An algorithm for the management of coagulopathy from postpartum hemorrhage, using fibrinogen concentrate as first-line therapy
Abstract
Background We constructed an algorithm for the management of coagulopathy from massive postpartum hemorrhage. Fibrinogen concentrate was administered preferentially, and the dose of both fibrinogen concentrate and fresh frozen plasma given was determined by the plasma fibrinogen concentration and prothrombin time. The efficacy of the algorithm and the amount of fibrinogen concentrate and fresh frozen plasma transfused were determined.Methods The study was conducted in a single teaching perinatal center. Nineteen patients were included between April 2011 and March 2014 (patient group). For a historical comparison group, we retrospectively analyzed the records of 19 patients who had been treated for coagulopathy from massive postpartum hemorrhage between April 2006 and March 2011 (control group).Results Blood loss was significantly lower in the patient group. No adverse events were associated with this management in either group. The dose of fibrinogen concentrate administered was significantly higher and that of fresh frozen plasma administered was significantly lower in the patient group.Conclusion This algorithm appeared to help reduce blood loss and the total amount of fresh frozen plasma transfused when treating coagulopathy from postpartum hemorrhage, and may represent another strategy for achieving hemostasis in this setting.
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Observational studies suggest that administration of fibrinogen concentrate may reduce blood loss in hemorrhage-associated hypofibrinogenemia associated with abruption.
“Observational studies suggest that administration of fibrinogen concentrate may result in reduced blood loss in hemorrhage associated hypofibrinogenemia associated with abruption (102, 103).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [103]
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- Authors
- Seto, S., Itakura, A., Okagaki, R., Suzuki, M., & Ishihara, O.
- Affiliations
- Saitama Medical University (JP)
- Juntendo University (JP)
- Corresponding author
- Itakura, A.
- Venue
- International Journal of Obstetric Anesthesia
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 32
- Pages
- 11-16
- ISSN
- 0959-289X (ISSN-L)
- OpenAlex
- W2601147717
- Cited by
- 35
- References
- 17
- Citations by year
- 2026: 1 · 2025: 4 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 1
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- International Journal of Obstetric Anesthesia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Blood transfusion and management
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
- Keywords
- postpartum hemorrhage, coagulopathy, fibrinogen concentrate, fresh frozen plasma, management algorithm, plasma fibrinogen concentration, prothrombin time, blood loss, hemostasis, transfusion strategy
- MeSH terms
- Adult, Algorithms, Blood Coagulation Disorders, Blood Transfusion, Female, Fibrinogen, Postpartum Hemorrhage, Humans, Plasma, Pregnancy, Retrospective Studies
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