Feasibility and safety of uninterrupted periprocedural apixaban administration in patients undergoing radiofrequency catheter ablation for atrial fibrillation: Results from a multicenter study
Abstract
Background Periprocedural anticoagulation management with uninterrupted warfarin and a "therapeutic" international normalized ratio is the best approach for reducing both thromboembolic and bleeding complications in the setting of catheter ablation for atrial fibrillation (AF).Objective The purpose of this study was to evaluate the safety and feasibility of uninterrupted apixaban in this setting.Methods This was a prospective multicenter registry of AF patients undergoing radiofrequency catheter ablation at 4 institutions in United States and Europe with uninterrupted apixaban. These patients were compared with an equal number of patients, matched for age, gender, and type of AF, undergoing AF ablation on uninterrupted warfarin. The apixaban group was comprised of consecutive patients who had taken their last dose of apixaban the morning of the procedure. A subset of 29 patients in the apixaban group underwent diffusion magnetic resonance imaging (dMRI) to detect silent cerebral ischemia.Results A total of 400 patients (200 patients in each group) were included in the study. The average age was 65.9 ± 9.9 years, 286 (71.5%) were male, and 334 (83.5%) had nonparoxysmal AF. There were no statistical differences with regard to major complications (1% vs 0.5%, P = 1), minor complications (3.5% vs 2.5%, P = .56), or total bleeding complications (4.5% vs 3%, P = .43) between the apixaban and warfarin groups. There were no symptomatic thromboembolic complications. All dMRIs were negative for "new" silent cerebral ischemia in the apixaban group.Conclusion Uninterrupted apixaban administration in patients undergoing AF ablation seems to be feasible and effective in preventing clinical and silent thromboembolic events without increasing the risk of major bleeding.
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There is no safety signal from observational cohorts treated with uninterrupted NOAC therapy undergoing catheter ablation in experienced centres.
“There is no safety signal from observational cohorts treated with uninterrupted NOAC therapy undergoing catheter ablation in experienced centres.761,763,766,767”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [761]
Anticoagulation with NOACs is an alternative to warfarin for patients undergoing catheter ablation.
“Anticoagulation with NOACs is an alternative to warfarin.478,[761][762][763][764][765]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [761]
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Self-citation
- Authors
- Di Biase, L., Lakkireddy, D., Trivedi, C., Deneke, T., Martinek, M., Mohanty, S., Mohanty, P., Prakash, S., Bai, R., Reddy, M., Gianni, C., Horton, R., Bailey, S., Sigmund, E., Derndorfer, M., Schade, A., Mueller, P., Szoelloes, A., Sanchez, J., Al-Ahmad, A., Hranitzky, P., Gallinghouse, G. J., Hongo, R. H., Beheiry, S., Pürerfellner, H., Burkhardt, J. D., & Natale, A.
- Affiliations
- The University of Kansas Health System (US)
- St David's Medical Center (US)
- Rhön-Klinikum (DE)
- Krankenhaus der Elisabethinen (AT)
- California Pacific Medical Center (US)
- Corresponding author
- Natale, Andrea
- ORCID
- Venue
- Heart Rhythm
- Publisher
- Elsevier BV
- Published
- 2015-06
- Volume
- 12
- Issue
- 6
- Pages
- 1162-1168
- ISSN
- 1547-5271 (ISSN-L)
- OpenAlex
- W1967591080
- Cited by
- 158
- References
- 36
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 10 · 2023: 1 · 2022: 2 · 2021: 8 · 2020: 21 · 2019: 12 · 2018: 23 · 2017: 34 · 2016: 34 · 2015: 10
- FWCI
- 24.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Heart Rhythm (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Keywords
- apixaban, uninterrupted anticoagulation, radiofrequency catheter ablation, atrial fibrillation, warfarin, periprocedural anticoagulation, thromboembolic events, bleeding complications, silent cerebral ischemia, non-paroxysmal atrial fibrillation
- MeSH terms
- Aged, Anticoagulants, Atrial Fibrillation, Feasibility Studies, Female, Humans, Male, Prospective Studies, Pyrazoles, Pyridones, Safety, Warfarin, Catheter Ablation, Postoperative Hemorrhage, Diffusion Magnetic Resonance Imaging, Factor Xa Inhibitors
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