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Cited by 106MicroRNA in disease regulationCardiac Fibrosis and RemodelingCardiac Ischemia and Reperfusion

Potential Clinical Implications of miR-1 and miR-21 in Heart Disease and Cardioprotection

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Kura, Branislav, Kalocayova, Barbora, Devaux, Yvan, Bartekova, Monika·2020·International Journal of Molecular Sciences
DOI 10.3390/ijms21030700PMC PMC7037063
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Abstract

The interest in non-coding RNAs, which started more than a decade ago, has still not weakened. A wealth of experimental and clinical studies has suggested the potential of non-coding RNAs, especially the short-sized microRNAs (miRs), to be used as the new generation of therapeutic targets and biomarkers of cardiovascular disease, an ever-growing public health issue in the modern world. Among the hundreds of miRs characterized so far, microRNA-1 (miR-1) and microRNA-21 (miR-21) have received some attention and have been associated with cardiac injury and cardioprotection. In this review article, we summarize the current knowledge of the function of these two miRs in the heart, their association with cardiac injury, and their potential cardioprotective roles and biomarker value. While this field has already been extensively studied, much remains to be done before research findings can be translated into clinical application for patient’s benefit.

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Cited by

Sorted by citations

Authors
Kura, B., Kalocayova, B., Devaux, Y., & Bartekova, M.
Affiliations
  • Slovak Academy of Sciences (SK)
  • Institute for Heart Research, Centre of Experimental Medicine, Slovak Academy of Sciences, 84104 Bratislava, Slovakia
  • Luxembourg Institute of Health (LU)
ORCID
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2020-01-21
Volume
21
Issue
3
Pages
700
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms21030700
PMC
PMC7037063
OpenAlex
W3002752101
Cited by
106
References
4
Citations by year
2026: 8 · 2025: 17 · 2024: 12 · 2023: 21 · 2022: 15 · 2021: 20 · 2020: 12 · 2019: 1
FWCI
1.81
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky (2/0061/16, 2/0104/20)
  • Agentúra na Podporu Výskumu a Vývoja (APVV-15-0376)
  • Fonds National de la Recherche Luxembourg (C14/BM/8225223, C17/BM/11613033)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
Keywords
miR-1, miR-21, microRNA, cardioprotection, cardiac injury, cardiovascular disease, biomarkers, therapeutic target, non-coding RNA
MeSH terms
Animals, Antineoplastic Agents, Arrhythmias, Cardiac, Cardiotonic Agents, Cardiovascular Diseases, Heart, Heart Diseases, Heart Injuries, Humans, Cardiomyopathies, Radiotherapy, Biomarkers, MicroRNAs, Cardiotoxins

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