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SARS-CoV-2 infections and COVID-19 mortalities strongly correlate with ACE1 I/D genotype
Open accessAbstract
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). The relentless spread and pathogenicity of the virus have become a global public health emergency. One of the striking features of this pandemic is the pronounced impact on specific regions and ethnic groups. In particular, compared with East Asia, where the virus first emerged, SARS-CoV-2 has caused high rates of morbidity and mortality in Europe. This has not been experienced in past global viral infections, such as influenza, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) and is unique to SARS-CoV-2. For this reason, we investigated the involvement of genetic factors associated with SARS-CoV-2 infection with a focus on angiotensin-converting enzyme (ACE)-related genes, because ACE2 is a receptor for SARS-CoV-2. We found that the ACE1 II genotype frequency in a population was significantly negatively correlated with the number of SARS-CoV-2 cases. Similarly, the ACE1 II genotype was negatively correlated with the number of deaths due to SARS-CoV-2 infection. These data suggest that the ACE1 II genotype may influence the prevalence and clinical outcome of COVID-19 and serve as a predictive marker for COVID-19 risk and severity.
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“Furthermore, the ACE1 II genotype is protective against COVID-19 as compared to the ACE1 DD genotype (358), and serum levels of ACE1 are higher in the DD genotype compared with the II genotype (359).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [358]
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IL-6 in inflammation, autoimmunity and cancer
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“Most previous findings report associations with COVID19 outcomes on a population level, indicating high variability on allelic frequencies across different populations (Delanghe et al., 2020; Pati et al., 2020; Yamamoto et al., 2020).”
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Metadata
- Authors
- Yamamoto, N., Ariumi, Y., Nishida, N., Yamamoto, R., Bauer, G., Gojobori, T., Shimotohno, K., & Mizokami, M.
- Affiliations
- National Center for Global Health and Medicine (JP)
- Joint Research Center for Human Retrovirus Infection, Kumamoto University (JP)
- Keio University (JP)
- University of Freiburg (DE)
- King Abdullah University of Science and Technology (SA)
- Corresponding author
- Yamamoto, Naoki
- Shimotohno, Kunitada
- Mizokami, Masashi
- ORCID
- Venue
- Gene
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 758
- Pages
- 144944
- ISSN
- 0378-1119 (ISSN-L)
- PMC
- PMC7833925
- OpenAlex
- W3038462367
- Cited by
- 141
- References
- 66
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 15 · 2023: 20 · 2022: 36 · 2021: 54 · 2020: 11
- FWCI
- 3.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gene (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion, cc-by-nc-nd)
- Funders
- Japan Society for the Promotion of Science (18K08438)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- SARS-CoV-2, COVID-19 pandemic, ACE2 receptor, genetic susceptibility, COVID-19 mortality
- MeSH terms
- Betacoronavirus, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Asia, Europe, Gene Frequency, Genotype, Humans, Peptidyl-Dipeptidase A, Pneumonia, Viral, Risk, Risk Factors, Severity of Illness Index, Treatment Outcome, Coronavirus Infections, Polymorphism, Single Nucleotide, Pandemics
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