Broadband Terahertz Light–Matter Interaction Enhancement for Precise Spectroscopy of Thin Films and Micro-Samples
Open accessPublished version of a preprint
Abstract
In biology, molecules and macromolecules such as sugars, proteins, DNA, RNA, etc., are of utmost importance. Detecting their presence as well as getting information on their actual structure is still a challenge in many cases. The vibrational states of such molecules correspond to a spectral range extending from infrared to terahertz. Spectroscopy is used for the detection and the identification of such compounds and their structure. Terahertz spectroscopy of a biosample is challenging for two main reasons: the high terahertz absorption by water molecules in the sample; and the small size of the sample—its volume is usually smaller than the cube of the terahertz wavelength, thus the light–matter interaction is extremely reduced. In this paper, we present the design, fabrication, characterization, and first typical use of a biophotonic device that aims to increase the light–matter interaction to enable terahertz spectroscopy of very small samples over a broad band (0.2–2 THz). Finally, we demonstrate the validity of our approach by time-domain spectroscopy of samples of a few µL.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Far-infrared time-domain spectroscopy with terahertz beams of dielectrics and semiconductors
Grischkowsky, D., Keiding, S., van Exter, M., & Fattinger, C. (1990) · Journal of the Optical Society of America B · doi:10.1364/josab.7.002006 · Cited by 2,239 · see citing works
Plasmonics: Localization and guiding of electromagnetic energy in metal/dielectric structures
Maier, S. A., & Atwater, H. A. (2005) · Journal of Applied Physics · doi:10.1063/1.1951057 · Cited by 1,915 · see citing works
Ablation of metals by ultrashort laser pulses
Nolte, S., Momma, C., Jacobs, H., Tünnermann, A., Chichkov, B. N., Wellegehausen, B., & Welling, H. (1997) · Journal of the Optical Society of America B · doi:10.1364/josab.14.002716 · Cited by 1,146 · see citing works
All-optical high-speed signal processing with silicon–organic hybrid slot waveguides
Koos, C. G., Vorreau, P., Vallaitis, T., Dumon, P., Bogaerts, W., Baets, R., Esembeson, B., Biaggio, I., Michinobu, T., Diederich, F., et al. (2009) · Nature Photonics · doi:10.1038/nphoton.2009.25 · Cited by 913 · see citing works
Terahertz time-domain spectroscopy of water vapor
van Exter, M., Fattinger, C., & Grischkowsky, D. (1989) · Optics Letters · doi:10.1364/ol.14.001128 · Cited by 862 · see citing works
Undistorted guided-wave propagation of subpicosecond terahertz pulses
Mendis, R., & Grischkowsky, D. (2001) · Optics Letters · doi:10.1364/ol.26.000846 · Cited by 456 · cited 6× · see citing works
“However, the main limitation of the PPMW is that it assumes a quasiinfinite height with the major consequence that there is no vertical confinement.”
BackgroundMethodResultInfluentialCunningham, P. D., Valdes, N. N., Vallejo, F. A., Hayden, L. M., Polishak, B. M., Zhou, X., Luo, J., Jen, A. K. ‐., Williams, J. C., & Twieg, R. J. (2011) · Journal of Applied Physics · doi:10.1063/1.3549120 · Cited by 447 · see citing works
Slot Line on a Dielectric Substrate
Cohn, S. B. (1969) · IEEE Transactions on Microwave Theory and Techniques · doi:10.1109/tmtt.1969.1127058 · Cited by 390 · see citing works
Precise laser ablation with ultrashort pulses
Momma, C., Nolte, S., Chichkov, B. N., von Alvensleben, F., & Tünnermann, A. (1997) · Applied Surface Science · doi:10.1016/s0169-4332(96)00613-7 · Cited by 326 · see citing works
Guided subwavelength plasmonic mode supported by a slot in a thin metal film
Veronis, G., & Fan, S. (2005) · Optics Letters · doi:10.1364/ol.30.003359 · Cited by 312 · see citing works
Laser Beam MicroMachining (LBMM) – A review
Mishra, S. K., & Yadava, V. (2015) · Optics and Lasers in Engineering · doi:10.1016/j.optlaseng.2015.03.017 · Cited by 263 · see citing works
Nonlinear Optical Properties of Core-Shell Nanocavities for Enhanced Second-Harmonic Generation
Pu, Y., Grange, R., Hsieh, C., & Psaltis, D. (2010) · Physical Review Letters · doi:10.1103/physrevlett.104.207402 · Cited by 263 · see citing works
High-Resolution Waveguide THz Spectroscopy of Biological Molecules
Laman, N., Harsha, S. S., Grischkowsky, D., & Melinger, J. S. (2007) · Biophysical Journal · doi:10.1529/biophysj.107.113647 · Cited by 175 · see citing works
Chemical Recognition With Broadband THz Spectroscopy
Fischer, B. M., Helm, H., & Jepsen, P. U. (2007) · Proceedings of the IEEE · doi:10.1109/jproc.2007.898904 · Cited by 162 · see citing works
Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopy
ZEITLER, J., KOGERMANN, K., RANTANEN, J., RADES, T., TADAY, P., PEPPER, M., AALTONEN, J., & STRACHAN, C. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.027 · Cited by 150 · see citing works
Surface‐plasmon‐based optical manipulation
Quidant, R., & Girard, C. (2008) · Laser & Photonics Review · doi:10.1002/lpor.200710038 · Cited by 138 · see citing works
Observation of Backaction and Self-Induced Trapping in a Planar Hollow Photonic Crystal Cavity
Descharmes, N., Dharanipathy, U. P., Diao, Z., Tonin, M., & Houdré, R. (2013) · Physical Review Letters · doi:10.1103/physrevlett.110.123601 · Cited by 129 · see citing works
Terahertz Nanofocusing with Cantilevered Terahertz-Resonant Antenna Tips
Mastel, S., Lundeberg, M. B., Alonso‐González, P., Gao, Y., Watanabe, K., Taniguchi, T., Hone, J., Koppens, F. H. L., Nikitin, A. Y., & Hillenbrand, R. (2017) · Nano Letters · doi:10.1021/acs.nanolett.7b01924 · Cited by 112 · see citing works
Material thickness optimization for transmission-mode terahertz time-domain spectroscopy
Withayachumnankul, W., Fischer, B. M., & Abbott, D. (2008) · Optics Express · doi:10.1364/oe.16.007382 · Cited by 108 · see citing works
Allis, D. G., Fedor, A. M., Korter, T. M., Bjarnason, J. E., & Brown, E. R. (2007) · Chemical Physics Letters · doi:10.1016/j.cplett.2007.04.032 · Cited by 107 · see citing works
Weber, R., Graf, T. G., Freitag, C., Feuer, A., Kononenko, T. V., & Конов, В. И. (2017) · Optics Express · doi:10.1364/oe.25.003966 · Cited by 83 · see citing works
Optimum design of tapered slot antenna profile
Oraizi, H., & Jam, S. (2003) · IEEE Transactions on Antennas and Propagation · doi:10.1109/tap.2003.811090 · Cited by 76 · see citing works
Conformational changes of photoactive yellow protein monitored by terahertz spectroscopy
Castro-Camus, E., & Johnston, M. B. (2008) · Chemical Physics Letters · doi:10.1016/j.cplett.2008.02.084 · Cited by 72 · see citing works
Metal-wire terahertz time-domain spectroscopy
Walther, M., Freeman, M. R., & Hegmann, F. A. (2005) · Applied Physics Letters · doi:10.1063/1.2158025 · Cited by 68 · see citing works
Optimisation of sample thickness for THz-TDS measurementsPreprint
Withayachumnankul, W., Fischer, B. M., & Abbott, D. (2007) · doi:10.48550/arxiv.0711.3815 · Cited by 58 · see citing works
Off-Chip Rough-Metal-Surface Propagation Loss Modeling and Correlation with Measurements
Braunisch, H., Gu, X., Camacho-Bragado, A., & Tsang, L. (2007) · IEEE Electronic Components and Technology Conference (ECTC) · doi:10.1109/ectc.2007.373887 · Cited by 56 · see citing works
Peytavit, E., Donche, C., Lépilliet, S., Ducournau, G., & Lampin, J. ‐. (2011) · Electronics Letters · doi:10.1049/el.2011.0369 · Cited by 50 · see citing works
Self-citationEfficient Excitation of Channel Plasmons in Tailored, UV-Lithography-Defined V-Grooves
Smith, C. L. C., Thilsted, A. H., Garcia‐Ortiz, C. E., Radko, I. P., Marie, R., Jeppesen, C. B., Vannahme, C., Bozhevolnyi, S. I., & Kristensen, A. S. (2014) · Nano Letters · doi:10.1021/nl5002058 · Cited by 46 · see citing works
Propagation characteristics of the slotline first higher order mode
Sheen, J.-W., & Lin, Y.-D. (1998) · IEEE Transactions on Microwave Theory and Techniques · doi:10.1109/22.734578 · Cited by 45 · see citing works
Gu, X., Tsang, L., & Braunisch, H. (2007) · IEEE Transactions on Microwave Theory and Techniques · doi:10.1109/tmtt.2007.891689 · Cited by 43 · see citing works
Single-shot terahertz spectroscopy using pulse-front tilting of an ultra-short probe pulse
Kawada, Y., Yasuda, T., Nakanishi, A., Akiyama, K., & Takahashi, H. (2011) · Optics Express · doi:10.1364/oe.19.011228 · Cited by 41 · see citing works
Analysis of the Dispersion Characteristic of Slot Line with Thick Metal Coating
Kitazawa, T., Hayashi, Y., & Suzuki, M. (1980) · IEEE Transactions on Microwave Theory and Techniques · doi:10.1109/tmtt.1980.1130081 · Cited by 30 · see citing works
Strong confinement of light in low index materials: the Photon Cage
Sieutat, C., Peretti, R., Leclercq, J., Viktorovitch, P., & Letartre, X. (2013) · Optics Express · doi:10.1364/oe.21.020015 · Cited by 23 · see citing works
Self-citationEfficient terahertz slot-line waveguides
Pahlevaninezhad, H., Heshmat, B., & Darcie, T. E. (2011) · Optics Express · doi:10.1364/oe.19.000b47 · Cited by 22 · see citing works
Gap independent coupling into parallel plate terahertz waveguides using cylindrical horn antennas
Shutler, A. J., & Grischkowsky, D. (2012) · Journal of Applied Physics · doi:10.1063/1.4754846 · Cited by 19 · see citing works
Slot Line with Thick Metal Coating (Short Papers)
Kitazawa, T., Fujiki, Y., Hayashi, Y., & Suzuki, M. (1973) · IEEE Transactions on Microwave Theory and Techniques · doi:10.1109/tmtt.1973.1128075 · Cited by 15 · see citing works
(2009) · doi:10.1109/icimw.2009.5324682 · Cited by 10 · see citing works
Peretti, R., Braud, F., Peytavit, E., et al. (2018) · Preprints.org · doi:10.20944/preprints201802.0157.v1 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Ramo, S.; Whinnery, J.R.; Van Duzer, T. Fields and Waves in Communication Electronics; John Wiley & Sons: Hoboken, NJ, USA, 2008.
Cited by
Sorted by citations
Terahertz optical fibers [Invited]
Islam, M. S., Cordeiro, C. M. B., Franco, M. A. R., Sultana, J., Cruz, A. L. S., & Abbott, D. (2020) · Optics Express · doi:10.1364/oe.389999 · Cited by 180 · see citing works
THz-TDS Time-Trace Analysis for the Extraction of Material and Metamaterial Parameters
Peretti, R., Mitryukovskiy, S., Froberger, K., Mebarki, M. A., Eliet, S., Vanwolleghem, M., & Lampin, J.-F. (2019) · IEEE Transactions on Terahertz Science and Technology · doi:10.1109/tthz.2018.2889227 · Cited by 78 · see citing works
Self-citationPolarization-sensitive terahertz resonator using asymmetrical F-shaped metamaterial
Lin, Z., Xu, Z., Liu, P., Liang, Z., & Lin, Y. (2019) · Optics & Laser Technology · doi:10.1016/j.optlastec.2019.105826 · Cited by 66 · see citing works
Recent advances of nucleic acid-based cancer biomarkers and biosensors
Zhao, J., Xia, K., He, P., Wei, G., Zhou, X., & Zhang, X. (2023) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2023.215456 · Cited by 44 · see citing works
Imaging of THz Photonic Modes by Scattering Scanning Near-Field Optical Microscopy
Thomas, L., Hannotte, T., Santos, C. N., Walter, B., Lavancier, M., Eliet, S., Faucher, M., Lampin, J., & Peretti, R. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c01871 · Cited by 30 · see citing works
Self-citationOptomechanics of a stable diffractive axicon light sail
Srivastava, P. R., & Swartzlander, G. A. (2020) · The European Physical Journal Plus · doi:10.1140/epjp/s13360-020-00542-1 · Cited by 28 · see citing works
THz spectroscopy for fundamental science and applications
Lampin, J., Mouret, G., Dhillon, S. S., & Mangeney, J. (2020) · Photoniques · doi:10.1051/photon/202010133 · Cited by 14 · see citing works
Self-citationEndoscope Capsules: The Present Situation and Future Outlooks
Gounella, R. H., Granado, T. C., Ando, O. H., Luporini, D. L., Gazziro, M., & Carmo, J. P. (2023) · Bioengineering · doi:10.3390/bioengineering10121347 · Cited by 10 · see citing works
Two-Conductor Ports Enabling Broadband Operation of Substrateless Microscale Silicon Waveguides
Headland, D. J., Gallego, D. C., & Carpintero, G. (2024) · IEEE Transactions on Terahertz Science and Technology · doi:10.1109/tthz.2024.3407686 · Cited by 10 · see citing works
Wideband dispersion-free THz waveguide platform
Rohrbach, D., Kang, B. J., Zyaee, E., & Feurer, T. (2023) · Scientific Reports · doi:10.1038/s41598-023-41843-6 · Cited by 9 · see citing works
Shining the light to terahertz spectroscopy of nl-volume biological samples
Mitryukovskiy, S., Lavancier, M., Braud, F., Roos, G., Hannotte, T., Dubois, E., Lampin, J.-F., & Peretti, R. (2019) · Conference on Lasers and Electro-Optics · doi:10.1364/cleo_at.2019.atu3k.6 · Cited by 7 · see citing works
Self-citationRetrieving material and metamaterial parameters directly from time-domain spectroscopy time trace
Peretti, R., Mitryukovskiy, S., Kevin, F., & Lampin, J.-F. (2018) · 2018 43rd International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) · doi:10.1109/irmmw-thz.2018.8510300 · Cited by 7 · see citing works
Self-citationCho, S.-W., & Jeon, T. (2025) · Optics Express · doi:10.1364/oe.558846 · Cited by 5 · see citing works
Peretti, R., Mitryukovskiy, S. I., Braud, F., Peytavit, E., Dubois, E., & Lampin, J. (2018) · International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) · doi:10.1109/irmmw-thz.2018.8510508 · Cited by 4 · see citing works
Self-citationTerahertz Thermal Sensing by Using a Defect-Containing Periodically Corrugated Gold Waveguide
Xue, J.-L., Xu, L., Wang, T., Fan, Y.-X., & Tao, Z.-Y. (2020) · Applied Sciences · doi:10.3390/app10124365 · Cited by 4 · see citing works
Towards broadband THz spectroscopy and analysis of sub-wavelength-size biological samples
Mitryukovskiy, S. I., Lavancier, M., Braud, F., Bai, Y., Dubois, E., Lampin, J., & Peretti, R. (2019) · International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) · doi:10.1109/irmmw-thz.2019.8874409 · Cited by 3 · see citing works
Self-citationPeretti, R. (2023) · Optical Methods for Inspection, Characterization, and Imaging of Biomaterials · doi:10.1117/12.2675742 · Cited by 2 · see citing works
Self-citationTerahertz dielectric characterisation of fibres in a time-domain spectrometer
Pacewicz, A., Kopyt, P., Cuper, J., Krysicki, M. M., & Salski, B. (2023) · Opto-Electronics Review · doi:10.24425/opelre.2023.144596 · Cited by 1 · see citing works
Terahertz radiation confinement using metallic resonators
Hannotte, T., Lavancier, M., Mitryukovskiy, S. I., Lampin, J., & Peretti, R. (2019) · International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) · doi:10.1109/irmmw-thz.2019.8873795 · Cited by 1 · see citing works
Self-citationDevice for Broadband THz Spectroscopy of 1-nL-Volume Samples
Mitryukovskiy, S. I., Lavancier, M., Braud, F., Hannotte, T., Dubois, E., Lampin, J., & Peretti, R. (2019) · International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) · doi:10.1109/irmmw-thz.2019.8874026 · Cited by 1 · see citing works
Self-citationTowards broadband THz spectroscopy and analysis of subwavelength size biological samples
Hannotte, T., Thomas, L., Lavancier, M., Mitryukovskiy, S. I., Lampin, J., & Peretti, R. (2020) · Terahertz Photonics · doi:10.1117/12.2554518
Self-citationUtkov, N. S., Drakin, A. E., & Mikaelyan, G. T. (2022) · Bulletin of the Lebedev Physics Institute · doi:10.3103/s1068335622130139
Zhou, X., Wang, J., Zhang, H., Zhou, X., & Han, Y. (2023) · AIP Advances · doi:10.1063/5.0138450
Farfield and Coupling Analysis of an Ultra Broadband THz Device
Banerjee, S., Wang, K., Reda, A., Hannotte, T., Lapin, J.-F., Braud, F., & Peretti, R. (2025) · International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) · doi:10.1109/irmmw-thz61557.2025.11319861
Self-citation
- Authors
- Peretti, R., Braud, F., Peytavit, E., Dubois, E., & Lampin, J.-F.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Peretti, Romain
- Venue
- Photonics
- Publisher
- MDPI AG
- Published
- 2018-05-17
- Volume
- 5
- Issue
- 2
- Pages
- 11
- ISSN
- 2304-6732 (ISSN-L)
- OpenAlex
- W2788506347
- Cited by
- 27
- References
- 37
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 5 · 2018: 4
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Photonics (publishedVersion, cc-by)
- Preprints.org (acceptedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Funders
- ANR (11-EQPX-0015, ANR-11-EQPX-0025)
- région hauts de France (Thotrov)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Terahertz technology and applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Physical Sciences › Chemistry › Spectroscopy › Spectroscopy and Laser Applications
- Keywords
- terahertz spectroscopy, light-matter interaction enhancement, thin films, water absorption, time-domain spectroscopy, biosamples, vibrational spectroscopy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
