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Cited by 561Spectroscopy and Chemometric AnalysesSpectroscopy Techniques in Biomedical and Chemical ResearchAnalytical Methods in Pharmaceuticals

The DOI matches its Crossref record; 111 of the 112 references it cites were found in a registry or an index.

Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

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De Beer, T., Burggraeve, A., Fonteyne, M., Saerens, L., Remon, J.P., Vervaet, C.·2011·International Journal of Pharmaceutics
DOI 10.1016/j.ijpharm.2010.12.012
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Abstract

Within the Process Analytical Technology (PAT) framework, it is of utmost importance to obtain critical process and formulation information during pharmaceutical processing. Process analyzers are the essential PAT tools for real-time process monitoring and control as they supply the data from which relevant process and product information and conclusions are to be extracted. Since the last decade, near infrared (NIR) and Raman spectroscopy have been increasingly used for real-time measurements of critical process and product attributes, as these techniques allow rapid and nondestructive measurements without sample preparations. Furthermore, both techniques provide chemical and physical information leading to increased process understanding. Probes coupled to the spectrometers by fiber optic cables can be implemented directly into the process streams allowing continuous in-process measurements. This paper aims at reviewing the use of Raman and NIR spectroscopy in the PAT setting, i.e., during processing, with special emphasis in pharmaceutics and dosage forms.

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Show all 112 references

Research works printed but not linked: 5

  1. Ciurczak, 1986, Determination of particle size of pharmaceutical raw materials using near infrared reflectance spectroscopy, Spectroscopy, 1, 36
  2. Cogdill, 2004, Using NIR spectroscopy as an integrated PAT tool, Spectroscopy, 19, 104
  3. Johansson, 2003, Raman spectroscopy opening the PAT toolbox, Eur. Pharm. Rev., 8, 36
  4. List, 1996, Supervising and controlling of granulation processes by near-infrared spectroscopy, Pharm. Ind., 58, 347
  5. Radtke, 1999, Near infrared (NIR) spectroscopy: fundamentals and application from a pharmaceutical point, Pharm. Ind., 61, 848

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Metadata

Authors
De Beer, T., Burggraeve, A., Fonteyne, M., Saerens, L., Remon, J. P., & Vervaet, C.
Affiliations
Ghent University (BE)
ORCID
Venue
International Journal of Pharmaceutics
Publisher
Elsevier BV
Published
2011-09
Volume
417
Issue
1-2
Pages
32-47
ISSN
0378-5173 (ISSN-L)
DOI
10.1016/j.ijpharm.2010.12.012
OpenAlex
W2083259132
Cited by
559
References
112
Citations by year
2026: 22 · 2025: 37 · 2024: 35 · 2023: 27 · 2022: 32 · 2021: 56 · 2020: 28 · 2019: 37 · 2018: 45 · 2017: 45 · 2016: 41 · 2015: 39 · 2014: 38 · 2013: 37 · 2012: 32
FWCI
2.72
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Journal of Pharmaceutics (publishedVersion)
  • PubMed (publishedVersion)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
  • Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
Keywords
near-infrared spectroscopy, Raman spectroscopy, process analytical technology, real-time process monitoring, pharmaceutical manufacturing, optical fiber probe, pharmaceutical dosage forms, non-destructive measurement
MeSH terms
Chemistry, Pharmaceutical, Dosage Forms, Quality Control, Spectrum Analysis, Raman, Technology, Pharmaceutical, Spectroscopy, Near-Infrared

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