Cited by 103Effects and risks of endocrine disrupting chemicalsBirth, Development, and HealthToxic Organic Pollutants Impact

Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals

Open access
Padmanabhan, Vasantha, Song, Wenhui, Puttabyatappa, Muraly·2021·Endocrine Reviews

Abstract

The burden of adverse pregnancy outcomes such as preterm birth and low birth weight is considerable across the world. Several risk factors for adverse pregnancy outcomes have been identified. One risk factor for adverse pregnancy outcomes receiving considerable attention in recent years is gestational exposure to endocrine-disrupting chemicals (EDCs). Humans are exposed to a multitude of environmental chemicals with known endocrine-disrupting properties, and evidence suggests exposure to these EDCs have the potential to disrupt the maternal-fetal environment culminating in adverse pregnancy and birth outcomes. This review addresses the impact of maternal and fetal exposure to environmental EDCs of natural and man-made chemicals in disrupting the maternal-fetal milieu in human leading to adverse pregnancy and birth outcomes—a risk factor for adult-onset noncommunicable diseases, the role lifestyle and environmental factors play in mitigating or amplifying the effects of EDCs, the underlying mechanisms and mediators involved, and the research directions on which to focus future investigations to help alleviate the adverse effects of EDC exposure.

Integrity signals

Registry

Crossref · 10.1210/endrev/bnaa035

Cites

634 of 634 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The most consistent evidence base for pregnancy environmental exposures and later cardiometabolic risk relates to ambient air pollution, persistent pollutants such as PFAS, and selected EDCs, with diet and built-environment features as modifiers and correlated determinants.

    “The most consistent evidence base relates to ambient air pollution, persistent pollutants such as per- and polyfluoroalkyl substances (PFAS), and selected endocrine-disrupting chemicals (EDCs), with diet and built-environment features functioning as modifiers and correlated determinants of risk across the life course [75,76,77].”

Cites

Flagged first, then by citations

4 of the 638 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Padmanabhan, V., Song, W., & Puttabyatappa, M.
Affiliations
University of Michigan (US)
Corresponding author
  • Padmanabhan, Vasantha
  • Song, Wenhui
Venue
Endocrine Reviews
Published
2021-01-03
Volume
42
Issue
3
Pages
295-353
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
OpenAlex
W3120509918
Cited by
103
References
638
Citations by year
2026: 17 · 2025: 24 · 2024: 19 · 2023: 29 · 2022: 10 · 2021: 4
FWCI
1.50
Type
journal article
Language
en
Open access
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Environmental Health Sciences (R01 ES 030374, UG3OD02325, UH3OD023)
  • Children’s Environmental Health and Disease Prevention Center (P01 ES022844, RD 83543601)
  • NIEHS Core Center (P30 ES017885)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords
endocrine disruptors, adverse pregnancy outcomes, preterm birth, low birth weight, prenatal exposure, non-communicable diseases, lifestyle factors, environmental chemicals
MeSH terms
Adult, Female, Humans, Infant, Newborn, Pregnancy, Maternal Exposure, Premature Birth, Endocrine Disruptors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review