The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Effect of the Novel Antifungal Drug F901318 (Olorofim) on Growth and Viability of Aspergillus fumigatus
Open accessAbstract
F901318 (olorofim) is a novel antifungal drug that is highly active against Aspergillus species. Belonging to a new class of antifungals called the orotomides, F901318 targets dihydroorotate dehydrogenase (DHODH) in the de novo pyrimidine biosynthesis pathway.
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F90138 is inactive against yeasts and Mucorales.
“However, F90138 is inactive against yeasts and Mucorales (41).”
From Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review (2023) · cites this paper as [41]
Citations
Cites
Ene, I. V., Adya, A. K., Wehmeier, S., Brand, A. C., MacCallum, D. M., Gow, N. A. R., & Brown, A. J. P. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01813.x · Cited by 313
Self-citationBowman, J. C., Hicks, P. S., Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., & Douglas, C. M. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.9.3001-3012.2002 · Cited by 303
Transcriptomic analysis of the exit from dormancy of Aspergillus fumigatus conidia
Lamarre, C., Sokol, S., Debeaupuis, J.-P., Henry, C., Lacroix, C., Glaser, P., Coppée, J.-Y., François, J.-M., & Latgé, J.-P. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-417 · Cited by 148
Moreno-Velásquez, S. D., Seidel, C., Juvvadi, P. R., Steinbach, W. J., & Read, N. D. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00710-17 · Cited by 57
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Cited by
Sorted by citations
The Future of Antifungal Drug Therapy: Novel Compounds and Targets
Mota Fernandes, C., Dasilva, D., Haranahalli, K., McCarthy, J. B., Mallamo, J., Ojima, I., & Del Poeta, M. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01719-20 · Cited by 124
Kirchhoff, L., Dittmer, S., Buer, J., Rath, P.-M., & Steinmann, J. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.106105 · Cited by 61
Recent Progress in Research on Mitochondrion-Targeted Antifungal Drugs: a Review
Qin, Y., Wang, J., Lv, Q., & Han, B. (2023) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00003-23 · Cited by 38
Antifungals in Clinical Use and the Pipeline
Johnson, M. D. (2021) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2021.03.005 · Cited by 35
Lv, Q., Yan, L., Wang, J., Feng, J., Gao, L., Qiu, L., Chao, W., Qin, Y.-L., & Jiang, Y. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03209-22 · Cited by 12
“The compound F901318, which targets mitochondrial dihydrolactate dehydrogenase, is also in phase II clinical research and is effective against Aspergillus infections (13).”
Background
Metadata
- Authors
- du Pré, S., Beckmann, N., Almeida, M. C., Sibley, G. E. M., Law, D., Brand, A. C., Birch, M., Read, N. D., & Oliver, J. D.
- Affiliations
- University of Manchester (GB)
- F2G (United Kingdom) (GB)
- University of Aberdeen (GB)
- ORCID
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2018-08
- Volume
- 62
- Issue
- 8
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC6105813
- OpenAlex
- W2805839259
- Cited by
- 111
- References
- 4
- Citations by year
- 2026: 10 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 16 · 2021: 21 · 2020: 16 · 2019: 13 · 2018: 2
- FWCI
- 10.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- Research Explorer (The University of Manchester) (submittedVersion)
- Funders
- EC | FP7 | FP7 People: Marie-Curie Actions (PITN-GA-2013-607963)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Keywords
- olorofim, Aspergillus fumigatus, antifungal agents, dihydroorotate dehydrogenase, de novo pyrimidine biosynthesis, fungal growth inhibition, fungal viability
- MeSH terms
- Acetamides, Antifungal Agents, Aspergillus fumigatus, Culture Media, Microbial Sensitivity Tests, Piperazines, Pyrimidines, Pyrroles, Spores, Fungal, Hyphae, Microscopy, Electron, Transmission
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