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Cited by 244

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Methicillin-resistant Staphylococcus aureus: the superbug

Open access
Ippolito, Giuseppe, Leone, Sebastiano, Lauria, Francesco N., Nicastri, Emanuele, Wenzel, Richard P.·2010·International Journal of Infectious Diseases

Abstract

Over the last decade, methicillin-resistant Staphylococcus aureus (MRSA) strains have emerged as serious pathogens in the nosocomial and community setting. Hospitalization costs associated with MRSA infections are substantially greater than those associated with methicillin-sensitive S. aureus (MSSA) infections, and MRSA has wider economic effects that involve indirect costs to the patient and to society. In addition, there is some evidence suggesting that MRSA infections increase morbidity and the risk of mortality. Glycopeptides are the backbone antibiotics for the treatment of MRSA infections. However, several recent reports have highlighted the limitations of vancomycin, and its role in the management of serious infections is now being reconsidered. Several new antimicrobials demonstrate in vitro activity against MRSA and other Gram-positive bacteria. Data from large surveys indicate that linezolid, daptomycin, and tigecycline are almost universally active against MRSA. This review will briefly discuss the epidemiology, costs, outcome, and therapeutic options for the management of MRSA infections.

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Metadata

Authors
Ippolito, G., Leone, S., Lauria, F. N., Nicastri, E., & Wenzel, R. P.
Venue
International Journal of Infectious Diseases
Publisher
Elsevier BV
Published
2010-10
Volume
14
Pages
S7-S11
ISSN
1201-9712 (ISSN-L)
OpenAlex
W2097390075
Cited by
244
References
1
FWCI
9.80
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Methicillin-resistant Staphylococcus aureus: the superbug. https://app.cochat.ai/papers/10.1016/j.ijid.2010.05.003
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Ippolito, G., Leone, S., Lauria, F. N., Nicastri, E., & Wenzel, R. P. (2010). Methicillin-resistant Staphylococcus aureus: the superbug. International Journal of Infectious Diseases. https://doi.org/10.1016/j.ijid.2010.05.003

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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