Cited by 119Advancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsNanoparticle-Based Drug Delivery

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles

Open access

Castro, Gisele A., Coelho, Anna Luíza L.R., Oliveira, Cleida A., Mahecha, Germán A.B., Oréfice, Rodrigo L., Ferreira, Lucas A.M.·2009·International Journal of Pharmaceutics

DOI 10.1016/j.ijpharm.2009.07.025

Open this paper in CoChat — free account Open PDF

Abstract

This work aims to investigate the influence of the formation of ion pairing between all-trans retinoic acid (RA) and a lipophilic amine (stearylamine; STE) on the drug encapsulation efficiency (EE) and stability of solid lipid nanoparticles (SLNs). The SLNs were characterized for EE and size. The EE and particle size were significantly improved and reduced, respectively, when the surfactant or co-surfactant concentration increased. However, while the formulation without STE allowed only 13% of RA encapsulation, the EE for RA-STE-loaded SLNs was 94%. The stability studies showed a significant decrease in EE for the SLNs without STE, while, for SLNs loaded with RA and STE, the EE remained constant after 360 days. The interactions among ion pairing components and the lipid matrix were investigated through small-angle X-ray scattering (SAXS). The SAXS analysis revealed the presence of RA in the crystalline form in SLNs without ion pairing, while crystalline RA was not observed in SLNs loaded with RA/amine. Skin irritation studies showed that the SLNs loaded with the ion pairing were significantly less irritating when compared to the marketed RA-cream. This novel SLN formulation represents a promising alternative for topical treatment of acne with RA.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.ijpharm.2009.07.025

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Solid lipid nanoparticles (SLN) for controlled drug delivery – a review of the state of the art
MÃ¼ller, R. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00087-4 · Cited by 3,836
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations
Müller, R. H., Radtke, M., & Wissing, S. A. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00118-7 · Cited by 2,116
Management of Acne
Gollnick, H. P. M., Cunliffe, W. J., Berson, D. S., Dréno, B., Finlay, A. Y., Leyden, J. J., Shalita, A. R., & Thiboutot, D. M. (2003) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2003.618 · Cited by 818
Lipid nanoparticles for improved topical application of drugs for skin diseases☆
SCHAFERKORTING, M., MEHNERT, W., & KORTING, H. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.006 · Cited by 614
Vitamin A-loaded solid lipid nanoparticles for topical use: drug release properties
Jenning, V., Schäfer‐Korting, M., & Gohla, S. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00223-0 · Cited by 548
Physicochemical characterization of lipid nanoparticles and evaluation of their drug loading capacity and sustained release potential
Westesen, K., Bunjes, H., & Koch, M. (1997) · Journal of Controlled Release · doi:10.1016/s0168-3659(97)00046-1 · Cited by 539
Solid lipid nanoparticles (SLN) of tretinoin: Potential in topical delivery
Shah, K. P., Date, A. A., Joshi, M. D., & Patravale, V. B. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.05.061 · Cited by 359
Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering☆
Bunjes, H., & Unruh, T. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.04.013 · Cited by 338
Encapsulation of retinoids in solid lipid nanoparticles (SLN)
Jenning, S. H. G. V. (2001) · Journal of Microencapsulation · doi:10.1080/02652040010000361 · Cited by 315
Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs
Hu, L., Tang, X., & Cui, F. (2004) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357044959 · Cited by 281

Show all 28 references

Research works printed but not linked: 2

Kayali, 1991, Interactions of retinoic acid with a model of stratum corneum lipids, J. Dermal. Clin. Eval. Soc., 2, 7
US Pharmacopoeia 26, 2003. US Pharmacopoeial Convention, Rockville, MD, pp. 1861–1862.

Sorted by citations

Nanoparticles and microparticles for skin drug delivery
Prow, T. W., Grice, J. E., Lin, L. L., Faye, R., Butler, M. K., Becker, W. H., Wurm, E. M. T., Yoong, C., Robertson, T. A., Soyer, H. P., et al. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.01.012 · Cited by 885
Nanotechnology based drug delivery system: Current strategies and emerging therapeutic potential for medical science
Sahu, T. A., Ratre, Y. K., Chauhan, S., Bhaskar, L. V., Nair, M. P., & Verma, H. K. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102487 · Cited by 518
Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: Current evidence from in vitro and in vivo evaluation
Doktorovová, S., Kovačević, A. B., García, M. L., & Souto, E. B. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.08.001 · Cited by 293
Nanocarrier-based topical drug delivery for the treatment of skin diseases
Gupta, M., Agrawal, U., & Vyas, S. P. (2012) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2012.686490 · Cited by 278
Hydrophobic ion pairing: encapsulating small molecules, peptides, and proteins into nanocarriers
Ristroph, K. D., & Prud’homme, R. K. (2019) · Nanoscale Advances · doi:10.1039/c9na00308h · Cited by 274
Nanoparticles Targeting Macrophages as Potential Clinical Therapeutic Agents Against Cancer and Inflammation
Hu, G., Guo, M., Xu, J., Wu, F., Fan, J., Huang, Q., Yang, G., Lv, Z., Wang, X., & Jin, Y. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01998 · Cited by 241
Nanoparticles in dermatology
Papakostas, D., Rancan, F., Sterry, W., Blume‐Peytavi, U., & Vogt, A. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1163-7 · Cited by 232
Nanoparticles for Topical Application in the Treatment of Skin Dysfunctions—An Overview of Dermo-Cosmetic and Dermatological Products
Raszewska-Famielec, M., & Flieger, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415980 · Cited by 208
Formulation optimization and topical delivery of quercetin from solid lipid based nanosystems
Bose, S., Du, Y., Takhistov, P., & Michniak‐Kohn, B. B. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.12.013 · Cited by 178
Development, characterization and in vivo assessment of effective lipidic nanoparticles for dermal delivery of fluconazole against cutaneous candidiasis
Gupta, M., & Vyas, S. P. (2012) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2012.01.006 · Cited by 158
High melting lipid based approach for drug delivery: Solid lipid nanoparticles
Kumar, S., & Randhawa, J. K. (2013) · Materials Science and Engineering C · doi:10.1016/j.msec.2013.01.037 · Cited by 152
Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine
Ferreira, R., Napoli, J., Enver, T., Bernardino, L., & Ferreira, L. (2020) · Nature Communications · doi:10.1038/s41467-020-18042-2 · Cited by 138
Self-citation
Applications and limitations of lipid nanoparticles in dermal and transdermal drug delivery via the follicular route
Lauterbach, A., & Müller-Goymann, C. C. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.06.020 · Cited by 133
New approach to improve encapsulation and antitumor activity of doxorubicin loaded in solid lipid nanoparticles
Mussi, S. V., Silva, R. C., Oliveira, M. C., Lucci, C. M., Azevedo, R. B., & Ferreira, L. A. M. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.10.025 · Cited by 113
Self-citation
Health benefits of phytochemicals from Brazilian native foods and plants: Antioxidant, antimicrobial, anti-cancer, and risk factors of metabolic/endocrine disorders control
de Carvalho, A. P. A., & Conte‐Júnior, C. A. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.006 · Cited by 115
Drug delivery vehicles with improved encapsulation efficiency: taking advantage of specific drug–carrier interactions
Kita‐Tokarczyk, K., & Dittrich, C. (2011) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2011.553216 · Cited by 107
Nanotechnology in Dermatology
Antonio, J. R., Antonio, C. R., Cardeal, I. L. S., Ballavenuto, J. M. A., & Oliveira, J. R. (2014) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20142228 · Cited by 107
Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review
Khater, D., Nsairat, H., Odeh, F., Saleh, M. M., Jaber, A. M., Alshaer, W., Bawab, A. A., & Mubarak, M. S. (2021) · Cosmetics · doi:10.3390/cosmetics8020039 · Cited by 108
Nanomaterials for transdermal drug delivery: beyond the state of the art of liposomal structures
Jijie, R., Barras, A., Boukherroub, R., & Szunerits, S. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02529g · Cited by 101
Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in in vivo study
Arantes, V. T., Faraco, A. A. G., Ferreira, F. B., Oliveira, C. A., Martins‐Santos, E., Vieira, P. C., Barcelos, L. S., Ferreira, L. A. M., & Goulart, G. A. C. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.110749 · Cited by 100
Self-citation
Squarticles as a Lipid Nanocarrier for Delivering Diphencyprone and Minoxidil to Hair Follicles and Human Dermal Papilla Cells
Aljuffali, I. A., Sung, C. T., Shen, F., Huang, C.-T., & Fang, J. (2013) · The AAPS Journal · doi:10.1208/s12248-013-9550-y · Cited by 92
Fabrication, characterization, and evaluation of microsponge delivery system for facilitated fungal therapy
Osmani, R. A. M., Moin, A., Deb, T., Bhosale, R. R., & Hani, U. (2016) · Journal of Basic and Clinical Pharmacy · doi:10.4103/0976-0105.177705 · Cited by 95
Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil
Padois, K., Cantiéni, C., Bertholle, V., Bardel, C., Pirot, F., & Falson, F. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.06.014 · Cited by 90
A retinyl palmitate-loaded solid lipid nanoparticle system: Effect of surface modification with dicetyl phosphate on skin permeation in vitro and anti-wrinkle effect in vivo
Jeon, H. S., Seo, J. E., Kim, M. S., Kang, M. H., Oh, D. H., Jeon, S. O., Jeong, S. H., Choi, Y. W., & Lee, S. K. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.05.023 · Cited by 94
Cationic solid lipid nanoparticles interfere with the activity of antioxidant enzymes in hepatocellular carcinoma cells
Doktorovová, S., Santos, D. L., Costa, I. H. D. S. E., Andreani, T., Souto, E. B., & Silva, A. M. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.05.011 · Cited by 83
A novel approach to oral iron delivery using ferrous sulphate loaded solid lipid nanoparticles
Zariwala, M. G., Elsaid, N., Jackson, T. L., López, F. C., Farnaud, S., Somavarapu, S., & Renshaw, D. W. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.08.070 · Cited by 82
Development of terbinafine solid lipid nanoparticles as a topical delivery system
Sheu, M., Chen, Liu, Chang, Ho, H., & Liu (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s33682 · Cited by 78
Co-encapsulation of imiquimod and copaiba oil in novel nanostructured systems: promising formulations against skin carcinoma
Venturini, C. G., Bruinsmann, F. A., Contri, R. V., da Fonseca, F. N., Frank, L. A., D'Amore, C. M., Raffin, R. P., Buffon, A., Pohlmann, A. R., & Guterres, S. S. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.08.016 · Cited by 75
Co-delivery of doxorubicin, docosahexaenoic acid, and α-tocopherol succinate by nanostructured lipid carriers has a synergistic effect to enhance antitumor activity and reduce toxicity
Lages, E. B., Fernandes, R. S., Silva, J. D. O., Malachias, Â., Cassali, G. D., de Barros, A. L. B., & Ferreira, L. A. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110876 · Cited by 71
Self-citation
Comedolytic effect and reduced skin irritation of a new formulation of all-trans retinoic acid-loaded solid lipid nanoparticles for topical treatment of acne
Goulart, G. A. C., Oliveira, C. A., Mahecha, G. A. B., & Ferreira, L. A. M. (2011) · Archives of Dermatological Research · doi:10.1007/s00403-011-1130-3 · Cited by 71
Self-citation
Preparation and Optimization of Triptolide-Loaded Solid Lipid Nanoparticles for Oral Delivery with Reduced Gastric Irritation
Zhang, C., Gu, C., Fan, P., Liu, W., Wan, J., Xu, H., Lam, C. W. K., & Yang, X. (2013) · Molecules · doi:10.3390/molecules181113340 · Cited by 71
Nanocarriers for Delivery of Antioxidants on the Skin
Vinardell, M. P., & Mitjans, M. (2015) · Cosmetics · doi:10.3390/cosmetics2040342 · Cited by 70
Lipid Nanoparticles for the Topical Delivery of Retinoids and Derivatives
Morales, J. O., Valdés, K., Morales, J. O., & Oyarzun-Ampuero, F. A. (2015) · Nanomedicine · doi:10.2217/nnm.14.159 · Cited by 67
Improved yeast delivery of fluconazole with a nanostructured lipid carrier system
Kelidari, H., Moazeni, M., Babaei, R., Saeedi, M., Âkbari, J., Parkoohi, P. I., Nabili, M., Gohar, A. A., Morteza‐Semnani, K., & Nokhodchi, A. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.008 · Cited by 67
Solid lipid nanoparticles for transdermal delivery of diclofenac sodium: preparation, characterization andin vitrostudies
Liu, D., Ge, Y., Tang, Y., Yuan, Y., Zhang, Q., Li, R., & Xu, Q. (2010) · Journal of Microencapsulation · doi:10.3109/02652048.2010.513456 · Cited by 66
Diclofenac sodium-loaded solid lipid nanoparticles prepared by emulsion/solvent evaporation method
Liu, D., Jiang, S., Shen, H., Qin, S., Liu, J., Zhang, Q., Li, R., & Xu, Q. (2010) · Journal of Nanoparticle Research · doi:10.1007/s11051-010-9998-y · Cited by 64
Inhalable Dual-Targeted Hybrid Lipid Nanocore–Protein Shell Composites for Combined Delivery of Genistein and All-Trans Retinoic Acid to Lung Cancer Cells
Kamel, N. M., Helmy, M. W., Abdelfattah, E.-Z. A., Khattab, S. N., Ragab, D., Samaha, M. W., Fang, J., & Elzoghby, A. O. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01374 · Cited by 62
Development of a topical adapalene-solid lipid nanoparticle loaded gel with enhanced efficacy and improved skin tolerability
Harde, H., Agrawal, A. K., Katariya, M., Kale, D. P., & Jain, S. (2015) · RSC Advances · doi:10.1039/c5ra06047h · Cited by 61
Comparative assessment of efficacy and safety potential of multifarious lipid based Tacrolimus loaded nanoformulations
Jain, S., Addan, R., Kushwah, V., Harde, H., & Mahajan, R. R. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.03.042 · Cited by 61
Development and characterization of polymeric nanoparticle-based formulation of adapalene for topical acne therapy
Ramezanli, T., Zhang, Z., & Michniak‐Kohn, B. B. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.08.008 · Cited by 59
Hydrophobic ion pairing as a strategy to improve drug encapsulation into lipid nanocarriers for the cancer treatment
Oliveira, M. S., Goulart, G. A. C., Ferreira, L. A. M., & Carneiro, G. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2017.1266329 · Cited by 57
Self-citation
Impact of nanostructured lipid carriers on dapsone delivery to the skin: in vitro and in vivo studies
Elmowafy, M., Shalaby, K., Ali, H. M., Alruwaili, N. K., Salama, A., Ibrahim, M. F., Akl, M. A., & Ahmed, T. A. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118781 · Cited by 57
Interplay of Drug–Polymer Interactions and Release Performance for HPMCAS-Based Amorphous Solid Dispersions
Bapat, P., Paul, S., Tseng, Y., & Taylor, L. S. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.3c01106 · Cited by 52
Minimization of Local and Systemic Adverse Effects of Topical Glucocorticoids by Nanoencapsulation: In Vivo Safety of Hydrocortisone–Hydroxytyrosol Loaded Chitosan Nanoparticles
Siddique, M. I., Katas, H., Amin, M. C. I. M., Ng, S., Zulfakar, M. H., Buang, F., & Jamil, A. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24666 · Cited by 54
The use of nanoencapsulation to decrease human skin irritation caused by capsaicinoids
Guterres, S. S., Contri, R. V., Frank, L. A., Kaiser, M., & Pohlmann, A. R. (2014) · International Journal of Nanomedicine · doi:10.2147/ijn.s56579 · Cited by 51
Advances in treatment formulations for acute myeloid leukemia
Briot, T., Roger, E., Thépot, S., & Lagarce, F. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.05.040 · Cited by 52
Solid lipid nanoparticles (SLN)
Campos, J. R. S., Severino, P. B., Santini, A., Silva, A. M., Shegokar, R., Souto, S. B., & Souto, E. B. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817778-5.00001-4 · Cited by 49
Lipid-based nanoparticles as drug delivery system for paclitaxel in breast cancer treatment
Marcial, S. P. D. S., Carneiro, G., & Leite, E. A. (2017) · Journal of Nanoparticle Research · doi:10.1007/s11051-017-4042-0 · Cited by 48
Nanocarriers as versatile delivery systems for effective management of acne
Patel, R., & Prabhu, P. S. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119140 · Cited by 47
Features, applications, and sustainability of lipid nanoparticles in cosmeceuticals
Assali, M., & Zaid, A. (2021) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2021.12.018 · Cited by 44
Solid Lipid Nanoparticles for Antifungal Drugs Delivery for Topical Applications
Trombino, S., Mellace, S., & Cassano, R. (2016) · Therapeutic Delivery · doi:10.4155/tde-2016-0040 · Cited by 46
Transdermal delivery system of nanostructured lipid carriers loaded with Celastrol and Indomethacin: optimization, characterization and efficacy evaluation for rheumatoid arthritis
Kang, Q., Liu, J., Zhao, Y., Liu, X., Liu, X., Wang, Y., Mo, N.-L., & Wu, Q. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1503599 · Cited by 43
Lipid nanoparticulate systems
Rawal, S. U., & Patel, M. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813687-4.00002-5 · Cited by 42
Fabrication and in-vivo evaluation of lipid nanocarriers based transdermal patch of colchicine
Joshi, S. A., Jalalpure, S. S., Kempwade, A. A., & Peram, M. R. (2017) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2017.08.013 · Cited by 39
Sclareol is a potent enhancer of doxorubicin: Evaluation of the free combination and co-loaded nanostructured lipid carriers against breast cancer
Borges, G. S. M., Silva, J. D. O., Fernandes, R. S., de Souza, A. M., Cassali, G. D., Yoshida, M. I., Leite, E. A., de Barros, A. L. B., & Ferreira, L. A. M. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116678 · Cited by 39
Self-citation
Formation of ion pairing as an alternative to improve encapsulation and anticancer activity of all-trans retinoic acid loaded in solid lipid nanoparticles
Ferreira, L. A. M., Carneiro, G., Silva, Pacheco, de Souza-Fagundes, E. M., Goes, Oliveira, M. C., & Correa (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s38953 · Cited by 38
Self-citation
Advances in biomimetic regeneration of elastic matrix structures
Balakrishnan, S., Bashur, C. A., & Ramamurthi, A. (2012) · Drug Delivery and Translational Research · doi:10.1007/s13346-012-0070-6 · Cited by 41
Percutaneous Absorption and Antibacterial Activities of Lipid Nanocarriers Loaded with Dual Drugs for Acne Treatment
Lin, C.-H., Fang, Y., Al‐Suwayeh, S. A., Yang, S.-Y., & Fang, J. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00793 · Cited by 36
A Comprehensive Review of the Strategies to Reduce Retinoid‐Induced Skin Irritation in Topical Formulation
Narsa, A. C., Suhandi, C., Afidika, J., Ghaliya, S., Elamin, K. M., & Wathoni, N. (2024) · Dermatology Research and Practice · doi:10.1155/2024/5551774 · Cited by 44
Potential Role of Growth Factors Controlled Release in Achieving Enhanced Neuronal Trans-differentiation from Mesenchymal Stem Cells for Neural Tissue Repair and Regeneration
Gupta, A., & Singh, S. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02646-w · Cited by 36
Solid Lipid Nanoparticles: A Potential Approach for Dermal Drug Delivery
Kakadia, P. G., & Conway, B. R. (2014) · American journal of pharmacological sciences · doi:10.12691/ajps-2-5a-1 · Cited by 32
Nanostructured lipid carriers loaded with tributyrin as an alternative to improve anticancer activity ofall-transretinoic acid
Silva, E. L., Carneiro, G., Caetano, P. A., Goulart, G. A. C., Costa, D. F. G., de Souza-Fagundes, E. M., Gomes, D. A., & Ferreira, L. A. M. (2015) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2015.1000868 · Cited by 28
Self-citation
A comparative histological study on the skin occlusion performance of a cream made of solid lipid nanoparticles and Vaseline.
Hamishehkar, H., Same, S., Adibkia, K., Zarza, K., Shokri, J., Taghaee, M., & Kouhsoltani, M. (2015) · Europe PMC (PubMed Central) · Cited by 26
Nanoencapsulated retinoic acid as a safe tolerogenic adjuvant for intranasal vaccination against cutaneous leishmaniasis
Bezerra, I., Souza, B. L. D. S. C., Carneiro, G., Ferreira, L. A. M., Guedes, H. L. D. M., & Rossi‐Bergmann, B. (2019) · Vaccine · doi:10.1016/j.vaccine.2019.05.043 · Cited by 24
Self-citation
Development and evaluation studies of Corylin loaded nanostructured lipid carriers gel for topical treatment of UV-induced skin aging
Zhao, Z., Liu, T., Zhu, S., Yang, Y. A., Wang, Z., Ma, H., Wang, X., Liu, T., Guo, P., Pi, J., et al. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111499 · Cited by 25
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment
Ebada, H. M. K., Nasra, M. M. A., Nassra, R. A., & Abdallah, O. Y. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2041130 · Cited by 22
Amphiphilic ion pairs of tobramycin with lipoamino acids
Pignatello, R., Mangiafico, A., Basile, L., Ruozi, B., & Furneri, P. M. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.02.015 · Cited by 22
All-trans retinoic acid in anticancer therapy: how nanotechnology can enhance its efficacy and resolve its drawbacks
Borges, G. S. M., Lima, F. A., Carneiro, G., Goulart, G. A. C., & Ferreira, L. A. M. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1919619 · Cited by 21
Self-citation
An intravenous clarithromycin lipid emulsion with a high drug loading, H-bonding and a hydrogen-bonded ion pair complex exhibiting excellent antibacterial activity
Gong, H., Geng, S., Zheng, Q., Wang, P., Luo, L., Wang, X., Zhang, Y., Zhang, Y. X., He, H., & Tang, X. (2016) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2016.04.002 · Cited by 18
pH-sensitive doxorubicin-tocopherol succinate prodrug encapsulated in docosahexaenoic acid-based nanostructured lipid carriers: An effective strategy to improve pharmacokinetics and reduce toxic effects
Lages, E. B., Fernandes, R. S., Andrade, M. M. S., Paiyabhroma, N., de Oliveira, R. B., Fernandes, C., Cassali, G. D., Sicard, P., Richard, S., de Barros, A. L. B., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112373 · Cited by 18
Self-citation
Ion Pair Strategy in Solid Lipid Nanoparticles: a Targeted Approach to Improve Epidermal Targeting with Controlled Adapalene Release, Resulting Reduced Skin Irritation
Rodrigues, L. B. O., Lima, F. A., Alves, C. P. B., Martins‐Santos, E., Aguiar, M. M. G. D., Oliveira, C. A., Oréfice, R. L., Ferreira, L. A. M., & Goulart, G. A. C. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02866-0 · Cited by 17
Self-citation
Preparation and characterization of oxybenzone-loaded solid lipid nanoparticles (SLNs) with enhanced safety and sunscreening efficacy: SPF and UVA-PF.
Ra, S., Ns, A. M., elBayoomy, T. S., & Aa, B. (2010) · PubMed · Cited by 17
Hyaluronic acid-coated nanoemulsions loaded with a hydrophobic ion pair of all-trans retinoic acid for improving the anticancer activity
Tinoco, L. M. D. S., da Silva, F. L. O., Ferreira, L. A. M., Leite, E. A., & Carneiro, G. (2018) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902018000417361 · Cited by 14
Self-citation
Clarithromycin ion pair in a liposomal membrane to improve its stability and reduce its irritation caused by intravenous administration
Geng, S., Liu, X., Xu, H., Cai, C., Zhang, Y., Yao, Q., Xu, H., Gou, J., Yin, T., Xiao, W., et al. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2016.1123247 · Cited by 13
Multicompartmental lipid–protein Nanohybrids for Combined tretinoin/herbal Lung Cancer Therapy
Kamel, N. M., Helmy, M. W., Samaha, M. W., Ragab, D., & Elzoghby, A. O. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0090 · Cited by 12
Recent Update on Nanoemulsion Impregnated Hydrogel: a Gleam into the Revolutionary Strategy for Diffusion-Controlled Delivery of Therapeutics
Rathee, J., Malhotra, S., Pandey, M., Jain, N., Kaul, S., Gupta, G., & Nagaich, U. (2023) · AAPS PharmSciTech · doi:10.1208/s12249-023-02611-x · Cited by 11
Histidine-based ionizable cationic surfactants: novel biodegradable agents for hydrophilic macromolecular drug delivery
Polidori, I., To, D., Kali, G., & Bernkop‐Schnürch, A. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01511-8 · Cited by 11
Physicochemical characterization and nanochemical analysis of ciprofloxacin hydrophobic ion Pairs for enhanced encapsulation in PLGA nanoparticle
Lee, J., Choi, M., Jeon, Y., Khanal, D., Lee, J., Kim, D., Chan, H., & Hwang, S. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125314 · Cited by 10
Nano-Encapsulated Antioxidant: Retinoic Acid as a Natural Mucosal Adjuvant for Intranasal Immunization against Chronic Experimental Toxoplasmosis
Said, D. E., Amer, E. I., Sheta, E., Makled, S., Arafa, F. M., & Diab, H. E. (2023) · Tropical Medicine and Infectious Disease · doi:10.3390/tropicalmed8020106 · Cited by 10
Nanostructured Lipid Carriers Enhances The Safety Profile of Tretinoin: In Vitro and Healthy Human Volunteers’ Studies
Lima, F. A., Vilela, R., Oréfice, R. L., Silva, I. R., Reis, E. C. O., Carvalho, L. A. D. C., Maria–Engler, S. S., Ferreira, L. A. M., & Goulart, G. A. C. (2021) · Nanomedicine · doi:10.2217/nnm-2021-0031 · Cited by 10
Self-citation
Bio-inspired apatite particles limit skin penetration of drugs for dermatology applications
Choimet, M., Tourrette, A., Marsan, O., Rassu, G., & Drouet, C. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.05.010 · Cited by 10
Characterization
Shah, R., Eldridge, D. S., Palombo, E. A., & Harding, I. H. (2014) · SpringerBriefs in pharmaceutical science & drug development · doi:10.1007/978-3-319-10711-0_4 · Cited by 10
Novel Self-Nanoemulsifying Drug-Delivery System Enhances Antileukemic Properties of All- Trans Retinoic Acid
Borges, G. S. M., Ferencs, M., Loures, C. D. M. G., Abdel-Salam, M. A. L., Evangelista, F. C. G., Sales, C. C., da Silva, P. H. R., de Oliveira, R. B., Malachias, Â., Yoshida, M. I., et al. (2020) · Nanomedicine · doi:10.2217/nnm-2020-0061 · Cited by 8
Self-citation
Development of D-α-Tocopherol polyethylene glycol 1000 succinate fabricated nanostructural lipid carrier of sorafenib tosylate for metastatic colorectal targeting application: Stability, physical characterization, cytotoxicity, and apoptotic studies against SW48 cells PTEN
Bhattacharya, S., Sharma, S., & Prajapati, B. G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.990841 · Cited by 8
Hyaluronate Targeted Solid Lipid Nanoparticles of Etoposide: Optimization and In Vitro Characterization
Varshosaz, J., Ghalaei, P. M., & Hassanzadeh, F. (2014) · Journal of Nanomaterials · doi:10.1155/2014/345845 · Cited by 8
Stałe nanocząsteczki lipidowe - charakterystyka, zastosowanie i otrzymywanie
Lasoń, E., & Ogonowski, J. (2011) · Chemik · Cited by 8
Development of levamlodipine long-acting patches based on an ion-pair strategy: Investigation of the mechanism for reducing skin irritation
Wu, J., Wang, J., Liu, J., Yang, M., Liu, C., Guo, J., & Fang, L. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124703 · Cited by 7
Impact of HPMCAS Grade on the Release of Weakly Basic Drugs from Amorphous Solid Dispersions
Bapat, P., & Taylor, L. S. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00986 · Cited by 7
Nanostructured lipid carriers as a novel tool to deliver sclareol: physicochemical characterisation and evaluation in human cancer cell lines
Borges, G. S. M., Prazeres, P. H. D. M., de Souza, A. M., Yoshida, M. I., Vilela, J. M. C., Silva, A. T. M. E., Oliveira, M. S., Gomes, D. A., Andrade, M. S., de Souza-Fagundes, E. M., et al. (2021) · Brazilian Journal of Pharmaceutical Sciences · doi:10.1590/s2175-97902020000418497 · Cited by 7
Self-citation
Determination of all-trans retinoic acid loaded in solid lipid nanoparticles by differential pulse voltammetry at glassy carbon electrode
da Silva, F. L. O., Tinoco, L. M. D. S., Ferreira, L. A. M., Malagutti, A. R., & Carneiro, G. (2015) · Electrochimica Acta · doi:10.1016/j.electacta.2015.10.018 · Cited by 6
Self-citation
Novel approaches in treatment of Acne vulgaris: Patents related to micro/nanoparticulated carrier systems
Sibinovska, N., Komoni, V., Netkovska, К. A., Vranić, E., Crcarevska, M. S., & Dodov, M. G. (2016) · Macedonian Pharmaceutical Bulletin · doi:10.33320/maced.pharm.bull.2016.62.02.001 · Cited by 6
Nanotechnology: Current Developments, Applications and Patents for Non-invasive Topical Cosmetics and Dermatological Therapeutic Delivery
Kumar, P., Mahor, A., Chaudhary, V., & Sharma, S. (2024) · Drug Delivery Letters · doi:10.2174/0122103031285090240418091630 · Cited by 6
Nanocarrier-mediated follicular targeting
Gökçe, B. B., & Güngör, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-822286-7.00015-2 · Cited by 6
Topical hydrogel formulation based on nano-aspasomes encapsulating Caffeic acid and Retinoic acid for antiaging effects
Shahid, M., Usman, F., & Abbas, S. R. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107360 · Cited by 5
Nanosystems with potential application as carriers for skin depigmenting actives
Castro, N. R., Pinto, C. D. S. C., dos Santos, E. P., & Mansur, C. R. E. (2024) · Nanotechnology · doi:10.1088/1361-6528/ad5a15 · Cited by 5
Topical Nanointerventions for Therapeutic and Cosmeceutical Applications
Patravale, V., & Desai, P. (2014) · Advances in delivery science and technology · doi:10.1007/978-1-4614-9434-8_24 · Cited by 3
Effect of Topical Application of Nano Retinol on Mild to Moderate Acne Vulgaris
El-Samahy, M., Sharara, M. A., & Elaziz, S. S. A. (2017) · The Egyptian Journal of Hospital Medicine · doi:10.12816/0038208 · Cited by 4
Silica Microparticles from Sugarcane By-Products as an Encapsulation System for Retinoids Aimed at Topical Sustained Release
Costa, J. R., Costa, A. H., Azevedo‐Silva, J., Tavares‐Valente, D., Sousa, S. C., Neto, T., Pintado, M., & Madureira, A. R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25063215 · Cited by 4
Nanomedicine in Dermatology: Nanotechnology in Prevention, Diagnosis, and Therapy
Hofmeier, K. S., & Surber, C. (2016) · doi:10.1002/9783527692057.ch16 · Cited by 4
In vitro and in vivo efficacy of a cosmetic product formulated with new lipid particles for the treatment of aged skin
Catalano, A., Mitri, K., Perugini, P., Condrò, G., & Sands, C. (2023) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.16016 · Cited by 12

Authors: Castro, G. A., Coelho, A. L. L. R., Oliveira, C. A., Mahecha, G. A. B., Oréfice, R. L., & Ferreira, L. A. M.
Affiliations: Universidade Federal de Minas Gerais (BR)
Corresponding author: Ferreira, Lucas A.M.
ORCID: Oliveira, Cleida A.
Mahecha, Germán A.B.
Oréfice, Rodrigo L.
Ferreira, Lucas A.M.
Venue: International Journal of Pharmaceutics
Publisher: Elsevier BV
Published: 2009-10
Volume: 381
Issue: 1
Pages: 77-83
ISSN: 0378-5173 (ISSN-L)
DOI: 10.1016/j.ijpharm.2009.07.025
OpenAlex: W2005760281
Cited by: 119
References: 28
Citations by year: 2025: 6 · 2024: 8 · 2023: 3 · 2022: 4 · 2021: 14 · 2020: 10 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 8 · 2015: 11 · 2014: 6 · 2013: 9 · 2012: 8
FWCI: 4.28
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 302 d)
Locations: International Journal of Pharmaceutics (publishedVersion)
PubMed (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Universidade Federal de Minas Gerais
Laboratório Nacional de Luz Síncrotron
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords: ion pairing, all-trans retinoic acid, solid lipid nanoparticles, octadecylamine, encapsulation efficiency, nanoparticle stability, skin irritation, topical retinoids, acne treatment
MeSH terms: Acne Vulgaris, Administration, Cutaneous, Amines, Animals, Chemistry, Pharmaceutical, Drug Stability, Emulsions, Exanthema, Excipients, Female, Mice, Hairless, Particle Size, Surface Properties, Surface-Active Agents, Tretinoin, X-Ray Diffraction, Drug Delivery Systems, Phase Transition, Mice, Nanoparticles, Scattering, Small Angle, Electrochemical Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Formation of ion pairing as an alternative to improve encapsulation and stability and to reduce skin irritation of retinoic acid loaded in solid lipid nanoparticles

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks