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Cited by 85Cancer-related molecular mechanisms researchGenomics and Chromatin DynamicsRNA Research and Splicing

Non-coding Transcripts from Enhancers: New Insights into Enhancer Activity and Gene Expression Regulation

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Chen, Hongjun, Du, Guangshi, Song, Xu, Li, Ling·2017·Genomics, Proteomics & Bioinformatics
DOI 10.1016/j.gpb.2017.02.003PMC PMC5487526
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Abstract

Long non-coding RNAs (lncRNAs) have gained widespread interest in the past decade owing to their enormous amount and surprising functions implicated in a variety of biological processes. Some lncRNAs exert function as enhancers, i.e., activating gene transcription by serving as the cis-regulatory molecules. Furthermore, recent studies have demonstrated that many enhancer elements can be transcribed and produce RNA molecules, which are termed as enhancer RNAs (eRNAs). The eRNAs are not merely the by-product of the enhancer transcription. In fact, many of them directly exert or regulate enhancer activity in gene activation through diverse mechanisms. Here, we provide an overview of enhancer activity, transcription of enhancer itself, characteristics of eRNAs, as well as their roles in regulating enhancer activity and gene expression.

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  • Enhancers are sites for the assembly of a complete Pol II preinitiation complex and bidirectional transcription of short-lived enhancer RNA (eRNA).

    “Relatively recently, enhancers have been shown to be sites for the assembly of a complete Pol II preinitiation complex and bidirectional transcription of short-lived enhancer RNA (eRNA) [57,58,59].”

    From Enhancer Function in the 3D Genome (2023) · cites this paper as [59]

    The sections “Enhancers produce non-coding transcripts” and “eRNAs share some properties with lncRNAs” report RNAPII at many enhancers and usually bidirectional transcription at RNAPII-controlled enhancers. Our copy does not establish that a complete Pol II preinitiation complex assembles there or that the resulting eRNAs are short-lived; it describes their length but not their lifetime. Page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Chen, H., Du, G., Song, X., & Li, L.
Affiliations
Sichuan University (CN)
Corresponding author
  • Song, Xu
  • Li, Ling
ORCID
Venue
Genomics, Proteomics & Bioinformatics
Publisher
Oxford University Press (OUP)
Published
2017-06-01
Volume
15
Issue
3
Pages
201-207
ISSN
  • 1672-0229 (ISSN-L)
  • 2210-3244
DOI
10.1016/j.gpb.2017.02.003
PMC
PMC5487526
OpenAlex
W2623141677
Cited by
85
References
12
Citations by year
2026: 2 · 2025: 2 · 2024: 14 · 2023: 7 · 2022: 5 · 2021: 15 · 2020: 19 · 2019: 13 · 2018: 8
FWCI
1.20
Type
journal article
Language
en
Open access
Licence
Locations
  • Genomics Proteomics & Bioinformatics (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Key Research and Development (2017YFA0504300)
  • National Basic Research Program of China (2011CB504203)
  • National Natural Science Foundation of China (81490752, 31671347, 31000579, 31371325, 30971634)
  • Doctoral Programs Foundation of the Ministry of Education, China (20130181130010)
  • Research Foundation of Sichuan University for Excellent Youth Scholars (2015SCU04A23)
  • Science Foundation for Excellent Youth Scholars of Sichuan University (2015SCU04A23)
  • National Key Research and Development Program of China (2011CB504203, 2017YFA0504300)
  • Ministry of Education of the People's Republic of China (20130181130010)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Keywords
enhancer RNA, long non-coding RNA, enhancer activity, enhancer transcription, cis-regulatory elements, gene expression regulation, gene activation, non-coding transcripts
MeSH terms
Animals, Chromatin, Enhancer Elements, Genetic, Gene Expression Regulation, Humans, RNA Polymerase II, Transcription, Genetic, CREB-Binding Protein, RNA, Long Noncoding

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