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Cited by 91Air Quality and Health ImpactsAntioxidant Activity and Oxidative StressIndoor Air Quality and Microbial Exposure

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Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns

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Ambroz, Antonin, Vlkova, Veronika, Rossner, Pavel, Rossnerova, Andrea, Svecova, Vlasta, Milcova, Alena, Pulkrabova, Jana, Hajslova, Jana, Veleminsky, Milos, Solansky, Ivo, Sram, Radim J.·2016·International Journal of Hygiene and Environmental Health
DOI 10.1016/j.ijheh.2016.05.010
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Abstract

Ambient air particulate matter (PM) represents a class of heterogeneous substances that form one component of air pollution. Oxidative stress has been implicated as an important action mechanism for PM on the human organism. Oxidative damage induced by reactive oxygen species (ROS) may affect any cellular macromolecule. The aim of our study was to investigate the impact of air pollution on oxidative DNA damage [8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG)] and lipid peroxidation [15-F2t-isoprostane (15-F2t-IsoP)] in the urine and blood from mothers and newborns from two localities with different levels of air pollution: Ceske Budejovice (CB), a locality with a clean air, and Karvina, a locality with high air pollution. The samples from normal deliveries (38-41 week+) of nonsmoking mothers and their newborns were collected in the summer and winter seasons. Higher PM2.5 concentrations were found in Karvina than in CB in the summer 2013 (mean±SD: 20.41±6.28 vs. 9.45±3.62μg/m(3), P<0.001), and in the winter 2014 (mean±SD: 53.67±19.76 vs. 27.96±12.34μg/m(3), P<0.001). We observed significant differences in 15-F2t-IsoP levels between the summer and winter seasons in Karvina for newborns (mean±SD: 64.24±26.75 vs. 104.26±38.18pg/ml plasma, respectively) (P<0.001). Levels of 8-oxodG differed only in the winter season between localities, they were significantly higher (P<0.001) in newborns from Karvina in comparison with CB (mean±SD: 5.70±2.94 vs. 4.23±1.51 nmol/mmol creatinine, respectively). The results of multivariate regression analysis in newborns from Karvina showed PM2.5 concentrations to be a significant predictor for 8-oxodG excretion, PM2.5 and B[a]P (benzo[a]pyrene) concentrations to be a significant predictor for 15-F2t-IsoP levels. The results of multivariate regression analysis in mothers showed PM2.5 concentrations to be a significant predictor of 8-oxodG levels.

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Metadata

Authors
Ambroz, A., Vlkova, V., Rossner, P., Rossnerova, A., Svecova, V., Milcova, A., Pulkrabova, J., Hajslova, J., Veleminsky, M., Solansky, I., & Sram, R. J.
Affiliations
Czech Academy of Sciences, Institute of Experimental Medicine (CZ)
Venue
International Journal of Hygiene and Environmental Health
Publisher
Elsevier BV
Published
2016-08
Volume
219
Issue
6
Pages
545-556
ISSN
1438-4639 (ISSN-L)
DOI
10.1016/j.ijheh.2016.05.010
OpenAlex
W2410919115
Cited by
91
References
4
Citations by year
2026: 8 · 2025: 12 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 11 · 2020: 12 · 2019: 7 · 2018: 5 · 2017: 4 · 2016: 3
FWCI
3.98
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Hygiene and Environmental Health (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • ASEP (submittedVersion, cc-by-nc-nd)
Funders
  • State University of New York
  • Grantová Agentura České Republiky (P301/13/13458S)
  • University at Albany
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Indoor Air Quality and Microbial Exposure
Keywords
air pollution, particulate matter, PM2.5, oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, lipid peroxidation, 8-isoprostane, oxidative stress, neonates, mothers, urinary biomarkers, blood biomarkers, benzo[a]pyrene, seasonal variation, Ceske Budejovice, Karviná, prenatal exposure
MeSH terms
8-Hydroxy-2'-Deoxyguanosine, Adult, Air Pollutants, Air Pollution, Cotinine, Deoxyguanosine, DNA Damage, Female, Humans, Infant, Newborn, Male, Mothers, Polycyclic Aromatic Hydrocarbons, Pregnancy, Lipid Peroxidation, Dinoprost, Czech Republic, Maternal Exposure, Isoprostanes, Particulate Matter, Young Adult

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CoChat. (2026). Citation check: Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. https://app.cochat.ai/papers/10.1016/j.ijheh.2016.05.010
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Ambroz, A., Vlkova, V., Rossner, P., Rossnerova, A., Svecova, V., Milcova, A., Pulkrabova, J., Hajslova, J., Veleminsky, M., Solansky, I., & Sram, R. J. (2016). Impact of air pollution on oxidative DNA damage and lipid peroxidation in mothers and their newborns. International Journal of Hygiene and Environmental Health. https://doi.org/10.1016/j.ijheh.2016.05.010