer specimens than control specimens.(10,13,92) Overall, the information availabl…”
BackgroundResultEnterotoxigenic Bacteroides fragilis : a Rogue among Symbiotes
Sears, C. L. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00053-08 · Cited by 428 · cited 2×
“fragilis.(78) BFT binds to a specific colonic epithelial receptor activating Wnt and NF-kB signaling pathways with increased cell proliferation, epithelial release of proinflammatory mediators, and induction of DNA damage(78,79) and ETBF promotes tumor formation in experimental animals.”
BackgroundSmoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans
Biedermann, L., Zeitz, J., Mwinyi, J., Sutter-Minder, E., Rehman, A., Ott, S. J., Steurer-Stey, C. A., Frei, A. L., Frei, P., Scharl, M. M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059260 · Cited by 424
Gradel, K. O., Nielsen, H. L., Schønheyder, H. C., Ejlertsen, T., Kristensen, B., & Nielsen, H. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.001 · Cited by 424 · cited 1×
“These chronic infections increase the risk of several gastrointestinal(138) diseases, including chronic cholecystitis and gallbladder cancer.(139,140) Recently, Kato et al reported that antibody against Salmonella flagellin was higher in colorectal cancer and pre-cancer cases than controls in two distinct populations…”
BackgroundGastric precancerous process in a high risk population: cohort follow-up.
Correa, P., Haenszel, W. M., Cuello, C., Zavala, D., Fontham, E., Zarama, G., Tannenbaum, S. R., Collazos, T., & Ruiz, B. (1990) · PubMed · Cited by 375
Suzuki, T., Yoshida, S., & Hara, H. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508888733 · Cited by 370
Is overexpression of HER-2 a predictor of prognosis in colorectal cancer?
Kavanagh, D. O., Chambers, G., Grady, L. O., Barry, K. M., Waldron, R. P., Bennani, F., Eustace, P. W., & Tobbia, I. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-1 · Cited by 368
Co-occurrence of anaerobic bacteria in colorectal carcinomas
Warren, R. L., Freeman, D. J., Pleasance, S., Watson, P., Moore, R. A., Cochrane, K., Allen-Vercoe, E., & Holt, R. A. (2013) · Microbiome · doi:10.1186/2049-2618-1-16 · Cited by 348
Ahn, J., Segers, S., & Hayes, R. B. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs112 · Cited by 342
Picco, M. F. (2010) · Yearbook of Gastroenterology · doi:10.1016/s0739-5930(09)79399-7 · Cited by 314
Ramadass, B., Rajendiran, E., George, S., Samuel, G. V., & Ramakrishna, B. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05490.x · Cited by 307 · cited 1×
“These include Desulfovibrio, Enterococcus faecalis due to hydrogen sulfide and superoxide respectively,(100) Faecalibacterium prausnitzii and Bifidobacteria due to butyrate and lactate, respectively.(101,102) The presence or density/quantity of these bacteria in feces or mucosa has been primarily studied by qPCR.”
BackgroundAssociation between intraepithelial Escherichia coli and colorectal cancer
Swidsinski, A. V., Khilkin, M., Kerjaschki, D., Schreiber, S., Ortner, M., Weber, J., & Lochs, H. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70194-5 · Cited by 302
Ito, M., Kanno, S., Nosho, K., Sukawa, Y., Mitsuhashi, K., Kurihara, H., Igarashi, H., Takahashi, T., Tachibana, M., Takahashi, H., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29488 · Cited by 288
Collier-Hyams, L. S., Zeng, H., Sun, J., Tomlinson, A. D., Bao, Z., Chen, H., Madara, J., Orth, K., & Neish, A. S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.2846 · Cited by 276
Mira‐Pascual, L., Cabrera‐Rubio, R., Ocon, S. M., Costales, P., Parra, A., Suárez, A., Morís, F., Rodrigo, L., Mira, Á., & Collado, M. C. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-0963-x · Cited by 269 · cited 1×
“But it is now clear that bacterial populations in feces and mucosa are distinct.(6,7) As summarized in Table 1, the majority of these studies have demonstrated beta diversity by principal coordinate or component analysis illustrating structural difference of gut microbiome, where samples belonging to different disease…”
BackgroundCoordination of tolerogenic immune responses by the commensal microbiota
Round, J. L., O’Connell, R. M., & Mazmanian, S. K. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.11.007 · Cited by 269 · cited 1×
“Polysaccharide A, produced by a commensal bacteria, increases local interleukin 10 by inducing Foxp3þ regulatory T-cell and this effect is mediated by Toll like receptor 2 signaling.(156,157) Although recent studies provide insights into the roles of the bacterial products, the molecular mechanisms of the beneficial e…”
BackgroundGastrin and colorectal cancer: A prospective study
Thorburn*, C. M., Friedman‡, G. D., Dickinson§, C. J., Vogelman∥, J. H., Orentreich∥, N., & Parsonnet*, #. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70193-3 · Cited by 267
Commensal Bacteria, Redox Stress, and Colorectal Cancer: Mechanisms and Models
Huycke, M. M., & Gaskins, H. R. (2004) · Experimental Biology and Medicine · doi:10.1177/153537020422900702 · Cited by 244
Hu, S., Dong, T. S., Dalal, S. R., Wu, F., Bissonnette, M., Kwon, J. H., & Chang, E. B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016221 · Cited by 233
Damman, C. J., Miller, S. I., Surawicz, C. M., & Zisman, T. L. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.93 · Cited by 229 · cited 2×
“Bacterial metabolic products Firmicutes and Bacteroidetes predominate the gut microbiota, followed by Proteobacteria and Actinobacteria, with minor contributors including Verrucomicrobia and Fusobacteria.123 Bacteroides and Ruminococcus are consistent with enriched intake of animal sources, while a plant-based diet fa…”
BackgroundOver-expression of COX-2 mRNA in colorectal cancer
Roelofs, H. M. J., Morsche, R. H. T., van Heumen, B. W. H., Nagengast, F. M., & Peters, W. H. M. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-1 · Cited by 225
Kim, M., Hwang, S., Park, E., & Bae, J. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12079 · Cited by 220 · cited 1×
“Although meat intake itself has been rarely studied, removal of animal products (vegan diet) was recently tested in a few clinical trials, showing changes in the Firmicutes/Bacteroidetes ratio and abundance of bacteria capable of triggering inflammation.(112,113) Moreover, as discussed above, meats are one of the susp…”
BackgroundStreptococcus bovis Septicemia and Carcinoma of the Colon
Klein, R. S., CATALANO, M. T., EDBERG, S. C., CASEY, J. I., & STEIGBIGEL, N. H. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-91-4-560 · Cited by 214
Salmonella Effector AvrA Regulation of Colonic Epithelial Cell Inflammation by Deubiquitination
Ye, Z., Petrof, E. O., Boone, D. L., Claud, E. C., & Sun, J. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070220 · Cited by 212
Hardt, W., & Galán, J. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9887 · Cited by 212
The gastrointestinal microbiota and colorectal cancer
Keku, T. O., Dulal, S., Deveaux, A. E., Jovov, B., & Han, X. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00360.2012 · Cited by 207 · cited 1×
“Transplanting feces from mice with CRC into germ-free mice leads to increased tumorigenesis.(153) While emerging evidence suggests a link between the gut microbiota and colon cancer, it is hard to say that certain bacteria strain(s) play a causal role in CRC.”
BackgroundLu, R., Wu, S., Zhang, Y.-G., Xia, Y., Liu, X., Zheng, Y., Chen, H., Schaefer, K. L., Zhou, Z., Bissonnette, M., et al. (2014) · Oncogenesis · doi:10.1038/oncsis.2014.20 · Cited by 206 · cited 2×
“Uninfected mice treated with AOM/DSS developed tumors in the distal colon.(150) In contrast, in mice infected with AvrAexpressing bacteria, tumors were found more in the proximal colon.”
BackgroundSelf-citationMicrobiome, demystifying the role of microbial communities in the biosphere
Wommack, K. E., & Ravel, J. (2013) · Microbiome · doi:10.1186/2049-2618-1-1 · Cited by 205
Association of Streptococcus bovis Bacteremia With Colonic Neoplasia and Extracolonic Malignancy
Gold, J. S. (2004) · Archives of Surgery · doi:10.1001/archsurg.139.7.760 · Cited by 202
Fite, A., Macfarlane, G. T., Cummings, J. H., Hopkins, M. J., Kong, S. C., Furrie, E., & Macfarlane, S. (2004) · Gut · doi:10.1136/gut.2003.031245 · Cited by 201 · cited 1×
“However, there have been only sporadic studies reporting a significant association with colorectal cancer itself,(101,102) while others found higher prevalence or density of these bacteria in IBD than in controls, which was further correlated with disease activity.(4,103,104) In addition to F.”
ResultRuoff, K. L., Miller, S. I., Garner, C., Ferraro, M. J., & Calderwood, S. B. (1989) · Journal of Clinical Microbiology · doi:10.1128/jcm.27.2.305-308.1989 · Cited by 197
Role of colonic microbiota in colorectal carcinogenesis: A systematic review
Borges‐Canha, M. (2015) · Revista Española de Enfermedades Digestivas · doi:10.17235/reed.2015.3830/2015 · Cited by 195 · cited 1×
“It is clear that bacteria metabolites amino acids are increased and butyrate is decreased throughout colonic carcinogenesis.(121) Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial activities could aid in ou…”
BackgroundDisease tolerance mediated by microbiome E. coli involves inflammasome and IGF-1 signaling
Schieber, A. M. P., Lee, Y. M., Chang, M. W., Leblanc, M., Collins, B., Downes, M., Evans, R. M., & Ayres, J. S. (2015) · Science · doi:10.1126/science.aac6468 · Cited by 189 · cited 2×
“This effect was dependent on engagement of the NLRC4 inflammasome.(161) Therefore, commensal bacteria in gut promote tolerance to diverse diseases.”
BackgroundShort- and Long-term Effects of Bacterial Gastrointestinal Infections
Ternhag, A., Törner, A., Svensson, Å., Ekdahl, K., & Giesecke, J. (2008) · Emerging infectious diseases · doi:10.3201/eid1401.070524 · Cited by 188 · cited 1×
“Two studies from Scandinavian countries have found that the probability of new IBD diagnosis significantly (2e3 fold) increases compared with general population following an episode of non-typhoid salmonella infection, particularly within the first 10 years.(97,98) Although data directly linking to colorectal cancer a…”
BackgroundBiedermann, L., Brülisauer, K., Zeitz, J., Frei, P., Scharl, M., Vavricka, S. R., Fried, M., Loessner, M. J., Rogler, G., & Schuppler, M. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000129 · Cited by 178
Human gut microbiota: Does diet matter?
Maukonen, J., & Saarela, M. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114000688 · Cited by 177 · cited 1×
“Dietary fiber and resistant starch are well known to stimulate gut bacterial fermentation to generate short chain fatty acids (SCFA) as well as lactate and to increase relative abundance of bacterial groups with the relevant metabolic activities.(111) Although meat intake itself has been rarely studied, removal of ani…”
BackgroundNagaraja, V., & Eslick, G. D. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12655 · Cited by 161 · cited 1×
“Salmonellosis has also been implicated in the development of various chronic sequelae, including reactive arthritis, irritable bowel syndrome, IBD(95) and even cancer.(96) Two studies from Scandinavian countries have found that the probability of new IBD diagnosis significantly (2e3 fold) increases compared with gener…”
BackgroundSalmonellosis and the gastrointestinal tract: More than just peanut butter
Crum-Cianflone, N. F. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0079-7 · Cited by 157
Burnett‐Hartman, A. N., Newcomb, P. A., & Potter, J. D. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-08-0571 · Cited by 157 · cited 1×
“In addition, there may be indirect consequences from gastric pathology, such as hypergastrinemia, which is common in patients with Helicobacter infection and has been hypothesized to stimulate colorectal tumor growth.(70)”
BackgroundEnteric Salmonella or Campylobacter infections and the risk of inflammatory bowel disease
Jess, T., Simonsen, J., Nielsen, N. M., Jørgensen, K. T., Bager, P., Ethelberg, S., & Frisch, M. (2010) · Gut · doi:10.1136/gut.2010.223396 · Cited by 154 · cited 1×
“Two studies from Scandinavian countries have found that the probability of new IBD diagnosis significantly (2e3 fold) increases compared with general population following an episode of non-typhoid salmonella infection, particularly within the first 10 years.(97,98) Although data directly linking to colorectal cancer a…”
BackgroundEndocarditis due to group D streptococci
Moellering, R. C., Watson, B. K., & Kunz, L. J. (1974) · The American Journal of Medicine · doi:10.1016/0002-9343(74)90448-3 · Cited by 153
Helicobacter pylori infection in gastric cancerogenesis.
Konturek, P. C., Konturek, S. J., & Brzozowski, T. (2009) · PubMed · Cited by 151
Maddocks, O. D. K., Short, A., Donnenberg, M. S., Bader, S. A., & Harrison, D. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005517 · Cited by 150
Allen‐Vercoe, E., Strauss, J., & Chadee, K. (2011) · Gut Microbes · doi:10.4161/gmic.2.5.18603 · Cited by 149
Rosignoli, P. (2001) · Carcinogenesis · doi:10.1093/carcin/22.10.1675 · Cited by 147 · cited 1×
“SCFA promotes and maintains colonic epithelial health through maintaining barrier function,(129) suppressing colonic cancer, inhibiting intestinal inflammation (Wu et al 2014), modulating immune response,(133) regulating DNA methylation for proliferation,(132) and diminishing oxidative DNA damage.(134) The balance bet…”
BackgroundStreptococcus bovis endocarditis, a silent sign for colonic tumour
Gupta, A., Madani, R., & Mukhtar, H. (2009) · Colorectal Disease · doi:10.1111/j.1463-1318.2009.01814.x · Cited by 143
Metagenomic profile of gut microbiota in children during cholera and recovery
Monira, S., Nakamura, S., Gotoh, K., Izutsu, K., Watanabe, H., Alam, N. H., Nakaya, T., Horii, T., Ali, S. I., Iida, T., et al. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-1 · Cited by 142
Bindels, L. B., Neyrinck, A. M., Salazar, N., Taminiau, B., Druart, C., Muccioli, G. G., François, E., Blecker, C. S., Richel, A., Daube, G., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131009 · Cited by 141
Tuomisto, S., Pessi, T., Collin, P., Vuento, R., Aittoniemi, J., & Karhunen, P. J. (2014) · BMC Gastroenterology · doi:10.1186/1471-230x-14-40 · Cited by 141
Streptococcus bovis Bacteremia and Underlying Gastrointestinal Disease
Murray, H. W. (1978) · Archives of Internal Medicine · doi:10.1001/archinte.1978.03630320037013 · Cited by 140
Fusobacterium and Enterobacteriaceae: Important players for CRC?
Allen‐Vercoe, E., & Jobin, C. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.05.014 · Cited by 137
Shazali, N., Foo, H. L., Loh, T. C., Choe, D. W., & Rahim, R. A. (2014) · Gut Pathogens · doi:10.1186/1757-4749-6-1 · Cited by 133
The Triad of Streptococcus Bovis Bacteremia, Colonic Pathology, and Liver Disease
Zarkin, B. A., Lillemoe, K. D., Cameron, J. L., Effron, P. N., Magnuson, T. H., & Pitt, H. A. (1990) · Annals of Surgery · doi:10.1097/00000658-199006000-00019 · Cited by 132
Salmonella regulation of intestinal stem cells through the Wnt/β‐catenin pathway
Liu, X., Lu, R., Wu, S., & Sun, J. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.024 · Cited by 130
Diversified pattern of the human colorectal cancer microbiome
Geng, J., Fan, H., Tang, X., Zhai, H., & Zhang, Z. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-2 · Cited by 127 · cited 1×
“On the contrary a richness index was higher in rectal mucosa of colorectal cancer patients than in that of control subjects(7) or in cancer tissues than paired normal tissue.(11) Others did not find differences in these alpha diversity indices.”
BackgroundRandazzo, C. L., Vaughan, E. E., & Caggia, C. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2005.11.002 · Cited by 126
Scanlan, P. D., Shanahan, F., & Marchesi, J. R. (2009) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2009.00709.x · Cited by 124 · cited 1×
“coli, hydrogen sulfide (H2S)-, and bile salt-producing bacteria was associated with increased risk of colon cancer.(5,136) Cancer is associated with reduced abundances of Clostridium, Roseburia, Eubacteria spp.”
BackgroundGueimonde, M. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i29.3985 · Cited by 124 · cited 1×
“These include Desulfovibrio, Enterococcus faecalis due to hydrogen sulfide and superoxide respectively,(100) Faecalibacterium prausnitzii and Bifidobacteria due to butyrate and lactate, respectively.(101,102) The presence or density/quantity of these bacteria in feces or mucosa has been primarily studied by qPCR.”
BackgroundBeck, M., Frodl, R., & Funke, G. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00078-08 · Cited by 122
Liao, A. P., Petrof, E. O., Kuppireddi, S., Zhao, Y., Xia, Y., Claud, E. C., & Sun, J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002369 · Cited by 121
Infection as a risk factor for gallbladder cancer
Kumar, S., Kumar, S., & Kumar, S. (2006) · Journal of Surgical Oncology · doi:10.1002/jso.20530 · Cited by 119 · cited 1×
“These chronic infections increase the risk of several gastrointestinal(138) diseases, including chronic cholecystitis and gallbladder cancer.(139,140) Recently, Kato et al reported that antibody against Salmonella flagellin was higher in colorectal cancer and pre-cancer cases than controls in two distinct populations…”
BackgroundProbiotics for the Treatment of Inflammatory Bowel Disease
Veerappan, G. R., Betteridge, J. D., & Young, P. E. (2012) · Current Gastroenterology Reports · doi:10.1007/s11894-012-0265-5 · Cited by 117
Corredoira, J., Garcı́a-Garrote, F., Rey, R. R., López-Rosés, L., García-Pais, M. J., Gracián-Castro, E., González-Soler, R., Coira, A., Pita, J., Lopez-Alvarez, M. J., et al. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis434 · Cited by 116
Corredoira, J., Alonso, M. P., García, J. F., Casariego, E., Coira, A., Rodríguez, A., Pita, J., Louzao, C., Pombo, B., López, M. J., et al. (2005) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-005-1314-x · Cited by 112
Fite, A., Macfarlane, S., Furrie, E., Bahrami, B., Cummings, J. H., Steinke, D. T., & Macfarlane, G. T. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.02574-12 · Cited by 110 · cited 1×
“However, there have been only sporadic studies reporting a significant association with colorectal cancer itself,(101,102) while others found higher prevalence or density of these bacteria in IBD than in controls, which was further correlated with disease activity.(4,103,104) In addition to F.”
ResultSchlegel, L., Grimont, F., COLLINS, M. D., Regnault, B., Grimont, P. A. D., & Bouvet, A. (2000) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-50-4-1425 · Cited by 110 · cited 3×
“Approximately 10% of healthy individuals have been estimated to carry this bacterium asymptomatically in their digestive tract.(20) While fecaleoral or oraleoral is a possible transmission route between humans, it may be acquired through dietary intake of ruminant-derived foods, such as unpasteurized dairy products,(2…”
BackgroundSelective Inhibition of Type III Secretion Activated Signaling by the Salmonella Effector AvrA
Du, F., & Galán, J. E. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000595 · Cited by 106
Bacterial activation of β-catenin signaling in human epithelia
Sun, J., Hobert, M. E., Rao, A. S., Neish, A. S., & Madara, J. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00498.2003 · Cited by 105
Wu, Q., Yang, Z., Xu, P., Gao, L., & Fan, D. (2013) · Colorectal Disease · doi:10.1111/codi.12284 · Cited by 102
Abdulamir, A. S., Hafidh, R. R., Mahdi, L. K., Al-jeboori, T., & Abubaker, F. (2009) · BMC Cancer · doi:10.1186/1471-2407-9-403 · Cited by 100
Tjalsma, H., Schöller‐Guinard, M., Lasonder, E., Ruers, T. J. M., Willems, H. L., & Swinkels, D. W. (2006) · International Journal of Cancer · doi:10.1002/ijc.22116 · Cited by 97
Co-occurrence of driver and passenger bacteria in human colorectal cancer
Geng, J., Song, Q., Tang, X., Xiao, L., Fan, H., Peng, H., Guo, Q., & Zhang, Z. (2014) · Gut Pathogens · doi:10.1186/1757-4749-6-26 · Cited by 90
Corredoira, J., Alonso, M. P., Coira, A., Casariego, E., Arias, C. A., Alonso, D., Pita, J., Rodríguez, A., López, M. J., & Varela, J. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0441-y · Cited by 89
Rates of production and utilization of lactate by microbial communities from the human colon
Belenguer, Á., Holtrop, G., Duncan, S. H., Anderson, S. E., Calder, A. G., Flint, H. J., & Lobley, G. E. (2011) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2011.01086.x · Cited by 85
Helicobacter pylori in colorectal neoplasms: is there an aetiological relationship?
Jones, M., Helliwell, P., Pritchard, C. W., Tharakan, J., & Mathew, J. (2007) · World Journal of Surgical Oncology · doi:10.1186/1477-7819-5-51 · Cited by 85
Burns, C., McCaughey, R. S., & Lauter, C. B. (1985) · PubMed · Cited by 82
Association of Streptococcus bovis Bacteremia with Bowel Disease
Reynolds, J. G., da Silva, E. T. G., & McCormack, W. M. (1983) · Journal of Clinical Microbiology · doi:10.1128/jcm.17.4.696-697.1983 · Cited by 82
Bongers, G., Pacer, M. E., Geraldino, T. H., Chen, L., He, Z., Hashimoto, D., Furtado, G. C., Ochando, J., Kelley, K. A., Clemente, J. C., et al. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20131587 · Cited by 79 · cited 1×
“This study indicates that the same genetic mutation in different individuals may have a different outcome.(152) One environmental factor e a diet low in fiber e may impact the intestinal microbiota in a way that affects host cell physiology, cellular homeostasis, energy regulation, and/or metabolism of xenobiotics.”
BackgroundSalmonella Promoters Preferentially Activated Inside Tumors
Arrach, N., Zhao, M. D., Porwollik, S., Hoffman, R. M., & McClelland, M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0552 · Cited by 78 · cited 1×
“In animal models, Salmonella and its derivatives have been observed invading transformed tissue more efficiently than normal tissue.(141,142) Salmonella AvrA is a multifunctional protein that influences eukaryotic cell pathways by altering ubiquitination and acetylation of target proteins.”
BackgroundCorredoira, J., Alonso, M. P., Coira, A., & Varela, J. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.00129-08 · Cited by 74 · cited 1×
“infantarius to non-colonic cancers, primarily in the pancreas and biliary tract.(19) Although SB is a member of normal gastrointestinal flora in ruminants, e.”
BackgroundInhibition by Resistant Starch of Red Meat–Induced Promutagenic Adducts in Mouse Colon
Winter, J. M., Nyskohus, L. S., Young, G. P., Hu, Y. C., Conlon, M. A., Bird, A. R., Topping, D. L., & Leu, R. K. L. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0176 · Cited by 74
Helicobacter pylori seropositivity and colorectal cancer risk: a prospective study of male smokers.
Limburg, P. J., Stolzenberg‐Solomon, R. Z., Colbert, L. H., Perez-Perez, G. I., Blaser, M. J., Taylor, P. R., Virtamo, J. R. K., & Albanes, D. (2002) · PubMed · Cited by 74
Association between Streptococcus bovis and Colon Cancer
Boleij, A., Schaeps, R. M. J., & Tjalsma, H. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.01755-08 · Cited by 71 · cited 1×
“These variations may also be due to the heterogeneous definition of the cases, as adenomas have been defined as diseased in some studies but not in the others.(46) A more recent study found that 52% of SB bacteremia patients had advanced adenoma/cancer, which was approximately 2.”
ResultGeographical difference of disease association in Streptococcus bovis bacteraemia
Lee, R. A., Woo, P. C. Y., To, A. P. C., Lau, S. K. P., Wong, S. S. Y., & Yuen, K. (2003) · Journal of Medical Microbiology · doi:10.1099/jmm.0.05199-0 · Cited by 69
Prevalence of Liver Disease in Patients with Streptococcus bovis Bacteraemia
Gonzlez-Quintela, A., Martínez-Rey, C., Castroagudı́n, J. F., Rajo-Iglesias, M. C., & Domínguez‐Santalla, M. J. (2001) · Journal of Infection · doi:10.1053/jinf.2001.0799 · Cited by 65
A prospective study of plasma inflammatory markers and risk of colorectal cancer in men
Song, M., Wu, K., Ogino, S., Fuchs, C. S., Giovannucci, E. L., & Chan, A. T. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.172 · Cited by 64
Alazmi, W. M., Bustamante, M., O’Loughlin, C. J., González, J. D., & Raskin, J. B. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-3199-7 · Cited by 59
A prospective controlled study of the association of Streptococcus bovis with colorectal carcinoma.
Potter, M. A., Cunliffe, N. A., Smith, M. H., Miles, R., Flapan, A. D., & Dunlop, M. G. (1998) · Journal of Clinical Pathology · doi:10.1136/jcp.51.6.473 · Cited by 59
Characteristics and regional variations of group D streptococcal endocarditis in France
Giannitsioti, E., Chirouze, C., Bouvet, A., Béguinot, I., Delahaye, F., Mainardi, J., Célard, M., Mihaïla-Amrouche, L., Moing, V. L., & Hoen, B. (2007) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2007.01753.x · Cited by 58
Clarridge, J. E., Attorri, S., Zhang, Q., & Bartell, J. G. (2001) · Journal of Clinical Microbiology · doi:10.1128/jcm.39.4.1549-1552.2001 · Cited by 58
Butt, J., Romero‐Hernández, B., Pérez‐Gómez, B., Willhauck‐Fleckenstein, M., Holzinger, D., Martín, V., Moreno, V. R., Linares, C., Dierssen‐Sotos, T., Barricarte, A., et al. (2015) · International Journal of Cancer · doi:10.1002/ijc.29914 · Cited by 55
Increased exposure to bacterial antigen RpL7/L12 in early stage colorectal cancer patients
Boleij, A., Roelofs, R., Schaeps, R. M. J., Schülin, T., Glaser, P., Swinkels, D. W., Kato, I., & Tjalsma, H. (2010) · Cancer · doi:10.1002/cncr.25212 · Cited by 54
Keithlin, J., Sargeant, J. M., Thomas, M. K., & Fazil, A. (2014) · Epidemiology and Infection · doi:10.1017/s0950268814002829 · Cited by 52
Serological investigation into the association between Streptococcus bovis and colonic cancer.
Darjee, R., & Gibb, A. P. (1993) · Journal of Clinical Pathology · doi:10.1136/jcp.46.12.1116 · Cited by 51
Fecal carriage of Streptococcus bovis and colorectal adenomas
Dubrow, R., Edberg, S. C., Wikfors, E., Callan, D. A., Troncale, F. J., Vender, R. J., Brand, M., & Yapp, R. G. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90531-o · Cited by 46
Partial associations of dietary iron, smoking and intestinal bacteria with colorectal cancer risk
Kato, I., Boleij, A., Kortman, G. A. M., Roelofs, R., Djuric, Z., Severson, R. K., & Tjalsma, H. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.748922 · Cited by 46
Bacteremic Streptococcus bovis infections at a university hospital, 1992-2001.
Jean, S., Teng, L., Hsueh, P., Ho, S. W., & Luh, K. T. (2004) · PubMed · Cited by 43
Wentling, G. K., Metzger, P. P., Dozois, E. J., Chua, H. K., & Krishna, M. (2006) · Diseases of the Colon & Rectum · doi:10.1007/s10350-006-0576-4 · Cited by 43
Boleij, A., Roelofs, R., Danne, C., Bellais, S., Dramsi, S., Kato, I., & Tjalsma, H. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0321 · Cited by 38
Sharara, A. I., Hamdan, T. A., Malli, A. H., El-Halabi, M. M., Hashash, J. G., Ghaith, O. A., & Kanj, S. S. (2013) · Journal of Digestive Diseases · doi:10.1111/1751-2980.12059 · Cited by 28 · cited 2×
“Similar prevalence (60%) of advanced adenoma/ cancer was reported in SB endocarditis patients by Sharara et al.(48) The second set of evidence is derived from studies comparing SB prevalence among various patient groups with or without colonic diseases.”
BackgroundWorthley, D. L., Whitehall, V., Leu, R. K. L., Irahara, N., Buttenshaw, R. L., Mallitt, K., Greco, S. A., Ramsnes, I., Winter, J. M., Hu, Y. C., et al. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1312-4 · Cited by 28
Inflammatory Bowel Disease and Streptococcus bovis
Teitelbaum, J. E., & Triantafyllopoulou, M. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-9053-5 · Cited by 24
Cancer Therapies Use a Little Help From Microbial Friends
Pennisi, E. (2013) · Science · doi:10.1126/science.342.6161.921 · Cited by 22
Streptococcus bovis septicaemia associated with uncomplicated colonic carcinoma
McMahon, A. J., Auld, C. D., Dale, B. A. S., Walls, A. D. F., & McCormick, J. S. (1991) · British journal of surgery · doi:10.1002/bjs.1800780734 · Cited by 22
Gentamicin-thallous-carbonate medium for isolation of fecal streptococci from foods
Thian, T. S., & Hartman, P. A. (1981) · Applied and Environmental Microbiology · doi:10.1128/aem.41.3.724-728.1981 · Cited by 20 · cited 1×
“In fact SB is a frequently detected contaminant in commercially available meat.(23,24) The correlation between SB and colonic disease has long been recognized.”
BackgroundStreptococcs bovis Bacteremia and Digestive System Neoplasms
Pigrau, C., Lorente, A., Pahissa, A., & Martinez-Vazquez, J. M. (1988) · Scandinavian Journal of Infectious Diseases · doi:10.3109/00365548809032490 · Cited by 20
Kato, I., Nechvatal, J. M., Dzinic, S. H., Basson, M. D., Majumdar, A. P. N., & Ram, J. L. (2010) · PubMed · Cited by 19
Efficient tumor targeting by anaerobic butyrate-producing bacteria
Tirandaz, H., & Mohammadi, E. (2013) · Medical Hypotheses · doi:10.1016/j.mehy.2013.01.024 · Cited by 17
Kim, S. Y., Joo, S.-I., Yi, J., & Kim, E. C. (2010) · Annals of Laboratory Medicine · doi:10.3343/kjlm.2010.30.2.160 · Cited by 16
Knudtson, L. M., & Hartman, P. A. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.936-938.1993 · Cited by 14
Streptococcus bovis bacteremia related to colon adenoma in a chronic hemodialysis patient
Kahveci, A., Arı, E., Arikan, I. H., Koç, M., Tuğlular, S., & Ozener, C. I. (2009) · Hemodialysis International · doi:10.1111/j.1542-4758.2009.00400.x · Cited by 8
The influence of endoscopic procedures upon the contamination of Helicobacter pylori cultures
Ribeiro, M. L., Godoy, A. P. O., Benvengo, Y. H. B., Ecclissato, C., Mendonça, S., & Pedrazzoli, J. (2004) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032004000200006 · Cited by 6 · cited 1×
“, cattle, sheep, horses, pigs, camels and deers, it is also found in human feces as well as gastric biopsy materials.(20,21) Approximately 10% of healthy individuals have been estimated to carry this bacterium asymptomatically in their digestive tract.”
BackgroundCheng, H., Zhang, T., Gu, W., Shu, X., Zhang, Y., Zhang, X., Wu, X., Chen, J., & Jiang, M. (2011) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182467538 · Cited by 6
[Molecular-biological methods of diagnosing colon-related Streptococcus bovis endocarditis].
Nielsen, S. D., Christensen, J. J., Laerkeborg, A., Haunsø, S., & Knudsen, J. D. (2007) · PubMed · Cited by 5
Flagged first, then by citations
1 of the 170 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- WCRF/AICR, 2011, Continuous update project report: food, nutrition, physical activity, and the prevention of colorectal cancer, Colorectal Cancer 2011 Rep Lond WCRF/AICR, 1
Cited by
Sorted by citations
NF-κB, inflammation, immunity and cancer: coming of age
Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679
Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer
Song, M., Chan, A. T., & Sun, J. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.06.048 · Cited by 752
The Gut Microbiota and Inflammation: An Overview
Bander, Z. A., Nitert, M. D., Mousa, A., & Naderpoor, N. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17207618 · Cited by 804
Tumor biomarkers for diagnosis, prognosis and targeted therapy
Zhou, Y., Tao, L., Qiu, J., Xu, J., Yang, X., Zhang, Y., Tian, X., Guan, X., Cen, X., & Zhao, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01823-2 · Cited by 836
Salguero, M. V., Al-Obaide, M. A. I., Singh, R., Siepmann, T., & Vasylyeva, T. L. (2019) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2019.7943 · Cited by 270
“The present study identified five previously reported genera in the phylum Bacteroidetes, including Porphyromonas , Prevotella , Paraprevotella and Flavobacterium (38,39).”
Metadata
- Authors
- Sun, J., & Kato, I.
- Affiliations
- University of Illinois Chicago (US)
- Wayne State University (US)
- Corresponding author
- Sun, Jun
- ORCID
- Venue
- Genes & Diseases
- Publisher
- Elsevier BV
- Published
- 2016-06
- Volume
- 3
- Issue
- 2
- Pages
- 130-143
- ISSN
- 2352-3042 (ISSN-L)
- PMC
- PMC5221561
- OpenAlex
- W2338446464
- Cited by
- 257
- References
- 170
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 25 · 2023: 27 · 2022: 34 · 2021: 29 · 2020: 39 · 2019: 29 · 2018: 27 · 2017: 14
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Genes & Diseases (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK105118)
- Cancer Center, University of Illinois at Chicago
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Keywords
- gut microbiota, colorectal cancer, inflammation, tumor progression, chronic infection, bacterial virulence factors, host-microbe interactions, intestinal barrier function, cancer prevention, cancer diagnosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
