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Cited by 65Cardiac Health and Mental HealthRheumatoid Arthritis Research and TherapiesCardiovascular Health and Risk Factors

Depression increases risk of incident myocardial infarction among Veterans Administration patients with rheumatoid arthritis

Scherrer, Jeffrey F., Virgo, Katherine S., Zeringue, Angelique, Bucholz, Kathleen K., Jacob, Theodore, Johnson, Robert G., True, William R., Carney, Robert M. +5 more·2009·General Hospital Psychiatry
DOI 10.1016/j.genhosppsych.2009.04.001
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Abstract

Objective This study evaluates whether depression is a risk factor for incident myocardial infarction (MI) in Department of Veterans Affairs (VA) patients with rheumatoid arthritis (RA) between 30 and 79 years of age.Methods We used a retrospective cohort study of 15,634 patients with RA. Diagnoses and sociodemographic data were obtained from VA administrative and pharmacy databases between fiscal years 1999 and 2006. Entry into the cohort required 2 years of patient time with no evidence of cardiovascular disease. Cox proportional hazard models with time-dependent covariates were computed to determine whether RA patients with depression as compared to RA patients without depression were at increased risk for MI during the maximum 6-year follow-up period.Results Unadjusted analyses indicated depressed RA patients were 1.4 times more likely than nondepressed RA patients to have an MI during follow-up. These results remained significant (HR=1.4; 95% CI: 1.1-1.8) in the adjusted Cox proportional hazards model which included the effects of sociodemographics and known physical risks (e.g., diabetes) for MI.Conclusions Depressed RA patients, without a history of cardiovascular disease, are 40% more likely to have a heart attack as compared to those without depression. These data demonstrate a rapid (within 6 years) transition to MI following onset of depression in RA patients. Increased monitoring of depression and heart disease status in this patient population may be warranted which in turn may result in longer duration of life.

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Crossref · 10.1016/j.genhosppsych.2009.04.001

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  • Major depressive disorder is a consistent predictor of the subsequent first onset of coronary artery disease, stroke, diabetes, heart attacks, and certain types of cancer, though evidence about major depressive disorder as a cause of physical disorders is spotty.

    “we know from meta-analyses of longitudinal studies that MDD is a consistent predictor of the subsequent first onset of coronary artery disease,97, 98 stroke,99 diabetes,100 heart attacks ,101, 102 and certain types of cancer.103”

    From The Costs of Depression (2012) · cites this paper as [101]

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Authors
Scherrer, J. F., Virgo, K. S., Zeringue, A., Bucholz, K. K., Jacob, T., Johnson, R. G., True, W. R., Carney, R. M., Freedland, K. E., Xian, H., Caplan, L., McDonald, J., & Eisen, S. A.
Affiliations
  • Washington University in St. Louis (US)
  • Saint Louis University Hospital (US)
  • VA Palo Alto Health Care System (US)
  • Denver VA Medical Center (US)
  • United States Department of Veterans Affairs (US)
Corresponding author
Scherrer, Jeffrey F.
ORCID
Venue
General Hospital Psychiatry
Publisher
Elsevier BV
Published
2009-07
Volume
31
Issue
4
Pages
353-359
ISSN
0163-8343 (ISSN-L)
DOI
10.1016/j.genhosppsych.2009.04.001
OpenAlex
W2170595056
Cited by
65
References
38
Citations by year
2025: 1 · 2024: 4 · 2023: 2 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 7 · 2012: 2
FWCI
3.24
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • General Hospital Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
depression, myocardial infarction, rheumatoid arthritis, veterans, cardiovascular risk, comorbidities, depression screening
MeSH terms
Adult, Aged, Arthritis, Rheumatoid, Depressive Disorder, Female, Follow-Up Studies, Humans, Inflammation, Male, Middle Aged, Myocardial Infarction, Population Surveillance, Retrospective Studies, Risk Factors, Severity of Illness Index, Socioeconomic Factors, United States, United States Department of Veterans Affairs, Veterans, Comorbidity, Incidence, Multivariate Analysis, Proportional Hazards Models

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