Exercise training for chronic heart failure (ExTraMATCH II): Protocol for an individual participant data meta-analysis
Abstract
Background Patients with chronic heart failure (HF) experience a marked reduction in their exercise capacity, health-related quality of life, and life expectancy. Despite substantive evidence supporting exercise training in HF, uncertainties remain in the interpretation and understanding of this evidence base. Clinicians and healthcare providers seek definitive estimates of impact on mortality, hospitalisation and health-related quality of life, and which HF patient subgroups are likely to most benefit. The original Exercise Training Meta-Analysis for Chronic Heart Failure (ExTraMATCH) individual participant data (IPD) meta-analysis conducted in 2004 will be updated by the current collaboration (ExTraMATCH II), to investigate the effects of exercise training in HF.Methods Randomised controlled trials have been identified from the updated 2014 Cochrane systematic review and the original ExTraMATCH IPD meta-analysis with exercise training of 3 weeks' duration or more compared with a non-exercise control and a minimum follow-up of 6 months. Particular outcomes of interest are mortality, hospitalisation and health-related quality of life plus key baseline patient demographic and clinical data. Original IPD will be requested from the authors of all eligible trials; we will check original data and compile a master dataset. IPD meta-analyses will be conducted using a one-step approach where the IPD from all studies are modelled simultaneously whilst accounting for the clustering of participants with studies.Discussion The information from ExTraMATCH II will help inform future national and international clinical and policy decision-making on the use of exercise-based interventions in HF and improve the quality, design and reporting of future trials in this field.
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Data harmonization will follow procedures described in Buffart et al.
“For data harmonization, we will apply the procedures described in Buffart et al. [84].”
From Acceptance and commitment therapy for chronic pain: Protocol of a systematic review and individual participant data meta-Analysis (2019) · cites this paper as [84]
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- Authors
- Taylor, R. S., Piepoli, M. F., Smart, N., Coats, A. J. S., Ellis, S., Dalal, H., O'Connor, C. M., Warren, F. C., Whellan, D., & Ciani, O.
- Affiliations
- University of Exeter (GB)
- Guglielmo da Saliceto Hospital (IT)
- University of New England (AU)
- University of Warwick (GB)
- Duke Clinical Research Institute (US)
- Royal Cornwall Hospital Trust (GB)
- ORCID
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 174
- Issue
- 3
- Pages
- 683-687
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W2158041024
- Cited by
- 28
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2021: 1 · 2020: 1 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 7 · 2014: 1
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-08-15)
- Open access
- closed
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- EPubDev Repository (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Archivio istituzionale della Ricerca - Bocconi (submittedVersion)
- RUNE (Research UNE) (submittedVersion)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion)
- CINECA IRIS Institutional Research Information System (Sant'Anna School of Advanced Studies) (submittedVersion)
- Funders
- National Institute for Health and Care Research (RP-DG-0709-10111, RP-PG-1210-12004)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- chronic heart failure, exercise training, mortality, hospitalization, health-related quality of life, exercise capacity, patient subgroups, individual patient data meta-analysis
- MeSH terms
- Chronic Disease, Exercise Therapy, Heart Failure, Humans, Patient Participation, Meta-Analysis as Topic, Exercise, Randomized Controlled Trials as Topic, Databases, Factual
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