The DOI matches its Crossref record; 28 of the 29 references it cites were found in a registry or an index.
Tretinoin-loaded nanocapsules: Preparation, physicochemical characterization, and photostability study
Abstract
The aim of this study was to prepare and characterize tretinoin-loaded nanocapsules as well as to evaluate the influence of this nanoencapsulation on tretinoin photostability. Tretinoin-loaded nanocapsules (0.5 mg ml(-1)) were prepared by interfacial deposition of preformed polymer (poly-epsilon-caprolactone) using two different oily phases: capric/caprylic triglycerides and sunflower seed oil. Tretinoin-loaded nanocapsules presented drug content close to the theoretical value, encapsulation efficiencies higher than 99.9%, nanometric mean size with a polydispersity index below 0.25, and pH values between 5.0 and 7.0. Regarding photodegradation studies, tretinoin methanolic solution showed a half-life time around 40 min according to a first order equation, whereas tretinoin nanocapsule suspensions showed a half-life between 85 and 100 min (twofold higher than in methanolic solution) according to a zero order equation. Tretinoin-loaded nanocapsules improved tretinoin photostability, independently on the type of oily phase used in this study, and represent a potential system to be incorporated in topical or systemic dosage forms containing tretinoin.
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“The protective effect of these formulations was linked to their ability to reflect and scatter UV radiation80.”
From Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine (2020) · cites this paper as [80]
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Metadata
- Authors
- Ourique, A. F., Pohlmann, A. R., Guterres, S. S., & Beck, R. C. R.
- Affiliations
- Universidade Federal de Santa Maria (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Beck, R.C.R.
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 352
- Issue
- 1-2
- Pages
- 1-4
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2006560775
- Cited by
- 145
- References
- 29
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 2 · 2022: 10 · 2021: 8 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 10 · 2016: 12 · 2015: 12 · 2014: 8 · 2013: 10 · 2012: 12
- FWCI
- 5.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- all-trans retinoic acid, nanocapsules, polycaprolactone, interfacial deposition, photostability, photodegradation, encapsulation efficiency, triglycerides, sunflower oil, topical drug delivery
- MeSH terms
- Sunflower Oil, Caprylates, Chemistry, Pharmaceutical, Decanoic Acids, Dermatologic Agents, Drug Compounding, Drug Stability, Feasibility Studies, Half-Life, Kinetics, Particle Size, Photolysis, Plant Oils, Polyesters, Solubility, Technology, Pharmaceutical, Tretinoin, Triglycerides, Ultraviolet Rays, Nanocapsules
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