Polymeric micelles: Theranostic co-delivery system for poorly water-soluble drugs and contrast agents
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Interest in theranostic agents has continued to grow because of their promise for simultaneous cancer detection and therapy. A platform-based nanosized combination agent suitable for the enhanced diagnosis and treatment of cancer was prepared using polymeric polyethylene glycol-phosphatidylethanolamine-based micelles loaded with both, poorly soluble chemotherapeutic agent paclitaxel and hydrophobic superparamagnetic iron oxide nanoparticles (SPION), a Magnetic Resonance Imaging contrast agent. The co-loaded paclitaxel and SPION did not affect each other's functional properties in vitro. In vivo, the resulting paclitaxel-SPION-co-loaded PEG-PE micelles retained their Magnetic Resonance contrast properties and apoptotic activity in breast and melanoma tumor mouse models. Such theranostic systems are likely to play a significant role in the combined diagnosis and therapy that leads to a more personalized and effective form of treatment.
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Polymeric micelles formed by amphiphilic block copolymers have gained attention due to their core/shell structure, excellent stability, and ideal encapsulation and delivery efficiency of hydrophobic drugs.
“Among them, polymeric micelles formed by amphiphilic block copolymers have gained more attention due to their unique properties such as the core/shell structure, excellent stability, and ideal encapsulation and delivery efficiency of hydrophobic drugs.34–37”
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- Authors
- Upponi, J. R., Jerajani, K., Nagesha, D. K., Kulkarni, P., Sridhar, S., Ferris, C., & Torchilin, V. P.
- Affiliations
- Northeastern University (US)
- Corresponding author
- Torchilin, Vladimir P.
- ORCID
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 170
- Pages
- 26-36
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC5918157
- OpenAlex
- W2794954838
- Cited by
- 105
- References
- 52
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 7 · 2023: 13 · 2022: 11 · 2021: 13 · 2020: 25 · 2019: 21 · 2018: 5
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (1RO1CA121838, 1U54CA151881)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- polymeric micelles, theranostics, co-delivery, paclitaxel, superparamagnetic iron oxide nanoparticles, MRI contrast agents, poorly water-soluble drugs, cancer diagnosis and treatment, breast cancer, melanoma, apoptosis
- MeSH terms
- Theranostic Nanomedicine, Animals, Contrast Media, Female, Magnetic Resonance Imaging, Male, Mice, Inbred BALB C, Mice, Inbred C57BL, Micelles, Neoplasms, Polymers, Solubility, Water, Drug Delivery Systems, Apoptosis, Paclitaxel, Cell Line, Tumor, Magnetite Nanoparticles
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