Cited by 561Spectroscopy and Chemometric AnalysesSpectroscopy Techniques in Biomedical and Chemical ResearchAnalytical Methods in Pharmaceuticals

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Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

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De Beer, T., Burggraeve, A., Fonteyne, M., Saerens, L., Remon, J.P., Vervaet, C.·2011·International Journal of Pharmaceutics

DOI 10.1016/j.ijpharm.2010.12.012

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Abstract

Within the Process Analytical Technology (PAT) framework, it is of utmost importance to obtain critical process and formulation information during pharmaceutical processing. Process analyzers are the essential PAT tools for real-time process monitoring and control as they supply the data from which relevant process and product information and conclusions are to be extracted. Since the last decade, near infrared (NIR) and Raman spectroscopy have been increasingly used for real-time measurements of critical process and product attributes, as these techniques allow rapid and nondestructive measurements without sample preparations. Furthermore, both techniques provide chemical and physical information leading to increased process understanding. Probes coupled to the spectrometers by fiber optic cables can be implemented directly into the process streams allowing continuous in-process measurements. This paper aims at reviewing the use of Raman and NIR spectroscopy in the PAT setting, i.e., during processing, with special emphasis in pharmaceutics and dosage forms.

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Authors: De Beer, T., Burggraeve, A., Fonteyne, M., Saerens, L., Remon, J. P., & Vervaet, C.
Affiliations: Ghent University (BE)
ORCID: Fonteyne, M.
Saerens, L.
Vervaet, C.
Venue: International Journal of Pharmaceutics
Publisher: Elsevier BV
Published: 2011-09
Volume: 417
Issue: 1-2
Pages: 32-47
ISSN: 0378-5173 (ISSN-L)
DOI: 10.1016/j.ijpharm.2010.12.012
OpenAlex: W2083259132
Cited by: 559
References: 112
Citations by year: 2026: 22 · 2025: 37 · 2024: 35 · 2023: 27 · 2022: 32 · 2021: 56 · 2020: 28 · 2019: 37 · 2018: 45 · 2017: 45 · 2016: 41 · 2015: 39 · 2014: 38 · 2013: 37 · 2012: 32
FWCI: 2.72
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: International Journal of Pharmaceutics (publishedVersion)
PubMed (publishedVersion)
Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
Topics: Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
Keywords: near-infrared spectroscopy, Raman spectroscopy, process analytical technology, real-time process monitoring, pharmaceutical manufacturing, optical fiber probe, pharmaceutical dosage forms, non-destructive measurement
MeSH terms: Chemistry, Pharmaceutical, Dosage Forms, Quality Control, Spectrum Analysis, Raman, Technology, Pharmaceutical, Spectroscopy, Near-Infrared

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Near infrared and Raman spectroscopy for the in-process monitoring of pharmaceutical production processes

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