The DOI matches its Crossref record; 21 of the 23 references it cites were found in a registry or an index.
Asymptomatic versus symptomatic atrial fibrillation: A systematic review of age/gender differences and cardiovascular outcomes
Open accessAbstract
Up to 40% of atrial fibrillation (AF) patients are asymptomatic. Despite this, scarce data are available about asymptomatic AF, with regard to its clinical profile and relationship to cerebrovascular and cardiovascular risks. Our objective was to conduct a systematic review and meta-analysis was to study the relationship between age and gender with asymptomatic AF and to establish whether patients with asymptomatic AF have a higher risk of death (all-cause and cardiovascular) and stroke/systemic thromboembolism, when compared to symptomatic AF patients. After a comprehensive search, 6 studies (2 randomized clinical trials and 4 observational studies) were entered in the meta-analysis. Despite significant heterogeneity, our data show that the prevalence of females amongst asymptomatic AF group was significantly less compared to the symptomatic AF group (RR, 0.57; 95% CI: 0.52-0.64). No difference in age between asymptomatic and symptomatic AF patients (P=0.72) was seen. No differences were found in all-cause death between patients with asymptomatic and symptomatic AF (RR, 1.38; 95% CI: 0.82-2.17), nor in cardiovascular death (RR, 0.85; 95% CI: 0.53-1.36) or stroke/thromboembolism (RR, 1.72 95% CI: 0.59-5.08). Asymptomatic AF is more associated with male sex, irrespective of age. Both general and cardiovascular death risks as well as thromboembolic risk do not seem to be affected by the asymptomatic clinical status. Symptomatic status should not determine our approach to stroke prevention and other cardiovascular prevention therapies, amongst patients with AF.
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Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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Self-citation2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
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Metadata
- Authors
- Xiong, Q., Proietti, M., Senoo, K., & Lip, G. Y. H.
- Affiliations
- Birmingham City Hospital (GB)
- Corresponding author
- Proietti, Marco
- Venue
- International Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 191
- Pages
- 172-177
- ISSN
- 0167-5273 (ISSN-L)
- OpenAlex
- W1496114842
- Cited by
- 161
- References
- 23
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 15 · 2023: 7 · 2022: 14 · 2021: 28 · 2020: 15 · 2019: 21 · 2018: 7 · 2017: 17 · 2016: 14 · 2015: 4
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- International Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- asymptomatic atrial fibrillation, symptomatic atrial fibrillation, sex differences, age differences, all-cause mortality, cardiovascular mortality, stroke, systemic thromboembolism, stroke prevention, cardiovascular risk
- MeSH terms
- Age Factors, Atrial Fibrillation, Female, Humans, Male, Sex Characteristics, Randomized Controlled Trials as Topic, Treatment Outcome, Asymptomatic Diseases, Observational Studies as Topic
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