Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium

Lupiañez, C. B.; Canet, L. M.; Carvalho, A.; Alcazar-Fuoli, L.; Springer, J.; Lackner, M.; Segura-Catena, J.; Comino, A.; Olmedo, C.; Ríos, R.; Fernández-Montoya, A.; Cuenca-Estrella, M.; Solano, C.; López-Nevot, M. Á.; Cunha, C.; Oliveira-Coelho, A.; Villaescusa, T.; Fianchi, L.; Aguado, J. M.; Pagano, L.; López-Fernández, E.; Potenza, L.; Luppi, M.; Lass-Flörl, C.; Loeffler, J.; Einsele, H.; Vazquez, L.; the PCRAGA Study Group; Jurado, M.; Sainz, J.

doi:10.1128/iai.01359-15

Cited by 42Antifungal resistance and susceptibilityImmunodeficiency and Autoimmune DisordersFungal and yeast genetics research

Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium

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Lupiañez, C. B., Canet, L. M., Carvalho, A., Alcazar-Fuoli, L., Springer, J., Lackner, M., Segura-Catena, J., Comino, A. +22 more·2016·Infection and Immunity

DOI 10.1128/iai.01359-15PMC PMC4771352

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Abstract

Recent studies suggest that immune-modulating single-nucleotide polymorphisms (SNPs) influence the risk of developing cancer-related infections. Here, we evaluated whether 36 SNPs within 14 immune-related genes are associated with the risk of invasive aspergillosis (IA) and whether genotyping of these variants might improve disease risk prediction. We conducted a case-control association study of 781 immunocompromised patients, 149 of whom were diagnosed with IA. Association analysis showed that the IL4Rrs2107356 and IL8rs2227307 SNPs (using dbSNP numbering) were associated with an increased risk of IA (IL4Rrs2107356 odds ratio [OR], 1.92; 95% confidence interval [CI], 1.20 to 3.09;IL8rs2227307 OR, 1.73; 95% CI, 1.06 to 2.81), whereas the IL12Brs3212227 and IFN γ rs2069705 variants were significantly associated with a decreased risk of developing the infection (IL12Brs3212227 OR, 0.60; 95% CI, 0.38 to 0.96;IFN γ rs2069705 OR, 0.63; 95% CI, 0.41 to 0.97). An allogeneic hematopoietic stem cell transplantation (allo-HSCT)-stratified analysis revealed that the effect observed for the IL4Rrs2107356 and IFN γ rs2069705 SNPs was stronger in allo-HSCT (IL4Rrs2107356 OR, 5.63; 95% CI, 1.20 to 3.09;IFN γ rs2069705 OR, 0.24; 95% CI, 0.10 to 0.59) than in non-HSCT patients, suggesting that the presence of these SNPs renders patients more vulnerable to infection, especially under severe and prolonged immunosuppressive conditions. Importantly,in vitro studies revealed that carriers of the IFN γ rs2069705C allele showed a significantly increased macrophage-mediated neutralization of fungal conidia (P= 0.0003) and, under stimulation conditions, produced higher levels of gamma interferon (IFNγ) mRNA (P= 0.049) and IFNγ and tumor necrosis factor alpha (TNF-α) cytokines (P value for 96 h of treatment with lipopolysaccharide [PLPS-96 h], 0.057;P value for 96 h of treatment with phytohemagglutinin [PPHA-96 h], 0.036;PLPS+PHA-96 h= 0.030;PPHA-72 h= 0.045;PLPS+PHA-72 h= 0.018;PLPS-96 h= 0.058;PLPS+PHA-96 h= 0.0058). Finally, we also observed that the addition of SNPs significantly associated with IA to a model including clinical variables led to a substantial improvement in the discriminatory ability to predict disease (area under the concentration-time curve [AUC] of 0.659 versus AUC of 0.564;P−2 log likehood ratio test= 5.2 · 10−4 and P50.000 permutation test= 9.34 · 10−5). These findings suggest that the IFN γ rs2069705 SNP influences the risk of IA and that predictive models built with IFN γ,IL8,IL12p70, and VEGFA variants can used to predict disease risk and to implement risk-adapted prophylaxis or diagnostic strategies.

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Polymorphisms within the interferon-gamma gene and its receptor are associated with fungal disease risk, and auto-antibodies to IFN-gamma are associated with an increased rate of fungal infections.
“Polymorphisms within the interferon-γ (INF-γ) gene [39] and its receptor have also been associated with fungal disease risk, and auto-antibodies to IFN-γ have similarly seen an increased rate of fungal infections and may be more frequent in some patient groups [40].”
From Race and ethnicity: Risk factors for fungal infections? (2023) · cites this paper as [39]

The Structure of Haplotype Blocks in the Human Genome
Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M., et al. (2002) · Science · doi:10.1126/science.1069424 · Cited by 5,863 · see citing works
Revised Definitions of Invasive Fungal Disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group
De Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/588660 · Cited by 4,917 · see citing works
Immunity to fungal infections
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793 · see citing works
A Simple Correction for Multiple Testing for Single-Nucleotide Polymorphisms in Linkage Disequilibrium with Each Other
Nyholt, D. R. (2004) · The American Journal of Human Genetics · doi:10.1086/383251 · Cited by 1,699 · see citing works
The Association of Atopy with a Gain-of-Function Mutation in the α Subunit of the Interleukin-4 Receptor
Hershey, G. K. K., Friedrich, M. F., Esswein, L. A., Thomas, M. L., & Chatila, T. A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712113372403 · Cited by 747 · see citing works
Involvement of Interleukin-8, Vascular Endothelial Growth Factor, and Basic Fibroblast Growth Factor in Tumor Necrosis Factor Alpha-Dependent Angiogenesis
Yoshida, S., Ono, M., Shono, T., Izumi, H., Ishibashi, T., Suzuki, H., & Kuwano, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.4015 · Cited by 688 · see citing works
Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk
Gringhuis, S. I., den Dunnen, J., Litjens, M., van der Vlist, M., Wevers, B. A., Bruijns, S. C. M., & Geijtenbeek, T. B. H. (2009) · Nature Immunology · doi:10.1038/ni.1692 · Cited by 490 · see citing works
Activation of Airway Epithelial Cells by Toll-Like Receptor Agonists
Sha, Q., Truong-Tran, A. Q., Plitt, J. R., Beck, L. A., & Schleimer, R. P. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0388oc · Cited by 485 · see citing works
Genetic Acceleration of AIDS Progression by a Promoter Variant of CCR5
Martin, M. P. (1998) · Science · doi:10.1126/science.282.5395.1907 · Cited by 473 · see citing works
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation
Bochud, P.-Y., Chien, J. W., Marr, K. A., Leisenring, W. M., Upton, A., Janer, M., Rodrigues, S. D., Li, S., Hansen, J. A., Zhao, L. P., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802629 · Cited by 453 · see citing works
Vascular Endothelial Growth Factor Gene Polymorphisms Are Associated with Acute Renal Allograft Rejection
Shahbazi, M., Fryer, A. A., Pravica, V., Brogan, I. J., Ramsay, H. M., Hutchinson, I. V., & Harden, P. (2002) · Journal of the American Society of Nephrology · doi:10.1681/asn.v131260 · Cited by 411 · see citing works
CCR5 promoter polymorphism and HIV-1 disease progression
McDermott, D. H., Zimmerman, P. A., Guignard, F., Kleeberger, C. A., Leitman, S. F., & Murphy, P. M. (1998) · The Lancet · doi:10.1016/s0140-6736(98)04158-0 · Cited by 388 · see citing works
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry
Steinbach, W. J., Marr, K. A., Anaissie, E. J., Azie, N. E., Quan, S.-P., Meier‐Kriesche, H., Apewokin, S. K., & Horn, D. L. (2012) · Journal of Infection · doi:10.1016/j.jinf.2012.08.003 · Cited by 347 · see citing works
Dectin-1 and TLRs Permit Macrophages to Distinguish between Different <i>Aspergillus fumigatus</i> Cellular States
Gersuk, G. M., Underhill, D. M., Zhu, L., & Marr, K. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.6.3717 · Cited by 334 · see citing works
Dendritic Cells Transport Conidia and Hyphae of Aspergillus fumigatus from the Airways to the Draining Lymph Nodes and Initiate Disparate Th Responses to the Fungus
Bozza, S., Gaziano, R., Spreca, A., Bacci, A., Montagnoli, C., Francesco, P. D., & Romani, L. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1362 · Cited by 331 · see citing works
Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation
Cunha, C., Aversa, F., de Lacerda, J. F., Busca, A., Kurzai, O., Grube, M., Löffler, J., Maertens, J. A., Bell, A. S., Inforzato, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1211161 · Cited by 304 · see citing works
Self-citation
Aspergillus fumigatus Stimulates the NLRP3 Inflammasome through a Pathway Requiring ROS Production and the Syk Tyrosine Kinase
Sadier, N. S., Padilla, E., Langsley, G., & Ojcius, D. M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010008 · Cited by 302 · see citing works
Toll-like Receptor (TLR) Signaling in Response toAspergillus fumigatus
Mambula, S. S., Sau, K., Henneke, P., Golenbock, D. T., & Levitz, S. M. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201683200 · Cited by 297 · see citing works
An IL-13 promoter polymorphism associated with increased risk of allergic asthma
Kraan, T. V. D. P., van Veen, A., Boeije, L. C. M., van Tuyl, S. A. P., de Groot, E. R., Stapel, S., Bakker, A., Verweij, C., Aarden, L. A., & van der Zee, J. S. (1999) · Genes and Immunity · doi:10.1038/sj.gene.6363630 · Cited by 291 · see citing works
Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
Cunha, C., Di Ianni, M., Bozza, S., Giovannini, G., Zagarella, S., Zelante, T., D'Angelo, C., Pierini, A., Pitzurra, L., Falzetti, F., et al. (2010) · Blood · doi:10.1182/blood-2010-04-279307 · Cited by 286 · see citing works
Self-citation
Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis.
Mehrad, B., Strieter, R. M., & Standiford, T. J. (1999) · PubMed · Cited by 264 · see citing works
VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer
Koukourakis, M. I., Papazoglou, D., Giatromanolaki, A. N., Bougioukas, G., Maltezos, E. S., & Siviridis, E. (2004) · Lung Cancer · doi:10.1016/j.lungcan.2004.04.037 · Cited by 262 · see citing works
Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis
Carvalho, A., Pasqualotto, A. C., Pitzurra, L., Romani, L., Denning, D. W., & Rodrigues, F. (2008) · The Journal of Infectious Diseases · doi:10.1086/526500 · Cited by 255 · see citing works
Self-citation
Cytokine‐ and T Helper–Dependent Lung Mucosal Immunity in Mice with Invasive Pulmonary Aspergillosis
Cenci, E., Mencacci, A., d’Ostiani, C. F., Sero, G. D., Mosci, P., Montagnoli, C., Bacci, A., & Romani, L. R. (1998) · The Journal of Infectious Diseases · doi:10.1086/314493 · Cited by 253 · see citing works
The polymorphisms S503P and Q576R in the interleukin‐4 receptor α gene are associated with atopy and influence the signal transduction
KRUSE, JAPHA, TEDNER, Sparholt, S. H., Förster, Kuehr, & DEICHMANN (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00705.x · Cited by 247 · see citing works
Role of TNF-α in Pulmonary Host Defense in Murine Invasive Aspergillosis
Mehrad, B., Strieter, R. M., & Standiford, T. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.3.1633 · Cited by 244 · see citing works
Genetics of HIV-1infection: chemokine receptor CCR5 polymorphism and its consequences
Carrington, M. N. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.10.1939 · Cited by 235 · see citing works
Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
Morrison, B. E., Park, S. J., Mooney, J. M., & Mehrad, B. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18125 · Cited by 234 · see citing works
CXC Chemokine Receptor-2 Ligands Are Necessary Components of Neutrophil-Mediated Host Defense in Invasive Pulmonary Aspergillosis
Mehrad, B., Strieter, R. M., Moore, T. A., Tsai, W. C., Lira, S. A., & Standiford, T. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.6086 · Cited by 232 · see citing works
Innate Immunity toAspergillusSpecies
Park, S. J., & Mehrad, B. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-09 · Cited by 230 · see citing works
Th1 and Th2 cytokines in mice with invasive aspergillosis
Cenci, E., Perito, S., Enssle, K.-H., Mosci, P., Latgé, J., Romani, L. R., & Bistoni, F. (1997) · Infection and Immunity · doi:10.1128/iai.65.2.564-570.1997 · Cited by 216 · see citing works
Enhancement of oxidative response and damage caused by human neutrophils to Aspergillus fumigatus hyphae by granulocyte colony-stimulating factor and gamma interferon
Roilides, E., Uhlig, K., Venzon, D. J., Pizzo, P. A., & Walsh, T. J. (1993) · Infection and Immunity · doi:10.1128/iai.61.4.1185-1193.1993 · Cited by 213 · see citing works
TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation
KESH, S., MENSAH, N. Y., PETERLONGO, P., JAFFE, D., HSU, K., VAN DEN BRINK, M., O'REILLY, R., PAMER, E., SATAGOPAN, J., & PAPANICOLAOU, G. A. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1358.012 · Cited by 208 · see citing works
Interleukin‐4 Causes Susceptibility to Invasive Pulmonary Aspergillosis through Suppression of Protective Type I Responses
Cenci, E., Mencacci, A., Sero, G. D., Bacci, A., Montagnoli, C., d’Ostiani, C. F., Mosci, P., Bachmann, M. F., Bistoni, F., Köpf, M., et al. (1999) · The Journal of Infectious Diseases · doi:10.1086/315142 · Cited by 204 · see citing works
The innate immune response to Aspergillus fumigatus
Balloy, V., & Chignard, M. (2009) · Microbes and Infection · doi:10.1016/j.micinf.2009.07.002 · Cited by 187 · see citing works
Interferon- and Tumor Necrosis Factor- Protect Mice from Invasive Aspergillosis
Nagai, H., Guo, J., Choi, H., & Kurup, V. P. (1995) · The Journal of Infectious Diseases · doi:10.1093/infdis/172.6.1554 · Cited by 173 · see citing works
Serum Galactomannan Versus a Combination of Galactomannan and Polymerase Chain Reaction-Based Aspergillus DNA Detection for Early Therapy of Invasive Aspergillosis in High-Risk Hematological Patients: A Randomized Controlled Trial
Aguado, J. M., Vázquez, L., Fernández‐Ruiz, M., Villaescusa, T., Ruíz-Camps, I., Barba, P., Silva, J. T., Batlle, M., Solano, C., Gallardo, D., et al. (2014) · Clinical Infectious Diseases · doi:10.1093/cid/ciu833 · Cited by 157 · see citing works
Self-citation
Mannose‐Binding Lectin Gene Polymorphisms as a Susceptibility Factor for Chronic Necrotizing Pulmonary Aspergillosis
Crosdale, D. J., Poulton, K., Ollier, W., Thomson, W., & Denning, D. W. (2001) · The Journal of Infectious Diseases · doi:10.1086/322791 · Cited by 148 · see citing works
Aspergillosis in Intensive Care Unit (ICU) patients: epidemiology and economic outcomes
Baddley, J. W., Stephens, J., Ji, X., Gao, X., Schlamm, H. T., & Tarallo, M. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-29 · Cited by 144 · see citing works
Upregulation of IL-13 concentration in vivo by the IL13 variant associated with bronchial asthma
Arima, K., Suyama, R., Sakata, Y., Akaiwa, M., Mao, X., Enomoto, T., Dake, Y., Shimazu, S.-I., Yamashita, T., Sugawara, N., et al. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.124656 · Cited by 144 · see citing works
Dectin-1 and DC-SIGN Polymorphisms Associated with Invasive Pulmonary Aspergillosis Infection
Sáinz, J., Lupiañez, C. B., Segura-Catena, J., Vázquez, L., Ríos, R., Oyonarte, S., Hemminki, K., Försti, A., & Jurado, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032273 · Cited by 139 · see citing works
Self-citation
Early NK Cell-Derived IFN-γ Is Essential to Host Defense in Neutropenic Invasive Aspergillosis
Park, S. J., Hughes, M. A., Burdick, M. D., Strieter, R. M., & Mehrad, B. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803462 · Cited by 136 · see citing works
Epidemiology, outcomes, and mortality predictors of invasive mold infections among transplant recipients: a 10‐year, single‐center experience
Neofytos, D., Treadway, S., Ostrander, D. B., Alonso, C. D., Dierberg, K. L., Nussenblatt, V. R., Durand, C. M., Thompson, C. B., & Marr, K. A. (2013) · Transplant Infectious Disease · doi:10.1111/tid.12060 · Cited by 134 · see citing works
The Y238X Stop Codon Polymorphism in the Human β-Glucan Receptor Dectin-1 and Susceptibility to Invasive Aspergillosis
Chai, L. Y. A., de Boer, M. G. J., van der Velden, W. J. F. M., Plantinga, T. S., van Spriel, A. B., Jacobs, C. W. M., Halkes, C. J. M., Vonk, A. G., Blijlevens, N. M. A., van Dissel, J. T., et al. (2011) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiq102 · Cited by 118 · see citing works
Role of IL-10 in invasive aspergillosis: increased resistance of IL-10 gene knockout mice to lethal systemic aspergillosis
Clemons, K. V., Grünig, G., Sobel, R. A., Mirels, L. F., Rennick, D. M., & Stevens, D. A. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01382.x · Cited by 112 · see citing works
Dectin-1 is inducible and plays a crucial role in Aspergillus-induced innate immune responses in human bronchial epithelial cells
Sun, W., Lu, X., Li, X., Sun, Q.-Y., Su, X., Song, Y., Sun, H., & Shi, Y. P. (2012) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-012-1624-8 · Cited by 110 · see citing works
Polymorphisms in Toll-like receptor genes and susceptibility to infections in allogeneic stem cell transplantation
Carvalho, A., Cunha, C., Carotti, A., Aloisi, T., Guarrera, O., Di Ianni, M., Falzetti, F., Bistoni, F., Aversa, F., Pitzurra, L., et al. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2009.06.004 · Cited by 104 · see citing works
Self-citation
Cytokine Networking in Lungs of Immunocompetent Mice in Response to Inhaled Aspergillus fumigatus
Brieland, J. K., Jackson, C. A., Menzel, F., Loebenberg, D., Cacciapuoti, A. F., Halpern, J., Hurst, S. D., Muchamuel, T., Debets, R., KASTELEIN, R. A., et al. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1554-1560.2001 · Cited by 104 · see citing works
Aspergillus fumigatus-induced Interleukin-8 Synthesis by Respiratory Epithelial Cells Is Controlled by the Phosphatidylinositol 3-Kinase, p38 MAPK, and ERK1/2 Pathways and Not by the Toll-like Receptor-MyD88 Pathway
Balloy, V., Sallenave, J.-M., Wu, Y., Touqui, L., Latgé, J.-P., Si-Tahar, M., & Chignard, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803149200 · Cited by 102 · see citing works
Polymorphisms in the chemokine (C-X-C motif) ligand 10 are associated with invasive aspergillosis after allogeneic stem-cell transplantation and influence CXCL10 epression in monocyte-derived dendritic cells
Mezger, M., Steffens, M., Beyer, M., Manger, C., Eberle, J., Toliat, M. R., Wienker, T. F., Ljungman, P. T., Hebart, H. F., Dornbusch, H. J., et al. (2007) · Blood · doi:10.1182/blood-2007-05-090928 · Cited by 101 · see citing works
Self-citation
Protective role of interleukin-10 promoter gene polymorphism in the pathogenesis of invasive pulmonary aspergillosis after allogeneic stem cell transplantation
Seo, K. W., Kim, D. H., Sohn, S. K., Lee, N. Y., Chang, H., Kim, S., Jeon, S., Baek, J. H., Kim, J. G., Suh, J. S., et al. (2005) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1705181 · Cited by 101 · see citing works
Mannan-binding lectin pathway deficiencies and invasive fungal infections following allogeneic stem cell transplantation
Granell, M., Urbano-Ispizúa, Á., Suárez, B., Rovira, M., Fernández‐Avilés, F., Martı́nez, C., Ortega, M., Uriburu, C., Gayà, A., Roncero, J. M., et al. (2006) · Experimental Hematology · doi:10.1016/j.exphem.2006.06.005 · Cited by 92 · see citing works
Cytokine Gene Polymorphisms and the Outcome of Invasive Candidiasis: A Prospective Cohort Study
Johnson, M. D., Plantinga, T. S., van de Vosse, E., Edwards, D. R. V., Smith, P. B., Alexander, B. D., Yang, J. C., Kremer, D., Laird, G. M., Oosting, M., et al. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir827 · Cited by 91 · see citing works
Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus
Kim, K.-W., Cho, S., Sestak, A. L., Namjou, B., Kang, C., & Bae, S. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.117572 · Cited by 90 · see citing works
Epidemiology, outcomes, and risk factors of invasive fungal infections in adult patients with acute myelogenous leukemia after induction chemotherapy
Neofytos, D., Lu, K. Y., Seung, A. H., Blackford, A. L., Marr, K. A., Treadway, S., Ostrander, D. B., Nussenblatt, V. R., & Karp, J. E. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.10.001 · Cited by 89 · see citing works
Macrophage Inflammatory Protein-1α Is a Critical Mediator of Host Defense Against Invasive Pulmonary Aspergillosis in Neutropenic Hosts
Mehrad, B., Moore, T. A., & Standiford, T. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.2.962 · Cited by 89 · see citing works
IL1 gene cluster polymorphisms and its haplotypes may predict the risk to develop invasive pulmonary aspergillosis and modulate C-reactive protein level
Sainz, J., Pérez, E., Gómez-Lopera, S., & Jurado, M. (2008) · Journal of Clinical Immunology · doi:10.1007/s10875-008-9197-0 · Cited by 84 · see citing works
Self-citation
Association between Severe Respiratory Syncytial Virus Infection andIL13/IL4Haplotypes
Puthothu, B., Krueger, M., Förster, J., & Heinzmann, A. (2006) · The Journal of Infectious Diseases · doi:10.1086/499316 · Cited by 84 · see citing works
Interleukin-10 promoter polymorphism as risk factor to develop invasive pulmonary aspergillosis
Sáinz, J., Hassan, L., Perez, E., Romero, A., Moratalla, A., López‐Fernández, E., Oyonarte, S., & Jurado, M. (2007) · Immunology Letters · doi:10.1016/j.imlet.2007.01.005 · Cited by 81 · see citing works
Self-citation
Variable number of tandem repeats of TNF receptor type 2 promoter as genetic biomarker of susceptibility to develop invasive pulmonary aspergillosis
Sainz, J., Pérez, E., Hassan, L., Moratalla, A., Romero, A., Collado, M. D., & Jurado, M. (2007) · Human Immunology · doi:10.1016/j.humimm.2006.10.011 · Cited by 81 · see citing works
Self-citation
Defective antifungal T-helper 1 (TH1) immunity in a murine model of allogeneic T-cell–depleted bone marrow transplantation and its restoration by treatment with TH2 cytokine antagonists
Mencacci, A., Perruccio, K., Bacci, A., Cenci, E., Benedetti, R., Martelli, M. F., Bistoni, F., Coffman, R. L., Velardi, A., & Romani, L. R. (2001) · Blood · doi:10.1182/blood.v97.5.1483 · Cited by 77 · see citing works
Invasive fungal disease in patients treated for newly diagnosed acute leukemia
Hammond, S. P., Marty, F. M., Porter, J., DeAngelo, D. J., & Baden, L. R. (2010) · American Journal of Hematology · doi:10.1002/ajh.21776 · Cited by 77 · see citing works
Aspergillus fumigatus Stimulates Leukocyte Adhesion Molecules and Cytokine Production by Endothelial Cells In Vitro and during Invasive Pulmonary Disease
Chiang, L. Y., Sheppard, D. C., Gravelat, F. N., Patterson, T. F., & Filler, S. G. (2008) · Infection and Immunity · doi:10.1128/iai.01510-07 · Cited by 76 · see citing works
Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients
Szeto, C., Chow, K., Poon, P., Szeto, C. Y.-K., Wong, T. Y.-H., & Li, P. K. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00605.x · Cited by 74 · see citing works
A novel polymorphism in the 5′ promoter region of the human interleukin-4 receptor α-chain gene is associated with decreased soluble interleukin-4 receptor protein levels
Hackstein, H., Hecker, M., Kruse, S., Bohnert, A., Ober, C., Deichmann, K. A., & Bein, G. (2001) · Immunogenetics · doi:10.1007/s002510100324 · Cited by 72 · see citing works
Aspergillus fumigatus germ tube growth and not conidia ingestion induces expression of inflammatory mediator genes in the human lung epithelial cell line A549
Bellanger, A., Millon, L., Khoufache, K., Rivollet, D., Bièche, I., Laurendeau, I., Vidaud, M., Botterel, F., & Bretagne, S. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.005488-0 · Cited by 70 · see citing works
Influence of Polymorphisms in Innate Immunity Genes on Susceptibility to Invasive Aspergillosis after Stem Cell Transplantation
de Boer, M. G. J., Jolink, H., Halkes, C. J. M., van der Heiden, P. L. J., Kremer, D., Falkenburg, J. H. F., van de Vosse, E., & van Dissel, J. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018403 · Cited by 68 · see citing works
SNP_tools: A compact tool package for analysis and conversion of genotype data for MS-Excel
Chen, B., Wilkening, S., Drechsel, M., & Hemminki, K. (2009) · BMC Research Notes · doi:10.1186/1756-0500-2-214 · Cited by 64 · see citing works
Association of VEGF genotype with mRNA level in colorectal adenocarcinomas
Yamamori, M., Sakaeda, T., Nakamura, T., Okamura, N., Tamura, T., Aoyama, N., Kamigaki, T., Ohno, M., Shirakawa, T., Gotoh, A., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.005 · Cited by 64 · see citing works
A Common Polymorphism in the Interleukin‐8 Gene Promoter Is Associated with an Increased Risk for RecurrentClostridium difficileInfection
Garey, K. W., Jiang, Z., Ghantoji, S. S., Tam, V. H., Arora, V., & DuPont, H. L. (2010) · Clinical Infectious Diseases · doi:10.1086/657398 · Cited by 63 · see citing works
DC-SIGN mediates the binding of Aspergillus fumigatus and keratinophylic fungi by human dendritic cells
Serrano‐Gómez, D., Leal, J. A., & Corbí, A. L. (2005) · Immunobiology · doi:10.1016/j.imbio.2005.05.011 · Cited by 62 · see citing works
Polymorphisms in Genes Involved in Innate Immunity Predispose Toward Mycetoma Susceptibility
van de Sande, W. W. J., Fahal, A. H., Verbrugh, H. A., & van Belkum, A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.5.3065 · Cited by 58 · see citing works
Cytokines in host defense againstAspergillus: recent advances
Phadke, A. P., & Mehrad, B. (2005) · Medical Mycology · doi:10.1080/13693780500052099 · Cited by 57 · see citing works
TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis
Sainz, J., Salas-Alvarado, I., López-Fernández, E., Olmedo, C., Comino, A., García, F., Blanco, A., Gómez-Lopera, S., Oyonarte, S., Bueno, P., et al. (2010) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201002300205 · Cited by 56 · see citing works
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Genetically-Determined Hyperfunction of the S100B/RAGE Axis Is a Risk Factor for Aspergillosis in Stem Cell Transplant Recipients
Cunha, C., Giovannini, G., Pierini, A., Bell, A. S., Sorci, G., Riuzzi, F., Donato, R., Rodrigues, F. J. S., Velardi, A., Aversa, F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027962 · Cited by 52 · see citing works
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Association between Chronic Disseminated Candidiasis in Adult Acute Leukemia and Common<i>IL4</i>Promoter Haplotypes
Choi, E. H., Foster, C. B., Taylor, J. G., Erichsen, H. C., Chen, R. A., Walsh, T. J., Anttila, V., Ruutu, T., Palotie, A., & Chanock, S. J. (2003) · The Journal of Infectious Diseases · doi:10.1086/368345 · Cited by 52 · see citing works
Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility
Scarel‐Caminaga, R. M., Kim, Y. J., Viana, A. C., Curtis, K. M. C., Corbi, S. C. T., Sogumo, P. M., Orrico, S. R. P., & Cirelli, J. A. (2010) · Biochemical Genetics · doi:10.1007/s10528-010-9407-3 · Cited by 48 · see citing works
Glucocorticoids inhibit IL-4 and mitogen-induced IL-4Rα chain expression by different posttranscriptional mechanisms☆☆☆★★★♢
Mozo, L., Gayo, A., Suárez, A., Rivas, D., Zamorano, J., & Gutiérrez, C. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70335-5 · Cited by 47 · see citing works
Increased susceptibility for aspergillosis and post‐transplant immune deficiency in patients with gene variants of TLR 4 after stem cell transplantation
Koldehoff, M., Beelen, D. W., & Elmaagacli, A. H. (2013) · Transplant Infectious Disease · doi:10.1111/tid.12115 · Cited by 45 · see citing works
Immunity toAspergillus fumigatus: the basis for immunotherapy and vaccination
Bellocchio, S., Bozza, S., Montagnoli, C., Perruccio, K., Gaziano, R., Pitzurra, L., & Romani, L. R. (2005) · Medical Mycology · doi:10.1080/14789940500051417 · Cited by 45 · see citing works
Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina
Morris, G. A. J., Edwards, D. R. V., Hill, P. C., Wejse, C. M., Bisseyé, C., Olesen, R., Edwards, T. L., Gilbert, J. R., Myers, J. L., Stryjewski, M. E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016656 · Cited by 44 · see citing works
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation
Grube, M., Loeffler, J., Mezger, M., Krüger, B., Echtenacher, B., Hoffmann, P., Edinger, M., Einsele, H., Andreesen, R., & Holler, E. (2013) · Medical Mycology · doi:10.3109/13693786.2013.809630 · Cited by 44 · see citing works
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Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil
Figueiredo, C. A., Barreto, M. L., Alcântara‐Neves, N. M., Rodrigues, L. C., Cooper, P. J., Cruz, Á. A., Pontes-de-Carvalho, L. C., Lemaire, D. C., Costa, R. D. S., Amorim, L. D. A. F., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.10.043 · Cited by 43 · see citing works
Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population
Gómez, L. M., Sánchez, E., Ruiz-Narváez, E., López‐Nevot, M. Á., Anaya, J., & Martin, J. J. (2007) · Tissue Antigens · doi:10.1111/j.1399-0039.2007.00843.x · Cited by 37 · see citing works
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Functional Polymorphisms of Interferon-gamma Affect Pneumonia-Induced Sepsis
Wang, D., Zhong, X., Huang, D., Chen, R., Bai, G., Li, Q., Yu, B., Fan, Y., & Sun, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087049 · Cited by 35 · see citing works
The 3′UTR 1188 A/C polymorphism in the interleukin-12p40 gene (IL-12B) is associated with lepromatous leprosy in the west of Mexico
Alvarado‐Navarro, A., Montoya‐Buelna, M., Muñóz-Valle, J. F., López-Roa, R. I., Guillen-Vargas, C. M., & Fafutis‐Morris, M. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.03.015 · Cited by 34 · see citing works
Pattern recognition receptors and their role in invasive aspergillosis
Gresnigt, M. S., Netea, M. G., & van de Veerdonk, F. L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06759.x · Cited by 33 · see citing works
Analysis of Interleukin-8 Gene Variants Reveals Their Relative Importance as Genetic Susceptibility Factors for Chronic Periodontitis in the Han Population
Zhang, N., Xu, Y., Zhang, B., Zhang, T., Yang, H., Zhang, B., Feng, Z., & Zhong, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104436 · Cited by 29 · see citing works
Genetic Polymorphisms and Susceptibility to Parenchymal Renal Infection Among Pediatric Patients
Cheng, C., Lee, Y.-S., Tsau, Y., & Lin, T. (2010) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3181ff84ff · Cited by 29 · see citing works
Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population
Sadki, K., Lamsyah, H., Rueda‐Medina, B., Akil, E., Sadak, A., Martin, J. J., & Aouad, R. E. (2010) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/s1673-8527(09)60044-8 · Cited by 28 · see citing works
An IL-8 gene promoter polymorphism is associated with the risk of the development of AIDS-related Kaposi's sarcoma
van der Kuyl, A. C., Polstra, A. M., Weverling, G. J., Zorgdrager, F., van den Burg, R., & Cornelissen, M. T. E. (2004) · AIDS · doi:10.1097/00002030-200405210-00016 · Cited by 27 · see citing works
Interleukin‐4 receptor polymorphisms in asthma and allergy: relation to different disease phenotypes
Hesselmar, B., Bergin, A., Park, H., Hahn‐Zoric, M., Eriksson, B., La, H., & Padyukov, L. (2010) · Acta Paediatrica · doi:10.1111/j.1651-2227.2009.01631.x · Cited by 26 · see citing works
Macrophage inflammatory protein-3 beta enhances IL-10 production by activated human peripheral blood monocytes and T cells.
Byrnes, H. D., Kaminski, H. J., Mirza, A., Deno, G., Lundell, D. J., & Fine, J. S. (1999) · PubMed · Cited by 20 · see citing works
Polymorphisms in cytokine genes IL6, TNF, IL10, IL17A and IFNG influence susceptibility to complicated skin and skin structure infections
Stappers, M. H. T., Thys, Y., Oosting, M., Plantinga, T. S., Ioana, M. I., Reimnitz, P., Mouton, J. W., Netea, M. G., Joosten, L., & Gyssens, I. C. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2201-0 · Cited by 20 · see citing works
Macrophage Inflammatory Protein-3β Enhances IL-10 Production by Activated Human Peripheral Blood Monocytes and T Cells
Byrnes, H. D., Kaminski, H., Mirza, A., Deno, G., Lundell, D. J., & Fine, J. S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.9.4715 · Cited by 18 · see citing works
Single nucleotide polymorphisms in CXCR1 gene and its association with hepatitis B infected patients in Saudi Arabia
Almajhdi, F. N., Al‐Ahdal, M. N., Abdo, A. A., Sanai, F. M., Al‐Anazi, M. R., Khalaf, N. Z., Viswan, N. A., Al-Ashgar, H. I., Al-Kahtani, K., Alhumaidan, H., et al. (2013) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31360-2 · Cited by 11 · see citing works

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European guidelines for primary antifungal prophylaxis in adult haematology patients: summary of the updated recommendations from the European Conference on Infections in Leukaemia
Maertens, J. A., Girmenia, C., Brüggemann, R. J. M., Duarte, R. F., Kibbler, C. C., Ljungman, P. T., Ráčil, Z., Ribaud, P., Slavin, M. A., Cornely, O. A., et al. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky286 · Cited by 355 · see citing works
Pathogenicity and virulence of Aspergillus fumigatus
Earle, K., Valero, C., Conn, D. P., Vere, G., Cook, P. C., Bromley, M., Bowyer, P., & Gago, S. (2023) · Virulence · doi:10.1080/21505594.2023.2172264 · Cited by 117 · see citing works
Race and ethnicity: Risk factors for fungal infections?
Jenks, J. D., Aneke, C. I., Al-Obaidi, M. M., Egger, M., Garcia, L., Gaines, T., Hoenigl, M., & Thompson, G. R. (2023) · PLOS Pathogens · doi:10.1371/journal.ppat.1011025 · Cited by 55 · see citing works
Aspergillus fumigatus biology, immunopathogenicity and drug resistance
van de Veerdonk, F. L., Carvalho, A., Wauters, J., Chamilos, G., & Verweij, P. E. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-025-01180-z · Cited by 58 · see citing works
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Recent Advances in Fungal Infections: From Lung Ecology to Therapeutic Strategies With a Focus on Aspergillus spp.
Palmieri, F., Koutsokera, A., Bernasconi, E., Junier, P., von Garnier, C., & Ubags, N. D. J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.832510 · Cited by 50 · see citing works
Characteristics of Sinus Fungus Ball: A Unique Form of Rhinosinusitis
Jiang, R., Huang, W., & Liang, K. (2018) · Clinical Medicine Insights Ear Nose and Throat · doi:10.1177/1179550618792254 · Cited by 39 · see citing works
Recent developments in Aspergillus fumigatus research: diversity, drugs, and disease
Kordana, N. E., Johnson, A., Quinn, K., Obar, J. J., & Cramer, R. A. (2025) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00011-23 · Cited by 27 · see citing works
Innate Lung Defense during Invasive Aspergillosis: New Mechanisms
Garth, J. M., & Steele, C. H. (2017) · Journal of Innate Immunity · doi:10.1159/000455125 · Cited by 28 · see citing works
Defective antifungal immunity in patients with COVID-19
Morton, C. O., Griffiths, J. S., Loeffler, J., Orr, S. J., & White, P. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1080822 · Cited by 27 · see citing works
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Genetic defects in fungal recognition and susceptibility to invasive pulmonary aspergillosis
Cunha, C., & Carvalho, A. (2018) · Medical Mycology · doi:10.1093/mmy/myy057 · Cited by 23 · see citing works
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Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium
Sánchez‐Maldonado, J. M., Moñiz-Díez, A., ter Horst, R., Campa, D., Cabrera-Serrano, A. J., Martínez‐Bueno, M., Garrido-Collado, M. D. P., Hernández‐Mohedo, F., Fernández‐Puerta, L., López‐Nevot, M. Á., et al. (2020) · Journal of Fungi · doi:10.3390/jof7010004 · Cited by 22 · see citing works
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Germline Genetic Variants of Viral Entry and Innate Immunity May Influence Susceptibility to SARS-CoV-2 Infection: Toward a Polygenic Risk Score for Risk Stratification
Grolmusz, V. K., Bozsik, A., Papp, J., & Patócs, A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.653489 · Cited by 19 · see citing works
Integrating genetic and immune factors to uncover pathogenetic mechanisms of viral-associated pulmonary aspergillosis
Gonçalves, S. M., Pereira, I. M., Feys, S., Cunha, C., Chamilos, G., Hoenigl, M., Wauters, J., van de Veerdonk, F. L., & Carvalho, A. (2024) · mBio · doi:10.1128/mbio.01982-23 · Cited by 17 · see citing works
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Risk stratification and immunogenetic risk for infections following stem cell transplantation
Wójtowicz, A., & Bochud, P. (2016) · Virulence · doi:10.1080/21505594.2016.1234566 · Cited by 17 · see citing works
Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis
Lupiañez, C. B., Villaescusa, M. T. L., Carvalho, A., Springer, J., Lackner, M., Sánchez‐Maldonado, J. M., Canet, L. M., Cunha, C., Segura-Catena, J., Alcázar‐Fuoli, L., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01243 · Cited by 15 · see citing works
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New advances in invasive aspergillosis immunobiology leading the way towards personalized therapeutic approaches
Obar, J. J., Hohl, T. M., & Cramer, R. A. (2016) · Cytokine · doi:10.1016/j.cyto.2016.05.015 · Cited by 15 · see citing works
NLRP3, NLRC4 and NLRC5 Gene Polymorphisms Associate with Susceptibility of Pulmonary Aspergillosis in Non-Neutropenic Patients
Zhong, J., Liu, L., Lu, Y., Gu, Y., Zhao, J., Chen, B., Zhou, W., & Su, X. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11071870 · Cited by 14 · see citing works
Association between single nucleotide polymorphisms (SNPs) of IL1, IL12, IL28 and TLR4 and symptoms of congenital cytomegalovirus infection
Jedlińska-Pijanowska, D., Kasztelewicz, B., Czech‐Kowalska, J., Jaworski, M., Charusta-Sienkiewicz, K., & Dobrzańska, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233096 · Cited by 12 · see citing works
Prediction of leprosy in the Chinese population based on a weighted genetic risk score
Wang, N., Wang, Z., Wang, C., Fu, X., Yu, G., Yue, Z., Liu, T., Zhang, H., Li, L., Chen, M., et al. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006789 · Cited by 12 · see citing works
Polymorphisms within the ARNT2 and CX3CR1 Genes Are Associated with the Risk of Developing Invasive Aspergillosis
Lupiañez, C. B., Martínez‐Bueno, M., Sánchez‐Maldonado, J. M., Badiola, J., Cunha, C., Springer, J., Lackner, M., Segura-Catena, J., Canet, L. M., Alcázar‐Fuoli, L., et al. (2020) · Infection and Immunity · doi:10.1128/iai.00882-19 · Cited by 12 · see citing works
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The Use of Host Biomarkers for the Management of Invasive Fungal Disease
Griffiths, J. S., Orr, S. J., Morton, C. O., Loeffler, J., & White, P. L. (2022) · Journal of Fungi · doi:10.3390/jof8121307 · Cited by 11 · see citing works
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The Relationship between Pneumocystis Infection in Animal and Human Hosts, and Climatological and Environmental Air Pollution Factors: A Systematic Review
Miller, R. F., Huang, L., & Walzer, P. D. (2018) · OBM Genetics · doi:10.21926/obm.genet.1804045 · Cited by 11 · see citing works
Antifungal prophylaxis during 7 + 3 induction chemotherapy for acute myeloid leukemia is associated with improved survival, in a setting with low incidence of invasive mold infections
Hsu, A., Matera, R. M., Vieira, K., Reagan, J. L., & Farmakiotis, D. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05535-5 · Cited by 8 · see citing works
What Is Different in Acute Hematologic Malignancy-Associated ARDS? An Overview of the Literature
Cotorogea-Simion, M., Pavel, B., Isac, S., Telecan, T., Matache, I., Bobirca, A. V., BOBIRCA, F. T., Rababoc, R., & Droc, G. (2022) · Medicina · doi:10.3390/medicina58091215 · Cited by 8 · see citing works
Associations between Single Nucleotide Polymorphisms from the Genes of Chemokines and the CXCR2 Chemokine Receptor and an Increased Risk of Endometrial Cancer
Wujcicka, W. I., Zając, A. E., Szyłło, K., Romanowicz, H., Smolarz, B., & Stachowiak, G. (2023) · Cancers · doi:10.3390/cancers15225416 · Cited by 7 · see citing works
Incorporating the Detection of Single Nucleotide Polymorphisms Associated With Invasive Aspergillosis Into the Clinic
White, P. L., & Price, J. S. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.860779 · Cited by 7 · see citing works
Genetic Risk Surveillance for Invasive Aspergillosis in Hematology Patients: A Prospective Observational Study
Tanpaibule, T., Jinawath, N., Taweewongsounton, A., Niparuck, P., & Rotjanapan, P. (2020) · Infectious Diseases and Therapy · doi:10.1007/s40121-020-00331-4 · Cited by 6 · see citing works
Understanding the genetic basis of immune responses to fungal infection
Gonçalves, S. M., Cunha, C., & Carvalho, A. (2022) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2022.2063839 · Cited by 6 · see citing works
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Challenges and Opportunities in Understanding Genetics of Fungal Diseases: Towards a Functional Genomics Approach
Bruno, M., Matzaraki, V., van de Veerdonk, F. L., Kumar, V., & Netea, M. G. (2021) · Infection and Immunity · doi:10.1128/iai.00005-21 · Cited by 6 · see citing works
Cytokine response as a biomarker for early diagnosis and outcome prediction of stem cell transplant recipients and acute leukemia patients with invasive aspergillosis
Puerta‐Alcalde, P., Ruíz-Camps, I., Gudiol, C., Salavert, M., Barba, P., Morandeira, F., Jarque, I., Cuervo, G., Ayats, J., Carratalà, J., et al. (2022) · Medical Mycology · doi:10.1093/mmy/myac038 · Cited by 5 · see citing works
Host immune genetic variations influence the risk of developing acute myeloid leukaemia: results from the NuCLEAR consortium
Sánchez‐Maldonado, J. M., Campa, D., Springer, J., Badiola, J., Niazi, Y., Moñiz-Díez, A., Hernández‐Mohedo, F., González-Sierra, P. A., ter Horst, R., Macauda, A., et al. (2020) · Blood Cancer Journal · doi:10.1038/s41408-020-00341-y · Cited by 5 · see citing works
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IL-4 gene polymorphisms and their association with nematodes infection in Pakistani population
Afshan, K., Sarfraz, K., Kayani, T., & Firasat, S. (2022) · African Health Sciences · doi:10.4314/ahs.v22i2.25 · Cited by 5 · see citing works
Immunopathogenesis of Aspergillosis
Singh, S., Kanaujia, R., & Rudramurthy, S. M. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98782 · Cited by 4 · see citing works
Feline Aspergillosis
Barrs, V. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-72093-7_15 · Cited by 2 · see citing works
Editorial: An Omics Perspective on Fungal Infection: Toward Next-Generation Diagnosis and Therapy
Carvalho, A., & Goldman, G. H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00085 · Cited by 2 · see citing works
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A review of prophylactic regimens to prevent invasive fungal infections in hematology patients undergoing chemotherapy or stem cell transplantation
Criscuolo, M., Fracchiolla, N., Farina, F., Verga, L., Pagano, L., & Busca, A. (2023) · Expert Review of Hematology · doi:10.1080/17474086.2023.2290639 · Cited by 1 · see citing works
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Genetic Determinants of Host Susceptibility to Fungal Diseases in Solid Organ Transplantation and Hematological Patients
Wójtowicz, A., Lamoth, F., & Bochud, P. (2017) · Springer eBooks · doi:10.1007/978-3-319-50842-9_6 · Cited by 1 · see citing works
Antifungals in pulmonary infections: to whom, when and how?
Ott, S. R. (2017) · European Respiratory Society eBooks · doi:10.1183/2312508x.10005316 · Cited by 1 · see citing works
Genetic Regulation of the Host-Fungus Interaction in the Pathogenesis of Aspergillosis
Antunes, D., Cunha, C., & Carvalho, A. (2019) · Current Fungal Infection Reports · doi:10.1007/s12281-019-00344-8
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Aspergilose pulmonar crônica: características clínicas, diagnóstico, tratamento e desafios
de Oliveira, V. F. (2024) · doi:10.11606/t.5.2024.tde-03122024-151328
Chronic Pulmonary Aspergillosis: Genomic Variant Analysis and Protein Dysfunction Susceptibility in a Brazilian Cohort
Mendes, R. D. S., Wolff, B. M., Costa, M. R., Oliveira, Y. G., Carvalho, G. F. D. S., Vieira, L. L., Moura, E. A., Nascimento, K. M., Rolim, L. D. S., Costa, A. N., et al. (2025) · Genes · doi:10.3390/genes16060676
The Elucidation of Hydrogen Sulfide Signalling Through Persulfidation
Kouroussis, E. (2019) · theses.fr (ABES) · doi:10.70675/7d7beb54z2f84z43cdz8a1fz2342abbe3731

Common Genetic Polymorphisms within NF kappa B-Related Genes and the Risk of Developing Invasive Aspergillosis
Lupiañez, C. B., Villaescusa, M. T., Carvalho, A., Springer, J., Lackner, M., Sánchez-Maldonado, J. M., Canet, L., Cunha, C., Segura-Catena, J., Alcázar‐Fuoli, L., et al. (2016) · Online Publication Service of Würzburg University (Würzburg University) · Cited by 1 · see citing works
Self-citation
Common Genetic Polymorphisms within NFκB-Related Genes and the Risk of Developing Invasive Aspergillosis
Lupiañez, C. B., Villaescusa, M. T. L., Carvalho, A., Springer, J., Lackner, M., Sánchez‐Maldonado, J. M., Canet, L. M., Cunha, C., Segura-Catena, J., Alcázar‐Fuoli, L., et al. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01243 · Cited by 15 · see citing works
Self-citation
Polymorphisms within the TNFSF4 and MAPKAPK2 Loci Influence the Risk of Developing Invasive Aspergillosis: A Two-Stage Case Control Study in the Context of the aspBIOmics Consortium
Sánchez‐Maldonado, J. M., Moñiz-Díez, A., ter Horst, R., Campa, D., Cabrera-Serrano, A. J., Martínez‐Bueno, M., Garrido-Collado, M. D. P., Hernández‐Mohedo, F., Fernández‐Puerta, L., López‐Nevot, M. Á., et al. (2020) · Journal of Fungi · doi:10.3390/jof7010004 · Cited by 22 · see citing works
Self-citation
Genetic Risk Surveillance for Invasive Aspergillosis in Hematologic Patients
Tanpaibule, T., Jinawath, N., Pakakasama, S., Niparuck, P., Techasaensiri, C., & Rotjanapan, P. (2016) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofw172.1755
Plasminogen alleles influence susceptibility to invasive aspergillosis. PLoS Genet 4: e1000101
Zaas, A. K., Liao, G., Chien, J. W., Weinberg, C., Shore, D., Giles, S. S., & Schwartz, D. A. (2008)

Authors: Lupiañez, C. B., Canet, L. M., Carvalho, A., Alcazar-Fuoli, L., Springer, J., Lackner, M., Segura-Catena, J., Comino, A., Olmedo, C., Ríos, R., Fernández-Montoya, A., Cuenca-Estrella, M., Solano, C., López-Nevot, M. Á., Cunha, C., Oliveira-Coelho, A., Villaescusa, T., Fianchi, L., Aguado, J. M., Pagano, L., López-Fernández, E., Potenza, L., Luppi, M., Lass-Flörl, C., Loeffler, J., Einsele, H., Vazquez, L., the PCRAGA Study Group, Jurado, M., & Sainz, J.
Affiliations: Universidad de Granada (ES)
University of Minho (PT)
Mycology Reference Laboratory, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain
Universitätsklinikum Würzburg (DE)
Innsbruck Medical University (AT)
Hospital Universitario Virgen de las Nieves (ES)
Blood Transfusion Regional Centre and Sectorial Tissue Bank, Granada, Spain
Hospital Clínico Universitario de Valencia (ES)
Immunology Department, Virgen de las Nieves University Hospital, Granada, Spain
Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal
Complejo Hospitalario de Salamanca (ES)
Università Cattolica del Sacro Cuore (IT)
Research Institute Hospital 12 de Octubre (ES)
Hematology Department, Virgen de las Nieves University Hospital, Granada, Spain
University of Modena and Reggio Emilia (IT)
Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Hematology Department, University Hospital of Salamanca, Salamanca, Spain
Genomic Oncology Department, GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain
ORCID: Lupiañez, C. B.
Carvalho, A.
Springer, J.
Lackner, M.
Segura-Catena, J.
Solano, C.
Cunha, C.
Fianchi, L.
Pagano, L.
Potenza, L.
Luppi, M.
Loeffler, J.
Einsele, H.
Jurado, M.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 2016-03
Volume: 84
Issue: 3
Pages: 643-657
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.01359-15
PMC: PMC4771352
OpenAlex: W2219758163
Cited by: 42
References: 96
Citations by year: 2025: 3 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 3
FWCI: 3.37
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion, cc-by)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by-nc-nd)
Funders: ERA-NET Pathogenomics (PIM2010EPA-00756)
Fondo de Investigaciones Sanitarias (PI12/02688)
The Collaborative Research Center/Transregio 124 FungiNet
Fundação para a Cincia e Tecnologia, Portugal, (SFRH/BPD/96176/2013)
Astellas Pharma
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: invasive aspergillosis, single nucleotide polymorphisms, interleukin-4 receptor, interleukin-8, IL12B, interferon-gamma, genetic susceptibility, immunocompromised patients, allogeneic hematopoietic stem cell transplantation, cancer-related infections, risk prediction, immunosuppression
MeSH terms: Adult, Aged, Alleles, Aspergillosis, Female, Genotype, Humans, Interferon-gamma, Male, Middle Aged, Case-Control Studies, Interleukin-8, Immunocompromised Host, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Interleukin-4 Receptor alpha Subunit, Interleukin-12 Subunit p40

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Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium

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