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Cited by 179Advancements in Transdermal Drug DeliverySurfactants and Colloidal SystemsDrug Solubulity and Delivery Systems

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation

Hoeller, Sonja, Sperger, Andrea, Valenta, Claudia·2009·International Journal of Pharmaceutics
DOI 10.1016/j.ijpharm.2008.11.014
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Abstract

Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsions by using sucrose laureate and polysorbate 80 as non-ionic surfactants. The positively charged nanoemulsions were generated by adding cationic phytosphingosine (PS). The relationship between the physicochemical properties of the nanoemulsions was shown by particle size and zeta potential measurements. These properties were dependent on the type of non-ionic surfactant and the concentration of PS. Furthermore the cationic PS had a positive impact on the skin permeation rates (flux) of the incorporated model drugs fludrocortisone acetate and flumethasone pivalate. An enhancement factor between 1.1 and 1.5 was obtained in relation to the control. The interaction of pre-impregnated porcine skin with positively and negatively charged nanoemulsions was confirmed by DSC analysis. The generated DSC-curves showed a slight difference in the phase transition temperature assigned to the characteristic lipid transition. However, it was not possible to assign the effect to one of the ingredients in the multicomponent system.

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Crossref · 10.1016/j.ijpharm.2008.11.014

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16 of 16 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Hoeller, S., Sperger, A., & Valenta, C.
Affiliations
University of Vienna (AT)
Corresponding author
Valenta, Claudia
ORCID
Hoeller, Sonja
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2009-03-31
Volume
370
Issue
1-2
Pages
181-186
ISSN
0378-5173 (ISSN-L)
DOI
10.1016/j.ijpharm.2008.11.014
OpenAlex
W2135727032
Cited by
179
References
16
Citations by year
2026: 5 · 2025: 9 · 2024: 13 · 2023: 5 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 17 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 13 · 2012: 9
FWCI
3.28
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
  • Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Keywords
nonionic surfactants, Tween 80, skin permeation, transdermal drug delivery, fludrocortisone acetate, flumethasone pivalate, particle size, zeta potential, porcine skin, lipid phase transition
MeSH terms
Administration, Topical, Animals, Anti-Inflammatory Agents, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Drug Compounding, Drug Stability, Electrochemistry, Fludrocortisone, Flumethasone, Particle Size, Polysorbates, Skin, Skin Absorption, Solubility, Sphingosine, Sucrose, Surface-Active Agents, Swine, Drug Delivery Systems, Nanoparticles, In Vitro Techniques

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