Conversion efficacy of intravenous ibutilide compared with intravenous amiodarone in patients with recent-onset atrial fibrillation and atrial flutter
Abstract
Aim The aim of our study was to compare the efficacy and safety of ibutilide and amiodarone (intravenously) in converting recent-onset atrial fibrillation (AF) and atrial flutter (Af) to sinus rhythm (SR).Methods The study was prospective, randomized and included 152 (103 men and 49 women) consecutive patients with AF or Af of 3-48 h duration. Ibutilide is a selective class III antiarrhythmic agent which when administered intravenously can terminate AF and Af. Amiodarone is also a class III antiarrhythmic agent that when given intravenously or orally has proved to be more effective than other agents in terminating AF and Af [B.N. Singh, F.V. Mody, B. Lopez, J.S. Sarma. Antiarrhythmic agents for atrial fibrillation: focus on prolonging atrial repolarization. Am J Cardiol 1999 Nov 4; 84: 161R-173R.]. Seventy-nine patients (56 with AF and 23 with Af) that consisted group A were treated with ibutilide. Seventy-three (52 with AF and 21 with Af) consisted group B and were treated with intravenous infusion of amiodarone.Results The conversion rate of group A (ibutilide) was significantly higher than the conversion rate of group B (amiodarone) (80% vs. 57%, p=0.0054). As regards the kind of arrhythmia separately, for AF there wasn't significant difference (77% vs. 69%, p=ns) whereas for Af ibutilide was superior to amiodarone (87% vs. 29%, p=0.003). The conversion rates of ibutilide didn't differ for AF and Af (77% vs. 87%, p=ns).Conclusions Ibutilide is more effective than amiodarone in converting recent-onset Af to SR whereas both drugs are equally effective in converting recent-onset AF to SR.
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Amiodarone may not be very effective acutely to reestablish sinus rhythm in AFL, but helps control ventricular rate if it is too fast.
“Amiodarone may not be very effective acutely to reestablish sinus rhythm, but it does help control ventricular rate if it is too fast.143,144”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [144]
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- Authors
- Kafkas, N. V., Patsilinakos, S. P., Mertzanos, G. A., Papageorgiou, K. I., Chaveles, J. I., Dagadaki, O. K., & Kelesidis, K. M.
- Affiliations
- KAT General Hospital of Attica (GR)
- Corresponding author
- Kafkas, Nikolaos V.
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2007-06
- Volume
- 118
- Issue
- 3
- Pages
- 321-325
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W1970252226
- Cited by
- 70
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 5
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- ibutilide, amiodarone, atrial fibrillation, atrial flutter, sinus rhythm restoration, class III antiarrhythmic agents, drug safety comparison
- MeSH terms
- Acute Disease, Aged, Aged, 80 and over, Amiodarone, Atrial Fibrillation, Atrial Flutter, Dose-Response Relationship, Drug, Drug Administration Schedule, Electrocardiography, Female, Follow-Up Studies, Humans, Infusions, Intravenous, Male, Middle Aged, Probability, Prospective Studies, Recurrence, Severity of Illness Index, Sulfonamides, Treatment Outcome, Risk Assessment, Statistics, Nonparametric
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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