Safety and efficacy of dabigatran etexilate during catheter ablation of atrial fibrillation: a meta-analysis of the literature
Open accessAbstract
AIMS: To summarize and analyse the published literature on the efficacy and safety of dabigatran for anticoagulation during atrial fibrillation (AF) ablation. METHODS AND RESULTS: A comprehensive search of the literature in the English language was conducted and 10 studies were identified which compared dabigatran therapy with warfarin. Data were extracted and meta-analysed using appropriate methodology. There was significant clinical heterogeneity among studies concerning study designs and methodologies. Most studies consisted of retrospective single-centre observational studies. A total of 3648 patients were included of whom 2241 were receiving warfarin and 1407 dabigatran. Only 12 thrombo-embolic events were reported, 3 during warfarin and 9 during dabigatran therapy [odds ratio (OR) 2.38, 95% confidence interval (CI) 0.82-6.85, P = n.s.). The pooled rate of major bleeding events was similar for warfarin and for dabigatran (OR 1.05, 95% CI 0.62-1.80; P = n.s.). Rates of minor bleeding events were also similar between the two treatment groups. CONCLUSION: Dabigatran has similar efficacy and safety compared with warfarin when used for periprocedural anticoagulation during AF ablation.
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Anticoagulation with NOACs is an alternative to warfarin for patients undergoing catheter ablation.
“Anticoagulation with NOACs is an alternative to warfarin.478,[761][762][763][764][765]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [762]
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2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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- Authors
- Hohnloser, S. H., & Camm, A. J.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Hohnloser, Stefan H.
- Venue
- EP Europace
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-08-16
- Volume
- 15
- Issue
- 10
- Pages
- 1407-1411
- ISSN
- 1099-5129 (ISSN-L)
- 1532-2092
- OpenAlex
- W1980921198
- Cited by
- 93
- References
- 19
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 2 · 2018: 14 · 2017: 16 · 2016: 17 · 2015: 12 · 2014: 16 · 2013: 6
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- EP Europace (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- dabigatran etexilate, atrial fibrillation, catheter ablation, periprocedural anticoagulation, warfarin, thromboembolic events, major bleeding, minor bleeding, direct oral anticoagulants
- MeSH terms
- Dabigatran, Administration, Oral, Anticoagulants, Atrial Fibrillation, Benzimidazoles, Hemorrhage, Humans, Pyridines, Risk Factors, Thromboembolism, Warfarin, Chi-Square Distribution, Odds Ratio, Treatment Outcome, Catheter Ablation
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