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Cited by 69Cardiac Arrhythmias and TreatmentsCardiac electrophysiology and arrhythmiasHeart Rate Variability and Autonomic Control

Epicardial neural ganglionated plexus of ovine heart: anatomic basis for experimental cardiac electrophysiology and nerve protective cardiac surgery

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Saburkina, Inga, Rysevaite, Kristina, Pauziene, Neringa, Mischke, Karl, Schauerte, Patrick, Jalife, José, Pauza, Dainius H.·2010·Heart Rhythm
DOI 10.1016/j.hrthm.2010.02.036PMC PMC3025183
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Abstract

Summary BACKGROUND The sheep is routinely used in experimental cardiac electrophysiology and surgery. OBJECTIVE We aimed at (1) ascertaining the topography and architecture of the ovine epicardial neural plexus (ENP), (2) determining the relationships of the ENP with the vagal and sympathetic cardiac nerves and ganglia, and (3) evaluating gross anatomical differences and similarities among ENPs in humans, sheep and other species. METHODS The ovine ENP, extrinsic sympathetic and vagal nerves were revealed histochemically for acetylcholinesterase on whole heart and/or thorax-dissected preparations from 23 newborn lambs with subsequent examination by a stereomicroscope. RESULTS The intrinsic cardiac nerves extend from the venous part of the ovine heart hilum (HH) along the roots of the cranial (superior) caval and left azygos veins to both atria and ventricles via five epicardial routes; i.e. the dorsal right atrial (DRA), middle (MD), left dorsal (LD), right ventral (VR) and ventral left atrial (VLA) nerve subplexuses. Intrinsic nerves proceeding from the arterial part of the HH along the roots of the aorta and pulmonary trunk extend exclusively into the ventricles as the right and left coronary subplexuses. The DRA, RV, and MD subplexuses receive the main extrinsic neural input from the right cervicothoracic and the right thoracic sympathetic T2, T3 ganglia, as well as from the right vagal nerve. The LD is supplied by sizeable extrinsic nerves from the left thoracic T4-T6 sympathetic ganglia and the left vagal nerve. Sheep hearts contained on average 769±52 epicardial ganglia. Cumulative areas of epicardial ganglia on the root of the cranial vena cava and on the wall of the coronary sinus were the largest of all regions (p<0.05). CONCLUSION Despite substantial interindividual variability in the morphology of the ovine ENP, the right-sided epicardial neural subplexuses supplying the sinuatrial and atrioventricular nodes are mostly concentrated at a fat pad between the right pulmonary veins and the cranial vena cava. This is in sharp contrast with a solely left lateral neural input to the human atrioventricular node which extends mainly from the LD and MD subplexuses. The abundance of epicardial ganglia distributed widely along the ovine ventricular nerves over respectable distances below the coronary groove implies a distinctive neural control of the ventricles in human and sheep hearts.

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Crossref · 10.1016/j.hrthm.2010.02.036

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  • Innervation may remain via the intrinsic cardiac nervous system after sympathectomy.

    “However, innervation may remain via the intrinsic cardiac nervous system. 107”

    From Inappropriate sinus tachycardia (2019) · cites this paper as [107]

    The Introduction (page unavailable) describes the intrinsic cardiac nervous system as a regulator of cardiac function, and the Results (page unavailable) identify intrinsic nerves and vagal input in ovine hearts. These passages support the existence of a potential route for innervation, but the paper does not establish that innervation remains after sympathectomy. (LLM, conf=0.82)

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Research works printed but not linked: 2

  1. [4]Levy MN Warner MR Parasympathetic effects on cardiac function Armour JA Ardell JL Neurocardiology New York Oxford University Press 1994 53 76
  2. [21]Doll N Aupperle H Borger M Czesla M Mohr FW [Efficacy and safety of various energy sources and application techniques for the surgical treatment of atrial fibrillation] Herzschrittmacherther Elektrophysiol 2007 18 83 91 17646940

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Authors
Saburkina, I., Rysevaite, K., Pauziene, N., Mischke, K., Schauerte, P., Jalife, J., & Pauza, D. H.
Affiliations
  • Lithuanian University of Health Sciences (LT)
  • RWTH Aachen University (DE)
  • University of Michigan (US)
ORCID
Venue
Heart Rhythm
Publisher
Elsevier BV
Published
2010-07
Volume
7
Issue
7
Pages
942-950
ISSN
1547-5271 (ISSN-L)
DOI
10.1016/j.hrthm.2010.02.036
PMC
PMC3025183
OpenAlex
W1978680171
Semantic Scholar
dab101f90e2e8fe5190fb8d3ced3de83f3cab3ef
Cited by
69
References
33
Citations by year
2025: 3 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 5
FWCI
3.95
Type
journal article
Language
en
Open access
Licence
Locations
  • Heart Rhythm (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Lithuanian University of Health Sciences (submittedVersion)
  • RWTH Publications (RWTH Aachen) (submittedVersion)
Funders
National Heart, Lung, and Blood Institute (P01-HL039707, R01-HL080159, P01-HL087226)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
ovine heart, cardiac innervation, vagus nerve, sympathetic nerves, acetylcholinesterase histochemistry, atrioventricular node, sinoatrial node, coronary sinus, cardiac electrophysiology, sheep model
MeSH terms
Acetylcholinesterase, Animals, Animals, Newborn, Azygos Vein, Ganglia, Autonomic, Heart, Heart Atria, Cardiac Surgical Procedures, Heart Ventricles, Immunohistochemistry, Neural Pathways, Pericardium, Sheep, Sympathetic Nervous System, Vagus Nerve, Electrophysiologic Techniques, Cardiac, Epicardial Mapping

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