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Cited by 499

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Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study

Open access
Tung, Roderick, Vaseghi, Marmar, Frankel, David S., Vergara, Pasquale, Di Biase, Luigi, Nagashima, Koichi, Yu, Ricky, Vangala, Sitaram, Tseng, Chi-Hong, Choi, Eue-Keun, Khurshid, Shaan, Patel, Mehul, Mathuria, Nilesh, Nakahara, Shiro, Tzou, Wendy S., Sauer, William H., Vakil, Kairav, Tedrow, Usha, Burkhardt, J. David, Tholakanahalli, Venkatakrishna N., Saliaris, Anastasios, Dickfeld, Timm, Weiss, J. Peter, Bunch, T. Jared, Reddy, Madhu, Kanmanthareddy, Arun, Callans, David J., Lakkireddy, Dhanunjaya, Natale, Andrea, Marchlinski, Francis, Stevenson, William G., Della Bella, Paolo, Shivkumar, Kalyanam·2015·Heart Rhythm

Abstract

Background The impact of catheter ablation of ventricular tachycardia (VT) on all-cause mortality remains unknown. Objective To examine the association between VT recurrence after ablation and survival in patients with scar-related VT. Methods Analysis of 2,061 patients with structural heart disease referred for catheter ablation of scar-related VT from 12 international centers was performed. Data on clinical and procedural variables, VT recurrence, and mortality were analyzed. Kaplan-Meier analysis was used to estimate freedom from recurrent VT, transplant, and death. Cox proportional hazards frailty models were used to analyze the effect of risk factors on VT recurrence and mortality. Results One-year freedom from VT recurrence was 70% (72% in ischemic and 68% in non-ischemic cardiomyopathy). 57 (3%) patients underwent cardiac transplantation and 216 (10%) died during follow-up. At one year, the estimated rate of transplant and/or mortality was 15% (same for ischemic and non-ischemic cardiomyopathy). Transplant-free survival was significantly higher in patients without VT recurrence compared to those with recurrence (90% vs. 71%, p<0.001). In multivariable analysis, recurrence of VT after ablation showed the highest risk for transplant and/or mortality (HR 6.9 (5.3-9.0); p<0.001). In patients with EF<30% and across all NYHA classes, improved transplant-free survival was seen in those without VT recurrence. Conclusions Catheter ablation of VT in patients with structural heart disease results in 70% freedom from VT recurrence, with an overall transplant and/or mortality rate of 15% at 1 year. Freedom from VT recurrence is associated with improved transplant-free survival, independent of heart failure severity.

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Authors
Tung, R., Vaseghi, M., Frankel, D. S., Vergara, P., Di Biase, L., Nagashima, K., Yu, R., Vangala, S., Tseng, C.-H., Choi, E.-K., Khurshid, S., Patel, M., Mathuria, N., Nakahara, S., Tzou, W. S., Sauer, W. H., Vakil, K., Tedrow, U., Burkhardt, J. D., Tholakanahalli, V. N., Saliaris, A., Dickfeld, T., Weiss, J. P., Bunch, T. J., Reddy, M., Kanmanthareddy, A., Callans, D. J., Lakkireddy, D., Natale, A., Marchlinski, F., Stevenson, W. G., Della Bella, P., & Shivkumar, K.
Venue
Heart Rhythm
Publisher
Elsevier BV
Published
2015-09
Volume
12
Issue
9
Pages
1997-2007
ISSN
1547-5271 (ISSN-L)
OpenAlex
W2159446154
Cited by
499
References
33
FWCI
30.78
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study. https://app.cochat.ai/papers/10.1016/j.hrthm.2015.05.036
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Tung, R., Vaseghi, M., Frankel, D. S., Vergara, P., Di Biase, L., Nagashima, K., Yu, R., Vangala, S., Tseng, C.-H., Choi, E.-K., Khurshid, S., Patel, M., Mathuria, N., Nakahara, S., Tzou, W. S., Sauer, W. H., Vakil, K., Tedrow, U., Burkhardt, J. D., . . . Shivkumar, K. (2015). Freedom from recurrent ventricular tachycardia after catheter ablation is associated with improved survival in patients with structural heart disease: An International VT Ablation Center Collaborative Group study. Heart Rhythm. https://doi.org/10.1016/j.hrthm.2015.05.036

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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