Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study)
Open accessAbstract
Background MicroRNAs (miRNAs) are associated with cardiovascular disease and control gene expression and are detectable in the circulation. Objective The purpose of this study was to test the hypothesis that circulating miRNAs may be associated with atrial fibrillation (AF). Methods Using a prospective study design powered to detect subtle differences in miRNAs, we quantified plasma expression of 86 miRNAs by high-throughput quantitative reverse transcriptase-polymerase chain reaction in 112 participants with AF and 99 without AF. To examine parallels between cardiac and plasma miRNA profiles, we quantified atrial tissue and plasma miRNA expression using quantitative reverse transcriptase-polymerase chain reaction in 31 participants undergoing surgery. We also explored the hypothesis that lower AF burden after ablation would be reflected in the circulating blood pool by examining change in plasma miRNAs after AF ablation (n = 47). Results Mean age of the cohort was 59 years; 58% of participants were men. Plasma miRs-21 and 150 were 2-fold lower in participants with AF than in those without AF after adjustment (P ≤.0006). Plasma levels of miRs-21 and 150 also were lower in participants with paroxysmal AF than in those with persistent AF (P <.05). Expression of miR-21, but not of miR-150, was lower in atrial tissue from patients with AF than in those without AF (P <.05). Plasma levels of miRs-21 and 150 increased 3-fold after AF ablation (P ≤.0006). Conclusion Cardiac miRs-21 and 150 are known to regulate genes implicated in atrial remodeling. Our findings show associations between plasma miRs-21 and 150 and AF, suggesting that circulating miRNAs can provide insights into cardiac gene regulation.
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Elite athletes may present higher levels of profibrotic markers which have been associated with incident or recurrent AF in the general population, including galectin-3, ST2, miR-21, TIMP-1, CITP, and PICP.
“Elite athletes may present higher levels of profibrotic markers which have been associated with incident or recurrent AF in the general population [66,67,68], including galectin-3 [69], the suppression of tumorigenicity 2 (ST2) [70], and microRNA-21 (miR-21) [71], as well as tissue inhibitors of metalloproteinase 1 (TIMP-1), C-terminal telopeptide of type I collagen (CITP), and procollagen type I”
From Atrial Fibrillation in Elite Athletes: A Comprehensive Review of the Literature (2024) · cites this paper as [68]
The Results (page unavailable) associate miR-21 with AF and describe its role in atrial fibrosis, supporting its inclusion as an AF-related marker. The study does not examine elite athletes or establish an association with incident or recurrent AF; it reports lower, not higher, plasma miR-21 levels in participants with AF than in controls. (LLM, conf=0.88)
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- Authors
- McManus, D. D., Tanriverdi, K., Lin, H., Esa, N., Kinno, M., Mandapati, D., Tam, S., Okike, O. N., Ellinor, P. T., Keaney, J. F., Donahue, J. K., Benjamin, E. J., & Freedman, J. E.
- Affiliations
- Boston University (US)
- University of Massachusetts Chan Medical School (US)
- Massachusetts General Hospital (US)
- Corresponding author
- McManus, David D.
- ORCID
- Venue
- Heart Rhythm
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 12
- Issue
- 1
- Pages
- 3-10
- ISSN
- 1547-5271 (ISSN-L)
- PMC
- PMC4277933
- OpenAlex
- W2130530789
- Cited by
- 116
- References
- 37
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 10 · 2023: 7 · 2022: 5 · 2021: 16 · 2020: 15 · 2019: 10 · 2018: 13 · 2017: 15 · 2016: 9 · 2015: 7 · 2014: 1 · 2013: 1
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Heart Rhythm (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
- Funders
- National Institutes of Health (n01hc25195-41-0-1)
- National Institute on Aging (R01AG028321)
- National Heart, Lung, and Blood Institute (U01HL105268, N01‐HC25195, R01HL087201, RFA-HL-12-008, N01-HC-025195, R01HL064753, R01HL087201A, U54HL112311, R01HL076784, 1R01-HL64753, R01HL092122)
- National Institute of Neurological Disorders and Stroke (6R01NS17950, R01NS017950)
- National Center for Research Resources (UL1RR031982, KL2RR031981)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- plasma microRNA, atrial fibrillation, catheter ablation, miR-21, miR-150, paroxysmal atrial fibrillation, persistent atrial fibrillation, atrial remodeling, circulating biomarkers, cardiac gene regulation
- MeSH terms
- Adult, Aged, Atrial Fibrillation, Female, Gene Expression Regulation, Heart Atria, Humans, Male, Middle Aged, Prospective Studies, Cohort Studies, Case-Control Studies, Catheter Ablation, MicroRNAs
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