Association between vaspin rs2236242 gene polymorphism and polycystic ovary syndrome risk
Abstract
Vaspin, an adipocytokine that has been isolated from the visceral adipose tissue, is a member of the serine protease inhibitor family. In humans, serum vaspin levels are correlated with body mass index (BMI) and obese women with polycystic ovary syndrome (PCOS). The present study is the first investigation to examine the association between vaspin rs2236242 gene polymorphism and risk of PCOS in Iranian patients. This case-control study was performed on 150 patients with PCOS and 150 healthy women. The vaspin genotypes were determined using tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR). Our finding showed that there are significant differences in genotype frequencies between case and control group regarding vaspin rs2236242 polymorphism (OR=0.59, CI=0.37-0.95, p=0.03). The A allele decreased the risk of PCOS (OR=0.67, CI=0.46-0.96, p=0.03) as compared to the T allele. There was no significant association between vaspin rs2236242 gene polymorphism and PCOS after adjusting genotypes for BMI. In conclusion, our data suggest a significant association between vaspin rs2236242 polymorphism and the PCOS but this relationship is affected by obesity status.
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Vaspin gene rs2236242 polymorphism is significantly different between PCOS patients and controls (OR: 0.59; 95% CI: 0.37 to 0.95; P=0.03).
“Another study shows that vaspin gene rs2236242 polymorphism is significantly different between PCOS patients and controls (odds ratio: 0.59; 95% CI: 0.37 to 0.95; P=0.03).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [48]
After adjusting for BMI, the association of vaspin gene rs2236242 polymorphism with PCOS is not significant.
“However, after adjusting for BMI, the results are not significant (48).”
From Circulating Adipokine Levels in Nonobese Women with Polycystic Ovary Syndrome and in Nonobese Control Women: A Systematic Review and Meta-Analysis (2021) · cites this paper as [48]
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- Authors
- Kohan, L., Zarei, A., Fallahi, S., & Tabiee, O.
- Affiliations
- Islamic Azad University of Arsanjan (IR)
- Shiraz University (IR)
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 539
- Issue
- 2
- Pages
- 209-212
- ISSN
- 0378-1119 (ISSN-L)
- OpenAlex
- W2065692137
- Cited by
- 23
- References
- 35
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2015: 2
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Shiraz University
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- vaspin, genetic polymorphism, polycystic ovary syndrome, genetic susceptibility, obesity, body mass index, adipokines, Iranian women
- MeSH terms
- Adult, Body Composition, DNA, Female, Follow-Up Studies, Genotype, Humans, Polycystic Ovary Syndrome, Polymorphism, Genetic, Prognosis, Risk Factors, Biomarkers, Serpins, Body Mass Index, Case-Control Studies, Polymerase Chain Reaction
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