Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals
Open accessAbstract
The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is considerable across the world. Several risk factors for adverse pregnancy outcomes have been identified. One risk factor for adverse pregnancy outcomes receiving considerable attention in recent years is gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed to a multitude of environmental chemicals with known endocrine-disrupting properties, and evidence suggests exposure to these EDCs have the potential to disrupt the maternal-fetal environment culminating in adverse pregnancy and birth outcomes. This review addresses the impact of maternal and fetal exposure to environmental EDCs of natural and man-made chemicals in disrupting the maternal-fetal milieu in human leading to adverse pregnancy and birth outcomes—a risk factor for adult-onset noncommunicable diseases, the role lifestyle and environmental factors play in mitigating or amplifying the effects of EDCs, the underlying mechanisms and mediators involved, and the research directions on which to focus future investigations to help alleviate the adverse effects of EDC exposure.
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The most consistent evidence base for pregnancy environmental exposures and later cardiometabolic risk relates to ambient air pollution, persistent pollutants such as PFAS, and selected EDCs, with diet and built-environment features as modifiers and correlated determinants.
“The most consistent evidence base relates to ambient air pollution, persistent pollutants such as per- and polyfluoroalkyl substances (PFAS), and selected endocrine-disrupting chemicals (EDCs), with diet and built-environment features functioning as modifiers and correlated determinants of risk across the life course [75,76,77].”
From Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures (2026) · cites this paper as [75]
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- Authors
- Padmanabhan, V., Song, W., & Puttabyatappa, M.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Padmanabhan, Vasantha
- Song, Wenhui
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2021-01-03
- Volume
- 42
- Issue
- 3
- Pages
- 295-353
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- PMC
- PMC8152448
- OpenAlex
- W3120509918
- Cited by
- 103
- References
- 638
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 19 · 2023: 29 · 2022: 10 · 2021: 4
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Environmental Health Sciences (R01 ES 030374, UG3OD02325, UH3OD023)
- Children’s Environmental Health and Disease Prevention Center (P01 ES022844, RD 83543601)
- NIEHS Core Center (P30 ES017885)
- Topics
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- endocrine disruptors, adverse pregnancy outcomes, preterm birth, low birth weight, prenatal exposure, non-communicable diseases, lifestyle factors, environmental chemicals
- MeSH terms
- Adult, Female, Humans, Infant, Newborn, Pregnancy, Maternal Exposure, Premature Birth, Endocrine Disruptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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