Isolation, structural characterization, biological activity, and application of Glycyrrhiza polysaccharides: Systematic review
Abstract
Glycyrrhiza, one of the most widely used Chinese herbal medicines, is a perennial plant with good medicinal value. Polysaccharides as one of the main bioactive components of Glycyrrhiza, mainly composed of arabinose, glucose, galactose, rhamnose, mannose, xylose, and galacturonic acid in different proportions and types of glycosidic bonds. Glycyrrhiza polysaccharides (GP) have many biological activities, such as anti-oxidation, immune regulation, anti-tumor, apoptosis, anti-microbial, anti-inflammatory and regulation of intestinal flora. In this paper, relevant articles on the isolations, structural characterizations, and biological activities of GP published in the last 15 years (2006-2020) were referred to for a systematic review of the species. A total of 947 articles were searched from the database including NCBI, Science Direct, Web of Science, and How Net, and 109 of them were cited on the summarization of the past scientific researches of the polysaccharides of Glycyrrhiza genus. We hope that this work may provide new insights for further study and development of Glycyrrhiza.
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The water retention ability of Glycyrrhiza polysaccharides was higher than that of glycerol solution, suggesting their potential use as a cosmetic moisturizing additive.
“A preliminary study on the moisture retention of polysaccharides highlighted that their water retention ability was higher than that of glycerol solution, suggesting their potential use as a cosmetic moisturizing additive [6].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [6]
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Cerulli, A., Masullo, M., Montoro, P., & Piacente, S. (2022) · Cosmetics · doi:10.3390/cosmetics9010007 · Cited by 83 · see citing works
Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61 · see citing works
- Authors
- Simayi, Z., Rozi, P., Yang, X., Ababaikeri, G., Maimaitituoheti, W., Bao, X., Ma, S., Askar, G., & Yadikar, N.
- Affiliations
- Xinjiang Agricultural University (CN)
- Corresponding author
- Rozi, Parhat
- Venue
- International Journal of Biological Macromolecules
- Publisher
- Elsevier BV
- Published
- 2021-07
- Volume
- 183
- Pages
- 387-398
- ISSN
- 0141-8130 (ISSN-L)
- OpenAlex
- W3155007861
- Cited by
- 79
- References
- 0
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 19 · 2023: 12 · 2022: 18 · 2021: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Biological Macromolecules (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Keywords
- Glycyrrhiza polysaccharide, Glycyrrhiza, polysaccharide extraction, polysaccharide structural characterization, antioxidant activity, immune regulation, anticancer activity, apoptosis, antimicrobial activity, anti-inflammatory activity, gut microbiota, Chinese herbal medicine, glycosidic linkage
- MeSH terms
- Glycyrrhiza, Polysaccharides
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