Cited by 158Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsAcute Ischemic Stroke Management

Feasibility and safety of uninterrupted periprocedural apixaban administration in patients undergoing radiofrequency catheter ablation for atrial fibrillation: Results from a multicenter study

Di Biase, Luigi, Lakkireddy, Dhanujaya, Trivedi, Chintan, Deneke, Thomas, Martinek, Martin, Mohanty, Sanghamitra, Mohanty, Prasant, Prakash, Sameer +19 more·2015·Heart Rhythm

Abstract

Background Periprocedural anticoagulation management with uninterrupted warfarin and a "therapeutic" international normalized ratio is the best approach for reducing both thromboembolic and bleeding complications in the setting of catheter ablation for atrial fibrillation (AF).Objective The purpose of this study was to evaluate the safety and feasibility of uninterrupted apixaban in this setting.Methods This was a prospective multicenter registry of AF patients undergoing radiofrequency catheter ablation at 4 institutions in United States and Europe with uninterrupted apixaban. These patients were compared with an equal number of patients, matched for age, gender, and type of AF, undergoing AF ablation on uninterrupted warfarin. The apixaban group was comprised of consecutive patients who had taken their last dose of apixaban the morning of the procedure. A subset of 29 patients in the apixaban group underwent diffusion magnetic resonance imaging (dMRI) to detect silent cerebral ischemia.Results A total of 400 patients (200 patients in each group) were included in the study. The average age was 65.9 ± 9.9 years, 286 (71.5%) were male, and 334 (83.5%) had nonparoxysmal AF. There were no statistical differences with regard to major complications (1% vs 0.5%, P = 1), minor complications (3.5% vs 2.5%, P = .56), or total bleeding complications (4.5% vs 3%, P = .43) between the apixaban and warfarin groups. There were no symptomatic thromboembolic complications. All dMRIs were negative for "new" silent cerebral ischemia in the apixaban group.Conclusion Uninterrupted apixaban administration in patients undergoing AF ablation seems to be feasible and effective in preventing clinical and silent thromboembolic events without increasing the risk of major bleeding.

Integrity signals

Registry

Crossref · 10.1016/j.hrthm.2015.02.028

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Di Biase, L., Lakkireddy, D., Trivedi, C., Deneke, T., Martinek, M., Mohanty, S., Mohanty, P., Prakash, S., Bai, R., Reddy, M., Gianni, C., Horton, R., Bailey, S., Sigmund, E., Derndorfer, M., Schade, A., Mueller, P., Szoelloes, A., Sanchez, J., Al-Ahmad, A., Hranitzky, P., Gallinghouse, G. J., Hongo, R. H., Beheiry, S., Pürerfellner, H., Burkhardt, J. D., & Natale, A.
Affiliations
  • The University of Kansas Health System (US)
  • St David's Medical Center (US)
  • Rhön-Klinikum (DE)
  • Krankenhaus der Elisabethinen (AT)
  • California Pacific Medical Center (US)
Corresponding author
Natale, Andrea
Venue
Heart Rhythm
Publisher
Elsevier BV
Published
2015-06
Volume
12
Issue
6
Pages
1162-1168
ISSN
1547-5271 (ISSN-L)
OpenAlex
W1967591080
Cited by
158
References
36
Citations by year
2026: 2 · 2025: 1 · 2024: 10 · 2023: 1 · 2022: 2 · 2021: 8 · 2020: 21 · 2019: 12 · 2018: 23 · 2017: 34 · 2016: 34 · 2015: 10
FWCI
24.42
Type
journal article
Language
en
Open access
closed
Locations
  • Heart Rhythm (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
apixaban, uninterrupted anticoagulation, radiofrequency catheter ablation, atrial fibrillation, warfarin, periprocedural anticoagulation, thromboembolic events, bleeding complications, silent cerebral ischemia, non-paroxysmal atrial fibrillation
MeSH terms
Aged, Anticoagulants, Atrial Fibrillation, Feasibility Studies, Female, Humans, Male, Prospective Studies, Pyrazoles, Pyridones, Safety, Warfarin, Catheter Ablation, Postoperative Hemorrhage, Diffusion Magnetic Resonance Imaging, Factor Xa Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review