Synthesis of micelles based on chitosan functionalized with gold nanorods as a light sensitive drug delivery vehicle
Abstract
This study aims to design photo-triggered micelles by using a natural base polymer. Chitosan was functionalized with thiourea, and in the next step, it was modified by grafting poly(l-lactide), poly(N-isopropylacrylamide), and poly(acrylamide) in determined ratio to form thermo-sensitive micelles. The sulfur content of chitosan@thiourea was measured about 2%. Grafting of polymers on chitosan was characterized by FT-IR and NMR techniques. The critical micellar concentration was measured by using photo luminescence spectroscopy. The size and surface morphology experiments revealed that average size of micelles is about 14 nm, and the length and width of GNRs are about 65 and 19 nm, respectively. The percent of conjugated GNRs to the micelles was about 11%. The conjugation of gold nanorods onto micelles, through gold-thiolate complex formation, induces photo sensitivity to the nano-vehicle. The exposure of NIR light creates local heat by GNRs, shrinkage of thermal-sensitive moiety of micelles, and drug release, simultaneously. Drug release studies demonstrated that at a determined time, paclitaxel was released 38% after exposure to NIR light compared to 15 and 35% in 37 and 45 °C, respectively. The cytotoxicity tests of Paclitaxel loaded micelles were carried out by MTT assay against MCF7 cells.
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Pourjavadi et al. developed amphiphilic micelles based on the chemical modification of chitosan biopolymer through conjugation with poly(acrylamide) and poly(N-isopropyl acrylamide).
“Pourjavadi et al. [187] developed amphiphilic micelles based on the chemical modification of chitosan biopolymer through conjugation with poly(acrylamide) and poly(N-isopropyl acrylamide).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [187]
The photoresponsiveness features of the prepared micelles were achieved through complexation with gold nanorods.
“The photoresponsiveness futures of the prepared micelles were achieved through complexation with the gold nanorods.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [187]
The drug release experiments displayed that about 38% of paclitaxel drug was released under NIR light irradiation.
“The drug release experiments displayed that about 38% of paclitaxel drug was released under NIR light irradiation (Figure 11).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [187]
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- Authors
- Pourjavadi, A., Bagherifard, M., & Doroudian, M.
- Affiliations
- Sharif University of Technology (IR)
- Corresponding author
- Pourjavadi, Ali
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 149
- Pages
- 809-818
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W2999694329
- Cited by
- 51
- References
- 71
- Citations by year
- 2026: 2 · 2025: 9 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 9 · 2020: 9
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- chitosan micelles, gold nanorods, near-infrared photothermal therapy, poly(N-isopropylacrylamide), poly(L-lactic acid), polyacrylamide, paclitaxel, MCF-7 cells, drug carriers
- MeSH terms
- Drug Carriers, Gold, Humans, Light, Micelles, Magnetic Resonance Spectroscopy, Polymers, Temperature, Molecular Structure, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, Nanotubes, Cell Line, Tumor, Chitosan, Chemistry Techniques, Synthetic, Drug Liberation
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