Cited by 179Advancements in Transdermal Drug DeliverySurfactants and Colloidal SystemsDrug Solubulity and Delivery Systems

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Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation

Hoeller, Sonja, Sperger, Andrea, Valenta, Claudia·2009·International Journal of Pharmaceutics

DOI 10.1016/j.ijpharm.2008.11.014

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Abstract

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsions by using sucrose laureate and polysorbate 80 as non-ionic surfactants. The positively charged nanoemulsions were generated by adding cationic phytosphingosine (PS). The relationship between the physicochemical properties of the nanoemulsions was shown by particle size and zeta potential measurements. These properties were dependent on the type of non-ionic surfactant and the concentration of PS. Furthermore the cationic PS had a positive impact on the skin permeation rates (flux) of the incorporated model drugs fludrocortisone acetate and flumethasone pivalate. An enhancement factor between 1.1 and 1.5 was obtained in relation to the control. The interaction of pre-impregnated porcine skin with positively and negatively charged nanoemulsions was confirmed by DSC analysis. The generated DSC-curves showed a slight difference in the phase transition temperature assigned to the characteristic lipid transition. However, it was not possible to assign the effect to one of the ingredients in the multicomponent system.

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Authors: Hoeller, S., Sperger, A., & Valenta, C.
Affiliations: University of Vienna (AT)
Corresponding author: Valenta, Claudia
ORCID: Hoeller, Sonja
Venue: International Journal of Pharmaceutics
Publisher: Elsevier BV
Published: 2009-03-31
Volume: 370
Issue: 1-2
Pages: 181-186
ISSN: 0378-5173 (ISSN-L)
DOI: 10.1016/j.ijpharm.2008.11.014
OpenAlex: W2135727032
Cited by: 179
References: 16
Citations by year: 2026: 5 · 2025: 9 · 2024: 13 · 2023: 5 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 17 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 13 · 2012: 9
FWCI: 3.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Pharmaceutics (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords: nonionic surfactants, Tween 80, skin permeation, transdermal drug delivery, fludrocortisone acetate, flumethasone pivalate, particle size, zeta potential, porcine skin, lipid phase transition
MeSH terms: Administration, Topical, Animals, Anti-Inflammatory Agents, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Drug Compounding, Drug Stability, Electrochemistry, Fludrocortisone, Flumethasone, Particle Size, Polysorbates, Skin, Skin Absorption, Solubility, Sphingosine, Sucrose, Surface-Active Agents, Swine, Drug Delivery Systems, Nanoparticles, In Vitro Techniques

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Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation

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