The DOI matches its Crossref record; 227 of the 234 references it cites were found in a registry or an index.
RETRACTED: Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy
Open accessAbstract
Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be antibodies, peptides, aptamers, or small molecules such as vitamins or hormones. Most research studies in this field have been devoted to targeting cancer. Moreover, the nanostructures can be designed with an additional level of targeting by being designed to be stimulus-responsive or "smart" by a judicious choice of materials to be incorporated into the hybrid nanostructures. This stimulus could be an acidic pH, raised temperature, enzyme, ultrasound, redox potential, an externally applied magnetic field, or laser irradiation. In this case, the smart capability can increase the accumulation at the tumor site or the on-demand drug release, while the ligand ensures selective binding to the tumor cells. The present review highlights some interesting studies classified according to the nanostructure material. These materials include natural substances (polysaccharides), multi-walled carbon nanotubes (and halloysite nanotubes), metal-organic frameworks and covalent-organic frameworks, metal nanoparticles (gold and silver), and polymeric micelles.
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“Owing to their biocompatibility and Food and Drug Administration (FDA) approval, AuNPs have become a leading candidate for multiple medical applications.”
From Targeted Nanoparticles for Drug Delivery Across the Blood–Brain Barrier in Early and Late Stages of Alzheimer's Disease: A Review (2026) · cites this paper as [86]
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A spectroscopic and computational study of a tough MOF with a fragile linker: Ce-UiO-66-ADC
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Synthesis and Processing of Nanomaterials
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Doxorubicin‐Conjugated Iron Oxide Nanoparticles: Surface Engineering and Biomedical Investigation
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Self-citationStructural analysis of binding functionality of folic acid-PEG dendrimers against folate receptor
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Exfoliated Graphene‐Based 2D Materials: Synthesis and Catalytic Behaviors
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Ceramic-Based Hybrid Nanoparticles in Drug Delivery
Chauhan, N. P. S. (2021) · Gels horizons: from science to smart materials · doi:10.1007/978-981-16-2119-2_5 · Cited by 6
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Zhang, W., Taheri‐Ledari, R., Ganjali, F., Mirmohammadi, S. S., Qazi, F. S., Saeidirad, M., Kashtiaray, A., Zarei-Shokat, S., Tian, Y., & Maleki, A. R. (2022) · RSC Advances · doi:10.1039/d2ra06888e · Cited by 220
Self-citationGrewal, A. K., & Salar, R. K. (2024) · Nano TransMed · doi:10.1016/j.ntm.2024.100040 · Cited by 164
Zhang, W., Taheri‐Ledari, R., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Ganjali, F., Tian, Y., & Maleki, A. R. (2022) · Journal of environmental chemical engineering · doi:10.1016/j.jece.2022.108836 · Cited by 132
Self-citationGhareeb, A., Fouda, A., Kishk, R. M., & El-Kazzaz, W. M. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02609-5 · Cited by 125
Beigi, P., Ganjali, F., Hassanzadeh‐Afruzi, F., Salehi, M. M., & Maleki, A. R. (2023) · Scientific Reports · doi:10.1038/s41598-023-38005-z · Cited by 75
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Metadata
- Authors
- Zhang, W., Taheri-Ledari, R., Ganjali, F., Afruzi, F. H., Hajizadeh, Z., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Sehat, S. S., Hamblin, M. R., & Maleki, A.
- Affiliations
- Sichuan University (CN)
- Iran University of Science and Technology (IR)
- University of Johannesburg (ZA)
- Corresponding author
- Maleki, Ali
- ORCID
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 8
- Issue
- 6
- Pages
- e09577
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC9189039
- OpenAlex
- W4281625127
- Cited by
- 79
- References
- 234
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 22 · 2023: 21 · 2022: 11
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Sichuan Province Science and Technology Support Program (2022YFH0047)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- nanobioconjugates, targeted drug delivery, cancer therapy, targeting ligands, tumor accumulation, on-demand drug release, polysaccharide nanoparticles, multi-walled carbon nanotubes, halloysite nanotubes, metal-organic frameworks, covalent organic frameworks, gold nanoparticles, silver nanoparticles, polymeric micelles, retracted article
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