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In vitro activity of olorofim (F901318) against fungi of the genus, Scedosporium and Rasamsonia as well as against Lomentospora prolificans, Exophiala dermatitidis and azole-resistant Aspergillus fumigatus
Abstract
In recent decades, invasive infections caused by fungal pathogens have been reported with increasing frequency. Concurrently, the rates of detected resistance mechanisms against commonly used antifungal agents in fungi are increasing. The need for novel antifungal drugs is thus imminent. In this study, the novel drug olorofim (F901318) was tested for its antifungal activity against the human fungal pathogens Lomentospora prolificans (n = 20), Scedosporium aurantiacum (n = 2), Scedosporium apiospermum (n = 6), Rasamsonia argillacea species complex (n = 23), Exophiala dermatitidis (n = 10) and azole-resistant Aspergillus fumigatus (ARAF) (n = 25) in an in vitro broth microdilution assay according to European Committee on Antimicrobial Susceptibility Testing (EUCAST) recommendations. Whilst olorofim was ascertained to be effective against R. argillacea species complex [minimum inhibitory concentrations (MICs) of ≤0.008 mg/L], Scedosporium spp. (MICs of 0.032-0.5 mg/L), L. prolificans (MICs of 0.032-0.5 mg/L) and ARAF (MICs of ≤0.008-0.032 mg/L), the drug had an MIC of >4 mg/L against E. dermatitidis. These data demonstrate the antifungal activity of olorofim against a broad range of filamentous fungal pathogens.
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Fosmanogepix and olorofim are active against the multidrug-resistant, pan-resistant mold genera Lomentospora and Scedosporium.
“Fosmanogepix and olorofim also possess activity against notoriously MDR pan-resistant mold genera, Lomentospora and Scedosporium.”
From Investigational Agents for the Treatment of Resistant Yeasts and Molds (2021) · cites this paper as [66]
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Research works printed but not linked: 1
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Metadata
- Authors
- Kirchhoff, L., Dittmer, S., Buer, J., Rath, P.-M., & Steinmann, J.
- Affiliations
- Essen University Hospital (DE)
- Nuremberg Hospital (DE)
- Corresponding author
- Steinmann, Joerg
- Venue
- International Journal of Antimicrobial Agents
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 56
- Issue
- 3
- Pages
- 106105
- ISSN
- 0924-8579 (ISSN-L)
- OpenAlex
- W3044548032
- Cited by
- 61
- References
- 24
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 12 · 2020: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Antimicrobial Agents (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- olorofim, antifungal activity, Scedosporium, Lomentospora prolificans, Exophiala dermatitidis, invasive fungal infections, filamentous fungi, minimum inhibitory concentration, antifungal resistance
- MeSH terms
- Acetamides, Antifungal Agents, Aspergillus fumigatus, Exophiala, Humans, Microbial Sensitivity Tests, Mycoses, Piperazines, Pyrimidines, Pyrroles, Scedosporium, Eurotiales
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