The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The Ccr4–Not complex
Open accessAbstract
The Ccr4-Not complex is a unique, essential and conserved multi-subunit complex that acts at the level of many different cellular functions to regulate gene expression. Two enzymatic activities, namely ubiquitination and deadenylation, are provided by different subunits of the complex. However, studies over the last decade have demonstrated a tantalizing multi-functionality of this complex that extends well beyond its identified enzymatic activities. Most of our initial knowledge about the Ccr4-Not complex stemmed from studies in yeast, but an increasing number of reports on this complex in other species are emerging. In this review we will discuss the structure and composition of the complex, and describe the different cellular functions with which the Ccr4-Not complex has been connected in different organisms. Finally, based upon our current state of knowledge, we will propose a model to explain how one complex can provide such multi-functionality. This model suggests that the Ccr4-Not complex might function as a "chaperone platform".
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886
A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis
Albuquerque, C. P., Smolka, M. B., Payne, S. H., Bafna, V., Eng, J., & Zhou, H. (2008) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m700468-mcp200 · Cited by 504
A Network of Multiple Regulatory Layers Shapes Gene Expression in Fission Yeast
Lackner, D. H., Beilharz, T. H., Marguerat, S., Mata, J., Watt, S., Schubert, F., Preiss, T., & Bähler, J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.002 · Cited by 204
Lee, D., Ezhkova, E., Li, B., Pattenden, S. G., Tansey, W. P., & Workman, J. L. (2005) · Cell · doi:10.1016/j.cell.2005.08.015 · Cited by 178
Widespread use of poly(A) tail length control to accentuate expression of the yeast transcriptome
Beilharz, T. H., & Preiss, T. (2007) · RNA · doi:10.1261/rna.569407 · Cited by 144
Dagley, M. J., Gentle, I. E., Beilharz, T. H., Pettolino, F. A., Djordjevic, J. T., Lo, T. L., Uwamahoro, N., Rupasinghe, T., Tull, D. L., McConville, M., et al. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07503.x · Cited by 128
Cited by
Amm, I., Sommer, T., & Wolf, D. H. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.031 · Cited by 493
De Keersmaecker, K., Atak, Z. K., Li, N., Vicente, C., Patchett, S., Girardi, T., Gianfelici, V., Geerdens, E., Clappier, E., Porcu, M., et al. (2013) · Nature Genetics · doi:10.1038/ng.2508 · Cited by 428
The Ccr4‐Not complex is a key regulator of eukaryotic gene expression
Collart, M. A. (2016) · WIREs RNA · doi:10.1002/wrna.1332 · Cited by 359
Self-citationRoquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs
Leppek, K., Schott, J., Reitter, S., Poetz, F., Hammond, M. C., & Stoecklin, G. (2013) · Cell · doi:10.1016/j.cell.2013.04.016 · Cited by 320
Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways
Ikeuchi, K., Tesina, P., Matsuo, Y., Sugiyama, T., Cheng, J., Saeki, Y., Tanaka, K., Becker, T., Beckmann, R., & Inada, T. (2019) · The EMBO Journal · doi:10.15252/embj.2018100276 · Cited by 315
Metadata
- Authors
- Collart, M. A., & Panasenko, O. O.
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 492
- Issue
- 1
- Pages
- 42-53
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2091544975
- Cited by
- 290
- References
- 6
- FWCI
- 10.23
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Ccr4–Not complex. https://app.cochat.ai/papers/10.1016/j.gene.2011.09.033
- The paper
- Collart, M. A., & Panasenko, O. O. (2012). The Ccr4–Not complex. Gene. https://doi.org/10.1016/j.gene.2011.09.033
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
