The role of Atg7-mediated autophagy in ionizing radiation-induced neural stem cell damage

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882 · see citing works

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J.-I., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., et al. (2006) · Nature · doi:10.1038/nature04723 · Cited by 3,500 · see citing works

ICRP PUBLICATION 118: ICRP Statement on Tissue Reactions and Early and Late Effects of Radiation in Normal Tissues and Organs — Threshold Doses for Tissue Reactions in a Radiation Protection Context

Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604 · see citing works

Cargo recognition and degradation by selective autophagy

Gatica, D., Lahiri, V., & Klionsky, D. J. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0037-z · Cited by 1,067 · see citing works

A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles.

Paglin, S., Hollister, T. C., Delohery, T. M., Hackett, N., McMahill, M., Sphicas, E., Domingo, D., & Yahalom, J. (2001) · PubMed · Cited by 952 · see citing works

The Atg8 and Atg12 ubiquitin‐like conjugation systems in macroautophagy

Geng, J., & Klionsky, D. J. (2008) · EMBO Reports · doi:10.1038/embor.2008.163 · Cited by 781 · see citing works

Neural stem and progenitor cells in nestin‐GFP transgenic mice

Mignone, J., Kukekov, V. G., Chiang, A., Steindler, D. A., & Enikolopov, G. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.10964 · Cited by 705 · see citing works

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration

Komatsu, M., Wang, Q. J., Holstein, G. R., Friedrich, V. L., Iwata, J.-I., Kominami, E., Chait, B. T., Tanaka, K., & Yue, Z. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701311104 · Cited by 614 · see citing works

MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling

Zhao, C., Sun, G., Li, S., Lang, M., Su, Y., Li, W., & Shi, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908750107 · Cited by 388 · see citing works

HsAtg4B/HsApg4B/Autophagin-1 Cleaves the Carboxyl Termini of Three Human Atg8 Homologues and Delipidates Microtubule-associated Protein Light Chain 3- and GABAA Receptor-associated Protein-Phospholipid Conjugates

Tanida, I., Sou, Y., Ezaki, J., Minematsu‐Ikeguchi, N., Ueno, T., & Kominami, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401461200 · Cited by 364 · see citing works

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

Scrivo, A., Bourdenx, M., Pampliega, O., & Cuervo, A. M. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30238-2 · Cited by 355 · see citing works

Effect of low doses of ionising radiation in infancy on cognitive function in adulthood: Swedish population based cohort study

Hall, P. N., Adami, H., Trichopoulos, D., Pedersen, N. L., Lagiou, P., Ekbom, A., Ingvar, M., Lundell, M., & Granath, F. (2004) · BMJ · doi:10.1136/bmj.328.7430.19 · Cited by 350 · see citing works

mTOR Pathways in Cancer and Autophagy

Paquette, M., El–Houjeiri, L., & Pause, A. (2018) · Cancers · doi:10.3390/cancers10010018 · Cited by 296 · see citing works

Molecular Pathways: Radiation-Induced Cognitive Impairment

Greene-Schloesser, D. M., Moore, E., & Robbins, M. E. C. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2903 · Cited by 275 · see citing works

Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration

Liang, C.-C., Wang, C., Xu, P., Gan, B., & Guan, J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.072389 · Cited by 234 · see citing works

Selective turnover of p62/A170/SQSTM1 by autophagy

Ichimura, Y., Kominami, E., Tanaka, K., & Komatsu, M. (2008) · Autophagy · doi:10.4161/auto.6826 · Cited by 228 · see citing works

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

Rubinsztein, D. C., Bento, C. F., & Deretic, V. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150956 · Cited by 202 · see citing works

Autophagy for tissue homeostasis and neuroprotection

Mariño, G., Madeo, F., & Kroemer, G. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.10.001 · Cited by 195 · see citing works

MAP‐LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis

Asanuma, K., Tanida, I., Shirato, I., Ueno, T., Takahara, H., Nishitani, T., Kominami, E., & Tomino, Y. (2003) · The FASEB Journal · doi:10.1096/fj.02-0580fje · Cited by 186 · see citing works

Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells

Vázquez, P., Arroba, A. I., Cecconi, F., de la Rosa, E. J., Boya, P., & De Pablo, F. (2012) · Autophagy · doi:10.4161/auto.8.2.18535 · Cited by 171 · see citing works

The Function of Autophagy in Neurodegenerative Diseases

Kiriyama, Y., & Nochi, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125990 · Cited by 168 · see citing works

Radiation-induced autophagy: mechanisms and consequences

Chaurasia, M., Bhatt, A. N., Das, A., Dwarakanath, B. S. R., & Sharma, K. (2016) · Free Radical Research · doi:10.3109/10715762.2015.1129534 · Cited by 114 · see citing works

Exposure to16O-Particle Radiation Causes Aging-Like Decrements in Rats through Increased Oxidative Stress, Inflammation and Loss of Autophagy

Poulose, S. M., Bielinski, D. F., Carrihill-Knoll, K. L., Rabin, B. M., & Shukitt‐Hale, B. (2011) · Radiation Research · doi:10.1667/rr2605.1 · Cited by 77 · see citing works

MENTAL FUNCTION FOLLOWING SCALP IRRADIATION DURING CHILDHOOD

Ron, E., Modan, B., Floro, S., HARKEDAR, I., & Gurewitz, R. (1982) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a113389 · Cited by 75 · see citing works

Cognitive, Psychological and Psychiatric Effects of Ionizing Radiation Exposure

Marazziti, D., Baroni, S., Catena-Dell’Osso, M., Schiavi, E., Ceresoli, D., Conversano, C., Dell’Osso, L., & Picano, E. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800099776 · Cited by 63 · see citing works

On the Role of Basal Autophagy in Adult Neural Stem Cells and Neurogenesis

Casares-Crespo, L., Calatayud-Baselga, I., García‐Corzo, L., & Mira, H. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00339 · Cited by 62 · see citing works

A new quinoline-based chemical probe inhibits the autophagy-related cysteine protease ATG4B

Bosc, D., Vezenkov, L., Bortnik, S. B., An, J., Xu, J., Choutka, C., Hannigan, A. M., Kovacic, S., Loo, S., Clark, P. G. K., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-29900-x · Cited by 56 · see citing works

Protective effects of blueberry- and strawberry diets on neuronal stress following exposure to 56Fe particles

Poulose, S. M., Bielinski, D. F., Carrihill-Knoll, K. L., Rabin, B. M., & Shukitt‐Hale, B. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.028 · Cited by 52 · see citing works

Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model

Chiu, H., Yeh, Y.-L., Wang, Y., Huang, W.-J., Ho, S., Lin, P., & Wang, Y. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0531-5 · Cited by 47 · see citing works

Ionizing radiation reduces ADAM10 expression in brain microvascular endothelial cells undergoing stress-induced senescence

McRobb, L. S., McKay, M. J., Gamble, J. R., Grace, M., Moutrie, V., Santos, E. D., Lee, V. S., Zhao, Z., Molloy, M. P., & Stoodley, M. A. (2017) · Aging · doi:10.18632/aging.101225 · Cited by 47 · see citing works

The autophagy-lysosomal pathway

Kenney‐Jung, D. L., & Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001860 · Cited by 46 · see citing works

Inhibition of autophagy prevents irradiation-induced neural stem and progenitor cell death in the juvenile mouse brain

Wang, Y., Zhou, K., Li, T., Xu, Y., Xie, C., Sun, Y., Zhang, Y., Rodríguez, J., Blomgren, K., & Zhu, C. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.120 · Cited by 45 · see citing works

To live or let die: Unclear task of autophagy in the radiosensitization battle

Ondrej, M., Čecháková, L., Ďurišová, K., Pejchal, J., & Tichý, A. (2016) · Radiotherapy and Oncology · doi:10.1016/j.radonc.2016.02.028 · Cited by 43 · see citing works

Minocycline ameliorates cognitive impairment induced by whole-brain irradiation: an animal study

Zhang, L., Li, K., Sun, R., Zhang, Y., Ji, J., Huang, P., Yang, H., & Tian, Y. (2014) · Radiation Oncology · doi:10.1186/s13014-014-0281-8 · Cited by 42 · see citing works

Unraveling the fundamental molecular mechanisms of morphological and cognitive defects in the irradiated brain

Verheyde, J., & Benotmane, M. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.004 · Cited by 37 · see citing works

Important Role of Autophagy in Endothelial Cell Response to Ionizing Radiation

Kalamida, D., Karagounis, I. V., Giatromanolaki, A. N., & Koukourakis, M. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102408 · Cited by 31 · see citing works

Long‐term cerebral effects of small doses of X‐irradiation in childhood as manifested in adult visual evoked responses

Yaar, I., Ron, E., Modan, M., Peretz, H., & Modan, B. (1980) · Annals of Neurology · doi:10.1002/ana.410080307 · Cited by 30 · see citing works

The inhibitory effect of minocycline on radiation-induced neuronal apoptosis via AMPKα1 signaling-mediated autophagy

Zhang, L., Huang, P. C., Chen, H., Tan, W., Lu, J., Liu, W., Wang, J., Zhang, S., Zhu, W., Cao, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16693-8 · Cited by 24 · see citing works

Ionizing Radiation Perturbs Cell Cycle Progression of Neural Precursors in the Subventricular Zone Without Affecting Their Long-Term Self-Renewal

Chen, H., Goodus, M. T., de Toledo, S. M., Azzam, E. I., Levison, S. W., & Souayah, N. (2015) · ASN NEURO · doi:10.1177/1759091415578026 · Cited by 21 · see citing works

A protocol for immunofluorescence staining of floating neurospheres

Sasaki, R., Aoki, S., Yamato, M., Uchiyama, H., Wada, K., Ogiuchi, H., Okano, T., & Ando, T. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.05.042 · Cited by 18 · see citing works

Effects of Aging on Hippocampal Neurogenesis After Irradiation

Cheng, Z., Li, Y.-Q., & Wong, C. S. (2015) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2015.12.364 · Cited by 18 · see citing works

Proliferation and differentiation of neural stem cells irradiated with X-rays in logarithmic growth phase

Isono, M., Otsu, M., Konishi, T., Matsubara, K., Tanabe, T., Nakayama, T., & Inoue, N. (2012) · Neuroscience Research · doi:10.1016/j.neures.2012.04.005 · Cited by 16 · see citing works

Stem Cell Therapies for the Resolution of Radiation Injury to the Brain

Smith, S. M., & Limoli, C. L. (2017) · Current Stem Cell Reports · doi:10.1007/s40778-017-0105-5 · Cited by 9 · see citing works

Integration of Neurons Derived from Transplanted BDNF-Overexpressing Neural Stem Cells into Circuit of the Irradiated Hippocampus

Zhang, Q., Zhong, X. B., Zhang, J., Zhu, H., Cai, S., Zhang, J., Cao, Y., & Tian, Y. (2019) · Radiation Research · doi:10.1667/rr15409.1 · Cited by 2 · see citing works

Early onset senescence and cognitive impairment in a murine model of repeated mTBI

Schwab, N., Ju, Y., & Hazrati, L.-N. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01190-x · Cited by 39 · see citing works

Defective autophagy of pericytes enhances radiation-induced senescence promoting radiation brain injury

Luo, N., Zhu, W., Li, X., Fu, M., Zhang, Y., Yang, F., Zhang, Y., Chen, Z., Zhang, Q., Peng, B., et al. (2024) · Neuro-Oncology · doi:10.1093/neuonc/noae153 · Cited by 38 · see citing works

Nanoparticles augment the therapeutic window of RT and immunotherapy for treating cancers: pivotal role of autophagy

Wu, Y.-H., Chen, R.-J., Chiu, H., Yang, L., Wang, Y., Chen, Y., Yeh, Y.-L., Liao, M., & Wang, Y. (2022) · Theranostics · doi:10.7150/thno.77233 · Cited by 31 · see citing works

Fe3O4 Nanozymes Improve Neuroblast Differentiation and Blood-Brain Barrier Integrity of the Hippocampal Dentate Gyrus in D-Galactose-Induced Aged Mice

Xia, Z., Gao, M., Sheng, P., Shen, M., Zhao, L., Gao, L., & Yan, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126463 · Cited by 25 · see citing works

Radiation-induced bystander effects may contribute to radiation-induced cognitive impairment

Yang, X., Ma, L., Ye, Z., Shi, W., Zhang, L., Wang, J., & Yang, H. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1864498 · Cited by 15 · see citing works

Tissue-Specific Knockdown of Genes of the Argonaute Family Modulates Lifespan and Radioresistance in Drosophila melanogaster

Николаевна, П. Е., Александровна, Ю. Е., Koval, L. A., Zemskaya, N. V., Shchegoleva, E., Solovev, I. A., Yakovleva, D. V., Ришатовна, П. Н., Ulyasheva, N. S., Shaposhnikov, M. V., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052396 · Cited by 11 · see citing works

Satellite Cells are Activated in a Rat Model of Radiation-Induced Muscle Fibrosis

Zeng, X., Xie, L., Ge, Y., Zhou, Y., Wang, H., Chen, Y., Zhu, X., Liu, H., Liao, Q., Kong, Y., et al. (2022) · Radiation Research · doi:10.1667/rade-21-00183.1 · Cited by 10 · see citing works

Dual Roles of Autophagy in Radiation‐Induced Brain Injury: Mechanistic Insights and Therapeutic Implications

Tian, J., Mao, Y.-N., Liu, D., Li, T., Shi, L.-H., Wang, Y., & Zhu, C.-L. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70464 · Cited by 8 · see citing works

Yiqi Jiedu decoction attenuates radiation injury of spermatogenic cells via suppressing IκBα/NF-κB pathway-induced excessive autophagy and apoptosis

Zhang, X., Chen, X., Wang, A., Wang, L., He, C., Shi, Z., Zhang, S., Fu, Q., Xu, W., Li, W., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116903 · Cited by 6 · see citing works

Irradiated microvascular endothelial cells may induce bystander effects in neural stem cells leading to neurogenesis inhibition

Ma, L., Ye, Z., Zhang, Y., Shi, W., Wang, J., & Yang, H. (2021) · Journal of Radiation Research · doi:10.1093/jrr/rrab125 · Cited by 4 · see citing works

ATG7 ‐mediated autophagy protects human gingival myofibroblasts from irradiation‐induced apoptosis

Zhuang, X., Lin, X.-X., Xu, R., Zhang, Z., Zhou, B., & Deng, F. (2023) · Journal of Oral Pathology and Medicine · doi:10.1111/jop.13490 · Cited by 4 · see citing works

The Pivotal Role of Irradiation-induced Autophagy Mechanisms in Glioma Therapy

Richard, S. A. (2025) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/0118715206371143250402175030 · Cited by 3 · see citing works

The Role of Autophagy in Childhood Central Nervous System Tumors

Wang, Y., Xu, Y., & Zhu, C. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-01015-6 · Cited by 3 · see citing works

Differentially expressed circRNA and mRNA profiles of neural stem cells with radiation irradiationPreprint

Cai, Z., Wang, S., Xie, Z., Wang, P., Shen, H., & Chen, K. (2020) · doi:10.21203/rs.3.rs-22716/v1

Differentially expressed circRNA and mRNA profiles of neural stem cells with radiation treatmentPreprint

Hong, J., Wang, S., Cai, Z., Wang, P., Xie, Z., & Chen, K. (2022) · Research Square · doi:10.21203/rs.3.rs-1831154/v1

Hesperidin relieves irradiation-induced cognitive dysfunction via regulation of HMGB1-mediated neuroinflammationPreprint

Huang, W., Xie, L. P., Ma, J., Lu, H., Chen, L., Yu, D., & Yao, C. (2023) · Research Square · doi:10.21203/rs.3.rs-3284325/v1

On the Developing of Ways to Mitigate the Effects of Ionizing Radiation

Александрович, Р. Л., & Ushakov, I. B. (2026) · BIOPHYSICS · doi:10.1134/s0006350926700326

The Protective Role of Autophagy in Irradiation-Induced Neural Stem Cell Damage

Wenyu, S., Yang, X., Yang, H., & LiYuan, Z. (2019) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2019.06.1052

Inhibition of autophagy prevents irradiation-induced neural stem and progenitor cell death in the juvenile mouse brain

Wang, Y., Zhou, K., Li, T., Xu, Y., Xie, C., Sun, Y., Zhang, Y., Rodríguez, J., Blomgren, K., & Zhu, C. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.120 · Cited by 45 · see citing works

Selective Neural Deletion of the Atg7 Gene Reduces Irradiation-Induced Cerebellar White Matter Injury in the Juvenile Mouse Brain by Ameliorating Oligodendrocyte Progenitor Cell Loss

Wang, Y., Zhou, K., Li, T., Xu, Y., Xie, C., Sun, Y., Rodríguez, J., Zhang, S., Song, J., Wang, X., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00241 · Cited by 13 · see citing works

The inhibitory effect of minocycline on radiation-induced neuronal apoptosis via AMPKα1 signaling-mediated autophagy

Zhang, L., Huang, P. C., Chen, H., Tan, W., Lu, J., Liu, W., Wang, J., Zhang, S., Zhu, W., Cao, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-16693-8 · Cited by 24 · see citing works

Ionizing radiation induces apoptosis and inhibits neuronal differentiation in rat neural stem cells via the c-Jun NH2-terminal kinase (JNK) pathway

Kanzawa, T., Iwado, E., Aoki, H., Iwamaru, A., Hollingsworth, E., Sawaya, R. A., Kondo, S., & Kondo, Y. (2006) · Oncogene · doi:10.1038/sj.onc.1209414 · Cited by 56 · see citing works