Guidelines for diagnosis and treatment of depression in older adults: a report from the Japanese Society of mood disorders.
Abstract
The Committee for Treatment Guidelines of Mood Disorders, Japanese Society of Mood Disorders, published a Japanese guideline for the treatment of late‐life depression in 2020. Based on that guideline, the present guideline was developed and revised to incorporate the suggestions of global experts and the latest published evidence. In the diagnosis of late‐life depression, it is important to carefully differentiate it from bipolar disorders, depressive states caused by physical and organic brain disease, drug effects, and dementia, and to determine the comorbidity between late‐life depression and dementia. It is necessary to fully understand the clinical characteristics and psychosocial background of late‐life depression, evaluate the patient's condition, and provide basic interventions based on these factors. Problem‐solving therapy, reminiscence therapy/life review therapy, and behavioral activation therapy, and other forms of psychotherapy can reduce depressive symptoms. In terms of pharmacotherapy, newer antidepressants or non‐tricyclic antidepressants are recommended for late‐life depression, and it is recommended that the efficacy of least the minimal effective dosage should first be determined. Switching antidepressants and aripiprazole augmentation can be used to treatment‐resistant therapy. Electroconvulsive therapy and repetitive transcranial magnetic stimulation have demonstrated usefulness for late‐life depression. Exercise therapy, high‐intensity light therapy, and diet therapy also show some effectiveness and are useful for late‐life depression. Continuation therapy should be maintained for at least 1 year after remission.
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Many global guidelines and recommendations for the treatment of depression advocate the use of high-intensity light therapy as an effective treatment approach.
“Furthermore, many global guidelines and recommendations for the treatment of depression advocate the use of high-intensity light therapy as an effective treatment approach.[52–54]”
From Effectiveness of visible light for seasonal affective disorder: A systematic review and network meta-analysis (2025) · cites this paper as [52]
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Self-citation
- Authors
- Baba, H., Kito, S., Nukariya, K., Takeshima, M., Fujise, N., Iga, J., Oshibuchi, H., Kawano, M., Kimura, M., Mizukami, K., Mimura, M., & Committee for Treatment Guidelines of Mood Disorders, J. S. O. M. D.
- Affiliations
- Juntendo University (JP)
- Jikei University School of Medicine (JP)
- Tokyo Medical University (JP)
- Kumamoto University (JP)
- Department of Neuropsychiatry Ehime University Graduate School of Medicine Ehime Japan
- Kanagawa Children's Medical Center (JP)
- Miyake Eye Hospital (JP)
- Department of Neuropsychiatry Nippon Medical School, Chiba Hokusoh Hospital Chiba Japan
- University of Tsukuba (JP)
- Keio University (JP)
- Corresponding author
- Baba, Hajime
- ORCID
- Venue
- Psychiatry and Clinical Neurosciences
- Publisher
- Wiley
- Published
- 2022-04-06
- Volume
- 76
- Issue
- 6
- Pages
- 222-234
- ISSN
- 1323-1316 (ISSN-L)
- 1440-1819
- OpenAlex
- W4220804164
- Cited by
- 50
- References
- 168
- Citations by year
- 2026: 3 · 2025: 15 · 2024: 13 · 2023: 11 · 2022: 8
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry and Clinical Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development (JP18dk0307060)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- geriatric depression, older adults, depression diagnosis, differential diagnosis, bipolar disorder, antidepressants, non-tricyclic antidepressants, treatment-resistant depression, electroconvulsive therapy, repetitive transcranial magnetic stimulation, psychotherapy, problem-solving therapy, reminiscence therapy, life review therapy, behavioral activation, exercise therapy, phototherapy, dietary therapy, continuation treatment
- MeSH terms
- Aged, Antidepressive Agents, Dementia, Depression, Humans, Japan, Mood Disorders
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