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Cited by 5Parkinson's Disease Mechanisms and TreatmentsDeep Brain Stimulation and Movement DisordersSleep and Work-Related Fatigue

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The Relationship Between Fatigue and Other Non-Motor Symptoms in Parkinson's Disease in Chinese Population

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Ding, Jian, Jiang, Si-Ming, Yuan, Yong-Sheng, Tong, Qing, Zhang, Li, Xu, Qin-Rong, Zhang, Ke-Zhong·2017·International Journal of Gerontology
DOI 10.1016/j.ijge.2016.05.011
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Abstract

The aim of our study was to explore in detail the relationship between fatigue and other non-motor symptoms in Parkinson's disease (PD). One hundred and four PD patients took part in our study. The Fatigue Severity Scale (FSS) was used to measure the severity of fatigue and a cut-off of 4 was used to define the presence of fatigue. Patients who scored more than 4 were divided into the “fatigue group” while the other patients were allocated to the “no fatigue group”. The Non-motor Symptoms Scale (NMSS) was used to screen other non-motor symptoms. The Parkinson's disease Sleep Scale (PDSS), Rapid Eye Movement Sleep Behavior Disorders Scale (RBD) and Epworth Sleepiness Scale (ESS) were used to measure different kinds of sleep disorders, and the affective sphere were measured with the Hamilton Anxiety Scale (HAMA) and the Hamilton Depression Scale (HAMD). Patients with fatigue in PD had higher levels in domain 2 (sleep disorders) (p < 0.001) and domain 3 (mood/anxiety) (p < 0.05) of the NMSS. The severity of fatigue was positively associated with excessive daytime sleepiness (rs = 0.254, p = 0.009), anxiety (rs = 0.268, p = 0.006) and depression (rs = 0.264, p = 0.007). Forty patients (42.4%) showed notable complaints of fatigue with FSS scores > 4. Among the patients with fatigue, the severity of fatigue in PD patients was related to sleep and affective disorders. Of the disorders, excessive daytime sleepiness, anxiety and depression were particularly linked to fatigue in PD.

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Metadata

Authors
Ding, J., Jiang, S.-M., Yuan, Y.-S., Tong, Q., Zhang, L., Xu, Q.-R., & Zhang, K.-Z.
Affiliations
Jiangsu Province Hospital (CN)
ORCID
Venue
International Journal of Gerontology
Publisher
Airiti Press, Inc.
Published
2017-09
Volume
11
Issue
3
Pages
171-175
ISSN
  • 1873-958X (ISSN-L)
  • 1873-9598
DOI
10.1016/j.ijge.2016.05.011
OpenAlex
W2749036603
Cited by
5
References
1
Citations by year
2026: 1 · 2025: 1 · 2022: 1 · 2020: 1 · 2018: 1
FWCI
0.38
Type
journal article
Language
en
Open access
Licence
Locations
  • International journal of gerontology (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Natural science foundation of Jiangsu Province (BK20141494)
  • Jiangsu Provincial Personnel Department “the Great of Six Talented Man Peak” Project (2014-WSN-013)
  • University Natural Science Research Project in Jiangsu Province (13KJB32009)
  • Opening Project of Jiangsu Key Laboratory of Neurodegeneration (SJ11KF01)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
  • Science and Technology Project of Jiangsu Bureau of Traditional Chinese Medicine (YB2015163)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
Parkinson's disease, fatigue, non-motor symptoms, excessive daytime sleepiness, sleep disorders, REM sleep behavior disorder, anxiety, depression, mood disorders, Chinese patients

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