Urinary di(2-ethylhexyl)phthalate (DEHP)—Metabolites and male human markers of reproductive function
Abstract
Introduction Phthalates are suspected to act as endocrine modulators in humans and exert reproductive toxicity. The general population is exposed to phthalates through nutrition, consumer products, medications and medical devices. The aim of the present study is to explore whether internal phthalate exposure represented by metabolites of di(2-ethylhexyl) phthalate (DEHP) can be related to human markers of reproductive function (i.e. semen concentration, motility and morphology). Methods We recruited 349 men who were part of subfertile couples and were referred for fertility work-up between April 2004 and November 2005. Semen analysis was performed according to recommendations of the World Health Organization (WHO). Parameters were dichotomized based on 1999 WHO reference values for sperm concentration ( Results DEHP metabolites of n=349 men (age: median=34ys) were analysed. Median concentrations [microg/l] were MEHP (n=337) 4.35, 5OH-MEHP (n=341) 12.66, 5oxo-MEHP (n=341) 9.02, and 5cx- MEPP (n=292) 14.53. Semen parameters of n=349 men were analysed by logistic regression. Semen concentration ( Discussion Metabolites of DEHP and other phthalates analyzed in urine are very specific for determining recent internal phthalate exposure. According to our evaluation human reproductive parameters from semen analyses do not show significant associations with concentrations of DEHP metabolites determined in spot urine sampled at the day of andrological examination.
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High concentrations of DEHP and its metabolites (∑40.6 μg/L) were found in semen from German men.
“High concentrations of DEHP and its metabolites (∑40.6 µg/L) were found in semen from German men [161].”
From A Review of Biomonitoring of Phthalate Exposures (2019) · cites this paper as [161]
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- Authors
- Herr, C., zur Nieden, A., Koch, H. M., Schuppe, H.-C., Fieber, C., Angerer, J., Eikmann, T., & Stilianakis, N. I.
- Affiliations
- Justus-Liebig-Universität Gießen (DE)
- Institute for Prevention and Occupational Medicine (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Venue
- International Journal of Hygiene and Environmental Health
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 212
- Issue
- 6
- Pages
- 648-653
- ISSN
- 1438-4639 (ISSN-L)
- OpenAlex
- W2042886252
- Cited by
- 68
- References
- 30
- Citations by year
- 2025: 6 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 11 · 2012: 5
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Hygiene and Environmental Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
- Keywords
- DEHP, phthalate metabolites, mono(2-ethylhexyl) phthalate, sperm concentration, sperm motility, sperm morphology, male infertility, subfertile couples
- MeSH terms
- Diethylhexyl Phthalate, Environmental Exposure, Environmental Monitoring, Humans, Male, Reproduction, Sperm Motility, Spermatozoa, Semen Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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