Lipid nanoparticles for improved topical application of drugs for skin diseases☆
Abstract
Due to the lower risk of systemic side effects topical treatment of skin disease appears favourable, yet the stratum corneum counteracts the penetration of xenobiotics into viable skin. Particulate carrier systems may mean an option to improve dermal penetration. Since epidermal lipids are found in high amounts within the penetration barrier, lipid carriers attaching themselves to the skin surface and allowing lipid exchange between the outermost layers of the stratum corneum and the carrier appear promising. Besides liposomes, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have been studied intensively. Here we describe the potential of these carrier systems and compare the dermal uptake from SLN and NLC to the one of alternative vehicle systems. A special focus is upon the interactions of active ingredients and the lipid matrix as well as the quantification of dermal penetration.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nanomaterials are better able to penetrate deeper skin layers because of their tiny size and precise optical properties, increasing product efficiency.
“Because of their tiny size and precise optical properties, nanomaterials are better able to penetrate deeper skin layers, which increases product efficiency.”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [70]
Using nanomaterials in cosmetic formulations has benefits including lower constituent amounts, reduced toxicity, and improved stability of active ingredients.
“Other benefits of using them in cosmetic product formulations include lower constituent amounts, reduced toxicity (some nanomaterials have antioxidant properties), and improved stability of the active ingredients [70].”
From AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY (2025) · cites this paper as [70]
Cites
Weerheim, A., & Ponec, M. (2001) · Archives of Dermatological Research · doi:10.1007/s004030100212 · Cited by 302 · see citing works
Dreher, F., Fouchard, F., Patouillet, C., Andrian, M., Simonnet, J.-T., & Benech-Kieffer, F. (2002) · Skin Pharmacology and Physiology · doi:10.1159/000066680 · Cited by 71 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products
Pardeike, J., Hommoss, A., & Müller, R. H. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.10.003 · Cited by 1,478 · see citing works
A brief review on solid lipid nanoparticles: part and parcel of contemporary drug delivery systems
Duan, Y., Dhar, A., Patel, C., Khimani, M., Neogi, S., Sharma, P., Siva Kumar, N., & Vekariya, R. L. (2020) · RSC Advances · doi:10.1039/d0ra03491f · Cited by 614 · see citing works
Rancan, F., Papakostas, D., Hadam, S., Hackbarth, S., Delair, T., Primard, C., Verrier, B., Sterry, W., Blume-Peytavi, U., & Vogt, A. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9919-x · Cited by 249 · see citing works
Pharmaceutical nanotechnology: from the bench to the market
Mazayen, Z. M., Ghoneim, A. M., Elbatanony, R. S., Basalious, E. B., & Bendas, E. R. (2022) · Future Journal of Pharmaceutical Sciences · doi:10.1186/s43094-022-00400-0 · Cited by 208 · see citing works
Cirri, M., Bragagni, M., Mennini, N., & Mura, P. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2011.07.015 · Cited by 155 · see citing works
Castro, G. A., Coelho, A. L. L. R., Oliveira, C. A., Mahecha, G. A. B., Oréfice, R. L., & Ferreira, L. A. M. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.07.025 · Cited by 119 · see citing works
Niculae, G., Lacatusu, I., Badea, N., Stan, R., Vasile, B. S., & Meghea, A. (2014) · Photochemical & Photobiological Sciences · doi:10.1039/c3pp50290b · Cited by 60 · see citing works
Landriscina, A., Rosen, J., & Friedman, A. (2015) · Cosmetics · doi:10.3390/cosmetics2020177 · Cited by 20 · see citing works
AN OVERVIEW OF NEW TRENDS IN THE COSMETICS INDUSTRY
JBOUR, N. D. A. (2025) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2025v17i3.53320 · Cited by 6 · see citing works
“Other benefits of using them in cosmetic product formulations include lower constituent amounts, reduced toxicity (some nanomaterials have antioxidant properties), and improved stability of the active ingredients [70].”
- Authors
- SCHAFERKORTING, M., MEHNERT, W., & KORTING, H.
- Affiliations
- Freie Universität Berlin (DE)
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2007-07-10
- Volume
- 59
- Issue
- 6
- Pages
- 427-443
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2028761028
- Cited by
- 614
- References
- 2
- Citations by year
- 2026: 15 · 2025: 29 · 2024: 21 · 2023: 30 · 2022: 27 · 2021: 38 · 2020: 55 · 2019: 38 · 2018: 27 · 2017: 43 · 2016: 53 · 2015: 32 · 2014: 39 · 2013: 28 · 2012: 46
- FWCI
- 16.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- lipid nanoparticles, topical drug delivery, skin diseases, skin penetration, stratum corneum, solid lipid nanoparticles, nanostructured lipid carriers, liposomes, lipid exchange, percutaneous absorption, drug-lipid interactions
- MeSH terms
- Administration, Topical, Animals, Drug Carriers, Pharmaceutical Preparations, Humans, Lipids, Skin Absorption, Skin Diseases, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
