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Preparation and characterization of polymeric nanoparticles surface modified with chitosan for target treatment of colorectal cancer

Badran, Mohamed M., Mady, Mohsen M., Ghannam, Magdy M., Shakeel, Faiyaz·2017·International Journal of Biological Macromolecules
DOI 10.1016/j.ijbiomac.2016.11.098
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Abstract

5-Fluorouracil (5-FU) loaded chitosan (C) coated polylactic-co-glycolic acid (PLGA) nanoparticles [NPs] (C-5-FU PLGA NPs) and polycaprolactone [PCL] (C-5-FU PCL NPs) were employed as the carriers for cancer treatment. The prepared NPs showed the spherical shape of NPs with the particle size in the range of 188.1-302.2nm with polydispersity index (PDI) of <0.30. C-coated NPs converted zeta potential from negative to positive value with small modification in particle size distribution. The entrapment efficiency of 5-FU was recorded in the range of 32-51%. The in vitro release studies showed an initial rapid 5-FU release followed by a sustained release profile. The in vitro cytotoxicity of C-5-FU PLGA NPs showed significant inhibition of colon cancer cells (HT-29) compared to the other NPs and drug solution. These results showed that C-5-FU PLGA NPs can be considered as a promising carrier for cancer therapy.

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Metadata

Authors
Badran, M. M., Mady, M. M., Ghannam, M. M., & Shakeel, F.
Venue
International Journal of Biological Macromolecules
Publisher
Elsevier BV
Published
2017-02
Volume
95
Pages
643-649
ISSN
0141-8130
DOI
10.1016/j.ijbiomac.2016.11.098
Cited by
85
References
2
Language
en
Licence
Funders
  • National Plan for Science, Technology and Innovation
  • King Abdulaziz City for Science and Technology (11-NAN1461-02)

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