The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation
Abstract
Charged drug delivery systems are interesting candidates for the delivery of drugs through skin. In the present study, it was possible to create negatively and positively charged oil/water nanoemulsions by using sucrose laureate and polysorbate 80 as non-ionic surfactants. The positively charged nanoemulsions were generated by adding cationic phytosphingosine (PS). The relationship between the physicochemical properties of the nanoemulsions was shown by particle size and zeta potential measurements. These properties were dependent on the type of non-ionic surfactant and the concentration of PS. Furthermore the cationic PS had a positive impact on the skin permeation rates (flux) of the incorporated model drugs fludrocortisone acetate and flumethasone pivalate. An enhancement factor between 1.1 and 1.5 was obtained in relation to the control. The interaction of pre-impregnated porcine skin with positively and negatively charged nanoemulsions was confirmed by DSC analysis. The generated DSC-curves showed a slight difference in the phase transition temperature assigned to the characteristic lipid transition. However, it was not possible to assign the effect to one of the ingredients in the multicomponent system.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Citations
Cites
Formation and stability of nano-emulsions
Tadros, T. F., Izquierdo, P., Esquena, J., & Solans, C. (2003) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2003.10.023 · Cited by 2,040
Nanoemulsions: a new vehicle for skincare products
Sonneville-Aubrun, O., Simonnet, J., & L'Alloret, F. (2004) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2003.10.026 · Cited by 591
Paolino, D., Ventura, C. A., Nisticò, S. P., Puglisi, G., & Fresta, M. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00295-8 · Cited by 201
Carbamazepine parenteral nanoemulsions prepared by spontaneous emulsification process
Kelmann, R. G., Kuminek, G., Teixeira, H. F., & Koester, L. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.05.004 · Cited by 181
The enhancement effect of surfactants on the penetration of lorazepam through rat skin
Nokhodchi, A., Shokri, J., Dashbolaghi, A., Hassanzadeh, D., Ghafourian, T., & Barzegar-Jalali, M. (2003) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00554-9 · Cited by 159
Piemi, M. P. Y., Korner, D., Benita, S., & Marty, J.-P. (1999) · Journal of Controlled Release · doi:10.1016/s0168-3659(98)00156-4 · Cited by 149
Yilmaz, E., & Borchert, H. (2005) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2004.11.009 · Cited by 148
Final Report on the Safety Assessment of Lecithin and Hydrogenated Lecithin
Fiume, Z. (2001) · International Journal of Toxicology · doi:10.1080/109158101750300937 · Cited by 87
Skin permeation enhancement by sucrose esters: A pH-dependent phenomenon
Cázares-Delgadillo, J., Naik, A., Kalia, Y. N., Quintanar‐Guerrero, D., & Ganem-Quintanar, A. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.03.020 · Cited by 66
Calderilla-Fajardo, S. B., Cázares-Delgadillo, J., Villalobos-García, R., Quintanar‐Guerrero, D., Ganem-Quintanar, A., & Robles, R. (2006) · Drug Development and Industrial Pharmacy · doi:10.1080/03639040500388540 · Cited by 55
Cited by
Sorted by citations
McClements, D. J., & Rao, J. (2011) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2011.559558 · Cited by 1,695
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2)
Honary, S., & Zahir, F. (2013) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v12i2.20 · Cited by 1,310
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 1)
Honary, S., & Zahir, F. (2013) · Tropical Journal of Pharmaceutical Research · doi:10.4314/tjpr.v12i2.19 · Cited by 1,144
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135
Nanoparticles and microparticles for skin drug delivery
Prow, T. W., Grice, J. E., Lin, L. L., Faye, R., Butler, M. K., Becker, W. H., Wurm, E. M. T., Yoong, C., Robertson, T. A., Soyer, H. P., et al. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.012 · Cited by 885
Metadata
- Authors
- Hoeller, S., Sperger, A., & Valenta, C.
- Affiliations
- University of Vienna (AT)
- Corresponding author
- Valenta, Claudia
- ORCID
- Hoeller, Sonja
- Venue
- International Journal of Pharmaceutics
- Publisher
- Elsevier BV
- Published
- 2009-03-31
- Volume
- 370
- Issue
- 1-2
- Pages
- 181-186
- ISSN
- 0378-5173 (ISSN-L)
- OpenAlex
- W2135727032
- Cited by
- 179
- References
- 16
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 13 · 2023: 5 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 14 · 2018: 12 · 2017: 17 · 2016: 10 · 2015: 11 · 2014: 7 · 2013: 13 · 2012: 9
- FWCI
- 3.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Pharmaceutics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › Surfactants and Colloidal Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- nonionic surfactants, Tween 80, skin permeation, transdermal drug delivery, fludrocortisone acetate, flumethasone pivalate, particle size, zeta potential, porcine skin, lipid phase transition
- MeSH terms
- Administration, Topical, Animals, Anti-Inflammatory Agents, Calorimetry, Differential Scanning, Chemistry, Pharmaceutical, Drug Compounding, Drug Stability, Electrochemistry, Fludrocortisone, Flumethasone, Particle Size, Polysorbates, Skin, Skin Absorption, Solubility, Sphingosine, Sucrose, Surface-Active Agents, Swine, Drug Delivery Systems, Nanoparticles, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
