Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis

Sainz, Juan; Pérez, Eva; Hassan, Laila; Moratalla, Antonio; Romero, Antonio; Collado, María Dolores; Jurado, Manuel

doi:10.1016/j.humimm.2006.10.011

Cited by 81Antifungal resistance and susceptibilityImmunodeficiency and Autoimmune DisordersFungal and yeast genetics research

Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis

Sainz, Juan, Pérez, Eva, Hassan, Laila, Moratalla, Antonio, Romero, Antonio, Collado, María Dolores, Jurado, Manuel·2007·Human Immunology

DOI 10.1016/j.humimm.2006.10.011

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Abstract

Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) are pivotal mediators of inflammatory responses in fungal infection diseases. We hypothesized that polymorphisms in genes of these cytokines or their receptors might increase the susceptibility of hematologic patients to develop invasive pulmonary aspergillosis (IPA). One hundred two hematologic patients and 124 age-matched controls were enrolled in the study, and the following standard single nucleotide polymorphisms were investigated: TNF-alpha -308 and +489, LT-alpha +252 and Tumor Necrosis Factor Receptor 2 (TNFR2) +676. Variable number of tandem repeats (VNTRs) at position -322 of the TNFR2 gene were also studied. Genotypic and allelic frequencies were similar between patients and controls. IPA was diagnosed in 54 of the 102 patients according to consensus criteria published by the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group. TNF-alpha and LT-alpha polymorphisms were not associated with presence of IPA. Susceptibility to IPA was strongly associated with VNTR at position -322 in the promoter region of the TNR2 gene (p = 0.029) but was not associated with the presence of TNFR2 +676 polymorphism. A genetic difference in TNFR2 promoter VNTR may play a major role in susceptibility to IPA infection.

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Polymorphisms within the tumor necrosis factor-alpha gene and its receptors are associated with susceptibility to aspergillosis.
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From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [38]

Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus
Aşçıoğlu, S., Rex, J. H., de Pauw, B., Bennett, J. E., Billé, J., Crokaert, F., Denning, D. W., Donnelly, J. P., Edwards, J. E., Erjavec, Z., et al. (2002) · Clinical Infectious Diseases · doi:10.1086/323335 · Cited by 2,315 · see citing works
Effects of a polymorphism in the human tumor necrosis factor α promoter on transcriptional activation
Wilson, A. G., Symons, J. A., McDowell, T. L., McDevitt, H. O., & Duff, G. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3195 · Cited by 2,217 · see citing works
The Tumor Necrosis Factor Ligand and Receptor Families
Bazzoni, F., & Beutler, B. (1996) · New England Journal of Medicine · doi:10.1056/nejm199606273342607 · Cited by 1,208 · see citing works
Variation in the TNF-α promoter region associated with susceptibility to cerebral malaria
McGuire, W. L., Hill, A. V. S., Allsopp, C. E. M., Greenwood, B. M., & Kwiatkowski, D. P. (1994) · Nature · doi:10.1038/371508a0 · Cited by 1,166 · see citing works
Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction
Ozaki, K., Ohnishi, Y., Iida, A., Sekine, A., Yamada, R., Tsunoda, T., Sato, H., Sato, H., Hori, M., Nakamura, Y., et al. (2002) · Nature Genetics · doi:10.1038/ng1047 · Cited by 940 · see citing works
Prolonged Granulocytopenia: The Major Risk Factor for Invasive Pulmonary Aspergillosis in Patients with Acute Leukemia
Gerson, S. L., TALBOT, G. H., Hurwitz, S., STROM, B. L., LUSK, E. J., & Cassileth, P. A. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-3-345 · Cited by 761 · see citing works
TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation
Peschon, J. J., Torrance, D., Stocking, K. L., Glaccum, M. B., Otten, C., Willis, C. R., Charrier, K., Morrissey, P., Ware, C. B., & Mohler, K. M. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.2.943 · Cited by 706 · see citing works
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.
Jacob, C. O., Fronek, Z., Lewis, G. D., Koo, M., Hansen, J. A., & McDevitt, H. O. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1233 · Cited by 622 · see citing works
Selective Protection against Conidia by Mononuclear and against Mycelia by Polymorphonuclear Phagocytes in Resistance to Aspergillus
Schaffner, A., Douglas, H., & Braude, A. I. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110489 · Cited by 618 · see citing works
Tumour necrosis factor (TNF) gene polymorphism influences TNF-α production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans
Louis, E. J., Franchimont, D. P., Piron, A., Gevaert, Y., Schaaf‐Lafontaine, N., Roland, S., Mahieu, P. R., Malaise, M., Groote, D. D., Louis, R. E., et al. (1998) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1998.00662.x · Cited by 575 · see citing works
Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.
Tartaglia, L. A., Pennica, D., & Goeddel, D. V. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46661-0 · Cited by 570 · see citing works
Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF‐a and TNF‐0 by human mononuclear cells: a possible link to insulin‐dependent diabetes mellitus
Pociot, F., Briant, L., Jongeneel, C. V., Mølvig, J., Worsaae, H., Abbal, M., Thomsen, M., Nerup, J., & Cambon‐Thomsen, A. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230135 · Cited by 549 · see citing works
A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis
Stuber, F. E., Petersen, M., Bokelmann, F., & Schade, U. F. (1996) · Critical Care Medicine · doi:10.1097/00003246-199603000-00004 · Cited by 549 · see citing works
Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.
Messer, G., Spengler, U., Jung, M., Honold, G., Blömer, K., Pape, G. R., Riethmüller, G., & Weiss, E. H. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.1.209 · Cited by 537 · see citing works
Invasive Aspergillosis in Transplant Recipients
Paterson, D. L., & Singh, N. (1999) · Medicine · doi:10.1097/00005792-199903000-00003 · Cited by 359 · see citing works
Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration
Marks, J. D., Marks, C. B., Ljuce, J. M., Montgomery, A. B., Turner, J., Metz, C. A., & Murray, J. F. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/141.1.94 · Cited by 329 · see citing works
Invasive Aspergillosis in Acute Leukemia: Correlation with Nose Cultures and Antibiotic Use
Aisner, J., MURILLO, J., SCHIMPFF, S. C., & Steere, A. C. (1979) · Annals of Internal Medicine · doi:10.7326/0003-4819-90-1-4 · Cited by 271 · see citing works
Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis.
Mehrad, B., Strieter, R. M., & Standiford, T. J. (1999) · PubMed · Cited by 264 · see citing works
Cytokine‐ and T Helper–Dependent Lung Mucosal Immunity in Mice with Invasive Pulmonary Aspergillosis
Cenci, E., Mencacci, A., d’Ostiani, C. F., Sero, G. D., Mosci, P., Montagnoli, C., Bacci, A., & Romani, L. R. (1998) · The Journal of Infectious Diseases · doi:10.1086/314493 · Cited by 253 · see citing works
Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor.
PERUSSIA, B., Kobayashi, M., Rossi, M., Anegón, I., & Trinchieri, G. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.3.765 · Cited by 247 · see citing works
In Vivo Bronchoalveolar Macrophage Defense Against Rhizopus oryzae and Aspergillus fumigatus
Waldorf, A. R., Levitz, S. M., & Diamond, R. D. (1984) · The Journal of Infectious Diseases · doi:10.1093/infdis/150.5.752 · Cited by 247 · see citing works
Role of TNF-α in Pulmonary Host Defense in Murine Invasive Aspergillosis
Mehrad, B., Strieter, R. M., & Standiford, T. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1633 · Cited by 244 · see citing works
Tumor necrosis factor mediates lung antibacterial host defense in murine Klebsiella pneumonia
Laichalk, L. L., Kunkel, S. L., Strieter, R. M., Danforth, J. M., Bailie, M. B., & Standiford, T. J. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5211-5218.1996 · Cited by 218 · see citing works
Receptor Binding and Activation of Polymorphonuclear Neutrophils by Tumor Necrosis Factor-Alpha
Shalaby, M. R., Palladino, M. A., Hirabayashi, S. E., Eessalu, T. E., Lewis, G. D., Shepard, H. M., & Aggarwal, B. B. (1987) · Journal of Leukocyte Biology · doi:10.1002/jlb.41.3.196 · Cited by 216 · see citing works
Th1 and Th2 cytokines in mice with invasive aspergillosis
Cenci, E., Perito, S., Enssle, K.-H., Mosci, P., Latgé, J., Romani, L. R., & Bistoni, F. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.564-570.1997 · Cited by 216 · see citing works
Emerging and less common fungal pathogens
Fleming, R. V., Walsh, T. J., & Anaissie, E. J. (2002) · Infectious Disease Clinics of North America · doi:10.1016/s0891-5520(02)00041-7 · Cited by 215 · see citing works
Recent trends in the epidemiology of invasive mycoses
Clark, T. A., & Hajjeh, R. A. (2002) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200212000-00003 · Cited by 210 · see citing works
In Vitro Killing of Spores and Hyphae of Aspergillus fumigatus and Rhizopus oryzae by Rabbit Neutrophil Cationic Peptides and Bronchoalveolar Macrophages
Levitz, S. M., Selsted, M. E., Ganz, T., Lehrer, R. I., & Diamond, R. D. (1986) · The Journal of Infectious Diseases · doi:10.1093/infdis/154.3.483 · Cited by 195 · see citing works
Effects of Tumour Necrosis Factor Alpha and Interleukin-1 Alpha and Beta on Human Neutrophil Migration, Respiratory Burst and Degranulation
Ferrante, A., Nandoskar, M., Walz, A., et al. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234610 · Cited by 174 · see citing works
Role of tumor necrosis factor alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa
Gosselin, D. R., DeSanctis, J., Boulé, M., Skamene, E., Matouk, C. C., & Radzioch, D. (1995) · Infection and Immunity · doi:10.1128/iai.63.9.3272-3278.1995 · Cited by 154 · see citing works
Tumor Necrosis Factor Alpha Enhances Antifungal Activities of Polymorphonuclear and Mononuclear Phagocytes againstAspergillus fumigatus
Roilides, E., Dimitriadou‐Georgiadou, A., Sein, T., Kadiltsoglou, I., & Walsh, T. J. (1998) · Infection and Immunity · doi:10.1128/iai.66.12.5999-6003.1998 · Cited by 153 · see citing works
Genetics of tumour necrosis factor-alpha in autoimmune, infectious, and neoplastic diseases.
Wilson, A. G., di Giovine, F. S., & Duff, G. W. (1995) · PubMed · Cited by 151 · see citing works
Increased susceptibility of TNF-alpha lymphotoxin-alpha double knockout mice to systemic candidiasis through impaired recruitment of neutrophils and phagocytosis of Candida albicans.
Netea, M. G., van Tits, L. J. H., Curfs, J. H. A. J., Amiot, F., Meis, J. F. G. M., van der Meer, J. W. M., & Kullberg, B. J. (1999) · PubMed · Cited by 147 · see citing works
Corticosteroid treatment as a risk factor for invasive aspergillosis in patients with lung disease.
Palmer, L. B., Greenberg, H. E., & Schiff, M. J. (1991) · Thorax · doi:10.1136/thx.46.1.15 · Cited by 145 · see citing works
Tumor necrosis factor alpha in the pathogenesis of cerebral malaria.
Gimenez, F., de Lagerie, S. B., Fernandez, C., Pino, P., & Mazier, D. (2003) · PubMed Central · doi:10.1007/s00018-003-2347-x · Cited by 135 · see citing works
Patterns of Infection in Patients with Aplastic Anemia and the Emergence of Aspergillus As a Major Cause of Death
Weinberger, M., Elattar, I. A., Marshall, D., Steinberg, S. M., Redner, R. L., Young, N. S., & Pizzo, P. A. (1992) · Medicine · doi:10.1097/00005792-199201000-00003 · Cited by 132 · see citing works
Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus
Komata, T., Tsuchiya, N., Matsushita, M., Hagiwara, K., & Tokunaga, K. (1999) · Tissue Antigens · doi:10.1034/j.1399-0039.1999.530602.x · Cited by 123 · see citing works
The G→A Single Nucleotide Polymorphism at the –308 Position in the Tumor Necrosis Factor-α Promoter Increases the Risk for Severe Sepsis after Trauma
O’Keefe, G. E., Hybki, D. P., & Munford, R. S. (2002) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-200205000-00001 · Cited by 121 · see citing works
Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
Gruss, H. J. (1996) · International Journal of Clinical & Laboratory Research · doi:10.1007/bf02592977 · Cited by 121 · see citing works
Increased Susceptibility of TNF-α Lymphotoxin-α Double Knockout Mice to Systemic Candidiasis Through Impaired Recruitment of Neutrophils and Phagocytosis of Candida albicans
Netea, M. G., van Tits, L. J. H., Curfs, J. H. A. J., Amiot, F., Meis, J. F. G. M., van der Meer, J. W. M., & Kullberg, B. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.3.1498 · Cited by 118 · see citing works
Epidemiology and diagnosis of invasive pulmonary aspergillosis in bone marrow transplant patients: results of a 5 year retrospective study.
Saugier-Véber, P., Devergié, A., Sulahian, A., et al. (1993) · PubMed · Cited by 112 · see citing works
Fungal infections after bone marrow transplant
Wingard, J. R. (1999) · Transplantation and Cellular Therapy · doi:10.1053/bbmt.1999.v5.pm10371357 · Cited by 109 · see citing works
Cytokine Networking in Lungs of Immunocompetent Mice in Response to Inhaled Aspergillus fumigatus
Brieland, J. K., Jackson, C. A., Menzel, F., Loebenberg, D., Cacciapuoti, A. F., Halpern, J., Hurst, S. D., Muchamuel, T., Debets, R., KASTELEIN, R. A., et al. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1554-1560.2001 · Cited by 104 · see citing works
Disparate effects of interferon-gamma and tumor necrosis factor-alpha on early neutrophil respiratory burst and fungicidal responses to Candida albicans hyphae in vitro.
Diamond, R. D., Lyman, C. A., & Wysong, D. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115050 · Cited by 97 · see citing works
Review of the safety, tolerability, and drug interactions of the new antifungal agents caspofungin and voriconazole
Ullmann, A. J. (2003) · Current Medical Research and Opinion · doi:10.1185/030079903125001884 · Cited by 84 · see citing works
The release of endotoxin from antibiotic-treated Escherichia coli and the production of tumour necrosis factor by human monocytes
Dofferhoff, A. S. M., Esselink, M., de Vries-Hospers, H. G., et al. (1993) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/31.3.373 · Cited by 78 · see citing works
Tumour necrosis factor production in fulminant hepatic failure: relation to aetiology and superimposed microbial infection
de la Mata, M., Meager, A., Rolando, N., Daniels, H. M., Nouri‐Aria, K. T., Goka, A. K. J., Eddleston, A. L. W. F., Alexander, G., & Williams, R. L. (1990) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1990.tb05475.x · Cited by 75 · see citing works
TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense
Steinshamn, S., Bemelmans, M. H. A., van Tits, L. J., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.5.2155 · Cited by 73 · see citing works
Phagocyte function and cytokine production in community acquired pneumonia.
Moussa, K., Michie, H. J., Cree, I. A., et al. (1994) · Thorax · doi:10.1136/thx.49.2.107 · Cited by 72 · see citing works
Pharmacologic Inhibitors of Tumor Necrosis Factor Production Exert Differential Effects in Lethal Endotoxemia and in Infection with Live Microorganisms in Mice
Netea, M. G., Blok, W. L., Kullberg, B. J., et al. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/171.2.393 · Cited by 69 · see citing works
Tumor necrosis factor receptor II (TNFRII) exon 6 polymorphism in systemic lupus erythematosus
Al-Ansari, A., Ollier, W., Villarreal, J. S. C., et al. (2000) · Tissue Antigens · doi:10.1034/j.1399-0039.2000.550122.x · Cited by 68 · see citing works
TNF and LTA gene polymorphisms reveal different risk in gastric and duodenal ulcer patients
Lanas, Á., García-González, M. A., Santolaria, S., et al. (2001) · Genes and Immunity · doi:10.1038/sj.gene.6363798 · Cited by 64 · see citing works
Production of cytokines by alveolar and peritoneal macrophages stimulated byAspergillus fumigatusconidia or hyphae
Taramelli, D., Malabarba, M. G., Sala, G., Basilico, N., & Cocuzza, G. (1996) · Medical Mycology · doi:10.1080/02681219680000081 · Cited by 62 · see citing works
Cytokines in host defense againstAspergillus: recent advances
Phadke, A. P., & Mehrad, B. (2005) · Medical Mycology · doi:10.1080/13693780500052099 · Cited by 57 · see citing works
Polymorphisms in or near tumour necrosis factor (TNF)-gene do not determine levels of endotoxin-induced TNF production
de Jong, B. A., Westendorp, R. G. J., Bakker, A. M., & Huizinga, T. W. J. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363824 · Cited by 51 · see citing works
Clinical efficacy of echinocandin antifungals
Arathoon, E. (2001) · Current Opinion in Infectious Diseases · doi:10.1097/00001432-200112000-00004 · Cited by 51 · see citing works
Induction of Tumor Necrosis Factor- in Murine Candida albicans Infection
Allendoerfer, R., Magee, D. M., Smith, J. G., Bonewald, L. F., & Graybill, J. R. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.5.1168 · Cited by 47 · see citing works
Cytokine- and T-helper-dependent immunity in murine aspergillosis
Cenci, E., Mencacci, A., Fèd'Ostiani, C., Montagnoli, C., Bacci, A., Sero, G. D., Perito, S., Bistoni, F., & Romani, L. R. (1998) · Research in Immunology · doi:10.1016/s0923-2494(98)80768-2 · Cited by 42 · see citing works
Delayed Clearance of Intraabdominal Abscesses Caused byCandida albicansin Tumor Necrosis Factor–α– and Lymphotoxin‐α–Deficient Mice
Vonk, A. G., Netea, M. G., van Krieken, J. H., van der Meer, J. W. M., & Kullberg, B. J. (2002) · The Journal of Infectious Diseases · doi:10.1086/345818 · Cited by 29 · see citing works
Genome scan analyses and positional cloning strategy in IBD: successes and limitations
Wild, G., & Rioux, J. D. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2003.12.007 · Cited by 22 · see citing works
A bi-allelic VNTR in the human TNFR2 (p75) gene promoter
Keen, L. J., Wood, N., Olomolaiye, O. O., et al. (1999) · Genes and Immunity · doi:10.1038/sj.gene.6363644 · Cited by 13 · see citing works
Immunomodulatory effects of anti-tumor necrosis factor alpha therapy on synovium in spondylarthropathy: histologic findings in eight patients from an open-label pilot study
Warrington (2001) · Pure Amsterdam UMC · doi:10.1002/1529-0131(200101)44:1 · Cited by 2 · see citing works

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Authors: Sainz, J., Pérez, E., Hassan, L., Moratalla, A., Romero, A., Collado, M. D., & Jurado, M.
Affiliations: Hospital Universitario Virgen de las Nieves (ES)
ORCID: Jurado, Manuel
Venue: Human Immunology
Publisher: Elsevier BV
Published: 2007-01
Volume: 68
Issue: 1
Pages: 41-50
ISSN: 0198-8859 (ISSN-L)
DOI: 10.1016/j.humimm.2006.10.011
OpenAlex: W2053563213
Cited by: 81
References: 62
Citations by year: 2024: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 2 · 2012: 4
FWCI: 3.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Human Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Servicio Andaluz de Salud (1/02/06)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: invasive pulmonary aspergillosis, variable number tandem repeats, promoter polymorphism, genetic susceptibility, hematologic patients, TNF-α, lymphotoxin, single nucleotide polymorphisms, fungal infection susceptibility, genetic biomarkers
MeSH terms: Aspergillosis, Female, Genetic Markers, Humans, Lung Diseases, Fungal, Male, Middle Aged, Promoter Regions, Genetic, Prospective Studies, Minisatellite Repeats, Genetic Predisposition to Disease, Receptors, Tumor Necrosis Factor, Type II

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Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis

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