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Bioaccumulation of lead (Pb) and its effects on human: A review

Open access
Collin, M Samuel, Venkatraman, Senthil Kumar, Vijayakumar, Naveensubramaniam, Kanimozhi, V, Arbaaz, S Muhammad, Stacey, R G Sibiya, Anusha, Jogannagari, Choudhary, Rajan, Lvov, Vladislav, Tovar, Gabriel Ibrahin, Senatov, Fedor, Koppala, Sivasankar, Swamiappan, Sasikumar·2022·Journal of Hazardous Materials Advances

Abstract

Lead is a prevalent heavy metal that pollutes the environment and accumulates in the human body via absorption, bioavailability, bioconcentration, and biomagnification disrupts the neurological, skeletal, reproductive, hematopoietic, renal, and cardiovascular systems. Lead's distinctive physical and chemical characteristics make it ideal for a variety of uses. It has been linked to human activities for ages and is harmful to health. This review article examines the long-term health consequences of lead exposure in humans. Acute and chronic symptoms of lead poisoning include kidney, brain, reproductive organ, and CNS/PNS damage. Toxic metals have a long half-life in the bone matrix and brain (2–3 years), causing neurological problems and bone loss. The article also shows the problems of high BPb in both men and women during pregnancy. Renal system blood lead levels of 30–60 g/dL may cause kidney failure in severe circumstances. The oxidative stress that occurs in human cells has also been explored. Finally, lead poisoning and lead buildup prevention and therapy have been reviewed. The use of micronutrients and antioxidants has demonstrated a reduction in harmful effects. Adults with BPb >45 g/dL should have chelation, whereas children should receive succimer.

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Metadata

Authors
Collin, M. S., Venkatraman, S. K., Vijayakumar, N., Kanimozhi, V, Arbaaz, S. M., Stacey, R. G. S., Anusha, J., Choudhary, R., Lvov, V., Tovar, G. I., Senatov, F., Koppala, S., & Swamiappan, S.
Venue
Journal of Hazardous Materials Advances
Publisher
Elsevier BV
Published
2022-08
Volume
7
Pages
100094
ISSN
2772-4166 (ISSN-L)
OpenAlex
W4280496153
Cited by
799
References
3
FWCI
56.18
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Bioaccumulation of lead (Pb) and its effects on human: A review. https://app.cochat.ai/papers/10.1016/j.hazadv.2022.100094
The paper
Collin, M. S., Venkatraman, S. K., Vijayakumar, N., Kanimozhi, V, Arbaaz, S. M., Stacey, R. G. S., Anusha, J., Choudhary, R., Lvov, V., Tovar, G. I., Senatov, F., Koppala, S., & Swamiappan, S. (2022). Bioaccumulation of lead (Pb) and its effects on human: A review. Journal of Hazardous Materials Advances. https://doi.org/10.1016/j.hazadv.2022.100094

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.