Preparation, characterization, and performance analysis of starch-based nanomicelles
Abstract
A novel amphiphilic starch-based polymer carrier (R-St-PEG; R = hexadecyl, St = starch, PEG = polyethylene glycol) was prepared using tapioca starch. It was then applied as an effective carrier for encapsulated drug, and used for sustained drug release. First, tapioca starch was made to react with hexadecane bromide (R 16) for hydrophobic modification, and then the hydrophobically-modified tapioca starch molecules were grafted onto hydrophilic carboxyl-terminated PEG (mPEG-COOH). The drug-loading capacity and drug release behavior of R-St-PEG were systematically evaluated using curcumin as drug. The results show that the polymer has good drug-loading capacity and sustained-release properties, and it can act as an effective drug carrier. Thus, this study provides a suitable platform for preparing stable amphiphilic polymer carriers and broadens the application range of tapioca starch.
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The release of curcumin from R-St-mPEG nanomicelles is slow, stable, and pH-responsive.
“The bioimaging release study demonstrates that the release of curcumin from the nanomicelles is a slow, stable, and pH-responsive.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [168]
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Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“[168] established a novel amphiphilic starch-based polymer (RSt-mPEG), with good self-assembly property into spherical micelles (~200 nm, CMC ~0.”
Background
- Authors
- Kou, Z., Dou, D., Lan, L., Zhang, J., Lan, P., Yu, Q., & Zhang, Y.
- Affiliations
- Guangxi Minzu University (CN)
- Corresponding author
- Lan, Ping
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2020-02
- Volume
- 145
- Pages
- 655-662
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2998560949
- Cited by
- 29
- References
- 38
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 2
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Guangxi Biological Polysaccharide Separation, Purification and Modification Research Platform (GKZY18076005)
- Guangxi University for Nationalities (gxun-chxzs2018049)
- Guangxi University Students Innovation and Entrepreneurship Training Program (20190608180, 20190608179)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- cassava starch, poly(ethylene glycol) grafting, hydrophobic modification, sustained drug release, curcumin encapsulation, drug loading capacity, drug delivery
- MeSH terms
- Drug Carriers, Kinetics, Micelles, Magnetic Resonance Spectroscopy, Polyethylene Glycols, Polymers, Starch, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, Nanoparticles, Chemical Phenomena, Hydrophobic and Hydrophilic Interactions, Drug Liberation
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