Performance of the Japanese version of the Patient Health Questionnaire-9 (J-PHQ-9) for depression in primary care
Abstract
Objective To assess the performance of the Japanese version of the Patient Health Questionnaire-9 (J-PHQ-9) for depression in primary care.Methods Participants in both phases completed the J-PHQ-9, while patients in the second phase also completed the SF-8 (the short form for the health-related QOL scale SF-36). Subjects (n = 284; male = 107, female = 177) had to return the questionnaires to their health care professional within 48 hours and undergo a diagnostic evaluation interview based on the Japanese version of M.I.N.I-Plus.Results 93 patients were diagnosed as having major depressive disorder (MDD). In the J-PHQ-9, the optimal cutpoint ≥ 10 had sensitivity of 90.5% and specificity of 76.6%. As for the categorical algorithms, the sensitivity was 80.6%; specificity was 89.5%, and a positive likelihood ratio of 7.7. The Stratum-specific likelihood ratios (SSLRs) of the J-PHQ-9 scores of 0-9, 10-14, 15-19, and 20-27 for major depression were 0.10 (95% CI: 0.05-0.20), 1.67 (95% CI: 1.02-2.76), 5.41 (95% CI: 2.87-10.22), and 11.98 (95% CI: 5.39-26.63), respectively. The relationship between the severity of J-PHQ-9 and the MCS of SF-8 was significant (χ 2 = 85.72, df = 4, P ≤ 0.0001).Conclusions This study has validated the J-PHQ-9 as a useful tool for the assessment of MDD in primary care in Japan.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The PHQ-9 is a self-administered tool for screening the severity of depression during the prior 2 weeks.
“The PHQ‐9 is self‐administered tool for screening. It examines the severity of depression during the prior 2 weeks and is described elsewhere.”
From Help‐seeking behavior of male victims of intimate partner violence in Japan (2024) · cites this paper as [47]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910 · see citing works
(1998) · The Journal of Clinical Psychiatry · Cited by 19,139 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
&NA; (1988) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-198802020-00022 · Cited by 12,603 · see citing works
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370 · see citing works
Spitzer, R. L. (1999) · JAMA · doi:10.1001/jama.282.18.1737 · Cited by 9,802 · see citing works
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,167 · see citing works
The PHQ-9: A New Depression Diagnostic and Severity Measure
Kroenke, K., & Spitzer, R. L. (2002) · Psychiatric Annals · doi:10.3928/0048-5713-20020901-06 · Cited by 5,898 · see citing works
Kroenke, K., Spitzer, R. L., Williams, J. B. W., & Löwe, B. (2010) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2010.03.006 · Cited by 4,057 · see citing works
Lecrubier, Y., Sheehan, D., Weiller, E., Amorim, P., Bonora, I., Sheehan, K. H., Janavs, J., & Dunbar, G. (1997) · European Psychiatry · doi:10.1016/s0924-9338(97)83296-8 · Cited by 3,513 · see citing works
Utility of a new procedure for diagnosing mental disorders in primary care. The PRIME-MD 1000 study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.272.22.1749 · Cited by 2,648 · see citing works
Manea, L., Gilbody, S., & McMillan, D. (2012) · Canadian Medical Association Journal · doi:10.1503/cmaj.110829 · Cited by 1,966 · see citing works
Utility of a New Procedure for Diagnosing Mental Disorders in Primary Care: The PRIME-MD 1000 Study
Spitzer, R. L. (1994) · JAMA · doi:10.1001/jama.1994.03520220043029 · Cited by 1,873 · see citing works
The NIMH Epidemiologic Catchment Area Program
Regier, D. A. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790210016003 · Cited by 1,259 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Preedy, V., & Watson, R. (2010) · Springer eBooks · doi:10.1007/978-0-387-78665-0_5485 · Cited by 1,146 · see citing works
LOWE, B. (2004) · Journal of Affective Disorders · doi:10.1016/s0165-0327(02)00237-9 · Cited by 1,060 · see citing works
Spitzer, R. L., Williams, J. B. W., Kroenke, K., Hornyak, R., & McMurray, J. (2000) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2000.106580 · Cited by 847 · see citing works
Manea, L., Gilbody, S., & McMillan, D. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2014.09.009 · Cited by 795 · see citing works
THE COMPOSITE INTERNATIONAL DIAGNOSTIC INTERVIEW (CIDI)
Robins, L. N. (1994) · IX World Congress of Psychiatry · doi:10.1142/9789814440912_0056 · Cited by 574 · see citing works
Reliability and validity of Japanese version of the Mini‐International Neuropsychiatric Interview
Otsubo, T., Tanaka, K., Koda, R., Shinoda, J., SANO, N., Tanaka, S., AOYAMA, H., Mimura, M., & Kamijima, K. (2005) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2005.01408.x · Cited by 508 · see citing works
Self-citationDiagnostic accuracy of the mood module of the patient health questionnaire: a systematic review
Wittkampf, K. A., Naeije, L., Schene, A. H., Huyser, J., & van Weert, H. C. (2007) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2007.06.004 · Cited by 493 · see citing works
Muramatsu, K., Kamijima, K., Yoshida, M., Otsubo, T., Miyaoka, H., Muramatsu, Y., & Gejyo, F. (2007) · Psychological Reports · doi:10.2466/pr0.101.3.952-960 · Cited by 433 · see citing works
Self-citationDiagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5)
(2021) · Springer eBooks · doi:10.1007/978-3-319-91280-6_300515 · Cited by 427 · see citing works
Moriarty, A. S., Gilbody, S., McMillan, D., & Manea, L. (2015) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2015.06.012 · Cited by 372 · see citing works
International Classification of Diseases ( ICD )
Israel, R. A. (2005) · Encyclopedia of Biostatistics · doi:10.1002/0470011815.b2a02025 · Cited by 369 · see citing works
Mitchell, A., Yadegarfar, M., Gill, J., & Stubbs, B. (2016) · BJPsych Open · doi:10.1192/bjpo.bp.115.001685 · Cited by 322 · see citing works
Muramatsu, K. (2007) · Psychological Reports · doi:10.2466/pr0.101.7.952-960 · Cited by 277 · see citing works
Self-citationEnhancing the clinical utility of depression screening
Kroenke, K. (2012) · Canadian Medical Association Journal · doi:10.1503/cmaj.112004 · Cited by 216 · see citing works
(1997) · PubMed · Cited by 211 · see citing works
International Classification of Diseases (ICD)
Hong, Y., & Zeng, M. L. (2022) · KNOWLEDGE ORGANIZATION · doi:10.5771/0943-7444-2022-7-496 · Cited by 198 · see citing works
Inagaki, M., Ohtsuki, T., Yonemoto, N., Kawashima, Y., Saitoh, A., Oikawa, Y., Kurosawa, M., Muramatsu, K., Furukawa, T. A., & Yamada, M. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2013.08.001 · Cited by 159 · see citing works
Self-citationThe overdiagnosis of depression in non-depressed patients in primary care
Aragonès, E. (2006) · Family Practice · doi:10.1093/fampra/cmi120 · Cited by 90 · see citing works
Zimmerman, M. A. (2012) · Psychotherapy and Psychosomatics · doi:10.1159/000342262 · Cited by 41 · see citing works
Ohtsuki, T., Inagaki, M., Oikawa, Y., Saitoh, A., Kurosawa, M., Muramatsu, K., & Yamada, M. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-30 · Cited by 23 · see citing works
Self-citationInagaki, M., Ohtsuki, T., Yonemoto, N., Oikawa, Y., Kurosawa, M., Muramatsu, K., Furukawa, T. A., & Yamada, M. (2013) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2012.11.013 · Cited by 13 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Nishimura, Y., Ochi, K., Tokumasu, K., Obika, M., Hagiya, H., Kataoka, H., & Otsuka, F. (2021) · Journal of Medical Internet Research · doi:10.2196/25232 · Cited by 133 · see citing works
Cassiani-Miranda, C. A., Cuadros-Cruz, A. K., Torres-Pinzón, H., Scoppetta, O., Pinzón-Tarrazona, J. H., López-Fuentes, W. Y., Paez, A., Cabanzo-Arenas, D. F., Ribero-Marulanda, S., & Llanes-Amaya, E. R. (2021) · Revista Colombiana de Psiquiatría · doi:10.1016/j.rcp.2019.09.001 · Cited by 89 · see citing works
Baba, H., Kito, S., Nukariya, K., Takeshima, M., Fujise, N., Iga, J., Oshibuchi, H., Kawano, M., Kimura, M., Mizukami, K., et al. (2022) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13349 · Cited by 50 · see citing works
Help‐seeking behavior of male victims of intimate partner violence in Japan
Morishita, J., Yasuda, M., & Suda, S. (2024) · Psychiatry and Clinical Neurosciences Reports · doi:10.1002/pcn5.70013 · Cited by 7 · see citing works
“The instruments employed included the DVSI (the question items are listed in Table 5), 45 the Patient Health Questionnaire ‐ 9 (PHQ ‐ 9), 46,47 and the 20 ‐ item questionnaire on IPV exposure (the question items are listed in Table 5).”
Method
- Authors
- Muramatsu, K., Miyaoka, H., Kamijima, K., Muramatsu, Y., Tanaka, Y., Hosaka, M., Miwa, Y., Fuse, K., Yoshimine, F., Mashima, I., Shimizu, N., Ito, H., & Shimizu, E.
- Affiliations
- Niigata Seiryo University (JP)
- Kitasato University (JP)
- SHOWA Medical University (JP)
- Niigata University (JP)
- Niigata Prefectural Government (JP)
- National Institute of Occupational Safety and Health (JP)
- Chiba University (JP)
- Corresponding author
- Muramatsu, Kumiko
- Venue
- General Hospital Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 52
- Pages
- 64-69
- ISSN
- 0163-8343 (ISSN-L)
- OpenAlex
- W2794702942
- Cited by
- 345
- References
- 35
- Citations by year
- 2026: 48 · 2025: 88 · 2024: 63 · 2023: 42 · 2022: 47 · 2021: 35 · 2020: 16 · 2019: 4 · 2018: 1 · 2015: 1
- FWCI
- 18.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- General Hospital Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Niigata Seiryo University
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- PHQ-9, major depressive disorder, depression screening, primary care, Japanese version, diagnostic accuracy, likelihood ratios, depression severity, SF-8, health-related quality of life
- MeSH terms
- Patient Health Questionnaire, Adult, Depression, Major Depressive Disorder, Female, Humans, Japan, Male, Middle Aged, Primary Health Care, Psychiatric Status Rating Scales, Sensitivity and Specificity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review