A rapid review on current and potential uses of large language models in nursing
Open accessAbstract
Background The application of large language models across commercial and consumer contexts has grown exponentially in recent years. However, a gap exists in the literature on how large language models can support nursing practice, education, and research. This study aimed to synthesize the existing literature on current and potential uses of large language models across the nursing profession.Methods A rapid review of the literature, guided by Cochrane rapid review methodology and PRISMA reporting standards, was conducted. An expert health librarian assisted in developing broad inclusion criteria to account for the emerging nature of literature related to large language models. Three electronic databases (i.e., PubMed, CINAHL, and Embase) were searched to identify relevant literature in August 2023. Articles that discussed the development, use, and application of large language models within nursing were included for analysis.Results The literature search identified a total of 2028 articles that met the inclusion criteria. After systematically reviewing abstracts, titles, and full texts, 30 articles were included in the final analysis. Nearly all (93 %; n = 28) of the included articles used ChatGPT as an example, and subsequently discussed the use and value of large language models in nursing education (47 %; n = 14), clinical practice (40 %; n = 12), and research (10 %; n = 3). While the most common assessment of large language models was conducted by human evaluation (26.7 %; n = 8), this analysis also identified common limitations of large language models in nursing, including lack of systematic evaluation, as well as other ethical and legal considerations.Discussion This is the first review to summarize contemporary literature on current and potential uses of large language models in nursing practice, education, and research. Although there are significant opportunities to apply large language models, the use and adoption of these models within nursing have elicited a series of challenges, such as ethical issues related to bias, misuse, and plagiarism.Conclusion Given the relative novelty of large language models, ongoing efforts to develop and implement meaningful assessments, evaluations, standards, and guidelines for applying large language models in nursing are recommended to ensure appropriate, accurate, and safe use. Future research along with clinical and educational partnerships is needed to enhance understanding and application of large language models in nursing and healthcare.
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Hobensack et al. (2024) focused on bibliometric trends rather than synthesising implementation strategies.
“Hobensack et al. (2024) focused on bibliometric trends rather than synthesising implementation strategies.”
From Patterns, advances, and gaps in using ChatGPT and similar technologies in nursing education: A PAGER scoping review (2025) · cites this paper as Hobensack et al., 2024
The Introduction and Study criteria and synthesis sections describe a rapid review that synthesizes literature on current and potential uses of large language models in nursing, not a study focused on bibliometric trends. The Study characteristics section reports publication patterns, but those are only one part of the review. The paper does not present itself as a synthesis specifically of implementation strategies either. (LLM, conf=0.88)
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Experimental — accuracy not yet measuredMost existing reviews of GenAI in nursing education lack structured analytical frameworks for systematically mapping evidence into actionable insights.
“A few reviews have begun to examine GenAI in nursing education, but most lack structured analytical frameworks for systematically mapping evidence into actionable insights.”
From Patterns, advances, and gaps in using ChatGPT and similar technologies in nursing education: A PAGER scoping review (2025) · cites this paper as Hobensack et al., 2024
The Introduction (page unavailable) says few earlier reviews synthesized the literature and that they focused mainly on healthcare broadly; it also says no prior study had summarized overarching themes across nursing practice, education, and research. This supports a gap in nursing-focused synthesis, but the paper does not assess whether most reviews of GenAI in nursing education lack structured analytical frameworks or actionable insights. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe 18 included studies collectively explored diverse applications of AI in nursing across research, practice, and education.
“The 18 included studies in this umbrella review collectively explored the diverse applications of AI in nursing across research, practice, and education [32-49].”
From The Role of AI in Nursing Education and Practice: Umbrella Review (2025) · cites this paper as [33]
This finding aligns with a previous review of ChatGPT in pharmacy practice, which highlighted a lack of standardized evaluation methods, and with broader healthcare reviews calling for standardized LLM evaluation approaches.
“This finding aligns with a previous review of ChatGPT in pharmacy practice, which highlighted a lack of standardized evaluation methods, 20 and with broader healthcare reviews calling for standardized LLM evaluation approaches.14,15”
From Large Language Models in Pharmacist-Led Direct Patient Care: A Rapid Review of Published Evaluations (2026) · cites this paper as [15]
A coherent synthesis of emerging evidence on GenAI in nursing education is lacking.
“However, a coherent synthesis of this emerging evidence is lacking.”
From Patterns, advances, and gaps in using ChatGPT and similar technologies in nursing education: A PAGER scoping review (2025) · cites this paper as Hobensack et al., 2024
Studies report technical issues, training data biases, and AI system opacity.
“Studies reporting technical issues, training data biases, and AI system opacity (Hobensack et al., 2024) underscore the need for empirical validation to support evidence-based implementation.”
From Patterns, advances, and gaps in using ChatGPT and similar technologies in nursing education: A PAGER scoping review (2025) · cites this paper as Hobensack et al., 2024
Randomised controlled trials represented approximately 2.5% of the corpus (n = 12).
“Randomised controlled trials represented approximately 2.5% of the corpus (n = 12), confirming at scale the observation by Hobensack et al. (2024) that the field is empirically thin.”
From When the algorithm enters the classroom: A critical integrative review of large language models, nursing education structural gaps, and the reconstitution of professional identity (2026) · cites this paper as Hobensack et al. (2024)
Hobensack et al. (2024) identified that most literature on LLMs in nursing is descriptive, based on commentaries and editorials, with limited empirical evidence to inform practice, education, and research.
“Similarly, Hobensack et al. (2024) identified that most literature on LLMs in nursing is descriptive, based on commentaries and editorials, with limited empirical evidence to inform practice, education, and research.”
From Current trends and future implications in the utilization of ChatGPT in nursing: a rapid review (2024) · cites this paper as Hobensack et al., 2024
In this rapid review, most included studies focused on nursing education.
“Our review also indicated that most studies focused on nursing education, consistent with Hobensack et al. (2024) and Yalcinkaya and Cinar Yucel's (2024) studies.”
From Current trends and future implications in the utilization of ChatGPT in nursing: a rapid review (2024) · cites this paper as Hobensack et al., 2024
The earliest systematic effort, a rapid review by Hobensack et al. (2024) synthesising 30 studies, found that 57% of included articles were editorials or letters to the editor and only seven reported original research findings.
“The earliest systematic effort, a rapid review by Hobensack et al. (2024) synthesising 30 studies across nursing education, clinical practice, and J o u r n a l P r e -p r o o f research, delivered a critical methodological assessment: 57% of included articles were editorials or letters to the editor, and only seven reported original research findings.”
From When the algorithm enters the classroom: A critical integrative review of large language models, nursing education structural gaps, and the reconstitution of professional identity (2026) · cites this paper as Hobensack et al., 2024
The field is empirically thin, as confirmed at scale by the low proportion of RCTs.
“confirming at scale the observation by Hobensack et al. (2024) that the field is empirically thin.”
From When the algorithm enters the classroom: A critical integrative review of large language models, nursing education structural gaps, and the reconstitution of professional identity (2026) · cites this paper as Hobensack et al. (2024)
The field is dominated by opinion and editorial commentary, as confirmed and quantified at scale by the Evidence Gap Map.
“Hobensack et al.'s (2024) observation that the field is dominated by opinion and editorial commentary is confirmed and quantified at scale by the Evidence Gap Map.”
From When the algorithm enters the classroom: A critical integrative review of large language models, nursing education structural gaps, and the reconstitution of professional identity (2026) · cites this paper as Hobensack et al.'s (2024)
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References 52 · Cited by 80
Research works printed but not linked: 3
- Cochrane Rapid Review (RR) Definition.
- Li T, Higgins JP, Deeks JJ. Chapter 5: Collecting data . In: Cochrane Handbook for Systematic Reviews of Interventions. Vol 6. 4th ed. ; 2023. Accessed December 28, 2023. https://training.cochrane.org/handbook/current/chapter-05
- McAdoo T. How to cite ChatGPT. APA Style. doi:10.1037/0000165-000 · DOI
- Authors
- Hobensack, M., von Gerich, H., Vyas, P., Withall, J., Peltonen, L.-M., Block, L. J., Davies, S., Chan, R., Van Bulck, L., Cho, H., Paquin, R., Mitchell, J., Topaz, M., & Song, J.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- University of Arizona (US)
- Columbia University (US)
- University of Turku (FI)
- University of British Columbia (CA)
- University of Regina (CA)
- Western University (CA)
- University of Florida (US)
- King's College London (GB)
- University of Colorado Anschutz (US)
- VNS Health (US)
- University of Pennsylvania (US)
- Corresponding author
- Hobensack, Mollie
- ORCID
- Venue
- International Journal of Nursing Studies
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 154
- Pages
- 104753
- ISSN
- 0020-7489 (ISSN-L)
- OpenAlex
- W4392755271
- Cited by
- 80
- References
- 52
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 16
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.utupub.fi
- Licence
- Locations
- International Journal of Nursing Studies (publishedVersion)
- PubMed (publishedVersion)
- UTUPub (University of Turku) (submittedVersion)
- Lirias (KU Leuven) (submittedVersion)
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Information Systems › Artificial Intelligence in Education
- Health Sciences › Health Professions › Health Information Management › Artificial Intelligence in Healthcare
- Keywords
- large language models, ChatGPT, nursing education, clinical practice, nursing research, ethical considerations, bias, plagiarism, AI adoption in healthcare
- MeSH terms
- Education, Nursing, Humans, Language
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